34 results on '"Xiu-fen, Qu"'
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2. Association of AGTR1 and ACE2 gene polymorphisms with structural atrial fibrillation in a Chinese Han population
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Wei, Feng, Lin, Sun, and Xiu-Fen, Qu
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Aged, 80 and over ,Male ,China ,Chromosomes, Human, X ,Polymorphism, Genetic ,Genotype ,Middle Aged ,Peptidyl-Dipeptidase A ,Polymorphism, Single Nucleotide ,Receptor, Angiotensin, Type 1 ,Electrocardiography ,Gene Frequency ,Atrial Fibrillation ,Humans ,Female ,Angiotensin-Converting Enzyme 2 ,Alleles ,Aged - Abstract
The renin-angiotensin system (RAS) is thought to play an important role in atrial fibrillation (AF). The RAS contains the ACE/AngII/AGTR1 axis and the ACE2/Ang(1-7)/MAS axis, which restrict each other via mutual antagonism and regulate myocardial hypertrophy, fibrosis and remodelling. The aim of our study was to investigate the association between single nucleotide polymorphisms (SNPs) in angiotensin-II type-1 receptor (AGTR1) and angiotensin-converting enzyme 2 (ACE2) and structural AF in a Chinese Han population. The SNPs (rs1492100, rs1492099, rs1492097, rs3772616) in AGTR1 and the SNP rs6632677 in ACE2 were compared in 300 structural AF patients (67.61±12.56 years) and 300 controls (66.08±12.47 years). The genotype frequencies of SNP rs1492099 in AGTR1 in the structural AF cohort vs controls were as follows: GG, 72.7 vs 83.0%; AG 26.0 vs 16.3%; AA 1.3 vs 0.7% (P=0.009). The frequency of the minor allele of SNP rs1492099 in AGTR1 was 14.2% in the structural AF group compared with 8.8% in the controls (t=0.004; odds ratio [OR], 1.727; 95% confidence interval [CI]: 1.154-2.487). In addition, the genotype frequencies of SNP rs6632677 in ACE2 in the structural AF male patients vs male controls were as follows: GG, 70.5 vs 83.1%; CG 26.3 vs 15.6%; and CC 3.2 vs 1.3% (P=0.029). The frequency of the minor allele of SNP rs6632677 in ACE2 was 16.3% in structural AF male patients compared with 9.1% in male controls (P=0.008; OR, 1.954; 95%CI: 1.196-3.192). Furthermore, we found an interaction between the SNP rs6632677 in ACE2 and the SNPs (rs1492100/rs1492099/rs3772616) in AGTR1 in structural AF patients by the multifactor dimensionality reduction (MDR) method. The results indicate that polymorphism rs1492099 in the AGTR1 gene is associated with structural AF in a Chinese Han population. It was hypothesized that the ACE2 gene, which maps to the X chromosome, may be correlated with the risk of structural AF in a Chinese Han male population. Furthermore, we found an interaction between ACE2 and AGTR1 in structural AF patients in a Chinese Han population. more...
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- 2018
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3. Effects of Rosuvastatin on Serum Asymmetric Dimethylarginine Levels and Atrial Structural Remodeling in Atrial Fibrillation Dogs
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Jingjie Li, Xiu-fen Qu, Wei Feng, and Wei Xia
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medicine.medical_specialty ,business.industry ,nutritional and metabolic diseases ,Atrial fibrillation ,General Medicine ,Interstitial fibrosis ,Structural remodeling ,medicine.disease ,Nitric oxide ,chemistry.chemical_compound ,Rosuvastatin Calcium ,chemistry ,Apoptosis ,Internal medicine ,cardiovascular system ,medicine ,Cardiology ,Rosuvastatin ,Cardiology and Cardiovascular Medicine ,Asymmetric dimethylarginine ,business ,medicine.drug - Abstract
Background: Circulating asymmetric dimethylarginine (ADMA), an endogenous nitric oxide synthase inhibitor, is increased in atrial fibrillation (AF). The purpose of this study was to investigate the effects of rosuvastatin on serum ADMA levels and atrial structural remodeling in AF dogs induced by chronic rapid atrial pacing. Methods: Twenty dogs were randomly divided into the sham-operated (n = 6), control (n = 7), or rosuvastatin (n = 7) groups. Sustained AF was induced by rapid pacing of the right atrium at 400 beats per minute for 6 weeks. Rosuvastatin was administered orally (1 mg/kg d) for 3 days before rapid pacing and was continued for 6 weeks. Transthoracic and transesophageal echocardiography were performed to detect left atrial structure and function. Serum levels of nitric oxide and ADMA were measured. Interstitial fibrosis and cardiomyocyte apoptosis in the atria were also identified. Results: After 6 weeks, compared with the control group, dramatic smaller left atrium and left atrial appendage volumes and higher atrial contractile function were observed in the rosuvastatin group. Serum nitric oxide concentration was increased, whereas ADMA was decreased in the rosuvastatin group compared with the control group. The percentages of interstitial fibrosis and atrial apoptosis in the control group were significantly higher than those in the sham-operated group, and rosuvastatin attenuated these changes induced by atrial rapid pacing. Conclusion: A short course of rosuvastatin treatment decreased apoptosis and prevented atrial structural remodeling in association with a decrease in ADMA levels in AF dogs. PACE 2012; 35:456–464) more...
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- 2012
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4. Parasympathetic and substance P-immunoreactive nerve denervation in atrial fibrillation models
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Jiu Yang Jiang, Guang Yu, Xiu Fen Qu, Li Liu, and Yang Yu
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Male ,medicine.medical_specialty ,Sympathetic Nervous System ,Substance P ,Baroreflex ,Pathology and Forensic Medicine ,chemistry.chemical_compound ,Dogs ,GAP-43 Protein ,Internal medicine ,Atrial Fibrillation ,Parasympathectomy ,medicine ,Animals ,Heart Atria ,Neurons ,Denervation ,Neurotransmitter Agents ,Atrial Septum ,Atrial pacing ,business.industry ,Cardiac Pacing, Artificial ,Heart ,Atrial fibrillation ,General Medicine ,medicine.disease ,Disease Models, Animal ,medicine.anatomical_structure ,chemistry ,Anesthesia ,cardiovascular system ,Cardiology ,Right atrium ,Immunohistochemistry ,Female ,Cardiology and Cardiovascular Medicine ,business ,Biomarkers ,Sprouting - Abstract
Recent studies demonstrated that atrial fibrillation (AF) induced heterogeneous sympathetic hyperinnervation and baroreflex impartation, but the changes of vagal and afferent nerve are not clear.Six dogs underwent atrial pacing at 600 beats/min (AF group). All paced dogs developed sustained AF by 5 weeks of pacing. Tissues from six healthy dogs were used as controls. Immunohistochemistry staining of cardiac nerves was performed using anti-growth-associated protein 43 (anti-GAP43), anti-tyrosine hydroxylase, antiacetylcholine (anti-ACh), and anti-substance P (anti-SP) antibodies.In AF group, the density of GAP43-positive in the right atrium (RA), atrial septum (AS), and left atrium (LA) was 5590.24±1417.51, 8083.22±1271.39, and 10854.56±1877.56 μm(2)/mm(2), respectively, which was significantly (P.01) higher than the control group. Most of the newly sprouting nerves are sympathetic nerve. Sympathetic nerve density in AF group was significantly higher than that of control group (P.001). Whereas denervation of parasympathetic and SP-immunoreactive nerve occurred in AF group. In the dogs with AF, the density of ACh-positive nerve in the RA, AS, and LA was 506.04±104.44, 317.72±84.10, and 114.9±29. 62 μm(2)/mm(2), respectively, which was lower than the control group (P.01). At the same time, the density of SP-positive nerve in the atria of AF dogs was also significantly lower than the control tissues (P.01).AF led to significant nerve sprouting and sympathetic hyperinnervation in the canine models, but the newly sprouting nerve did not include parasympathetic and SP-immunoreactive nerve. Heterogeneous parasympathetic and SP-immunoreactive nerve denervation occurred in the AF dogs. more...
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- 2012
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5. Effects of Rosuvastatin on Asymmetric Dimethylarginine Levels and Early Atrial Fibrillation Recurrence after Electrical Cardioversion
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Xiu-fen Qu, Wei Xia, Ying Song, Jingjie Li, and Zuomin Yin
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Male ,medicine.medical_specialty ,Heart disease ,Electric Countershock ,Arginine ,chemistry.chemical_compound ,Recurrence ,Left atrial ,Internal medicine ,Atrial Fibrillation ,medicine ,Humans ,Rosuvastatin ,Rosuvastatin Calcium ,Aged ,Sulfonamides ,business.industry ,Atrial fibrillation ,General Medicine ,Middle Aged ,medicine.disease ,Confidence interval ,Fluorobenzenes ,Electrical cardioversion ,Pyrimidines ,chemistry ,Relative risk ,Cardiology ,Female ,Hydroxymethylglutaryl-CoA Reductase Inhibitors ,Cardiology and Cardiovascular Medicine ,Asymmetric dimethylarginine ,business ,Follow-Up Studies ,medicine.drug - Abstract
High levels of asymmetric dimethylarginine (ADMA) are associated with an increased risk of early recurrence of atrial fibrillation (AF) after electrical cardioversion. We aimed to investigate the effects of rosuvastatin on serum ADMA levels and early recurrence of AF following successful electrical cardioversion.A total of 64 patients with persistent AF, but without known heart disease, who underwent elective electrical cardioversion were randomized to the rosuvastatin (group I, n = 32) and control (group II, n = 32) groups. The end point was the recurrence of AF during the 3 months of follow-up.The baseline ADMA levels were not different between the two groups. At the end of follow-up, serum ADMA levels in group I decreased compared with the baseline levels, whereas no significant change occurred in group II. During the follow-up, five patients in group I (15.6%) and 13 in group II (40.6%) had AF recurrence (P0.05, log-rank test). With the Cox proportional model, the predictors of recurrence included ageor =65 years, left atrial diameter45 mm, and baseline ADMA levelsor =2.0 micromol/l. Rosuvastatin was associated with a reduced risk of AF recurrence (relative risk 0.35, 95% confidence interval 0.12-0.96, P0.05).Rosuvastatin decreased the early recurrence of AF following successful electrical cardioversion with reduced ADMA levels. more...
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- 2009
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6. Variance of Peptidic Nerve Innervation in a Canine Model of Atrial Fibrillation Produced by Prolonged Atrial Pacing
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Jiuyang Jiang, Bing Bai, Yang Yu, Ying Song, Xiu-fen Qu, and Hong Guo
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Denervation ,medicine.medical_specialty ,Atrial pacing ,business.industry ,Vasoactive intestinal peptide ,Atrial fibrillation ,General Medicine ,medicine.disease ,Neuropeptide Y receptor ,Nerve sprouting ,Endocrinology ,Left atrial ,Internal medicine ,Medicine ,Cardiology and Cardiovascular Medicine ,business ,Canine model - Abstract
BACKGROUND Long-term rapid atrial pacing may result in nerve sprouting and sympathetic hyperinnervation in atrial fibrillation (AF) in dogs. Whether peptidic nerve is involved in neural remodeling is unclear. METHOD AND RESULTS We performed rapid left atrial pacing in six dogs to induce sustained AF. Tissues from six healthy dogs were used as controls. Nerve was identified by immunocytochemical techniques. The degree of nerve innervation was quantified by measuring the amount of staining area for each antibody and the heterogeneity of nerve distribution was qualitatively studied. In dogs with AF, the density of growth-associated protein 43 (GAP43) immunopositivenerve fibers in the left atrium (LA), atrial septum (AS), and right atrium (RA) was significantly (19,454.31 +/- 1,592.81 microm(2)/mm(2) vs 1,673.41 +/- 142.62 microm(2)/mm(2)P < 0.001, 3,931.26 +/- 361.78 microm(2)/mm(2) vs 1,614.20 +/- 140. 41 microm(2)/mm(2) P < 0.05 and 2,324.15 +/- 1,123.77 microm(2)/mm(2) vs 1,620.47 +/- 189.05 microm(2)/mm(2) P < 0.05, respectively) higher than the nerve density in control tissues. The density of (neuropeptide Y) NPY-positive nerves in the, AS, and RA was (13,547.62 +/- 2,983.37 microm(2)/mm(2) vs 703.72 +/- 287.52 microm(2)/mm(2) P < 0.01, 2,689.22 +/- 340.93 microm(2)/mm(2) vs 651.7 +/- 283.02 microm(2)/mm(2) P < 0.01 and 1,574.70 +/- 424.37 microm(2)/mm(2) vs 580.42 +/- 188.12 microm(2)/mm(2) P < 0.001, respectively) higher than the nerve density in control tissues. At the same time, vasoactive intestinal polypeptide (VIP) positive nerve innervation shrank in dogs with AF. The density of VIP positive in LA, AS, and RA was statistically lower than the nerve density in control tissues, respectively. (110.48 +/- 45.63microm(2)/mm(2) vs 1679.32 +/- 1020.34microm(2)/mm(2) P < 0.01, 265.92 +/- 52.51 microm(2)/mm(2) vs 2602.68 +/- 1257.16microm(2)/mm(2) P < 0.001 and 609.56 +/- 139.75microm(2)/mm(2) vs 2771.68 +/- 779.08microm(2)/mm(2) P < 0.01, respectively). CONCLUSIONS Combined with VIP-ergic nerve denervation, significant nerve sprouting and NPY-ergic nerve hyperinnervation are present in a canine model of sustained AF produced by prolonged atrial pacing. more...
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- 2008
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7. Arsenic trioxide eluting stent reduces neointima formation in a rabbit iliac artery injury model
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Wei Yang, Aijun Sun, Xue-bo Liu, Yonglin Huang, Hong-ling Liu, Weimin Li, Junbo Ge, Xiu-fen Qu, Kan Zhao, and Yunzeng Zou
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Male ,Neointima ,medicine.medical_specialty ,Paclitaxel ,Physiology ,medicine.medical_treatment ,Myocytes, Smooth Muscle ,Urology ,Apoptosis ,Iliac Artery ,Arsenicals ,Muscle, Smooth, Vascular ,Blood Vessel Prosthesis Implantation ,chemistry.chemical_compound ,Arsenic Trioxide ,Coated Materials, Biocompatible ,Restenosis ,Physiology (medical) ,Angioplasty ,medicine ,Animals ,Cell Proliferation ,Neointimal hyperplasia ,Antibiotics, Antineoplastic ,Hyperplasia ,business.industry ,Cell Cycle ,Stent ,Oxides ,Flow Cytometry ,equipment and supplies ,medicine.disease ,Tunica intima ,Growth Inhibitors ,Surgery ,medicine.anatomical_structure ,chemistry ,Drug-eluting stent ,Models, Animal ,Microscopy, Electron, Scanning ,Stents ,Rabbits ,Tunica Intima ,Cardiology and Cardiovascular Medicine ,business - Abstract
Objective: In-stent restenosis is caused by the neointimal hyperplasia, which involves abnormal growth of vascular smooth muscle cells (VSMC). Arsenic trioxide (As2O3) is known to be a potent inhibitor of cell proliferation. We therefore studied the role of an As2O3 eluting stent in the prevention of restenosis in a rabbit iliac artery model. Methods and results: Bare stents, or stents coated with poly-l-lactic acid (PLLA) and either 40 μg of As2O3, 180 μg of paclitaxel or vehicle were implanted into the left proximal iliac arteries of New Zealand rabbits. The delivery of drugs from stents in vitro and in vivo was evaluated by atomic fluorescence spectrophotometry and high-performance liquid chromatography, respectively. Histomorphometric measurements at 7 or 28 days showed that, comparing to rabbits receiving the PLLA stent, in animals treated with As2O3 eluting or paclitaxel eluting stent neointima thickness was reduced by 50% and 46%, the absolute neointimal area was reduced by 53% and 44%, while the absolute luminal area was increased by 46% and 43%, respectively. There were no significant differences in injury or inflammation scores among PLLA, As2O3 eluting and paclitaxel eluting stents. As2O3 eluting stent induced more TUNEL-positive VSMC than the other stents. As2O3 levels measured in the arterial tissue were much higher than those in serum, which were nearly undetectable at 7 days after stent implantation. In in vitro studies, cultured rabbit arterial VSMC were stimulated with As2O3 or paclitaxel and analyzed for their cell cycle progression and apoptosis by flow cytometry and electron microscopy. As2O3 treatment resulted in a reduction of VSMC number in G1 phase with a concomitant increase in apoptosis of VSMC, whereas paclitaxel treatment led to blocking of VSMC in the G2/M phase. Conclusion: In a rabbit iliac artery model PLLA coated As2O3 eluting stent significantly suppressed in-stent restenosis by reducing proliferation and inducing apoptosis of VSMC. more...
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- 2006
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8. Prognostic significance of heart rate turbulence parameters in patients with chronic heart failure
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Zhao-Jun Wang, Wei Qiu, Lin Sun, Hong-Yu Xie, Xiu-fen Qu, De-Chun Yin, Wei Feng, and Shuai Guo
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Adult ,Male ,medicine.medical_specialty ,Time Factors ,Kaplan-Meier Estimate ,Severity of Illness Index ,Ventricular Function, Left ,Heart rate turbulence ,Heart Rate ,Predictive Value of Tests ,Risk Factors ,Internal medicine ,Heart rate ,medicine ,Humans ,cardiovascular diseases ,Aged ,Proportional Hazards Models ,Angiology ,Aged, 80 and over ,Heart Failure ,Chi-Square Distribution ,Ejection fraction ,Proportional hazards model ,business.industry ,Arrhythmias, Cardiac ,Stroke Volume ,Stroke volume ,Middle Aged ,Prognosis ,medicine.disease ,Echocardiography, Doppler ,Chronic heart failure ,humanities ,Case-Control Studies ,Predictive value of tests ,Heart failure ,Chronic Disease ,Multivariate Analysis ,Electrocardiography, Ambulatory ,cardiovascular system ,Cardiology ,Female ,Cardiology and Cardiovascular Medicine ,business ,Research Article ,circulatory and respiratory physiology - Abstract
Background This study is aimed to evaluate the clinical significance of heart rate turbulence (HRT) parameters in predicting the prognosis in patients with chronic heart failure (CHF). Methods From June 2011 to December 2012, a total of 104 CHF patients and 30 healthy controls were enrolled in this study. We obtained a 24-hour Holter ECG recording to assess the HRT parameters, included turbulence onset (TO), turbulence slope (TS), standard deviation of N-N intervals (SDNN), and resting heart rate (RHR). The relationships between HRT parameters and the prognosis of CHF patients were determined. Results The assessment follow-up period lasted until January 31, 2013. The overall mortality of CHF patients was 9.6% (10/104). Our results revealed that CHF patients had higher levels of TO than those of healthy subjects, but the TS levels of CHF patients were lower than that of the control group. CHF patients with NYHA grade IV had higher HRT1/2 rate than those with NYHA grade II/III. There were statistical differences in TS, LVEF, SDNN and RHR between the non-deteriorating group and the non-survivor group. Significant differences in TS among the three groups were also found. Furthermore, CHF patients in the non-survivor group had lower levels of TS than those in the deteriorating group. Correlation analyses indicated that TO negatively correlate with SDNN, while TS positively correlated with SDNN and left ventricular ejection fraction (LVEF). We also observed negative correlations between TS and left ventricular end-diastolic cavity dimension (LVEDD), RHR, homocysteine (Hcy) and C-reactive protein (CRP). Multivariate Cox regression analysis further confirmed that LVEF (≤30%), HRT2, SDNN and RHR were independent risk factors which can indicate poor prognosis in CHF patients. Conclusions Our findings indicate that HRT may have good clinical predictive value in patients with CHF. Thus, quantifying HRT parameters could be a useful tool for predicting mortality in CHF patients. more...
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- 2014
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9. Relationship between c-reactive protein and the asymmetric dimethylarginine-induced endothelial dysfunction pathway in vasospastic angina
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Wei, Feng, Lin, Sun, Ying, Song, and Xiu-Fen, Qu
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Male ,Brachial Artery ,Smoking ,Coronary Vasospasm ,Middle Aged ,Arginine ,Coronary Angiography ,Lipoproteins, LDL ,Vasodilation ,C-Reactive Protein ,Logistic Models ,Risk Factors ,Humans ,Hyperventilation ,Female ,Angina, Unstable ,Endothelium, Vascular ,Tomography, X-Ray Computed ,Biomarkers ,Aged - Abstract
Vasospastic angina (VSA) is a special form of atherosclerotic disease. There is some evidence suggesting a relationship between inflammation and VSA. We sought to demonstrate the relationship between high-sensitivity c-reactive protein (hs-CRP), a sensitive marker of inflammation, and the asymmetric dimethylarginine (ADMA)-induced endothelial dysfunction pathway in patients with VSA. We studied 68 patients who were diagnosed with VSA with typical symptoms and had a positive hyperventilation test. We determined plasma levels of hs-CRP, ADMA, brachial flow-mediated dilation (FMD), and other biochemical parameters in these 68 VSA patients and 68 age-matched non-VSA subjects. Multivariate logistic regression indicated that hs-CRP (OR, 3.81 P0.001) and a history of smoking (OR, 3.06 P = 0.008) were independently associated with the incidence of VSA. Moreover, we found that CRP was directly related to ADMA (r = 0.69, P0.001) but inversely related to brachial FMD (r = -0.66, P0.001) in patients with VSA. Additionally, ADMA was inversely related to brachial FMD (r = -0.75, P0.001) in patients with VSA. These results indicate that there is a relationship between CRP and the ADMA-induced endothelial dysfunction pathway in patients with VSA. Anti-inflammatory agents may be a potential strategy for the treatment of endothelial dysfunction in VSA. more...
- Published
- 2014
10. A computer-aided diagnostic algorithm improves the accuracy of transesophageal echocardiography for left atrial thrombi: a single-center prospective study
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Xiu Fen Qu, Ying Tao Zhang, Feng Hua Xue, Lin Sun, Jing Xia Shen, Yang Li, and Heng-Da Cheng
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Adult ,Male ,medicine.medical_specialty ,CAD ,Single Center ,Sensitivity and Specificity ,Internal medicine ,Atrial Fibrillation ,Image Interpretation, Computer-Assisted ,medicine ,Humans ,Radiology, Nuclear Medicine and imaging ,cardiovascular diseases ,Heart Atria ,Prospective Studies ,Thrombus ,Prospective cohort study ,Aged ,Aged, 80 and over ,Radiological and Ultrasound Technology ,Receiver operating characteristic ,business.industry ,Reproducibility of Results ,Atrial fibrillation ,Thrombosis ,Middle Aged ,medicine.disease ,Image Enhancement ,Confidence interval ,Computer-aided diagnosis ,Cardiology ,Female ,business ,human activities ,Algorithm ,Algorithms ,Echocardiography, Transesophageal - Abstract
OBJECTIVES We investigated whether transesophageal echocardiography (TEE) assisted with a computer-aided diagnostic (CAD) algorithm was superior to TEE in diagnosing left atrial (LA)/left atrial appendage (LAA) thrombi in patients with atrial fibrillation (AF) in a single prospective study. METHODS Transesophageal echocardiography was performed in patients with AF, and images were reconstructed. Gray level co-occurrence matrix-based features were calculated and then classified using an artificial neural network. The original data and processed images by the CAD system were studied by 5 radiologists independently in a blind manner. The diagnostic performance of each radiologist was evaluated. RESULTS One hundred thirty patients with AF were investigated. Thirty-one patients (23.9%) had a diagnosis of LA/LAA thrombi. The mean sensitivity ± SD of TEE for LA/LAA thrombi was 0.933 ± 0.027, which was noticeably improved by CAD (0.955 ± 0.021; P < .05). The specificity of TEE was 0.811 ± 0.055, which was markedly lower than that by TEE plus CAD (0.970 ± 0.009; P < .05). The positive predictive value of TEE was low (0.613 ± 0.073) compared to that of TEE plus CAD (0.908 ± 0.027; P < .001), whereas the negative predictive values were comparable for TEE, CAD, and TEE plus CAD. Diagnosis of an LA/LAA thrombus by TEE plus CAD had a higher accuracy rate (0.966 ± 0.011) than that by TEE (0.840 ± 0.047; P < .01). The mean area under the receiver operating characteristic curve (Az) for TEE was 0.834 ± 0.009 (95% confidence interval [CI], 0.815-0.852), which was markedly lower than the Az for TEE plus CAD (0.932 ± 0.005; 95% CI, 0.921-0.943). The use of CAD significantly improved the Az values for all 5 radiologists (P < .001). CONCLUSIONS The CAD algorithm significantly improves the diagnostic accuracy of TEE for LA/LAA thrombi in patients with AF. more...
- Published
- 2013
11. Atrial fibrillation increases sympathetic and parasympathetic neurons in the intrinsic cardiac nervous system
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Yang, Yu, Cao, Wei, Li, Liu, Ai Ling, Lian, Xiu Fen, Qu, and Guang, Yu
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Neurons ,Dogs ,Sympathetic Nervous System ,Parasympathetic Nervous System ,Atrial Fibrillation ,Animals ,Heart - Abstract
Chronic atrial fibrillation (AF) leads to heterogeneous autonomic nerve innervation termed neural remodeling. The quantitative changes in neural density as a function of autonomic remodeling and its association with sustained AF has not been previously determined.Seven dogs (paced group) were chronically paced with electrodes sutured to the epicardium of left atrial appendages. Seven dogs (control animals) were not paced. All paced dogs developed sustained AF by 5 weeks of pacing. The fat pads on the atrial epicardium containing ganglionated plexuses (GP) were separated along with underlying myocardial tissue. Immunocytochemical techniques were used to identify the neurons immunoreactive to anti-tyrosine hydroxylase (TH) and anti-acetylcholine antibodies. After chronic AF, sympathetic and parasympathetic neurons in the atrial intrinsic cardiac ganglia increased significantly. In paced dogs, the density of sympathetic neurons was 3,022 ± 507 μm(2) /mm(2) in the right atrial GP (vs control P0.01), 8,571 ± 476 μm(2) /mm(2) in the ventral left atrial GP (vs control P0.0001), 6,422 ± 464 μm(2) /mm(2) in the dorsal atrial GP (vs control P0.0001) and 5,392 ± 595 μm(2) /mm(2) in the inferior vena cava-inferior atrial GP (vs control P0.0001), respectively. The density of parasympathetic neurons was 4,396 ± 877 μm(2) /mm(2) in the right atrial GP, 7,769 ± 465 μm(2) /mm(2) in the ventral left atrial GP, 7,016.47 ± 687 μm(2) /mm(2) in the dorsal atrial GP and 5,485 ± 554 μm(2) /mm(2) in the inferior vena cava-inferior atrial GP, respectively, which was higher than control cohorts in corresponding GP (P0.05).This study provides evidence for the remodeling in atrial intrinsic cardiac ganglia in the dogs with pacing induced AF. A significant increase of sympathetic and parasympathetic neurons was present in atrial intrinsic cardiac ganglia. more...
- Published
- 2012
12. Increased expression of myocardial semaphorin 3A in isoproterenol-induced heart failure rats
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Shu-qin, Sun, Xin-tao, Wang, Xiu-fen, Qu, Yang, Li, Yang, Yu, Ying, Song, and Shao-jun, Wang
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Heart Failure ,Male ,Echocardiography ,Myocardium ,Blotting, Western ,Hemodynamics ,Isoproterenol ,Animals ,Semaphorin-3A ,Rats, Wistar ,Real-Time Polymerase Chain Reaction ,Immunohistochemistry ,Rats - Abstract
Maintenance of normal cardiac function is controlled by the autonomic nervous system. In congestive heart failure (CHF), sympathetic nerve denervation is increasingly recognized. The sympathetic fiber density depends on the balance between neurotrophins and neural guidance molecules. Semaphorin 3A (sema3a), a secreted neural guidance factor, is a well characterized member of the newly found semaphorin family. It can induce sympathetic growth cone collapse and axon repulsion. We conducted this study to investigate cell sources of sema3a in the heart, the expression level of sema3a in CHF and discuss the possible role of sema3a in CHF.Rats were divided into four groups: 30 days control group rats, 30 days CHF rats, 60 days control group rats, 60 days CHF rats. The heart failure model was induced by injection of isoproterenol (ISO) 340 mg/kg continuously two days. All animals underwent echocardiography and haemodynamics measurements. Cardiac expression of sema3a was determined by real time polymerase chain reaction (RT-PCR) and Western blotting analysis. Immunohistochemical analysis was used to determine the cell source of sema3a in the heart.Isoproterenol induced 30 days and 60 days CHF rats displayed left ventricular dilation, systolic and diastolic function decrease. Sema3a was secreted by the cardiocytes and increased significantly in 30 days and 60 days CHF rats compared with the controls (RT-PCR: 30 days group: 0.32 ± 0.05 vs. 0.58 ± 0.06, P0.01; 60 days group: 0.34 ± 0.08 vs. 0.71 ± 0.07, P0.01. Western blotting: 30 days group: 0.25 ± 0.10 vs. 0.46 ± 0.10, P0.05; 60 days group: 0.29 ± 0.10 vs. 0.55 ± 0.16, P0.01. Immunohistochemical analysis: 30 days group: 2.91 ± 0.20 vs. 5.31 ± 0.30, P0.01; 60 days group: 2.94 ± 0.30 vs. 5.80 ± 0.30, P0.01).Sema3a was expressed in the heart by cardiocytes. Increased expression of sema3a may partly account for sympathetic denervation in CHF; modulation of this pathway may prove beneficial in heart failure sympathetic remodeling. more...
- Published
- 2011
13. Increased levels of asymmetric dimethylarginine and C-reactive protein are associated with impaired vascular reactivity in essential hypertension
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Mingde Guan, Jing-jie Li, Xiu-fen Qu, Yang Yu, Wei Xia, and Wei Feng
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Adult ,Male ,medicine.medical_specialty ,Brachial Artery ,Physiology ,Inflammation ,Endogeny ,Essential hypertension ,Arginine ,chemistry.chemical_compound ,medicine.artery ,Internal medicine ,Internal Medicine ,medicine ,Humans ,Brachial artery ,Endothelial dysfunction ,Aged ,biology ,business.industry ,C-reactive protein ,General Medicine ,Middle Aged ,medicine.disease ,Nitric oxide synthase ,Vasodilation ,Endocrinology ,C-Reactive Protein ,chemistry ,Hypertension ,biology.protein ,Female ,medicine.symptom ,Asymmetric dimethylarginine ,business ,Blood Flow Velocity - Abstract
Asymmetric dimethylarginine (ADMA) is an endogenous inhibitor of nitric oxide synthase and has been implicated in endothelial dysfunction. We sought to assess weather inflammation is involved in the impaired vascular reactivity induced by ADMA in essential hypertension. Brachial artery flow-mediated dilation (FMD), serum ADMA, and C-reactive protein were determined in 71 never-treated hypertensive patients. Serum ADMA was related directly to C-reactive protein and reversely to FMD. In multiple regression analysis, ADMA was the only independent determinant of FMD. Probably, the chronic inflammation documented in these patients may be considered the mechanistic link between ADMA and vascular damage. more...
- Published
- 2010
14. [Sympathetic nerve in rat with pressure overload left ventricular hypertrophy]
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Ying, Liao, Xiu-fen, Qu, Li, Liu, Xing-mo, Dong, and De-chun, Yin
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Male ,Sulfonamides ,Sympathetic Nervous System ,Myocardium ,Rats ,Fluorobenzenes ,Pyrimidines ,Pressure ,Animals ,Hypertrophy, Left Ventricular ,Acyl Coenzyme A ,Hydroxymethylglutaryl-CoA Reductase Inhibitors ,Rats, Wistar ,Rosuvastatin Calcium - Abstract
To explore the remodeling mechanism of myocardium and sympathetic nerve in pressure overload left ventricular hypertrophy and elucidate the protective effect of statins.Pressure-overload left ventricular hypertrophy (LVH) of rats was induced by partial coarctation of abdominal aorta; a sham-operated group served as the control (SHAM, n = 22). At 8 weeks post-operation, the animals were divided into two groups and a 12-week treatment period was investigated. At the end of treatment period, echocardiographic evaluations and hemodynamic measurements were performed. Sympathetic innervation was investigated by analyzing nerve growth factor (NGF), growth associated protein-43 (GAP43) and tyrosine hydroxylase (TH).In LVH rats, a significant increase of left ventricular weight, left ventricular weight/body weight, echocardiographic left ventricular end-diastolic diameter, interventricular septum thickness, posterior left ventricular wall thickness, left ventricular systolic pressure and dP/dt was observed. The expressions of NGF and GAP43 protein were significantly down-regulated (0.82 +/- 0.06 vs 1.53 +/- 0.10, 0.68 +/- 0.06 vs 0.81 +/- 0.10) and TH level was up-regulated (0.44 +/- 0.10 vs 0.62 +/- 0.06) by RSV treatment.A HMG CoA inhibitor reverses the development of left ventricular hypertrophy and inhibits sympathetic innervation in abdominal aortic-clamped animals. more...
- Published
- 2010
15. [Causes of death analysis in 133 congestive heart failure patients]
- Author
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Dong-xiu, Xu, Xiao-wei, Xu, Cui-ling, Ji, Ying, Song, Li-ting, Gong, Xiu-fen, Qu, and Yong-lin, Huang
- Subjects
Adult ,Heart Failure ,Male ,Death, Sudden, Cardiac ,Treatment Outcome ,Cause of Death ,Humans ,Female ,Middle Aged ,Prognosis ,Aged - Abstract
To analyze the causes of death in patients with heart failure.A total of 133 heart failure patients died during hospitalization in our hospital between January 2005 and December 2008 were enrolled in this study. Patients were divided to two groups: sudden death (group A, n = 73, 54.9%), chronic end-stage pump failure (group B, n = 55, 41.4%). The remaining 5 cases died of other causes were excluded from the final analysis. Clinical data (medical history, blood pressure, clinical manifestation, NYHA cardiac function class, left ventricular diameter of diastole, left ventricular ejection fraction, ventricular arrhythmias, drug therapy) of group A and B were analyzed.There were no significant differences in terms of medical history (including hypertension and diabetes), blood pressure, heart rate and the incidence of ventricular arrhythmia between the two groups. In group A, the NYHA functional class was mostly II or III grade, and LVEF value was significantly higher than that of group B. The incidence of angina pectoris was significantly higher in group A compared to group B. beta-blocker and angiotensin-converting enzyme inhibitor or angiotensin II receptor blocker use was also significantly higher in group A than in group B, however, the treatment dose was significantly lower and therapy duration was significantly shorter in group A than in group B. There were significantly less patients received statins and anti-platelet aggregation drugs in group A compared to group B.In our patient cohort, sudden cardiac death often occurred in heart failure patients with NYHA cardiac function II to III grade, angina pectoris, probably due to the unstable coronary plaque and less statins and anti-platelet drug use in these patients. more...
- Published
- 2010
16. [Effect of benazepril on atrial cytoskeleton remodeling in the canine atrial fibrillation models]
- Author
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Li, Liu, Xiu-Fen, Qu, Yang, Yu, Bing, Bai, and Yong-Lin, Huang
- Subjects
Disease Models, Animal ,Dogs ,Tubulin ,Atrial Fibrillation ,Animals ,Angiotensin-Converting Enzyme Inhibitors ,Myocytes, Cardiac ,Heart Atria ,RNA, Messenger ,Benzazepines ,Cytoskeleton ,Desmin - Abstract
To investigate the effect of benazepril on atrial cytoskeleton remodeling in atrial fibrillation (AF) canines induced by chronic rapid atrial pacing (RAP).Twenty canines were randomly divided into 3 groups: (1) Sham-operated group without RAP; (2) AF group: AF established by RAP at 600 beats per minute for 6 weeks; (3) Benazepril group: benazepril was dosed from 1 week pre-pacing to 6 weeks post-pacing. The diameter of atrial cardiomyocyte was measured, collagen volume fraction (CVF) analyzed by Masson staining and the expression and distribution of desmin were assayed by immunohistochemistry. RT-PCR method was used to semi-quantify the mRNA expression of beta-tubulin and desmin.The diameter of atrial cardiomyocyte increased in AF group [LA:(27.9 +/- 3.8) microm; RA: (26.8 +/- 3.2) microm] and benazepril group[LA: (25.1 +/- 3.4) microm; RA: (25.2 +/- 3.5) microm] than sham-operated group [LA: (19.6 +/- 2.9) microm; RA: (18.7 +/- 2.6) microm] (P0.01). CVF increased in AF group than sham-operated group [LA: (16.9 +/- 1.1)% vs (9.2 +/- 0.9)%, RA: (15.7 +/- 2.3)% vs (9.3 +/- 0.8)%, P0.01] and it decreased in benazepril group than AF group [LA: (11.3 +/- 0.8)% vs (16.9 +/- 1.1)%, RA: (10.9 +/- 0.8)% vs (15.7 +/- 2.3)%, P0.01]. Normal desmin cross-striations were lost in atrial cardiomyocyte and the desmin organization became irregular in AF group. The A values analyzed by immunohistochemistry of desmin increased in AF group than sham-operated group and they decreased in benazepril group than AF group (P0.01). The expression of mRNA level of desmin and beta-tubulin were up-regulated in AF group than sham-operated group, (LA:1.0 +/- 0.3 vs 0.6 +/- 0.3, 0.9 +/- 0.4 vs 0.6 +/- 0.3; RA: 1.0 +/- 0.6 vs 0.6 +/- 0.2, 1.1 +/- 0.3 vs 0.7 +/- 0.4, P0.01) and they were down-regulated in benazepril group than AF group (LA:0.8 +/- 0.4 vs 1.0 +/- 0.3, 0.7 +/- 0.3 vs 0.9 +/- 0.4; RA:0.7 +/- 0.3 vs 1.0 +/- 0.6, 0.7 +/- 0.3 vs 1.1 +/- 0.3, P0.01).Benazepril can favorably improve atrial cytoskeleton remodeling in the canine atrial fibrillation model. more...
- Published
- 2010
17. [Reduced left ventricular systolic atrioventricular plane displacement in heart failure patients with preserved ejection fraction]
- Author
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Yong-Qiang, Ren, Wei, Feng, Li, Liu, Wei, Xia, and Xiu-Fen, Qu
- Subjects
Adult ,Aged, 80 and over ,Heart Failure ,Male ,Adolescent ,Heart Ventricles ,Stroke Volume ,Middle Aged ,Myocardial Contraction ,Ventricular Dysfunction, Left ,Young Adult ,Echocardiography ,Case-Control Studies ,Humans ,Female ,Aged - Abstract
To determine whether patients with suspected heart failure but preserved left ventricular ejection fraction (LVEF) have systolic dysfunction in left ventricular long axis detected by left ventricular systolic atrioventricular plane displacement (AVPD).The data of 96 patients with heart failure who admitted to our hospital between August 2007 and October 2008 were collected. Heart failure with preserved LVEF was diagnosed in 48 patients and heart failure with reduced LVEF was diagnosed in another 48 patients. Fifty age-matched healthy subjects served as the control group. The NYHA classification, etiology of heart failure, AVPD and plasma NT-proBNP concentration were compared among the 3 groups.There was no difference in terms of NYHA classification between patients with preserved LVEF and reduced LVEF. Hypertension and coronary heart disease were often diagnosed in heart failure patients with preserved LVEF. The degree of AVPD decrease was more significant in heart failure patients with reduced LVEF than those with preserved LVEF. In all subjects, the AVPD was negatively correlated with the NT-proBNP concentration (r = -0.35, P0.05).Left ventricular systolic atrioventricular plane displacement was decreased in heart failure patients with preserved LVEF, therefore, besides "diastolic heart failure", systolic dysfunction was also impaired in these patients. more...
- Published
- 2010
18. [Coronary artery and myocardium lesion comparison post atrioventricular ring radiofrequency catheter ablation with different catheters]
- Author
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Hong-yue, Gu, Ming-yu, Shi, Yong-wei, Zhao, Xue-song, Yin, and Xiu-fen, Qu
- Subjects
Cardiac Catheterization ,Dogs ,Myocardium ,Catheter Ablation ,Animals ,Coronary Vessels - Abstract
To analyze the extent of myocardium and coronary artery lesion post atrioventricular ring radiofrequency catheter ablation with different tip catheters.Twenty-one healthy dogs were randomly divided into 64 degrees C/50 W/100 s, 64 degrees C/100 W/100 s, 45 degrees C/45 W/100 s groups and ablated by 4 mm tip catheter, 8 mm tip catheter and irrigated tip catheter respectively. Left atrioventricular ring and right atrioventricular ring ablation were performed in all dogs. After ablation, myocardium lesion volume was calculated as 1/6pi x length x width x depth. Histological examinations were performed at the myocardium tissue at ablation sites.The lesion depths post 8 mm tip catheter ablation (7.18 +/- 1.72) mm and irrigated tip catheter ablation (7.99 +/- 1.77) mm were similar and significantly deeper than that post 4 mm tip catheter ablation (4.54 +/- 1.38) mm, P0.01. Similar results were found in terms of lesion volume [(356.76 +/- 94.44) mm(3) post 8 mm tip catheter ablation, (391.69 +/- 109.54) mm(3) post irrigated tip catheter ablation and (191.34 +/- 74.52) mm(3) post 4 mm tip catheter ablation]. Five (5/42, 11.9%) transmural myocardium necrosis and 8 (8/42, 19%) coronary artery lesions were observed post ablations.The extents of post ablation myocardium and coronary artery lesion were significantly higher induced by 8 mm tip catheter and irrigate tip catheter compared those by 4 mm tip catheter. more...
- Published
- 2009
19. The relationship between plasma level of adiponectin and coronary lesion complexity in the population of north-east China
- Author
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L Liu, Y Song, Yang Yu, Y Liao, N N Xi, Xiu-fen Qu, J J Li, and L Z Liu
- Subjects
Male ,medicine.medical_specialty ,China ,North east china ,Population ,Coronary Artery Disease ,Coronary Angiography ,Biochemistry ,Coronary artery disease ,Population Groups ,Risk Factors ,Internal medicine ,Medicine ,Humans ,cardiovascular diseases ,education ,education.field_of_study ,medicine.diagnostic_test ,Adiponectin ,business.industry ,Biochemistry (medical) ,Cell Biology ,General Medicine ,Plasma levels ,Coronary Lesion Complexity ,Middle Aged ,medicine.disease ,Stenosis ,Angiography ,Cardiology ,Female ,business - Abstract
The relationship between plasma adiponectin and severity of coronary artery disease (CAD) in 683 cases of suspected CAD from north-east China was determined. Cases were divided into four groups, as follows: group 1, no stenosis; group 2, > 50% stenosis of one vessel; group 3, > 50% stenosis of two vessels; group 4, > 50% stenosis of three or more vessels. Group 1 was classified as a non-CAD group (control) and groups 2, 3 and 4 were classified as CAD groups. Plasma adiponectin levels were significantly correlated with coronary artery stenosis and were lower in the CAD groups than in the non-CAD group. Adiponectin concentration decreased from group 2 to group 4, but this difference was not significant. Adiponectin levels among females were also lower than for males in the CAD groups. There was a significant difference between plasma adiponectin levels in patients with coronary stenoses versus those without, but there were no significant differences between the three CAD groups in terms of plasma adiponectin levels. more...
- Published
- 2009
20. [On angiotensin II receptor distribution after myocardial infarction in dogs]
- Author
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Xiu-fen, Qu, Jing-jie, Li, Yang, Xi, Jing-xia, Shen, Chun-hong, Xiu, Le, Yue, Gui-zhao, Wang, and Yong-lin, Huang
- Subjects
Male ,Dogs ,Myocardium ,Myocardial Infarction ,Animals ,Tetrazoles ,Valsartan ,Female ,Valine ,RNA, Messenger ,Angiotensin II Type 1 Receptor Blockers ,Receptor, Angiotensin, Type 2 ,Receptor, Angiotensin, Type 1 - Abstract
To investigate the effects of valsartan on expression of angiotensin II receptors in different regions of heart after myocardial infarction (MI).Canines were divided into sham-operated control group (n=7), infarction group (n=7) and Valsartan group (10 mg x kg(-1) x day(-1) for 4 weeks after MI operation, n=7). Four weeks after operation, Doppler tissue imaging (DTI) was used to evaluate regional ventricular function in the noninfarcted myocardium (apical and basal near to the infarction region). The mRNA and protein expressions of angiotensin II type 1 receptor (AT1-R) and angiotensin II type 2 receptor (AT2-R) on the corresponding regions were detected by competitive reverse-transcriptase polymerase chain reaction technique and immunohistochemical technique respectively. Results The protein and mRNA expressions of AT1-R were significantly increased in both apical and basal regions near to the infarction in dogs with MI compared with those in control group (P0.05) which could be downregulated by valsartan (P0.05). AT2-R expressions were significantly upregulated in infarction group in both apical and basal regions compared with those in control group and valsartan further increased AT2-R expressions in both areas (P0.05). Myocardial peak systolic velocity (Sm), myocardial peak early diastolic velocity (Em) and myocardial peak late diastolic velocity (Am) at both apical and basal regions near to the infarction regions were significantly lower in MI group than those in the control group which could be significantly improved by valsartan.Both mRNA and protein expressions of AT1-R and AT2-R are upregulated in noninfarcted regions near MI, valsartan improved myocardial function via inhibiting AT1-R upregulation and enhancing AT2-R upregulation. more...
- Published
- 2009
21. [Clinical evaluation of catheter ablation for idiopathic ventricular arrhythmia originating from ventricular outflow tract]
- Author
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Xiao-yu, Wu, Hong-yue, Gu, Zhao-guang, Liang, Shu, Zhang, Xiu-rong, Jiang, Guang-ming, Wu, Xiu-fen, Qu, Wei-min, Li, and Shao-wen, Liu
- Subjects
Adult ,Male ,Adolescent ,Middle Aged ,Ventricular Premature Complexes ,Electrophysiology ,Electrocardiography ,Treatment Outcome ,Catheter Ablation ,Tachycardia, Ventricular ,Humans ,Female ,Child ,Aged ,Follow-Up Studies - Abstract
To study the ECG and electrophysiological characteristic of idiopathic ventricular tachycardia (VT) and premature ventricular contraction (PVC) originating from ventricular outflow tract and assess the clinical effect of radiofrequency catheter ablation (RFCA) for treatment.105 patients aged from 12 to 73 years old were treated with RFCA. Activation mapping, pace mapping and non-contact mapping system of Ensite 3000 were used during the procedure.(1) VT and PVC were successfully ablated in 97 out of the 105 patients (93.3%), 15 were recurrent but succeed in the second time. (2) 84 patients originated from right ventricle outflow tract (RVOT) and the remaining 21 patients from left ventricle outflow tract (LVOT). (3) 3 patients have the pericardial tamponade during ablation.RFCA is an effective and curative therapy for ventricular arrhythmia originating from ventricular outflow tract. more...
- Published
- 2008
22. [Investigation of heart rate turbulence after atrial premature beats before onset of paroxysmal atrial fibrillation]
- Author
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Xiu-fen, Qu, Li, Liu, Xiao-ning, Guo, Jing-yan, Piao, Guan-yu, Gao, and Yong-lin, Huang
- Subjects
Adult ,Male ,Electrocardiography ,Heart Rate ,Atrial Fibrillation ,Humans ,Female ,Vagus Nerve ,Atrial Premature Complexes ,Middle Aged ,Circadian Rhythm - Abstract
To discuss the clinical significance of heart rate turbulence (HRT) after atrial premature beats in accessing the temporal changes of vagus nerve before the onset of paroxysmal atrial fibrillation.The HRT parameters: turbulence onset (TOA) and turbulence slope (TSA) after atrial premature impulses occurring 0 to 60 min before and after the onset of AF 56 patients with atrial fibrillation (AF). The heart rate variability (HRV) time domain parameter SDNN and the frequency-domain parameters, low frequency (LF), high frequency (HF), and LF/HF ratio were also analyzed. TOA and TSA were calculated for 3 periods reflecting morning hours (6-10 am), afternoon hours (1-5 pm), and night hours (0-4 am).(1) The TOA and TSA were significantly higher 1 h preceding AF than 1 h after AF(0.47+/-0.32 vs 0.24+/-0.18 and 16+/-6 vs 13+/-4, both P0.05). The HRV time domain parameters and frequency-domain parameters did not change remarkably after the onset of PAF. (2) The TOA and TSA were significantly higher in night hours than in morning hours (1.2+/-0.6 vs 0.8+/-0.4 and 17+/-6 vs 14+/-4 respectively, both P0.05), the two parameters of HRT maintained significant circadian variations.Vagal inhibition in response to premature atrial excitation is absent and transient enhancement of vagal outflow would occur before AF. HRT before atrial premature beats is of significance in accessing the changes of autonomic nervous system before onset of AF. more...
- Published
- 2008
23. [Effect of chronic myocardial infarction on the distribution of beta-adrenoceptors in heart: experiment with dogs]
- Author
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Jing-jie, Li, Xiu-fen, Qu, Ke-shen, Li, Yang, Yu, Yang, Xi, Le, Yue, Gui-zhao, Wang, and Yong-lin, Huang
- Subjects
Reverse Transcriptase Polymerase Chain Reaction ,Myocardium ,Adrenergic beta-Antagonists ,Myocardial Infarction ,Gene Expression ,Adrenergic beta-1 Receptor Antagonists ,Disease Models, Animal ,Random Allocation ,Dogs ,Adrenergic beta-2 Receptor Antagonists ,Chronic Disease ,Animals ,RNA, Messenger ,Receptors, Adrenergic, beta-2 ,Receptors, Adrenergic, beta-1 ,Metoprolol - Abstract
To investigate the distribution of beta-adrenoceptors at different sites of heart after myocardial infarction (MI).14 dogs were randomly divided into 2 equal groups: MI group, undergoing ligation of the left anterior descending coronary artery, and control group undergoing sham-operation. Four weeks later metoprolol, a beta 1-adrenergic receptor antagonist, was injected intravenously. Doppler tissue imaging (DTI) was used to evaluate the peak systolic myocardial velocity (Sm) of the regions apical and basal to the infarction region before and after the injection. Then the dogs were killed with their hearts taken out. Reverse-transcriptase polymerase chain reaction was used to examine the mRNA expression of beta 1-receptor and beta 2-receptor in the non-infracted myocardial tissues apical and basal to the infarction region.The Sm values at the regions apical and basal to the infarction region of the MI group were 3.93 +/- 0.47 and 0.81 +/- 0.19 cm/s respectively, both significantly lower than those of the control group (10.84 +/- 1.97 and 5.85 +/- 1.15 cm/s respectively, both P0.05). After injection of metoprolol, the Sm values at the regions apical and basal to the infarction region of the MI group were 3.43 +/- 0.37 and 0.73 +/- 0.14 cm/s respectively, not significantly different from those before the injection; however, the corresponding Sm values of the control group were 8.69 +/- 1.14 and 4.33 +/- 0.29 cm/s respectively, both significantly lower than those before the injection (both P0.05). The mRNA expression levels of beta 1-receptor decreased in both apical and basal regions in the MI group compared with those in the control group, and the degree of expression decrease at the apical region was significantly greater than that at the basal region. However, there was no significant difference in the expression level of beta 1-receptor mRNA between the apical and basal regions in the control group. There was no significant difference in the mRNA expression of beta 2-receptor in different regions of the heart in both groups.After MI regional variation occurs for the beta 1-receptor mRNA expression, but not to the beta 2-receptor. more...
- Published
- 2008
24. [Effects of catheter ablation of ventricular tachycardia and premature ventricular contraction originating from left and right ventricular outflow tracts]
- Author
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Xiao-yu, Wu, Wei-min, Li, Zhen, Tan, Zhao-guang, Liang, Hong-yue, Gu, Zhao-jun, Wang, Xiu-fen, Qu, and Shao-wen, Liu
- Subjects
Adult ,Male ,Young Adult ,Adolescent ,Catheter Ablation ,Tachycardia, Ventricular ,Humans ,Female ,Middle Aged ,Ventricular Premature Complexes ,Aged ,Ventricular Outflow Obstruction - Abstract
To observe the ECG and electrophysiological characteristic of patients with idiopathic ventricular tachycardia (VT) and premature ventricular contraction (PVC) originating from left (LVOT) and right (RVOT) ventricular outflow tracts and assess the clinical effect of radio frequency catheter ablation (RFCA) on these patients.RFCA was performed in 58 patients (10 with VT and 48 with PVC, 5 patients with VT from RVOT under the guidance of non-contact mapping system Ensite3000). VT or PVC originated from LVOT in 15 patients (12 out of 15 from left sinus of Valsalva) and RVOT in 43 patients.(1) R wave in II, III, aVF leads was the common characteristics of VT or PVC originated from LVOT and RVOT and difference in wave duration index and R/S-wave amplitude ratio in V(1) or V(2) could be used to define VT and PVC originated from LVOT or RVOT. (2) Ablation was successful in 55 out of 58 patients (9 patients with the 2nd ablation, evaluated as arrhythmia-free at 3 months post ablation without medication) and failed in 3 patients. One patient developed pericardial tamponade during ablation and recovered without complication after related treatments.RFCA is an effective, safe and curative therapy for VT or PVC originated from LVOT and RVOT. Non-contact mapping system (Ensite3000) is a safe and reliable tool to guide mapping and ablation in patients with complex VT and unstable hemodynamics. more...
- Published
- 2007
25. [The tone of sympathetic and expression of beta1 receptor in the dogs with sustained atrial fibrillation]
- Author
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Xiu-fen, Qu, Yang, Yu, Li, Liu, Bing, Bai, and Jing-jie, Li
- Subjects
Disease Models, Animal ,Dogs ,Sympathetic Nervous System ,Heart Rate ,Reverse Transcriptase Polymerase Chain Reaction ,Myocardium ,Atrial Fibrillation ,Nerve Growth Factor ,Animals ,Heart ,RNA, Messenger ,Receptors, Adrenergic, beta-1 - Abstract
To detect the influence of sustained atrial fibrillation on autonomic nerve.7 healthy mongrel dogs were paced at 600/min. ter sustained reversing into sinus rhythm. HRV was obtained by Holter. Noradrenaline in left atrial appendage, left atrial, atrial septal, right atrial appendage and right atrial was detected. Nerve growth factor was determined and beta1 receptor in atrial myocardium was evaluated. All the indexes were compared with control animals.ter sustained, the tone of sympathetic increased. LF in dogs with long term (1682 +/- 362) ms2 and short term (1247 +/- 219) ms2 were higher than control dogs (798 +/- 154) ms2 (P0.01). The HF in dogs with long term (232 +/- 75) ms2 and short term (310 +/- 165) ms2 was lower than control dogs (1041 +/- 195) ms2 (P0.01). The SDNN [long term (32 +/- 7) ms, short term (51 +/- 7) ms] and HRV indexes (long term 16 +/- 4, short term 24 +/- 8) in group were inferior to corresponding indexes in control group [(103 +/- 14) ms and 38 +/- 5 respectively, P0.01]. The content of noradrenaline in myocardium was higher in group (P0.01). Furthermore, the increase of noradrenaline in the atrium was heterogeneous (P0.01), which was not observed in control group. The expression of NGF increased in group. beta1 receptor down regulated in group.Sustained caused increased tone of sympathetic, heterogeneous accumulation of noradrenaline and down regulation of beta1 receptor, which was mediated by NGF. more...
- Published
- 2007
26. Effects of metoprolol treatment on a disintegrin metalloproteinase expression and extracellular matrix remodeling after myocardial infarction in rats
- Author
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Tao Zhou, Juan Zhao, Xiu-Fen Qu, Yonglin Huang, Wei-min Li, Feng-Lin Cao, and Chun-Yu Zhao
- Subjects
Male ,medicine.medical_specialty ,Adrenergic beta-Antagonists ,Myocardial Infarction ,ADAM17 Protein ,Ventricular Function, Left ,Extracellular matrix ,Internal medicine ,Disintegrin ,Medicine ,Animals ,Myocardial infarction ,RNA, Messenger ,Rats, Wistar ,Ventricular remodeling ,Metoprolol ,Metalloproteinase ,biology ,Ventricular Remodeling ,business.industry ,Tumor Necrosis Factor-alpha ,General Medicine ,medicine.disease ,Rats ,ADAM Proteins ,Endocrinology ,biology.protein ,business ,medicine.drug - Published
- 2007
27. [Relationship between plasma asymmetrical dimethylarginine and coronary artery disease]
- Author
-
Ying, Song, Xiu-fen, Qu, Yan-wei, Yu, Tian-zhu, Luan, Jing-jie, Li, Hong, Guo, and Yang, Yu
- Subjects
Male ,Humans ,Enzyme-Linked Immunosorbent Assay ,Female ,Coronary Artery Disease ,Middle Aged ,Nitric Oxide Synthase ,Arginine ,Coronary Angiography ,Nitric Oxide ,Aged - Abstract
To investigate whether the plasma asymmetrical dimethylarginine (ADMA) level correlates with the extent and severity of coronary atherosclerosis.110 consecutive patients undergoing coronary angiography were divided into five groups according to the result thereof: control group (n = 22, with normal coronary artery), mild coronary artery disease (CAD) group (n = 21, with stenosis50% of the major coronary arteries), single branch CAD group III (n = 22, with stenosis/= 50% of one major coronary artery); double branch CAD group IV (n = 23, with stenosis/= 50% of two major coronary arteries); and multi-branch CAD group (n = 22, with significant stenosis/= 50% of more than two major coronary arteries or companies with stenosis of left major coronary). ELISA was used to detect the plasma ADMA. Nitric acid reductase method and colorimetry were used to measure the levels of plasma nitric oxide (NO) and nitrogen oxide synthase (NOS). The relationship between the plasma ADMA and severity of CAD was analyzed.The plasma ADMA levels of in last three a groups were 1.52 micromol/L +/- 0.61 micromol/L, 1.67 micromol/L +/- 0.80 micromol/L, and 2.60 micromol/L +/- 0.62 micromol/L all significantly higher than that of the control group (0.79 micromol/L +/- 0.54 micromol/L, P0.01). The plasma NO and NOS levels of the multi-branch CAD group were significantly lower than those of the other groups (all P0.01), and there were not significant differences in Plasma NO and NOS levels among the other groups. Multivariate stepwise logistic regression analysis showed that the plasma ADMA level was significantly positively correlated with the severity of coronary atherosclerosis (r = 0.684, P = 0.007) and total cholesterol and triglyceride (r = 0.623 and 0.536 respectively), and significantly negatively correlated with the NO and NOS levels (r = -0.709 and -0.701 respectively).Correlated significantly with the severity of coronary atherosclerosis, the plasma ADMA level may become a novel marker of CAD. more...
- Published
- 2007
28. [Arsenic trioxide eluting stents to prevent restenosis of injured iliac arteries in rabbits]
- Author
-
Wei, Yang, Jun-bo, Ge, Hong-ling, Liu, Yi, An, Xue-bo, Liu, Ye, Tian, Xiu-fen, Qu, Wei-min, Li, and Yong-lin, Huang
- Subjects
Coronary Restenosis ,Male ,Random Allocation ,Arsenic Trioxide ,Animals ,Apoptosis ,Drug-Eluting Stents ,Oxides ,Rabbits ,Iliac Artery ,Arsenicals ,Muscle, Smooth, Vascular - Abstract
To assess the efficiency of eluting stent coated with arsenic trioxide (As(2)O(3)) suspended in poly-L-lactic acid (PLLA) to prevent in-stent restenosis in rabbits.Forty-five male New Zealand white rabbits were assigned to three groups (n = 15 for each group) at random: uncoated stents, stents coated with PLLA or stents coated with As(2)O(3) in PLLA. Animals were euthanized 28 days after stent implantation into the iliac arteries of rabbits. Neointimal thicknesses and apoptosis of vascular smooth muscle cell (VSMC) were measured. Stents coated with As(2)O(3) in PLLA were implanted in another 48 male New Zealand white rabbits, As(2)O(3) concentrations in serum and arterial tissue at implantation site were measured at 2 h and 1, 3, 7, 14, 28 days after As(2)O(3) eluting stent implantation (n = 8 for each time point).Neointimal hyperplasia was significantly reduced 51% and 31% and apoptosis significantly increased (21.0 +/- 3.3; 6.2 +/- 1.9(*); 5.3 +/- 2.1(*), (*)P0.01 vs. As(2)O(3) eluting stent) with As(2)O(3) eluting stent, versus PLLA-coated stents and uncoated stents. As(2)O(3) concentrations in arterial tissue at implantation site were 18.6 +/- 9.1 (ng/mg) at 1 day and 0.3 +/- 0.1 (ng/mg) at 28 days after stent implantation.As(2)O(3) coated stents released As(2)O(3) to local tissue for at least 28 days, suppressed neointimal hyperplasia in rabbit iliac arteries and increased local VSMC apoptosis might be one of the mechanisms for inhibiting restenosis by As(2)O(3) coated stents. more...
- Published
- 2006
29. [Regional denervation after myocardial infarction and its effect on ventricular repolarization]
- Author
-
Jing-jie, Li, Xiu-fen, Qu, Le, Yue, Yang, Xi, Hong-yue, Gu, Gui-zhao, Wang, and Yong-lin, Huang
- Subjects
Male ,Disease Models, Animal ,Dogs ,Autonomic Nervous System Diseases ,Refractory Period, Electrophysiological ,Ventricular Remodeling ,Myocardial Infarction ,Animals ,Female ,Heart ,Denervation - Abstract
To investigate whether myocardial infarction (MI) causes heterogeneity of sympathetic innervation and to evaluate the effects of sympathetic stimulation on myocardial repolarization in the regions of denervation after MI.Fourteen dogs were randomly divided into 2 equal groups: MI Group, undergoing ligation of the left anterior descending coronary artery, and Control Group, undergoing sham operation. Four weeks later thoracotomy was performed for the second time, the effective refractory period (ERP) of the non-infarcted myocardium at the base of heart proximal to the infarcted myocardium and the ERP of the non-infarcted myocardium at the cardiac apex distal to the infarcted myocardium by S(1)S(2) programmed stimulation. Then the left satellite ganglion was exposed, ligated, cut, and stimulated at the proximal end, and ERP was determined at the above mentioned regions again. After the ERP measurement the heart was taken out to undergo immunohistochemistry to observe the distribution of tyrosine hydroxylase (TH) positive nerve fibers.The ERP of the non-infarcted myocardium at the base of heart proximal to the infarcted myocardium was not significantly different from that of the non-infarcted myocardium at the cardiac apex distal to the infarcted myocardium before sympathetic stimulation in both groups. In MI Group, however, the ERP of the non-infarcted myocardium at the base of heart proximal to the infarcted myocardium was significantly shortened after stimulation at the satellite ganglion (141 ms +/- 10 ms) in comparison with that before the stimulation (162 ms +/- 9 ms, P0.01); and the ERP of the non-infarcted myocardium at the cardiac apex distal to the infarcted myocardium after sympathetic stimulation (157 ms +/- 8 ms) was not significantly different from that before sympathetic stimulation (161 ms +/- 6 ms), however, was significantly longer than that of the non-infarcted myocardium at the base of heart proximal to the infarcted myocardium (P0.05). In Control Group the ERP values of both the basal and apical regions were significantly shorter than those before stimulation at the same region (both P0.01), however, there were no significant differences in the ERP values at the same region before and after the stimulation for the 2 regions. Immunohistochemistry showed that TH positive nerve fibers were distributed in the whole heart of Control Group and in the heart base of MI Group, and no TH positive nerve fiber was seen in the cardiac apex of MI Group.Regional denervation occurs after MI; Spatial variation of regional sympathetic innervation leads to heterogeneity in cardiac repolarization after sympathetic stimulation. more...
- Published
- 2006
30. [The relationship between the levels of lysophosphatidic acid and left ventricular remodeling after acute myocardial infarction]
- Author
-
Xiu-fen, Qu, Ying, Song, Jing-jie, Li, Yan-wei, Yu, Juan, Zhao, and Dong-xiu, Xu
- Subjects
Male ,Collagen Type III ,Ventricular Remodeling ,Myocardial Infarction ,Humans ,Female ,Lysophospholipids ,Middle Aged ,Ventricular Function, Left ,Aged - Abstract
To investigate the relationship between the levels of lysophsophatidic acid (LPA) and function of left ventricular after acute myocardial infarction (AMI) and the role of LPA in ventricular remodeling and the potential mechanism.In this study, we selected 86 patients with AMI and measured the levels of LPA and type III procollagen (PCIII) on admission and 4 day after admission, and performed echocardiographic examinations on admission and 8 approximately 10 day after admission. And according to their serum LPA value at day 4 patients were stratified into two group (group A, LPA6.0 micro mol/L, n = 45; group B, LPA/= 6.0 micro mol/L, n = 41). In 40 normal individuals, level of LPA and PCIII were measured.(1) The patient's levels of LPA after AMI were increased (5.1 micro mol/L +/- 1.1 micro mol/L and 6.4 micro mol/L +/- 1.3 micro mol/L vs 2.5 micro mol/L +/- 1.1 micro mol/L, P = 0.0001). (2) PCIII was significantly higher in group B than that in group A (136 micro g/L +/- 10 micro g/L vs 113 micro g/L +/- 12 micro g/L, P0.05). Left ventricular end-diastolic diameter was significantly higher in group B than in group A (54.0 mm +/- 3.3 mm vs 51.1 mm +/- 2.7 mm, P0.05). (3) The elevation of LPA after AMI was closed related to the function of left ventricular (P0.05).The levels of LPA after AMI were increased, which may play a role in ventricular remodeling. The potential mechanism may be that LPA can stimulate cardiac myocyte hypertrophy and cardiac fibroblast proliferation and cause collagen production increasing. more...
- Published
- 2004
31. [Effect of arsenic trioxide on rabbit vascular smooth muscle cells after balloon angioplasty]
- Author
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Tian-zhu, Luan, Yu, Mei, Dong-xiu, Xu, Yong-lin, Huang, and Xiu-fen, Qu
- Subjects
Arsenic Trioxide ,In Situ Nick-End Labeling ,Animals ,Apoptosis ,Oxides ,Rabbits ,Angioplasty, Balloon ,Arsenicals ,Cell Division ,Muscle, Smooth, Vascular - Abstract
To study the apoptotic effect of arsenic trioxide on rabbit vascular smooth muscle cells (RVSMCs) after balloon angioplasty.A New Zealand rabbit underwent balloon angioplasty three times at one of its iliac arteries. The iliac artery at the opposite side was used as control. Three days after the rabbit was killed. The VSMCs of the iliac artery undergoing balloon angioplasty were cultured. Arsenic trioxide of different concentrations was added into the culture. VSMCs not co-incubated with arsenic trioxide was used as controls. Cell proliferation curve was drawn. DNA was extracted and underwent electrophoresis. Transmission electron microscopy was used to observe the ultramicroscopic structure. TUNEL technique was used to examine the apoptosis of cells.Cell proliferation curve showed that the control cells grew geometrically and reached a plateau stage by day 3. The cells co-incubated with arsenic trioxide proliferated more slowly and the plateau stage appeared earlier dose-dependently (P0.05). Electrophoresis showed obscure ladder band of DNA specific to cell apoptosis, especially at the concentrations of arsenic trioxide of 3.0 and 4.0 micro mol/L. Transmission electron microscopy showed apoptotic cells with apoptosis nodes. TUNEL technique showed that the number of yellow-dyed cells was significantly larger after the addition of arsenic trioxide. The above-mentioned manifestations were not seen in the control group.Arsenic trioxide increases the apoptosis of rabbit vascular smooth muscle cells after balloon angioplasty and inhibits RVSMCs over-proliferation. It is a hopeful measure in prevention of re-stenosis after angioplasty. more...
- Published
- 2003
32. Usefulness of the heart-rate variability complex for predicting cardiac mortality after acute myocardial infarction.
- Author
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Tao Song, Xiu Fen Qu, Ying Tao Zhang, Wei Cao, Bai He Han, Yang Li, Jing Yan Piao, Lei Lei Yin, and Heng Da Cheng
- Subjects
HEART beat ,MYOCARDIAL infarction ,CORONARY disease ,ELECTROCARDIOGRAPHY ,HEART diseases ,CARDIOVASCULAR diseases - Abstract
Background Previous studies indicate that decreased heart-rate variability (HRV) is related to the risk of death in patients after acute myocardial infarction (AMI). However, the conventional indices of HRV have poor predictive value for mortality. Our aim was to develop novel predictive models based on support vector machine (SVM) to study the integrated features of HRV for improving risk stratification after AMI. Methods A series of heart-rate dynamic parameters from 208 patients were analyzed after a mean follow-up time of 28 months. Patient electrocardiographic data were classified as either survivals or cardiac deaths. SVM models were established based on different combinations of heart-rate dynamic variables and compared to left ventricular ejection fraction (LVEF), standard deviation of normal-to-normal intervals (SDNN) and deceleration capacity (DC) of heart rate. We tested the accuracy of predictors by assessing the area under the receiver-operator characteristics curve (AUC). Results We evaluated a SVM algorithm that integrated various electrocardiographic features based on three models: (A) HRV complex; (B) 6 dimension vector; and (C) 8 dimension vector. Mean AUC of HRV complex was 0.8902, 0.8880 for 6 dimension vector and 0.8579 for 8 dimension vector, compared with 0.7424 for LVEF, 0.7932 for SDNN and 0.7399 for DC. Conclusions HRV complex yielded the largest AUC and is the best classifier for predicting cardiac death after AMI. [ABSTRACT FROM AUTHOR] more...
- Published
- 2014
- Full Text
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33. Prognostic significance of heart rate turbulence parameters in patients with chronic heart failure.
- Author
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De-Chun Yin, Zhao-Jun Wang, Shuai Guo, Hong-Yu Xie, Lin Sun, Wei Feng, Wei Qiu, and Xiu-Fen Qu
- Subjects
HEART beat ,HEART failure patients ,ELECTROCARDIOGRAPHY ,LEFT heart ventricle ,MULTIVARIATE analysis ,REGRESSION analysis - Abstract
Background This study is aimed to evaluate the clinical significance of heart rate turbulence (HRT) parameters in predicting the prognosis in patients with chronic heart failure (CHF). Methods From June 2011 to December 2012, a total of 104 CHF patients and 30 healthy controls were enrolled in this study. We obtained a 24-hour Holter ECG recording to assess the HRT parameters, included turbulence onset (TO), turbulence slope (TS), standard deviation of N-N intervals (SDNN), and resting heart rate (RHR). The relationships between HRT parameters and the prognosis of CHF patients were determined. Results The assessment follow-up period lasted until January 31, 2013. The overall mortality of CHF patients was 9.6% (10/104). Our results revealed that CHF patients had higher levels of TO than those of healthy subjects, but the TS levels of CHF patients were lower than that of the control group. CHF patients with NYHA grade IV had higher HRT1/2 rate than those with NYHA grade II/III. There were statistical differences in TS, LVEF, SDNN and RHR between the non-deteriorating group and the non-survivor group. Significant differences in TS among the three groups were also found. Furthermore, CHF patients in the non-survivor group had lower levels of TS than those in the deteriorating group. Correlation analyses indicated that TO negatively correlate with SDNN, while TS positively correlated with SDNN and left ventricular ejection fraction (LVEF). We also observed negative correlations between TS and left ventricular end-diastolic cavity dimension (LVEDD), RHR, homocysteine (Hcy) and C-reactive protein (CRP). Multivariate Cox regression analysis further confirmed that LVEF (⩽30%), HRT
2 , SDNN and RHR were independent risk factors which can indicate poor prognosis in CHF patients. Conclusions Our findings indicate that HRT may have good clinical predictive value in patients with CHF. Thus, quantifying HRT parameters could be a useful tool for predicting mortality in CHF patients. [ABSTRACT FROM AUTHOR] more...- Published
- 2014
- Full Text
- View/download PDF
34. Usefulness of the heart-rate variability complex for predicting cardiac mortality after acute myocardial infarction
- Author
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Ying Tao Zhang, Tao Song, Jing Yan Piao, Bai He Han, Lei Lei Yin, Xiu Fen Qu, Heng-Da Cheng, Wei Cao, and Yang Li
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Male ,medicine.medical_specialty ,Support Vector Machine ,Time Factors ,Myocardial Infarction ,Acute myocardial infarction ,Ventricular Function, Left ,Decision Support Techniques ,Heart Rate ,Predictive Value of Tests ,Risk Factors ,Internal medicine ,Machine learning ,Heart rate ,medicine ,Humans ,Heart rate variability ,Myocardial infarction ,cardiovascular diseases ,Cardiac death ,Aged ,Aged, 80 and over ,Ejection fraction ,medicine.diagnostic_test ,business.industry ,Stroke Volume ,Stroke volume ,Middle Aged ,Prognosis ,medicine.disease ,Heart-rate variability ,ROC Curve ,Area Under Curve ,Predictive value of tests ,Electrocardiography, Ambulatory ,Cardiology ,Female ,Myocardial infarction diagnosis ,business ,Cardiology and Cardiovascular Medicine ,Electrocardiography ,Algorithms ,Research Article ,circulatory and respiratory physiology - Abstract
Background Previous studies indicate that decreased heart-rate variability (HRV) is related to the risk of death in patients after acute myocardial infarction (AMI). However, the conventional indices of HRV have poor predictive value for mortality. Our aim was to develop novel predictive models based on support vector machine (SVM) to study the integrated features of HRV for improving risk stratification after AMI. Methods A series of heart-rate dynamic parameters from 208 patients were analyzed after a mean follow-up time of 28 months. Patient electrocardiographic data were classified as either survivals or cardiac deaths. SVM models were established based on different combinations of heart-rate dynamic variables and compared to left ventricular ejection fraction (LVEF), standard deviation of normal-to-normal intervals (SDNN) and deceleration capacity (DC) of heart rate. We tested the accuracy of predictors by assessing the area under the receiver-operator characteristics curve (AUC). Results We evaluated a SVM algorithm that integrated various electrocardiographic features based on three models: (A) HRV complex; (B) 6 dimension vector; and (C) 8 dimension vector. Mean AUC of HRV complex was 0.8902, 0.8880 for 6 dimension vector and 0.8579 for 8 dimension vector, compared with 0.7424 for LVEF, 0.7932 for SDNN and 0.7399 for DC. Conclusions HRV complex yielded the largest AUC and is the best classifier for predicting cardiac death after AMI. more...
- Full Text
- View/download PDF
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