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A series of chiral 1-(β-arylalkyl)-1H-1,2,4-triazole derivatives has been designed as potential antifungal agents. The target triazoles have been synthesized by using a chiral auxiliary as a controlling reagent. All of the compounds were obtained with high ee values, reaching up to 99%. Preliminary bioassay results have revealed that most of the synthesized compounds display significantly higher fungicidal activities against the species Fusarium oxysporium, Rhizoctonia solani, Botrytis cinereapers, Gibberella zeae, Dothiorella gregaria, and Colletotrichum gossypii than the commercial agent triadimefon. Moreover, some of the enantiomers have been found to display significant differences in activity.

A series of chiral gamma-aryl-1H-1,2,4-triazole derivatives has been synthesized and the respective analogues have been tested for their inhibitory activities against Penicillium digitatum (P. digitatum). In vitro experiments were indicative of a strong inhibitory effect of all of the compounds on P. digitatum, and seven of the compounds 5 exhibited better inhibition than the commercial fungicides triadimefon and triadimenol. The respective pairs of enantiomers showed significantly different inhibitory activities, most notably in the case of 5g-R and 5g-S, for which a 230-fold difference was observed. These observations suggest that P. digitatum discriminates the enantiomers and that the R enantiomer better fits the active site of cytochrome P450.

A phosphor atom was introduced into photochromic dithienylethene and the corresponding dithienylethene bis(phosphine)ligands were obtained by the lithiation of 1,2-bis-(5-chloro-2-methylthien-3-yl) cyclopentene in the presence of n-butyllithium which were then reacted with Ph2PCl or Cy2PCl, respectively. The bis(phosphine)ligands were oxidised with H2O2, sulfurated by S8 and selenated by Se and their structures were characterized.

A novel series of chiral gamma-aryl-1H-1,2,4-triazole derivatives as highly potential antifungal agents have been designed and synthesized conveniently by using the chiral auxiliary as a controlling reagent. All of the compounds exhibit moderate to high ee values reaching up to 99%, and the preliminary bioassay results demonstrated that most of the target compounds take on a significantly wide spectrum activity against Fusarium oxysporium, Rhizoctonia solani, Botrytis cinereapers, Gibberella zeae, Dothiorella gregaria, and Colletotrichum gossypii species.

Asymmetric conjugate addition of Grignard reagents to aryl substituted α,β-unsaturated carbonyl compounds (1) has been achieved with great regioselectivity (>20:1) and good to excellent diastereoselectivity (de up to 98%). The nucleophilicity and stereospecific blockade of the Grignard reagents play a key role in controlling the regioselectivities and diastereoselectivities of the conjugate addition reaction.

Two novel photochromic macrocycles composed of thiophene and ethylene building blocks have been synthesized, and their crystal structure and photochromic properties are described. Macrocycle 2 shows good photochromic properties.

Asymmetric conjugate addition of Grignard reagents to aryl substituted α,β-unsaturated carbonyl compounds (1) has been achieved with great regioselectivity (>20:1) and good to excellent diastereoselectivity (de up to 98%). The nucleophilicity and stereospecific blockade of the Grignard reagents play a key role in controlling the regioselectivities and diastereoselectivities of the conjugate addition reaction.

In the title compound, C21H28FNO3S, six-membered ring of sultam shows a boat form. C—H⋯O inter­actions exist between mol­ecules.

In the crystal structure of the title compound, C26H30ClNO3S, mol­ecules are linked via C—H⋯O inter­actions.

In the crystal structure of the title compound, C22H29Cl2NO3S, molecules are linked via C—H...O interactions, forming chains along the a axis.

In the title compound, C23H32ClNO3S, mol­ecules are linked via C—H⋯N/O inter­actions, forming two-dimensional sheets parallel to the (100) plane.