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In order to solve the problem of energy consumption, improve the efficiency of energy utilization and develop new energy, the total energy consumption and fluctuation of thermal integrated energy were analyzed. Four suggestions are put forward for the integrated power system of flexible thermal power plant, namely, electric heat storage system, electric heat pump heat storage system, g, heating system and high pressure heating system via steam turbine, which can improve the air energy consumption capacity of the system and reduce the total coal consumption of the system. Among them, in the case of small air conditioning units or small air conditioning units do not use electric heating furnace and electric heat pump furnace. Heat storage technology of thermal power unit is not suitable for daily exhaust. In contrast, the high pressure/IP bypass heating process of steam turbine is more flexible and less restrictive, which is the best method for comparison. Compared with other schemes discussed by the author, this scheme has the highest flexibility and the least restrictions, and is the best one among the four.

ObjectiveTo investigate the effective exercise prescription in randomized controlled trials (RCTs) for patellofemoral pain (PFP).DesignA network meta-analysis.Data sourcesPubMed (including Medline), Embase, Web of Science, PEDro,Clinicaltrials.govand other resourses for RCTs.Eligibility criteria for selecting studiesRCTs of exercise interventions for PFP with outcomes of pain intensity or functional improvement.Primary outcome measurePain intensity is measured by ‘worst pain in the past week’ on a Visual Analogue Scale (VAS) or Numerical Rating Pain Scale (NRS).Data extractionTwo researchers independently extracted data and assessed the bias of risks. We used Grading of Recommendations, Assessment, Development, and Evaluation to appraise the strength of the evidence.ResultsA total of 45 trials with 42,319 patients were included in this network meta-analysis (NMA). For the primary outcomes, all included treatments were superior to a wait-and-see approach: PNF + exercise (SMD -2.88, 95%CIs -4.75 to -1.02), whole body exercise (-1.57, -3.15 to -0.00), hip-and knee-focused exercise therapy (-1.32, -2.57 to -0.06), foot orthoses + exercise (-1.06, -2.92 to -0.06), hip exercise (-1.10, -2.44 to 0.24), knee brace + exercise(-0.91, -2.54 to 0.72), gait retraining exercise (-2.55, -4.72 to -0.37), knee exercise (-0.92, -2.16 to 0.33), knee arthroscopy + exercise (-0.61, -2.44 to 1.22), target exercise (-0.52, -2.38 to 1.33), kinesiotaping + exercise (-0.54, -2.07 to 0.99), education + exercise (-0.47, -2.31 to 1.38), feedback exercise (-0.22, -1.86 to 1.43). Exercise therapy with education (SMD -0.25, 95%CIs -1.76 to 1.26) was better than exercise alone in alleviating pain intensity.ConclusionThe knee and hip combination strength training is highly effective in muscle strength improvement. All treatments in our NMA were superior to nontreatment, we recommend avoiding a wait-and-see approach. Comprehensive therapy based on individual evaluation can effectively improve the symptoms of patients.Key points (what are the new findings?)The combination of knee and hip strength training is highly effective in pain relief and function improvement for PFP.The exercise therapy with biomechanical devices, such as foot orthoses, braces, and kinesiotaping can improve knee function.Education with exercise therapy shows a great effect on pain relief and function improvement than exercise alone.Target exercise based on individual evaluation is superior to general exercise therapy for keen function.

In electrical exploration techniques, an effective suppression method for Gaussian and impulsive random noise in spread-spectrum induced-polarization (SSIP) data continues to be challenging for conventional denoising methods. Remnant noise influences the complex resistivity spectrum and damages the subsequent interpretation of geophysical surveys. We have developed a hybrid method based on a correlation function and complex resistivity, which introduces the correlation analyses among the transmitting source, the measured potential, and the injected current signal. According to the analyses, reliable results for complex resistivity spectra can be calculated, which can be further used for noise suppression. We apply the hybrid method to numerical and field experiments to process the measured SSIP data. Simulation tests find that the hybrid method not only suppresses the two types of noise but also improves the relative error of the complex resistivity spectrum. Field data processing indicates that the hybrid method can minimize the standard deviation of the data and can have a greater ability to distinguish adjacent objects, which can improve the reliability of the data in subsequent processing and interpretation.

To analyze the predictive value of acute phase proteins (APPs) on the prognosis of patients with acute myeloid leukemia (AML).293 AML patients who met the study requirements from January 2015 to April 2021 were collected, their clinical characteristics and pre-treatment APPs levels ［including albumin (ALB), fibrinogen (FIB), C-reactive protein (CRP), Ferritin (FER)］ were followed up and investigated. Pearson correlation coefficient was used to analyze the correlation between APPs. Logistic regression was used to analyze the risk factors for mortality in AML patients. ROC curve was used to analyze the predictive value of APP for mortality in AML patients, and Kaplan-Meier survival analysis was used to compare the effect of APPs on complete remission (CR) rate, overall survival (OS), disease-free survival (DFS), and progression-free survival rate (PFS) of AML patients.Pearson correlation analysis showed that there were negative correlations between ALB and CRP (r=-0.134, P=0002), as well as ALB and FER (r=-0.148, P=0.001). There were correlations between FER and CRP (r=0361, P＜0.001), as well as FER and FIB (r=0.293, P＜0.001). Logistic regression analysis showed that advanced age (50 years) (OR=1.87, 95% CI=1.25-2.15, P＜0.001), relapse after treatment (OR=2.11, 95% CI=111-3.18, P=0.003), FLT3-ITD mutation (OR=2.59, 95% CI=1.10-4.12, P＜0.001), CRP≥524 mg/L (OR=1.21, 95% CI=1.02-2.14, P=0.024), CFA (CFA=CRP*FIB/ ALB)≥3 (OR=2.41, 95% CI=1.65-6.47, P＜0.001), and FER≥1145.58 mg/ml (OR=1.67, 95% CI=1.15-3.75, P＜0.001) were the risk factors for the survival of AML patients. ROC curve analysis showed that FER (AUC=0.752, 95% CI=0.681-0823, P＜0.001, the best cut-off value=1220.56 mg/ml) and CFA (AUC=0.804, 95% CI=0.741-0.868, P＜0.001, the best cut-off value=3.00) had higher predictive value for the survival of AML patients. The remission rate, PFS, DFS, and OS in the low CFA group (CFA≤3) were significantly higher than those in the high CFA group (CFA＞3), and the overall mortality rate was lower than that in the high CFA group; the remission rate, PFS, DFS, and OS in the low FER group (FER≤1220.56 mg/ml) were significantly higher than those in the high FER group (FER＞1220.56 mg/ml), while the overall mortality rate was lower than that in the high FER group, and the difference is statistically significant.The CFA value and FER level before treatment in AML patients can independently predict the prognosis of patients, and high levels of CFA and FER are associated with poor prognosis of AML patients.急性期蛋白对急性髓系白血病患者预后的预测价值.分析急性期蛋白(APPs)对急性髓系白血病（AML）患者预后的预测价值.收集2015年1月-2021年4月符合研究要求的293例AML患者，随访并调查其临床特征和治疗前APP［包括白蛋白(ALB）、纤维蛋白原（FIB）、C-反应蛋白（CRP）、铁蛋白（FER）］。使用Pearson相关系数分析APP间的相关性，使用Logistic回归分析AML患者死亡的危险因素，使用ROC曲线分析APP对AML患者死亡的预测价值，使用Kaplan-Meier生存分析比较APP对AML患者的缓解（CR）率、总体生存期（OS）、无病生存期（DFS）、无进展生存期（PFS）的影响.相关性分析结果显示，ALB与CRP（r=-0.134，P=0.002）和FER（r=-0.148，P=0.001）间存在一定的负相关关系。FER与CRP（r=0.361，P＜0.001）和FIB（r=0.293，P＜0.001）间存在相关关系。Logistic回归分析显示，高龄（＞50岁）（OR=1.87，95% CI=1.25-2.15，P＜0.001）、治疗后复发（OR=2.11，95% CI=1.11-3.18，P=0003）、FLT3-ITD变异（OR=2.59，95% CI=1.10-4.12，P＜0.001）、CRP≥5.24 mg/L（OR=1.21，95% CI=1.02-2.14，P=0.024）、CFA（CFA=CRP*FIB/ALB）≥3（OR=2.41，95% CI=1.65-6.47，P＜0.001）、FER≥1145.58 mg/ml（OR=1.67，95% CI=1.15-3.75，P＜0.001）为AML患者生存的危险因素。ROC曲线分析显示，FER（AUC=0.752，95% CI=0.681-0.823，P＜0.001，最佳切点=1220.56 mg/ml）和CFA（AUC=0.804，95% CI=0.741-0.868，P＜0.001，最佳切点=3.00）对AML患者生存预测价值较高。低CFA组（CFA≤3）的CR率、PFS、DFS、OS均显著高于高CFA组（CFA＞3），而总体死亡率低于高CFA组；低FER组（FER≤1220.56 mg/ml）的CR率、PFS、DFS、OS均显著高于高FER组（FER＞1220.56 mg/ml），而总体死亡率低于高FER组，差异具有统计学意义.AML患者治疗前的CFA值和FER水平可独立预测患者的预后，高水平的CFA和FER与AML患者预后不良相关.

HIV/AIDS pandemic remains the world's most severe public health challenge, especially for HIV/AIDS immunological nonresponders (HIV/AIDS-INRs), who tend to have higher mortality. Due to the advantages in promoting patients' immune reconstitution, Traditional Chinese medicine (TCM) has become one of the mainstays of complementary treatments for HIV/AIDS-INRs. Given that effective TCM treatments largely depend on precise syndrome differentiation, there is an increasing interest in exploring biological evidence for the classification of TCM syndromes in HIV/AIDS-INRs. In our study, to identify the typical HIV/AIDS-INRs syndrome, an epidemiological survey was first conducted in the Liangshan prefecture (China), a high HIV/AIDS prevalence region. The key TCM syndrome, Yang deficiency of spleen and kidney (YDSK), was evaluated by using a tandem mass tag combined with liquid chromatography-tandem mass spectrometry (TMT-LC-MS/MS). A total of 62 differentially expressed proteins (DEPs) of YDSK syndrome compared with healthy people were screened out. Comparative bioinformatics analyses showed that DEPs in YDSK syndrome were mainly associated with response to wounding and acute inflammatory response in the biological process. The pathway annotation is mainly enriched in complement and coagulation cascades. Finally, the YDSK syndrome-specific DEPs such as HP and S100A9 were verified by ELISA, and confirmed as potential biomarkers for YDSK syndrome. Our study may lay the biological and scientific basis for the specificity of TCM syndromes in HIV/AIDs-INRs, and may provide more opportunities for the deep understanding of TCM syndromes and the developing more effective and stable TCM treatment for HIV/AIDS-INRs.中文摘要艾滋病仍然是全世界最严重的公共卫生挑战, 尤其是对艾滋病免疫无应答者而言, 他们往往有更高的死亡率。由于中医药在促进患者免疫重建方面优势突出, 现已成为艾滋病免疫无应答者补充治疗的支柱之一。鉴于有效的中医药治疗基于精准的辨证, 探索艾滋病免疫重建不全中医证候分类的生物学依据备受青睐。在我们的研究中, 为了确定艾滋病免疫无应答者的中医证候分布规律, 首先在我国艾滋病高发区凉山州进行了流行病学调查。接着我们采用TMT-LC-MS/MS技术对典型中医证候脾肾阳虚证进行了蛋白组学研究, 筛选出62种差异表达蛋白。通过生物信息分析显示, 脾肾阳虚证中的差异表达蛋白主要与生物过程中的创伤反应和急性炎症反应等有关。通路富集主要集中在补体和凝血级联等方面。最后, 利用ELISA检测方法对脾肾阳虚证候特异性蛋白HP和S100A9进行验证, 最终将这两种证候特异性蛋白确认为脾肾阳虚证的生物标记物。这为艾滋病免疫无应答中医证候的特异性奠定了生物学和科学基础, 为深入了解中医证候, 开发更有效、更稳定的中医治疗提供了更多机会。.

Let Mob( $$\mathbb{S}^{{n + 1}}$$ ) denote the Mobius transformation group of $$\mathbb{S}^{{n + 1}}$$ . A hypersurface f: $${M^n} \to \mathbb{S}^{{n + 1}}$$ is called a Mobius homogeneous hypersurface, if there exists a subgroup $$G \triangleleft {\text{M}}\ddot o{\text{b}}{(^{n + 1}})$$ such that the orbit G(p) = {ϕ(p) ∣ ϕ ∈ G} = f (Mn),p ∈ f (Mn). In this paper, we classify the Mobius homogeneous hypersurfaces in $$\mathbb{S}^{{n + 1}}$$ with at most one simple principal curvature up to a Mobius transformation.

Three-dimensional (3D) registration plays a pivotal step in augmented reality (AR) systems. Traditional 3D registration methods have the disadvantages of poor accuracy and robustness. This paper proposes a novel registration method, we believe, for AR systems based on the AKAZE and Tanimoto similarity measurement method. In this paper, the image feature points are extracted and matched by combining the AKAZE algorithm and the Tanimoto similarity measurement method. Then, the camera pose is estimated by calculating the constraint relationship of the feature points. Finally, the 3D registration and real-time tracking of the virtual objects are realized by the Lucas–Kanade (LK) optical flow tracking algorithm. We use Tanimoto to determine the similarity of feature points to improve the matching accuracy of the AKAZE algorithm, and this method not only retains the advantages of strong scale adaptation but also has the advantage of high-precision matching. Experiments show that the method proposed in this paper has the benefits of high registration accuracy, low time consumption, and strong robustness. Under the premise of ensuring accuracy, when the marker is rotated or blocked, it can be accurately registered. In addition, when the external environment changes, for example, the light intensity or the size of the parallax, the registration can still be stable.

In order to promote energy mutual aid among microgrids, expand the types of energy interaction, and improve the utilization of renewable energy, a two-layer sharing strategy for multi-microgrids (MMGs) based on the Nash game is proposed. Firstly, the low-carbon transformation of the micro-grid model is carried out, and the source side is transformed into a comprehensive and flexible operation mode for carbon capture thermal power plants. Then, the multi-microgrid subject electro-thermal double-layer sharing model based on the Nash game is constructed, which is decomposed into a revenue maximization sub-problem and a revenue redistribution sub-problem. In the sub-problem of revenue maximization, considering the lowest operation cost of carbon allowances and stepped carbon trading as the goal, the alternating direction multiplier method is used for a distributed solution. In the revenue redistribution sub-problem, the reasonable redistribution of income is realized by constructing the asymmetric energy mapping contribution function for different periods and energy types. Finally, the simulation results have verified the effectiveness of the proposed method. The results showed that the strategy of this paper can achieve the optimization of the economic objectives of the multi-microgrid (MMG) alliance and has the advantages of reasonable redistribution of benefits, promotion of wind and solar consumption, and reduction of carbon emissions.