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10 results on '"Xiong, Yan-Lu"'

5. The downregulation of fibrinogen-like protein 1 inhibits the proliferation of lung adenocarcinoma via regulating MYC-target genes

Author

Tang, Xi-Yang, primary, Xiong, Yan-Lu, additional, Shi, An-Ping, additional, Sun, Ying, additional, Han, Qing, additional, Lv, Yao, additional, Shi, Xian-Gui, additional, Frattini, Milo, additional, Malhotra, Jyoti, additional, Zheng, Kai-Fu, additional, Liu, Yu-Jian, additional, Jiang, Tao, additional, Ma, Nan, additional, and Zhao, Jin-Bo, additional

Published
2022
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6. Immune Checkpoint LAG3 and Its Ligand FGL1 in Cancer

Author

Shi, An-Ping, primary, Tang, Xi-Yang, additional, Xiong, Yan-Lu, additional, Zheng, Kai-Fu, additional, Liu, Yu-Jian, additional, Shi, Xian-Gui, additional, Lv, Yao, additional, Jiang, Tao, additional, Ma, Nan, additional, and Zhao, Jin-Bo, additional

Published
2022
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7. Regular Aerobic Exercise Attenuates Pain and Anxiety in Mice by Restoring Serotonin-Modulated Synaptic Plasticity in the Anterior Cingulate Cortex

Author

Zhou, Yong-Sheng, primary, Meng, Fan-Cheng, additional, Cui, Yue, additional, Xiong, Yan-Lu, additional, Li, Xu-Yang, additional, Meng, Fan-Bo, additional, Niu, Zi-Xuan, additional, Zheng, Jia-Xin, additional, Quan, Ya-Qi, additional, Wu, Sheng-Xi, additional, Han, Yong, additional, and Xu, Hui, additional

Published
2021
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8. PD-L1 expression and immune cells infiltration in primary tracheobronchial neoplasm

Author

Zheng, Kai-Fu, primary, Liu, Yu-Jian, additional, Ma, Nan, additional, Xiong, Yan-Lu, additional, Tang, Xi-Yang, additional, Zhang, Qian, additional, Luo, Zhong-Lin, additional, Tian, Huan-Huan, additional, Hofman, Paul, additional, Ichiki, Yoshinobu, additional, Metro, Giulio, additional, Tachihara, Motoko, additional, Gong, Li, additional, Li, Xiao-Fei, additional, and Zhao, Jin-Bo, additional

Published
2021
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10. Aberrantly High Expression Of NOK/STYK1 Is Tightly Associated With The Activation Of The AKT/GSK3β/N-Cadherin Pathway In Non-Small Cell Lung Cancer

Author

Huang,Zhao, Ma,Nan, Xiong,Yan-Lu, Wang,Lei, Li,Wei-Miao, Lai,Yuan-Yang, Zhang,Chen-Xi, Zhang,Zhi-Pei, Li,Xiao-Fei, and Zhao,Jin-Bo

Subjects
OncoTargets and Therapy
Abstract

Zhao Huang,1,* Nan Ma,2,* Yan-Lu Xiong,1,* Lei Wang,1 Wei-Miao Li,1 Yuan-Yang Lai,1 Chen-Xi Zhang,1 Zhi-Pei Zhang,1 Xiao-Fei Li,1 Jin-Bo Zhao1 1Department of Thoracic Surgery, Tangdu Hospital, Fourth Military Medical University, Xi’an, Shaanxi 710038, People’s Republic of China; 2Department of Ophthalmology, Tangdu Hospital, Fourth Military Medical University, Xi’an, Shaanxi 710038, People’s Republic of China*These authors contributed equally to this workCorrespondence: Jin-Bo Zhao; Xiao-Fei LiDepartment of Thoracic Surgery, Tangdu Hospital, Fourth Military Medical University, 1 Xinsi Road, Baqiao, Xi’an, Shaanxi 710038, People’s Republic of ChinaTel +86 29 8471 7367Fax +86 29 8471 7367Email zhaojinbo@aliyun.com; lxfchest@fmmu.edu.cnPurpose: High metastasis is a leading risk factor for the survival of non-small cell lung cancer (NSCLC) and epithelial-mesenchymal transition (EMT) is a vital step of metastasis. The expression of novel oncogene with kinase domain (NOK) has been observed in some human malignancies, including non-small cell lung cancer (NSCLC); however, the biological function of NOK in NSCLC remains unclear. In the study, we explored the function of NOK in NSCLC, with an aim to elucidate the relevant underlying mechanisms.Patients and methods: We investigate the expression of NOK, p-Akt, p-GSK-3β, E-cadherin and N-cadherin expression by immunohistochemical analysis using tissue microarrays of 72 paired NSCLC samples of cancerous and adjacent normal tissues. The associations between NOK expression and clinicopathological factors, overall survival, other proteins were assessed. Immunofluorescence analysis of NSCLC tissues was performed to study the location of NOK, Akt and GSK-3β. Up or down-regulated of NOK were conducted in two NSCLC cell lines to analyze its impact on AKT/GSK3β pathway.Results: Statistical analysis revealed NOK expression increased in NSCLC tissues compared with normal tissues (P

Published
2019

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