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5. Heparan Sulfate in Normal and Cancer Stem Cells of the Brain

Author

Xiong, Anqi, Roy, Ananya, Spyrou, Argyris, Forsberg-Nilsson, Karin, Karamanos, Nikos K., Series Editor, Kletsas, Dimitris, Editorial Board Member, Oh, Eok-Soo, Editorial Board Member, Passi, Alberto, Editorial Board Member, Pihlajaniemi, Taina, Editorial Board Member, Ricard-Blum, Sylvie, Editorial Board Member, Sagi, Irit, Editorial Board Member, Savani, Rashmin, Editorial Board Member, Watanabe, Hideto, Editorial Board Member, Götte, Martin, editor, and Forsberg-Nilsson, Karin, editor

Published
2021
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7. A novel IgE epitope-specific antibodies-based sandwich ELISA for sensitive measurement of immunoreactivity changes of peanut allergen Ara h 2 in processed foods

Author

Yan, Yan, primary, Li, Liming, additional, Long, Caiyun, additional, Dong, Yaping, additional, Li, Jinyu, additional, Shen, Caiyi, additional, Zhao, Yiqian, additional, Zhao, Jiangqiang, additional, Wang, Jianbin, additional, Xiong, Anqi, additional, Li, Xin, additional, Chen, Hongbing, additional, and He, Shengfa, additional

Published
2024
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9. Utilizing the Dog Genome in the Search for Novel Candidate Genes Involved in Glioma Development—Genome Wide Association Mapping followed by Targeted Massive Parallel Sequencing Identifies a Strongly Associated Locus

Author

Truvé, Katarina, Dickinson, Peter, Xiong, Anqi, York, Daniel, Jayashankar, Kartika, Pielberg, Gerli, Koltookian, Michele, Murén, Eva, Fuxelius, Hans-Henrik, Weishaupt, Holger, Swartling, Fredrik J, Andersson, Göran, Hedhammar, Åke, Bongcam-Rudloff, Erik, Forsberg-Nilsson, Karin, Bannasch, Danika, and Lindblad-Toh, Kerstin

Subjects
Biological Sciences, Genetics, Rare Diseases, Brain Cancer, Neurosciences, Cancer, Brain Disorders, Human Genome, Aetiology, 2.1 Biological and endogenous factors, Animals, Calcium-Calmodulin-Dependent Protein Kinase Kinase, Dog Diseases, Dogs, Eukaryotic Initiation Factors, Genetic Association Studies, Genome, Genome-Wide Association Study, Genotype, Glioma, Humans, Polymorphism, Single Nucleotide, Receptors, Purinergic P2X7, Developmental Biology
Abstract

Gliomas are the most common form of malignant primary brain tumors in humans and second most common in dogs, occurring with similar frequencies in both species. Dogs are valuable spontaneous models of human complex diseases including cancers and may provide insight into disease susceptibility and oncogenesis. Several brachycephalic breeds such as Boxer, Bulldog and Boston Terrier have an elevated risk of developing glioma, but others, including Pug and Pekingese, are not at higher risk. To identify glioma-associated genetic susceptibility factors, an across-breed genome-wide association study (GWAS) was performed on 39 dog glioma cases and 141 controls from 25 dog breeds, identifying a genome-wide significant locus on canine chromosome (CFA) 26 (p = 2.8 x 10-8). Targeted re-sequencing of the 3.4 Mb candidate region was performed, followed by genotyping of the 56 SNVs that best fit the association pattern between the re-sequenced cases and controls. We identified three candidate genes that were highly associated with glioma susceptibility: CAMKK2, P2RX7 and DENR. CAMKK2 showed reduced expression in both canine and human brain tumors, and a non-synonymous variant in P2RX7, previously demonstrated to have a 50% decrease in receptor function, was also associated with disease. Thus, one or more of these genes appear to affect glioma susceptibility.

Published
2016

15. Kundu et al, Supplementary Figure 3 from Heparanase Promotes Glioma Progression and Is Inversely Correlated with Patient Survival

Author

Kundu, Soumi, primary, Xiong, Anqi, primary, Spyrou, Argyris, primary, Wicher, Grzegorz, primary, Marinescu, Voichita D., primary, Edqvist, Per-Henrik D., primary, Zhang, Lei, primary, Essand, Magnus, primary, Dimberg, Anna, primary, Smits, Anja, primary, Ilan, Neta, primary, Vlodavsky, Israel, primary, Li, Jin-Ping, primary, and Forsberg-Nilsson, Karin, primary

Published
2023
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16. Data from Heparanase Promotes Glioma Progression and Is Inversely Correlated with Patient Survival

Author

Kundu, Soumi, primary, Xiong, Anqi, primary, Spyrou, Argyris, primary, Wicher, Grzegorz, primary, Marinescu, Voichita D., primary, Edqvist, Per-Henrik D., primary, Zhang, Lei, primary, Essand, Magnus, primary, Dimberg, Anna, primary, Smits, Anja, primary, Ilan, Neta, primary, Vlodavsky, Israel, primary, Li, Jin-Ping, primary, and Forsberg-Nilsson, Karin, primary

Published
2023
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17. Kundu et al, Supplementary Figure 2 from Heparanase Promotes Glioma Progression and Is Inversely Correlated with Patient Survival

Author

Kundu, Soumi, primary, Xiong, Anqi, primary, Spyrou, Argyris, primary, Wicher, Grzegorz, primary, Marinescu, Voichita D., primary, Edqvist, Per-Henrik D., primary, Zhang, Lei, primary, Essand, Magnus, primary, Dimberg, Anna, primary, Smits, Anja, primary, Ilan, Neta, primary, Vlodavsky, Israel, primary, Li, Jin-Ping, primary, and Forsberg-Nilsson, Karin, primary

Published
2023
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18. Kundu et al, Supplementary Figure 1 from Heparanase Promotes Glioma Progression and Is Inversely Correlated with Patient Survival

Author

Kundu, Soumi, primary, Xiong, Anqi, primary, Spyrou, Argyris, primary, Wicher, Grzegorz, primary, Marinescu, Voichita D., primary, Edqvist, Per-Henrik D., primary, Zhang, Lei, primary, Essand, Magnus, primary, Dimberg, Anna, primary, Smits, Anja, primary, Ilan, Neta, primary, Vlodavsky, Israel, primary, Li, Jin-Ping, primary, and Forsberg-Nilsson, Karin, primary

Published
2023
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19. Kundu et al, Supplementary Figure 4 from Heparanase Promotes Glioma Progression and Is Inversely Correlated with Patient Survival

Author

Kundu, Soumi, primary, Xiong, Anqi, primary, Spyrou, Argyris, primary, Wicher, Grzegorz, primary, Marinescu, Voichita D., primary, Edqvist, Per-Henrik D., primary, Zhang, Lei, primary, Essand, Magnus, primary, Dimberg, Anna, primary, Smits, Anja, primary, Ilan, Neta, primary, Vlodavsky, Israel, primary, Li, Jin-Ping, primary, and Forsberg-Nilsson, Karin, primary

Published
2023
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20. Rabbit genome analysis reveals a polygenic basis for phenotypic change during domestication

Author

Carneiro, Miguel, Rubin, Carl-Johan, Di Palma, Federica, Albert, Frank W., Alföldi, Jessica, Barrio, Alvaro Martinez, Pielberg, Gerli, Rafati, Nima, Sayyab, Shumaila, Turner-Maier, Jason, Younis, Shady, Afonso, Sandra, Aken, Bronwen, Alves, Joel M., Barrell, Daniel, Bolet, Gerard, Boucher, Samuel, Burbano, Hernán A., Campos, Rita, Chang, Jean L., Duranthon, Veronique, Fontanesi, Luca, Garreau, Hervé, Heiman, David, Johnson, Jeremy, Mage, Rose G., Peng, Ze, Queney, Guillaume, Rogel-Gaillard, Claire, Ruffier, Magali, Searle, Steve, Villafuerte, Rafael, Xiong, Anqi, Young, Sarah, Forsberg-Nilsson, Karin, Good, Jeffrey M., Lander, Eric S., Ferrand, Nuno, Lindblad-Toh, Kerstin, and Andersson, Leif

Published
2014

24. EVOLUTIONARY GENOMICS: Rabbit genome analysis reveals a polygenic basis for phenotypic change during domestication

Author

Carneiro, Miguel, Rubin, Carl-Johan, Di Palma, Federica, Albert, Frank W., Alföldi, Jessica, Barrio, Alvaro Martinez, Pielberg, Gerli, Rafati, Nima, Sayyab, Shumaila, Turner-Maier, Jason, Younis, Shady, Afonso, Sandra, Aken, Bronwen, Alves, Joel M., Barrell, Daniel, Bolet, Gerard, Boucher, Samuel, Burbano, Hernán A., Campos, Rita, Chang, Jean L., Duranthon, Veronique, Fontanesi, Luca, Garreau, Hervé, Heiman, David, Johnson, Jeremy, Mage, Rose G., Peng, Ze, Queney, Guillaume, Rogel-Gaillard, Claire, Ruffier, Magali, Searle, Steve, Villafuerte, Rafael, Xiong, Anqi, Young, Sarah, Forsberg-Nilsson, Karin, Good, Jeffrey M., Lander, Eric S., Ferrand, Nuno, Lindblad-Toh, Kerstin, and Andersson, Leif

Published
2014
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25. Nuclear Receptor Binding Protein 2 Is Downregulated in Medulloblastoma, and Reduces Tumor Cell Survival upon Overexpression

Author

Xiong, Anqi, Roy, Ananya, Spyrou, Argyris, Weishaupt, Holger, Marinescu, Voichita D., Olofsson, Tommie, Hermanson, Ola, Swartling, Fredrik J., and Forsberg-Nilsson, Karin

Subjects
Cell- och molekylärbiologi, apoptosis, pseudokinase, lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens, NRBP, lcsh:RC254-282, Article, Cell and Molecular Biology, brain tumor, pediatric cancer
Abstract

Pseudokinases, comprising 10% of the human kinome, are emerging as regulators of canonical kinases and their functions are starting to be defined. We previously identified the pseudokinase Nuclear Receptor Binding Protein 2 (NRBP2) in a screen for genes regulated during neural differentiation. During mouse brain development, NRBP2 is expressed in the cerebellum, and in the adult brain, mainly confined to specific neuronal populations. To study the role of NRBP2 in brain tumors, we stained a brain tumor tissue array for NRPB2, and find its expression to be low, or absent, in a majority of the tumors. This includes medulloblastoma (MB), a pediatric tumor of the cerebellum. Using database mining of published MB data sets, we also find that NRBP2 is expressed at a lower level in MB than in the normal cerebellum. Recent studies indicate that MB exhibits frequent epigenetic alternations and we therefore treated MB cell lines with drugs inhibiting DNA methylation or histone deacetylation, which leads to an upregulation of NRBP2 mRNA expression, showing that it is under epigenetic regulation in cultured MB cells. Furthermore, forced overexpression of NRBP2 in MB cell lines causes a dramatic decrease in cell numbers, increased cell death, impaired cell migration and inhibited cell invasion in vitro. Taken together, our data indicate that downregulation of NRBP2 may be a feature by which MB cells escape growth regulation.

Published
2020

31. Heparanase confers a growth advantage to differentiating murine embryonic stem cells, and enhances oligodendrocyte formation.

Author

Xiong, Anqi, Kundu, Soumi, Forsberg, Maud, Xiong, Yuyuan, Bergström, Tobias, Paavilainen, Tanja, Kjellén, Lena, Li, Jin-Ping, Forsberg-Nilsson, Karin, Xiong, Anqi, Kundu, Soumi, Forsberg, Maud, Xiong, Yuyuan, Bergström, Tobias, Paavilainen, Tanja, Kjellén, Lena, Li, Jin-Ping, and Forsberg-Nilsson, Karin

Abstract

Heparan sulfate proteoglycans (HSPGs), ubiquitous components of mammalian cells, play important roles in development and homeostasis. These molecules are located primarily on the cell surface and in the pericellular matrix, where they interact with a multitude of macromolecules, including many growth factors. Manipulation of the enzymes involved in biosynthesis and modification of HSPG structures alters the properties of stem cells. Here, we focus on the involvement of heparanase (HPSE), the sole endo-glucuronidase capable of cleaving of HS, in differentiation of embryonic stem cells into the cells of the neural lineage. Embryonic stem (ES) cells overexpressing HPSE (Hpse-Tg) proliferated more rapidly than WT ES cells in culture and formed larger teratomas in vivo. In addition, differentiating Hpse-Tg ES cells also had a higher growth rate, and overexpression of HPSE in NSPCs enhanced Erk and Akt phosphorylation. Employing a two-step, monolayer differentiation, we observed an increase in HPSE as wild-type (WT) ES cells differentiated into neural stem and progenitor cells followed by down-regulation of HPSE as these NSPCs differentiated into mature cells of the neural lineage. Furthermore, NSPCs overexpressing HPSE gave rise to more oligodendrocytes than WT cultures, with a concomitant reduction in the number of neurons. Our present findings emphasize the importance of HS, in neural differentiation and suggest that by regulating the availability of growth factors and, or other macromolecules, HPSE promotes differentiation into oligodendrocytes.

Published
2017
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33. Utilizing the Dog Genome in the Search for Novel Candidate Genes Involved in Glioma Development-Genome Wide Association Mapping followed by Targeted Massive Parallel Sequencing Identifies a Strongly Associated Locus

Author

Truve, Katarina, Dickinson, Peter, Xiong, Anqi, York, Daniel, Jayashankar, Kartika, Pielberg, Gerli, Koltookian, Michele, Murén, Eva, Fuxelius, Hans-Henrik, Weishaupt, Holger, Swartling, Fredrik J., Andersson, Göran, Hedhammar, Ake, Bongcam-Rudloff, Erik, Forsberg-Nilsson, Karin, Bannasch, Danika, Lindblad-Toh, Kerstin, and Hunter, Kent W

Subjects
Gene Expression, Receptors, Medicine and Health Sciences, 2.1 Biological and endogenous factors, Dog Diseases, Aetiology, Eukaryotic Initiation Factors, Neurological Tumors, Cancer, Mammals, Genome, Mammalian Genomics, Pets and Companion Animals, Single Nucleotide, Glioma, Genomics, Oncology, Neurology, Vertebrates, Purinergic P2X7, Research Article, Genotyping, lcsh:QH426-470, Genotype, Animal Types, Calcium-Calmodulin-Dependent Protein Kinase Kinase, Research and Analysis Methods, Polymorphism, Single Nucleotide, Rare Diseases, Dogs, Genetics, Genome-Wide Association Studies, Animals, Humans, Genetik, Polymorphism, Molecular Biology Techniques, Molecular Biology, Genetic Association Studies, Human Genome, Gene Mapping, Neurosciences, Organisms, Cancers and Neoplasms, Biology and Life Sciences, Computational Biology, Human Genetics, Genome Analysis, Brain Disorders, Brain Cancer, lcsh:Genetics, Animal Genomics, Amniotes, Receptors, Purinergic P2X7, Zoology, Developmental Biology, Genome-Wide Association Study
Abstract

Gliomas are the most common form of malignant primary brain tumors in humans and second most common in dogs, occurring with similar frequencies in both species. Dogs are valuable spontaneous models of human complex diseases including cancers and may provide insight into disease susceptibility and oncogenesis. Several brachycephalic breeds such as Boxer, Bulldog and Boston Terrier have an elevated risk of developing glioma, but others, including Pug and Pekingese, are not at higher risk. To identify glioma-associated genetic susceptibility factors, an across-breed genome-wide association study (GWAS) was performed on 39 dog glioma cases and 141 controls from 25 dog breeds, identifying a genome-wide significant locus on canine chromosome (CFA) 26 (p = 2.8 x 10−8). Targeted re-sequencing of the 3.4 Mb candidate region was performed, followed by genotyping of the 56 SNVs that best fit the association pattern between the re-sequenced cases and controls. We identified three candidate genes that were highly associated with glioma susceptibility: CAMKK2, P2RX7 and DENR. CAMKK2 showed reduced expression in both canine and human brain tumors, and a non-synonymous variant in P2RX7, previously demonstrated to have a 50% decrease in receptor function, was also associated with disease. Thus, one or more of these genes appear to affect glioma susceptibility., Author Summary Gliomas are devastating malignant brain tumors that are very rarely curable. Despite extensive research to define pathways and genes involved in the development of disease, there is still an urgent need to improve therapy. Some dog breeds have a considerable elevated risk of glioma, making the dog a suitable model for locating genes potentially of importance also for development of human glioma. In this study we defined a genomic region strongly associated with glioma in dogs. We also showed that this genomic region had likely been under selection in the dog breeds with the highest risk of developing glioma. Sometimes selection for breed specific traits results in amplification of disease causing mutations together with the variant selected for. We located three candidate genes in the identified region: CAMKK2, P2RX7 and DENR. We performed further functional studies to evaluate the potential role of these genes in both canine and human glioma. By comparing normal and tumor tissue we could show that two of the genes—CAMKK2 and P2RX7, were affected at the level of gene expression and protein structure, respectively. We propose that further investigation of all three genes could be of interest with potential benefit to both dog and human.

Published
2015

34. Heparanase Promotes Glioma Progression and Is Inversely Correlated with Patient Survival

Author

Kundu, Soumi, primary, Xiong, Anqi, additional, Spyrou, Argyris, additional, Wicher, Grzegorz, additional, Marinescu, Voichita D., additional, Edqvist, Per-Henrik D., additional, Zhang, Lei, additional, Essand, Magnus, additional, Dimberg, Anna, additional, Smits, Anja, additional, Ilan, Neta, additional, Vlodavsky, Israel, additional, Li, Jin-Ping, additional, and Forsberg-Nilsson, Karin, additional

Published
2016
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35. Novel Regulators of Brain Tumor Development : – From neural stem cell differentiation to in vivo models

Author

Xiong, Anqi

Subjects
neural stem cell, Cancer och onkologi, dog models, glioma, Cell- och molekylärbiologi, Cancer and Oncology, NRBP2, medulloblastoma, susceptibility, Cell and Molecular Biology, heparanase
Abstract

Malignant brain tumors are diseases with poor prognosis and/or severe long-term side effects of treatment. This thesis aimed to discover novel regulators in brain tumor development, based on studying neural stem cell and progenitor cell (NSPC) differentiation and using animal models to introduce new insights to mechanisms of human brain tumors. The enzyme heparanase (HPSE) that degrades heparan sulfate (HS) is active in cell signaling and ECM remodeling. In paper I, we found an enhanced differentiation to oligodendrocytes in ES cell-derived NSPCs overexpressing HPSE. Further analysis suggested that this enhanced formation of oligodendrocytes was associated with alterations in receptor tyrosine kinase signaling, and that HPSE might also exert anti-apoptotic functions. Subsequently, in paper II we studied the involvement of HPSE in glioma development. We observed that high HPSE levels associated with poor survival in glioma patients. In experimental models, we found that HPSE promoted glioma growth, and that an inhibitor of HPSE reduced glioma progression both in vitro and in vivo. We hypothesize that regulators in NSPC differentiation could have a potential role in brain tumor development. In paper III, we explored the function of NRBP2, a pseudokinase that is up-regulated during NSPC differentiation. We found low expression of NRBP2 in brain tumors, in comparison to normal brain. In medulloblastoma, in particular, low NRBP2 expression is linked to poor prognosis. Overexpression of NRBP2 in medulloblastoma cells led to impaired cell growth and migration, concomitant with an increased cell death. In paper IV, we searched for novel glioma susceptibility genes by sequencing dog breeds from the same ancestor but with different glioma incidence. In this way we identified three new glioma-associated genes. Two of these are significantly regulated in human glioma and one of those might have a role in glioblastoma stem cell differentiation.

Published
2015

36. Heparanase Promotes Glioma Progression and is Inversely Correlated with Patient Survival.

Author

Kundu, Soumi, Xiong, Anqi, Spyrou, Argyris, Wicher, Grzegorz, Marinescu, Voichita D, Edqvist, Per-Henrik D, Zhang, Lei, Essand, Magnus, Dimberg, Anna, Smits, Anja, Ilan, Neta, Vlodavsky, Israel, Li, Jin-Ping, Forsberg-Nilsson, Karin, Kundu, Soumi, Xiong, Anqi, Spyrou, Argyris, Wicher, Grzegorz, Marinescu, Voichita D, Edqvist, Per-Henrik D, Zhang, Lei, Essand, Magnus, Dimberg, Anna, Smits, Anja, Ilan, Neta, Vlodavsky, Israel, Li, Jin-Ping, and Forsberg-Nilsson, Karin

Abstract

Malignant glioma continues to be fatal, despite improved insight into its underlying molecular mechanisms. The most malignant form, glioblastoma (GBM), is characterized by aberrant activation of receptor tyrosine kinases (RTK) and infiltrative growth. Heparan sulfate proteoglycans (HSPGs), integral components of the extracellular matrix of brain tumors (HPSE), which cleaves HSPGs, for its role in glioma. This hypothesis was evaluated using tissue microarrays, GBM cells derived from patients, murine in vitro and in vivo can regulate activation of many RTK pathways. This prompted us to investigate heparanase models of glioma, and public databases. Down-regulation of HPSE attenuated glioma cell proliferation, while addition of HPSE stimulated growth, and activated ERK and AKT signaling. Using HPSE transgenic and knockout mice it was demonstrated that tumor development in vivo was positively correlated to HPSE levels in the brain. HPSE also modified the tumor microenvironment, influencing reactive astrocytes, microglia/monocytes and tumor angiogenesis. Furthermore, inhibition of HPSE reduces tumor cell numbers, both in vitro and in vivo. HPSE was highly expressed in human glioma and GBM cell lines, compared to normal brain tissue. Indeed, a correlation was observed between high levels of HPSE and shorter survival of patients with high-grade glioma. In conclusion, these data provide proof-of-concept for anti-HPSE treatment of malignant glioma, as well as novel insights for the development of HPSE as a therapeutic target. IMPLICATIONS: This study aims to target both the malignant brain tumor cells per se, and their microenvironment by changing the level of an enzyme, heparanase, that breaks down modified sugar chains on cell surfaces and in the extracellular space.

Published
2016
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37. In VivoEffects of Porcine and Rabbit Antithymocyte Globulin in Patients with Severe Aplastic Anemia

Author

Zhang, Yawen, Zhang, Yingying, Xiong, Anqi, Gong, Yuemin, Chen, Xiaoyu, Sun, Yu, He, Guangsheng, and Li, Jianyong

Abstract

Background:Severeaplastic anemia (SAA) is a bone marrow failure disorder mediated by T lymphocytes, resulting in severe deficiency of hematopoietic stem cells. Horse antithymocyte globulin (H-ATG) plus cyclosporin was the first-line therapy for SAA patients in the absence of an HLA-matched sibling 1. The inhibitory effect of Rabbit-ATG (R-ATG) on lymphocytes is more deeply than that of H-ATG, and the recovery of CD4 T cells is slower, resulting in poor efficacy in SAA patients 2. Porcine ATG (P-ATG) and R-ATG are two available immunosuppressive choices in China mainland, the first-line formulation of ATG remains unknown.

Published
2023
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38. NDST1 as a novel regulator of glioblastoma cell growth and stemness

Author

Spyrou, Argyris, Xiong, Anqi, Kundu, Soumi, Marinescu, Voichita Dana, Götte, Martin, Riethmüller, Christoph, Greve, Burkhard, Kjellén, Lena, Forsberg-Nilsson, Karin, Spyrou, Argyris, Xiong, Anqi, Kundu, Soumi, Marinescu, Voichita Dana, Götte, Martin, Riethmüller, Christoph, Greve, Burkhard, Kjellén, Lena, and Forsberg-Nilsson, Karin

39. Genome-Wide Association Mapping of Canine Glioma Followed by Targeted Massive Parallel Sequencing Identifies CAMKK2, P2RX7 and DENR as Novel Candidate Genes for Canine and Human Glioma

Author

Truvé, Katarina, Dickinson, Peter, Xiong, Anqi, York, Daniel, Jayashankar, Kartika, Pielberg, Gerli, Koltookian, Michele, Murén, Eva, Fuxelius, Hans-Henrik, Weishaupt, Holger, J. Swartling, Fredrik, Andersson, Göran, Hedhammar, Åke, Bongcam-Rudloff, Erik, Forsberg-Nilsson, Karin, Bannasch, Danika, Lindblad-Toh, Kerstin, Truvé, Katarina, Dickinson, Peter, Xiong, Anqi, York, Daniel, Jayashankar, Kartika, Pielberg, Gerli, Koltookian, Michele, Murén, Eva, Fuxelius, Hans-Henrik, Weishaupt, Holger, J. Swartling, Fredrik, Andersson, Göran, Hedhammar, Åke, Bongcam-Rudloff, Erik, Forsberg-Nilsson, Karin, Bannasch, Danika, and Lindblad-Toh, Kerstin

41. Nuclear Receptor Binding Protein 2 is down-regulated in Medulloblastoma, and reduces tumor cell survival when overexpressed in Medulloblastoma cells in vitro

Author

Xiong, Anqi, Spyrou, Argyris, Marinescu, Voichita D., Alemayehu, Groom, Weishaupt, Holger, Olofsson, Tommie, Hermanson, Ola, Swartling, Fredrik J., Forsberg-Nilsson, Karin, Xiong, Anqi, Spyrou, Argyris, Marinescu, Voichita D., Alemayehu, Groom, Weishaupt, Holger, Olofsson, Tommie, Hermanson, Ola, Swartling, Fredrik J., and Forsberg-Nilsson, Karin

43. Heparanase promotes glioma progression and is inversely correlated with patient survival

Author

Kundu, Soumi, Xiong, Anqi, Spyrou, Argyris, Wicher, Grzegorz, Marinescu, Voichita D., Edqvist, Per-Henrik D., Zhang, Lei, Essand, Magnus, Dimberg, Anna, Smits, Anja, Ilan, Neta, Israel, Vlodavsky, Li, Jin-Ping, Forsberg-Nilsson, Karin, Kundu, Soumi, Xiong, Anqi, Spyrou, Argyris, Wicher, Grzegorz, Marinescu, Voichita D., Edqvist, Per-Henrik D., Zhang, Lei, Essand, Magnus, Dimberg, Anna, Smits, Anja, Ilan, Neta, Israel, Vlodavsky, Li, Jin-Ping, and Forsberg-Nilsson, Karin

44. Rabbit genome analysis reveals a polygenic basis for phenotypic change during domestication

Author

Jeremy A. Johnson, Guillaume Queney, Sarah Young, G. Bolet, Frank W. Albert, Anqi Xiong, Gerli Pielberg, Rose G. Mage, Leif Andersson, Samuel Boucher, Alvaro Martinez Barrio, Shady Younis, Carl-Johan Rubin, Nima Rafati, Kerstin Lindblad-Toh, Magali Ruffier, Eric S. Lander, Sandra Afonso, Bronwen Aken, Shumaila Sayyab, Federica Di Palma, Miguel Carneiro, Claire Rogel-Gaillard, Jessica Alföldi, Karin Forsberg-Nilsson, Jeffrey M. Good, Nuno Ferrand, Steve Searle, Rita Campos, Jean L. Chang, Luca Fontanesi, Daniel Barrell, Rafael Villafuerte, Hernán A. Burbano, Joel M. Alves, Ze Peng, Hervé Garreau, David I. Heiman, Véronique Duranthon, Jason Turner-Maier, Centro de Investigaçao em Biodiversidade e Recursos Genéticos, Science of Life Laboratory Uppsala - Department of Medical Biochemistry and Microbiology, Uppsala University, Broad Institute of MIT and Harvard (BROAD INSTITUTE), Harvard Medical School [Boston] (HMS)-Massachusetts Institute of Technology (MIT)-Massachusetts General Hospital [Boston], Vertebrate and Health Genomics, Department of Evolutionary Genetics, Max Planck Institute for Evolutionary Anthropology [Leipzig], Max-Planck-Gesellschaft-Max-Planck-Gesellschaft, Department of Human Genetics, University of California, Science of Life Laboratory Uppsala - Department of Medical Biochemistry and Microbioology, Department of Animal Bredding and Genetics, Swedish University of Agricultural Sciences (SLU), Department of Animal Production, Université Ain Shams, The Wellcome Trust Sanger Institute [Cambridge], University of Cambridge [UK] (CAM), Génétique Physiologie et Systèmes d'Elevage (GenPhySE ), École nationale supérieure agronomique de Toulouse [ENSAT]-Institut National de la Recherche Agronomique (INRA)-Ecole Nationale Vétérinaire de Toulouse (ENVT), Institut National Polytechnique (Toulouse) (Toulouse INP), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut National Polytechnique (Toulouse) (Toulouse INP), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées, Labovet Conseil, Max-Planck-Gesellschaft, Biologie du développement et reproduction (BDR), Centre National de la Recherche Scientifique (CNRS)-École nationale vétérinaire d'Alfort (ENVA)-Institut National de la Recherche Agronomique (INRA), Department of Agricultural and Food Sciences - Division of Animal Sciences, Alma Mater Studiorum University of Bologna (UNIBO), Laboratory of Immunology, National Institute of Allergy and Infectious Deseases (NIAID), Lawrence Berkeley National Laboratory [Berkeley] (LBNL), Antagene - Animal Genomics Laboratory, Génétique Animale et Biologie Intégrative (GABI), Institut National de la Recherche Agronomique (INRA)-AgroParisTech, Spanish National Research Council (CSIC), Science for Life Laboratory - Department of Immunology , Genetics and Pathology, Science for Life Laboratory - Department of Immunology, Genetics and Pathology, Department of Veterinary Integrative Biosciences, College of Veterinary Medicine and Biomedical Sciences, U54 HG003067 NHGRI NIH HHS, WT095908 Wellcome Trust, WT098051 Wellcome Trust, Carneiro, Miguel, Rubin, Carl-Johan, Palma, Federica Di, Albert, Frank W., Alföldi, Jessica, Barrio, Alvaro Martinez, Pielberg, Gerli, Rafati, Nima, Sayyab, Shumaila, Turner-Maier, Jason, Younis, Shady, Afonso, Sandra, Aken, Bronwen, Alves, Joel M., Barrell, Daniel, Bolet, Gerard, Boucher, Samuel, Burbano, Hernán A., Campos, Rita, Chang, Jean L., Duranthon, Veronique, Fontanesi, Luca, Garreau, Herve, Heiman, David, Johnson, Jeremy, Mage, Rose G., Peng, Ze, Queney, Guillaume, Rogel-Gaillard, Claire, Ruffier, Magali, Searle, Steve, Villafuerte, Rafael, Xiong, Anqi, Young, Sarah, Forsberg-Nilsson, Karin, Good, Jeffrey M., Lander, Eric S., Ferrand, Nuno, Lindblad-Toh, Kerstin, Andersson, Leif, Max Planck Institute for Evolutionary Anthropology, Department of Animal Breeding and Genetics, Institut National de la Recherche Agronomique (INRA)-Ecole Nationale Vétérinaire de Toulouse (ENVT), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-École nationale supérieure agronomique de Toulouse [ENSAT], Biologie du Développement et Reproduction (BDR), and Institut National de la Recherche Agronomique (INRA)

Subjects
Molecular Sequence Data, Animals, Wild, Single-nucleotide polymorphism, Rabbit, Breeding, Biology, Polymorphism, Single Nucleotide, Genome, Article, Evolution, Molecular, Gene Frequency, Animals, Selection, Genetic, Allele, Domestication, [SDV.BDD]Life Sciences [q-bio]/Development Biology, Gene, Allele frequency, Genetics, Multidisciplinary, Base Sequence, Behavior, Animal, Animal, Medicine (all), Sequence Analysis, DNA, Phenotype, Genetic Loci, Animals, Domestic, Rabbits, Reference genome
Abstract

Rabbits softly swept to domestication When people domesticate animals, they select for tameness and tolerance of humans. What else do they look for? To identify the selective pressures that led to rabbit domestication, Carneiro et al. sequenced a domestic rabbit genome and compared it to that of its wild brethren (see the Perspective by Lohmueller). Domestication did not involve a single gene changing, but rather many gene alleles changing in frequency between tame and domestic rabbits, known as a soft selective sweep. Many of these alleles have changes that may affect brain development, supporting the idea that tameness involves changes at multiple loci. Science , this issue p. 1074 ; see also p. 1000

Published
2014

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