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Cattle are one of the six livestock species that have occupied an important place in Chinese history. Previous ancient DNA studies have indicated that Chinese taurine cattle (Bos taurus taurus) are exotic, but the exact route and diffusion by which they were introduced to China is unknown. In this study, we extracted the mitochondrial genomes of 34 cases of ancient taurine cattle (from the late Neolithic to Qin and Han dynasties) excavated from sites in northern China and the eastern Eurasian steppe, and successfully obtained 14 mitochondrial genome sequences. The results of ancient DNA analysis reveal that with cultural exchange and trade, there was close genetic exchange between domestic taurine cattle in different regions. The haplotypes shared by domestic cattle have genetic continuity, reflecting the strong cultural influence of the large capital city sites such as Taosi, Shimao and Erlitou on the surrounding areas. This study suggests that ancient northern Chinese taurine cattle may have accompanied the westward transmission of agricultural or painted pottery culture and thus had a maternal genetic contribution to modern Tibetan cattle.

Human cancers typically express a high level of tumor-promoting mutant p53 protein (Mutp53) with a minimal level of tumor-suppressing wild-type p53 protein (WTp53). In this regard, inducing Mutp53 degradation while activating WTp53 is a viable strategy for precise anti-tumor therapy. Herein, a new carrier-free nanoprodrug (

The exceptionally-rich fossil record available for the equid family has provided textbook examples of macroevolutionary changes. Horses, asses and zebras represent three extant subgenus of Equus lineage, while the Sussemionus subgenus is another remarkable Equus lineage ranging from North America to Ethiopia in Pleistocene. We sequenced 26 archaeological specimens from northern China in Holocene showing morphological features reminiscent of Equus ovodovi, a species representative of Sussemionus, and further confirmed them as this species by genetic analyses. Thus, we present the first high-quality complete genome of the Sussemionus that we sequenced to 12.0× depth-of-coverage and demonstrate that it survived until ∼3,500 years ago, despite the continued demographic collapse during the Last Glacial Maximum and the great human expansion in East Asia. We also confirmed the Equus phylogenetic tree, and found Sussemionus diverged from the ancestor of non-caballine equids ∼2.3-2.7 Million years ago and admixture events could have taken place between them. Our works suggest the small genetic diversity but not the enhanced inbreeding mainly limited the chances of survival of the species, and illustrates how ancient DNA can inform on extinction dynamics and the long-term resilience of species surviving in cryptic population pockets.

The exceptionally rich fossil record available for the equid family has provided textbook examples of macroevolutionary changes. Horses, asses, and zebras represent three extant subgenera of

The time around 4000 BP marks a key stage from the Late Neolithic to the Early Bronze Age in China. During the time, sheep and cattle husbandry saw rapid development under the Qijia Culture in the Gansu-Qinghai region and also became more common in the Central Plains and Inner Mongolia. In this study, we performed ancient DNA analysis on sheep and cattle remains from four archaeological sites (Changning, Shimao, Taosi and Dashanqian) in northern China, and we obtained mtDNA D-loop fragments (overlapping 271 bp for sheep and overlapping 294 bp for cattle) from 22 of 26 sheep and 44 of 52 cattle remains. The mtDNA haplogroup data reveal that all the sheep DNA samples belong to sub-haplogroups A or B, and all the cattle DNA samples belong to haplogroup T3 or T4. The identification of these common haplogroups again confirms that the ancestors of these early sheep and cattle must have been introduced from outside China, likely from the Near East. The more detailed comparison of haplogroups also indicates potential intensified trade and cultural exchanges between different regions. Furthermore, this study also provides new ancient DNA data for better understanding the origins and spread of sheep and cattle in ancient China.

The focus of this paper is on control design and simulation for an air-breathing hypersonic cruise vehicle (HCV). Aiming at the highly nonlinear and strong coupling for HCV mathematical model, the theory of feedback linearization based Lie derivative introduced can convert accurately nonlinear mathematic model into equivalent linear model for control design. By the proper transformation, dynamic inversion flight control systems for hypersonic vehicle designed can stabilize the system and relieve the coupling effects. Simulation results show the correctness of the simulation platform and the effectiveness of the control approach.