Search

The construction duration of long-span arch bridges is excessively prolonged due to insufficient closing precision and the non-convergence of traditional cable adjustment calculation methods. This study investigates cable force management in long-span concrete-filled steel tubular (CFST) arch bridges during cable-stayed buckle construction, aiming to improve construction safety and precision in arch rib alignment. Using the Pingnan Third Bridge and Tian’e Longtan Bridge as practical examples, the research develops a multi-objective optimization method for cable forces that integrates influence matrices, constrained minimization, and a forward iterative approach. This method offers a robust strategy for tensioning and cable-stayed buckling, enabling real-time monitoring, calculation, and adjustment during the construction of large-span CFST arch bridges. The results reveal that the iterative approach notably enhances calculation efficiency compared to conventional methods. For instance, field measurements at the Pingnan Third Bridge show a minimal arch closure error of only 3 mm. Additionally, the study addresses concerns about excessive stress in exposed steel tubes during concrete casting. By optimizing the sequence of main arch closure and concrete casting, stress in the exposed steel tube is reduced from 373 MPa to 316 MPa, thus meeting specification requirements. In summary, the multi-objective cable force optimization method demonstrates superior efficiency in determining cable tension and controlling rib alignment during cable-stayed buckle construction of long-span CFST arch bridges.

Joint attention (JA), a core deficit in children with autism spectrum disorder (ASD), is crucial for social interaction, emotional understanding, and cognitive development. This study aims to compare and analyze the eye-tracking data of ASD and typically developing children (TDC) during virtual games, exploring how different cue types affect JA performance in ASD children. A total of 31 TDC and 40 ASD children participated in the study. Using eye-tracking devices, we recorded the children’s eye movements as they played virtual games, selecting the correct target based on cues provided by virtual characters. Our findings revealed that different cue types significantly impacted the game scores of ASD children but had no significant effect on TDC, highlighting a notable disparity between the two groups. ASD children showed a lower fixation frequency, irregular fixation paths, and increased attention to non-target objects compared to TDC. Interestingly, among the three cue types, ASD children exhibited a preference for the third type, leading to longer fixation on the region of interest and higher game scores. These results underscore the importance of cue selection in enhancing JA in ASD children. This study provides novel insights into the JA deficits in ASD children and offers a scientific basis for the development of targeted and individualized intervention programs.

The accurate installation of long-span arch bridges’ arch ribs remains a challenge due to the complex calculations required for cable forces and arch rib displacements, as well as the significant influence of environmental and construction loads. In this study, we propose a practical approach to alignment and error feedback control for long-span arch bridges. Cable forces were optimized using multiple control objectives based on influence matrix principles. The impact of temperature on the next segment to be installed was analyzed using the metastatic GM(1, 1) model and fitting results. Several tunable parameters were employed to account for parameter errors and environmental interference. These parameters were adjusted based on the deviations between practical and theoretical alignments for different arch rib segments, achieving a model output of an offset-free-tracking arch rib structure. This technology was applied to monitor the construction of the Tian’e Longtan Grand Bridge. Compared to conventional alignment control approaches, the proposed method achieved excellent arch ring alignment after the closure of the high-accuracy arch rib and cable release, as well as effective control of cable force uniformity and tower deviation. Field measurement data indicate that the closing deviation of the arch ring is only 3 mm. This study provides a valuable reference for the construction control of long-span arch bridges.

Under the condition of weakly cemented soft rock in Western China, the surrounding rock deformation of gob-side entry is obvious, especially under the influence of fault, and the problem of surrounding rock control becomes increasingly prominent. To solve this issue, this paper firstly studied and obtained the evolution law of the ground pressure appearance of the gob-side entry in the fault area, then put forward the concept of surrounding rock control in the fault area of the gob-side entry, put forward a targeted pressure relief + increase preload + passive reinforcement parallel to the roadway surrounding rock strengthening control scheme, and carried out field applications. The results show that the roof subsidence and mining side heave of the roadway in the fault area increase significantly, accompanied by the characteristics of broken cables, the length of the broken cable is 0.2 m–0.6 m, and the breaking process is divided into multiple breaks. The stress evolution of gob-side entry in fault area presents a stage characteristic of “rapid growth-stable.” The surrounding rock control effect is improved under the bolt cable high pre-tightening support, and the roadway deformation is effectively controlled under the pressure relief + active + passive support, with a good application effect.

Psoriasis is a complex, chronic autoimmune disorder predominantly affecting the skin. Accumulating evidence underscores the critical role of localized cellular inflammation in the development and persistence of psoriatic skin lesions, involving cell types such as keratinocytes, mesenchymal cells, and Schwann cells. However, the underlying mechanisms remain largely unexplored. Long non-coding RNAs (lncRNAs), known to regulate gene expression across various cellular processes, have been particularly implicated in immune regulation. We utilized our neural-network learning pipeline to integrate 106,675 cells from healthy human skin and 79,887 cells from psoriatic human skin. This formed the most extensive cell transcriptomic atlas of human psoriatic skin to date. The robustness of our reclassified cell-types, representing full-layer zonation in human skin, was affirmed through neural-network learning-based cross-validation. We then developed a publicly available website to present this integrated dataset. We carried out analysis for differentially expressed lncRNAs, co-regulated gene patterns, and GO-bioprocess enrichment, enabling us to pinpoint lncRNAs that modulate localized cellular inflammation in psoriasis at the single-cell level. Subsequent experimental validation with skin cell lines and primary cells from psoriatic skin confirmed these lncRNAs’ functional role in localized cellular inflammation. Our study provides a comprehensive cell transcriptomic atlas of full-layer human skin in both healthy and psoriatic conditions, unveiling a new regulatory mechanism that governs localized cellular inflammation in psoriasis and highlights the therapeutic potential of lncRNAs in this disease’s management.

In recent years, virtual reality technology, which is able to simulate real-life environments, has been widely used in the field of intervention for individuals with autism and has demonstrated distinct advantages. This review aimed to evaluate the impact of virtual reality technology on safety skills intervention for individuals with autism. After searching and screening three databases, a total of 20 pertinent articles were included. There were six articles dedicated to the VR training of street-crossing skills for individuals with autism, nine articles focusing on the training of driving skills for individuals with ASD, and three studies examining the training of bus riding for individuals with ASD. Furthermore, there were two studies on the training of air travel skills for individuals with ASD. First, we found that training in some complex skills (e.g., driving skills) should be selected for older, high-functioning individuals with ASD, to determine their capacity to participate in the training using scales or questionnaires before the intervention; VR devices with higher levels of immersion are not suitable for younger individuals with ASD. Second, VR is effective in training safety skills for ASD, but there is not enough evidence to determine the relationship between the level of VR immersion and intervention effects. Although the degree of virtual reality involvement has an impact on the ability of ASD to be generalized to the real world, it is important to ensure that future virtual reality settings are realistic and lifelike. Again, adaptive models that provide personalized training to individuals with ASD in VR environments are very promising, and future research should continue in this direction. This paper also discusses the limitations of these studies, as well as potential future research directions.

Here, we treated moderately traumatic brain injury (TBI) rats with different modalities, including transplantation with mesenchymal stem cells (MSCs), treatment with low-intensity transcranial ultrasound stimulation (LITUS), and a combination of the two. After the TBI rat model was established, MSCs (in situ injection within 24 h after injury), LITUS (continuous uninterrupted treatment for 28 days) or combined MSCs + LITUS were administered, and mNSS score, performance of behavior and multiple protein levels were compared between groups by behavioral observation, neurological function assessment and pathological analysis. Nestin, neuron-specific enolase (NSE), growth-associated protein 43 (GAP-43) and postsynaptic density protein (PSD-95) were significantly increased and glial fibrillary acidic protein (GFAP) was significantly decreased in the hippocampus of rats in the combination treatment group; brain-derived neurotrophic factor (BDNF), tumor necrosis factor-α (TNF-α) and aquaporin-4 (AQP-4) were significantly decreased in the injured peripheral cortex. The result of mNSS scores was: TBI group > LITUS group > MSCs group > MSCs+LITUS group > sham group. The alternate correct rate of Y-maze was: sham group > MSCs+LITUS group > MSCs group > LITUS group > TBI group. This data compares the efficacy of MSCs, LITUS, and combination therapy on the level expression of stem cell differentiation related proteins, synaptic plasticity-related proteins, neurotrophic factors, inflammatory factors, and edema-related proteins after TBI by quantitative pathological examination. For a complete description, interpretation, and discussion of the data refer to the article in press [1].

Abstract Previous studies have demonstrated that cardiomyocyte apoptosis, ferroptosis, and inflammation participate in the progress of sepsis-induced cardiomyopathy (SIC). Although Islet cell autoantigen 69 (ICA69) is an imperative molecule that could regulate inflammation and immune response in numerous illnesses, its function in cardiovascular disease, particularly in SIC, is still elusive. We confirmed that LPS significantly enhanced the expression of ICA69 in wild-type (WT) mice, macrophages, and cardiomyocytes. The knockout of ICA69 in lipopolysaccharide(LPS)-induced mice markedly elevated survival ratio and heart function, while inhibiting cardiac muscle and serum inflammatory cytokines, reactive oxygen (ROS), and ferroptosis biomarkers. Mechanistically, increased expression of ICA69 triggered the production of STING, which further resulted in the production of intracellular lipid peroxidation, eventually triggering ferroptosis and heart injury. Intriguingly, ICA69 deficiency only reversed the ferroptotic marker levels, such as prostaglandin endoperoxide synthase 2 (PTGS2), malonaldehyde (MDA), 4-hydroxynonenal (4HNE), glutathione peroxidase 4 (GPX4), superoxide dismutase (SOD), iron and lipid ROS, but had no effects on the xCT-dependent manner. Additionally, greater ICA69 level was identified in septic patients peripheralblood mononuclear cells (PBMCs) than in normal control groups. Generally, we unveil that ICA69 deficiency can relieve inflammation and ferroptosis in LPS-induced murine hearts and macrophages, making targeting ICA69 in heart a potentially promising treatment method for SIC.

As a layered topological nodal line semimetals hosting a quasi-one-dimensional (quasi-1D) crystalline structure, TaNiTe5 has attracted intensive attention. In this research, we analyze the low temperature (low-T) transport properties in single crystals of TaNiTe5. The high anisotropic transport behaviors confirm the anisotropic electronic structure in quasi-1D TaNiTe5. The resistivity shows a magnetic field-induced resistivity upturn followed by a plateau at low temperatures when current is parallel to the c axis and magnetic field is parallel to the b axis. An extremely large magnetoresistance of 1000% has been observed at 2 K and 13 T. Such a magnetic field-induced phenomenon can be generally explained using the topological theory, but we find that the behaviors are well accounted with the classical Kohler’s rule. The analysis of the Hall resistivity points to carrier compensation in TaNiTe5, fully justifying Kohler’s rule. Our findings imply that analogous magnetic field-induced low-T properties in nodal line semimetals TaNiTe5 can be understood in the framework of classical magnetoresistance theories that do not require to invoke the topological surface states.

Random numbers are widely used in numerical computing, statistical simulation, random sampling, etc. At present, the mechanism for generating random numbers by computers is at risk of being attacked. The generated random numbers may be predicted in some cases,. However, current RNGs used in blockchain are not sufficient enough to handle attacks. Therefore, it is necessary to improve the security of random numbers. This paper improves the random number generator and designs a secure random number generator based on blockchain (BCsRNG). In practice, an encapsulated function algorithm of the secure random number is developed with the smart contract. Moreover, an API is provided to facilitate input and output. The experimental results show that the random numbers generated by BCsRNG are difficult to decipher and have higher randomness and security.

Summary: The ability of humans to mediate environmental variation through tool use is likely the key to our success. However, our current knowledge of early cultural evolution derives almost exclusively from studies of stone tools and fossil bones found in the archaeological record. Tools made of plants are intrinsically perishable, and as such are almost entirely absent in the early record of human material culture. Modern human societies as well as nonhuman primate species use plant materials for tools far more often than stone, suggesting that current archaeological data are missing a substantial component of ancient technology. Here, we develop methods that quantify internal and external damage pattern in percussive wooden tools of living primates. Our work shows that the inflicted damage is irreversible, potentially persisting throughout fossilization processes. This research presents opportunities to investigate organic artifacts, a significant and highly neglected aspect of technological evolution within the Primate order.

For complex structures, the existing optimization method for suspender cable forces involves extensive matrix operations during the solution process, requiring high computational power and time. As a result, obtaining a more accurate solution becomes challenging. To address this issue and improve the stress distribution of suspenders in the completed state, while minimizing the need for frequent cable force adjustments and grid beam elevation changes during construction, a novel method for cable force optimization is proposed. In this study, the Pingnan Third Bridge, which is the world’s longest large span arch bridge with a span of 575 m, is taken as the engineering background. This study combines finite element analysis and multi-objective optimization methods to develop a cable force optimization approach for real-time correction during the panel girder lifting of long-span concrete-filled steel tube (CFST) arch bridges. The optimization method involves treating the panel girder weight and displacement during construction as parameter variables, and considering the displacement and unevenness of the panel girder in the completed state as constraint conditions. The objective equation is defined based on the displacement and cable force during the lifting construction process and, through optimization, the cable forces and displacements of each lifting section are calculated. The results demonstrate the feasibility of integrating optimization theory into the cable force optimization process during panel girder lifting. In this study, we have taken into account the characteristics of real-world engineering and focused on specific key points to reduce the order of the influence matrix. Consequently, the computational costs are reduced, facilitating the development of a multi-objective tension optimization program. By minimizing segment displacement variations and ensuring even cable force distribution in the completed state, the method ensures that the bridge meets the required completion requirements without the need for repetitive iterations or cumbersome calculations. It provides higher optimization efficiency and superior outcomes, offering significant value for cable force calculations during suspender construction of similar bridge types and guiding construction processes.

PurposeIn order to evaluate the neuroprotective effect of low-intensity pulsed ultrasound (LIPUS) for acute traumatic brain injury (TBI), we studied the potential of apparent diffusion coefficient (ADC) values and ADC-derived first-order features regarding this problem.MethodsForty-five male Sprague Dawley rats (sham group: 15, TBI group: 15, LIPUS treated: 15) were enrolled and underwent magnetic resonance imaging. Scanning layers were acquired using a multi-shot readout segmentation of long variable echo trains (RESOLVE) to decrease distortion. The ultrasound transducer was applied to the designated region in the injured cortical areas using a conical collimator and was filled with an ultrasound coupling gel. Regions of interest were manually delineated in the center of the damaged cortex on the diffusion weighted images (b = 800 s/mm2) layer by layer for the TBI and LIPUS treated groups using the open-source software ITK-SNAP. Before analysis and modeling, the features were normalized using a z-score method, and a logistic regression model with a backward filtering method was employed to perform the modeling. The entire process was completed using the R language.ResultsDuring the observation time, the ADC values ipsilateral to the trauma in the TBI and LIPUS groups increased rapidly up to 24 h. After statistical analysis, the 10th percentile, 90th percentile, mean, skewness, and uniformity demonstrated a significant difference among three groups. The receiver operating characteristic curve (ROC) analysis shows that the combined LR model exhibited the highest area under the curve value (AUC: 0.96).ConclusionThe combined LR model of first-order features based on the ADC map can acquire a higher diagnostic performance than each feature only in evaluating the neuroprotective effect of LIPUS for TBI. Models based on first-order features may have potential value in predicting the therapeutic effect of LIPUS in clinical practice in the future.

Abstract Psoriasis is the most common skin disease in adults. Current experimental and clinical evidences suggested the infiltrating immune cells could target local skin cells and thus induce psoriatic phenotype. However, recent studies indicated the existence of a potential feedback signaling loop from local resident skin cells to infiltrating immune cells. Here, we deconstructed the full-thickness human skins of both healthy donors and patients with psoriasis vulgaris at single cell transcriptional level, and further built a neural-network classifier to evaluate the evolutional conservation of skin cell types between mouse and human. Last, we systematically evaluated the intrinsic and intercellular molecular alterations of each cell type between healthy and psoriatic skin. Cross-checking with psoriasis susceptibility gene loci, cell-type based differential expression, and ligand-receptor communication revealed that the resident psoriatic skin cells including mesenchymal and epidermis cell types, which specifically harbored the target genes of psoriasis susceptibility loci, intensively evoked the expression of major histocompatibility complex (MHC) genes, upregulated interferon (INF), tumor necrosis factor (TNF) signalling and increased cytokine gene expression for primarily aiming the neighboring dendritic cells in psoriasis. The comprehensive exploration and pathological observation of psoriasis patient biopsies proposed an uncovered immunoregulatory axis from skin local resident cells to immune cells, thus provided a novel insight for psoriasis treatment. In addition, we published a user-friendly website to exhibit the transcriptional change of each cell type between healthy and psoriatic human skin.

Abstract Background Surgical resection and reconstruction for low-grade bone sarcoma in the metaphysis of the distal femur remain challenging. We hypothesized that 3D printing osteotomy guide plate could assist to accurately resect the tumor lesion and save the joint function. Methods From January 2017 to August 2019, five patients diagnosed with low-grade bone sarcoma in the metaphysis of the distal femur were treated with hemicortical resection using 3D printing guide plate. Autologous bone graft was inactivated in a high-temperature water bath and re-implanted in situ fixed with plate and screw. Patients were followed up from 17 to 33 months. The Musculoskeletal Tumor Society Score was used to evaluate the joint function. X-ray was used to evaluate the bone union. Results One patient was paracorticular osteosarcoma, and four cases had highly differentiated chondrosarcoma. All cases were involved in the metaphysis of the distal femur. Patients were followed up from 13 to 33 months, with an average of 23.6 months. There was neither post-operation infection, internal fixation loosening, nor fracture occurrence in any of the patients. The Musculoskeletal Tumor Society Score averaged at 28.1, while the International Society of Limb Salvage imaging score examination averaged 89.8%. Conclusions Here, we demonstrate that the 3D printing osteotomy guide plate-assisted hemicortical bone resection is a beneficial strategy to effectively resect the primary low-grade malignant bone tumors in the metaphysis of the distal femur and retained satisfied joint function.

BackgroundIntrauterine devices (IUDs) are commonly used as a contraceptive method. IUD migration and colon perforation are rare but serious complications occurring sometimes years after insertion.CaseA 42-year-old woman with complaints of slight abdominal pain underwent a colonoscopy. Colonoscopy showed that a “nail” had penetrated the ascending colon wall and that an arm of the “nail” was embedded in the colon wall. We did not remove the “nail” rashly under colonoscopy. Considering the safety and effectiveness of the patient's operation, we were able to remove the “nail” easily by performing laparoscopic-endoscopic cooperative surgery (LECS) combined with hysteroscopy at the same time.ConclusionWe report a case of successful removal of a colonic perforation device by colonoscopy, laparoscopy, and hysteroscopy, which is the first method used.

Abstract Background The aim of this study was to evaluate the influence of patient body mass index (BMI) and estimated creatinine clearance (CrCl) on serum vancomycin concentrations to define a possible optimal dosage regimen in overweight patients based on data obtained during therapeutic drug monitoring. Methods This retrospective study used data collected from January 2017 to January 2019. Adult patients (n = 204) received vancomycin treatment at a dose of 1000 mg every 12 h and underwent serum monitoring. Data collected included patient disease category, sex, age, height, weight, vancomycin concentrations, and serum creatinine. The CrCl values were estimated using the Cockcroft-Gault formula. In this study, statistical comparisons were performed on the results of patients according to serum vancomycin concentration. Results Serum vancomycin concentration was significantly related to BMI (P

Concrete pouring steel tube arch is a critical part in the construction of a long-span concrete-filled steel tube arch bridge. With the adoption of the improved TOPSIS, this study summarized five indicators that controlled the concrete-filled steel tube pouring sequence. The indicators include the vertical displacement of the arch rib, lateral offset of the arch rib, steel tube stress, concrete stress, and elastic safety factor of the arch rib. Furthermore, a comprehensive objective function-rationalization index was proposed, based on which a practical evaluation and determination method for pouring scheme of the long-span concrete-filled steel tube arch bridge was developed. The results showed that a pouring sequence with relatively small stress in the arch rib, advanced alignment, and good stability could be determined using the proposed method.

In order to simplify the completion process of cable force optimization and adjustment in long-span concrete-filled steel tube arch bridges, a new method was proposed in the present study. To this end, a reasonable completion cable force calculation method was proposed based on the influence matrix principle of cable force optimization. Then combined with the mechanical characteristics of concrete-filled steel tube arch bridge, the weighted matrix was introduced to simplify the influence matrix of cable force and optimize the suspender cable force. The performed comparative study showed that the maximum difference of single cable force between the measured and calculated values is less than 5%, and the calculation error satisfies the requirements of the specification. It is concluded that the proposed method can accurately control the suspender tension construction in the arch bridge, optimize the cable force of long-span concrete filled-steel tube arch bridge, and realize the comparison and selection of various optimization schemes. The research results have been successfully applied to the suspender force adjustment of Third Pingnan Bridge, which greatly simplifies the adjustment steps and the total cable force difference in the whole bridge is 1.37%, the difference between the measured and designed suspender tensions of Heshan Hongshui River Bridge at completion state is less than 2%. The successful application of this method effectively saves the labor and material cost of suspender adjustment and further enhances the superiority of steel tube concrete arch bridge. The proposed method is expected to be an excellent choice to monitor constructions, adjust the bridge completion stage, and provide a reference for the suspender tension construction control of similar bridges.

Species distribution models are widely used in conservation biology and invasive biology. MaxEnt models are the most widely used models among the existing modeling tools. In the MaxEnt modeling process, the default parameters are used most often to build the model. However, these models tend to be overfit. Aiming at this problem, this study uses an optimized MaxEnt model to analyze the impact of past, present and future climate on the distributions of Codonopsis pilosula, an economic species, to provide a theoretical basis for its introduction and cultivation. Based on 264 distribution records and eight environmental variables, the potential distribution areas of C. pilosula in the last interglacial, middle Holocene and current periods and 2050 and 2070 were simulated. Combined with the percentage contribution, permutation importance, and jackknife test, the environmental factors affecting the suitable distribution area of this species were discussed. The results show that the parameters of the optimal model are: the regularization multiplier is 1.5, and the feature combination is LQHP (linear, quadratic, hinge, product). The main temperature factors affecting the distribution of C. pilosula are the annual mean temperature, mean diurnal range, and isothermality. The main precipitation factors are the precipitation seasonality, precipitation in the wettest quarter, and precipitation in the driest quarter, among which the annual average temperature contributes the most to the distribution area of this species. With climate warming, the suitable area of C. pilosula exhibits a northward expansion trend. It is estimated that in 2070, the suitable area of this species will expand to its maximum, reaching 2.5108 million square kilometers. The highly suitable areas of C. pilosula are mainly in Sichuan, Gansu, Shaanxi, Shanxi, and Henan Provinces. Our findings can be used to provide theoretical support related to avoiding the blind introduction of C. pilosula.

This paper presents a numerical study on the high-temperature mechanical properties of a long-span double-deck suspension bridge. The main focus of this paper is the behavior analysis of Wuhan Yangtze River Bridge. A three-dimensional thermal model of the bridge was established by the Fire Dynamics software (FDS) to obtain the 3D temperature field distribution, and the thermal analysis result was then applied to the three-dimensional finite element model of the suspension bridge. The shortest failure time of the main cable and sling was determined to obtain the rescue time of a bridge fire. According to the calculation results of the suspension bridge under a tanker fire initiated at the upper deck of the bridge, the middle lane in the upper deck of the suspension bridge was determined to be a safe lane. Thus, the tanker should be guided to go in this lane of the bridge. The numerical analysis of the experimental results shows that when the fuel tanker is located on the upper and lower floors of the bridge, the bridge structure is affected by the fire. When the oil tanker burns in the outermost lane of the upper bridge, it will have a great impact on the main cables and slings of the bridge. When the fuel tanker burns in the lower nonmotorized lane of the bridge, it will have a great impact on the upper stiffening beam steel plates and truss rods.

In order to control the tower deviation in the cable hoisting process of long-span concrete-filled steel tubular arch bridge during construction monitoring, a practical method of tower deviation correction was studied and established. In the paper, based on the studies about the deviation error formation mechanism of tower in the process of cable lifting, the relevant formulas of the arch rib elevation changes caused by the change of tower state were deduced. The traditional control methods including increase of tower stiffness and strength of the anchor cable, are not effective, costly, and require a longer construction period. To overcome these defects, in virtue of the Beidou GNSS measurement system and hydraulic jack active control system, the active control technology of the CFST (Concrete Filled Steel Tube) arch bridge tower deviation was thoroughly studied. Besides, a perfect active control theory was established. Finally, the author puts forward the idea of reverse pulling tower deviation. The field measurement and comparative study show that after the optimization of this method, the tower deviation is within 2 cm, and the error meets the specification requirements. The proposed method can accurately control the tower deviation in the process of arch bridge cable hoisting, and establish a set of perfect active control related systems and theories, which is especially suitable for the construction monitoring and adjustment in the construction stage of arch bridge, and can provide reference for the construction control of tower deviation of the same type of bridge.

Objectives: This study aimed to assess electronic health (eHealth) literacy and self-management ability among gout patients in China and analyze their correlation. Patients and methods: A cross-sectional study was conducted on 168 male gout patients (mean age: 44.5±13.8 years, range, 22 to 76 years) using a gout patient self-management assessment scale and the Chinese version of eHealth Literacy Scale between August 2020 and February 2021. The correlation between eHealth literacy and gout self-management was examined. Multivariate regression analysis was conducted to identify the predictors of gout patients’ self-management ability. Results: The scores of eHealth literacy and self-management were 28.56±1.72 and 3.59±0.78, respectively, which were both in the medium level, with the lowest score in the lifestyle management dimension. Pearson’s correlation analysis showed that eHealth literacy was significantly and positively associated with the total score of gout self-management and its four dimensions. Literacy in eHealth (β=0.399, p<0.001, 95% confidence interval [CI]: 0.023-0.069), living with family members (β=0.336, p=0.001, 95% CI: 0.313-1.234), living in an urban area (β=0.312, p=0.005, 95% CI: 0.191-1.022), and having college or a higher level of education (β=0.268, p=0.016, 95% CI: 0.032-0.302) were the significant predictors of gout patients’ self-management ability, explained 30.6% of the total variance. Conclusion: Literacy in eHealth was the most significant predictor of gout self-management ability. Gout patients had the lowest score in the perceived ability of searching and applying online health-related information, indicating that both the quantity and quality of gout-specific information needs to be enlarged in electronic resources. Healthcare providers could design and implement eHealth literacy interventions to strengthen patients’ gout self-management ability. [ABSTRACT FROM AUTHOR]

As a recently discovered waste removal system in the brain, cerebral lymphatic system is thought to play an important role in regulating the homeostasis of the central nervous system. Currently, more and more attention is being focused on the cerebral lymphatic system. Further understanding of the structural and functional characteristics of cerebral lymphatic system is essential to better understand the pathogenesis of diseases and to explore therapeutic approaches. In this review, we summarize the structural components and functional characteristics of cerebral lymphatic system. More importantly, it is closely associated with peripheral system diseases in the gastrointestinal tract, liver, and kidney. However, there is still a gap in the study of the cerebral lymphatic system. However, we believe that it is a critical mediator of the interactions between the central nervous system and the peripheral system. [ABSTRACT FROM AUTHOR]

Basic oxygen furnace (BOF) slag, which has good mechanical properties, can be recycled as pavement materials. However, BOF slag contains several kinds of heavy metals. Batch leaching tests are usually conducted to investigate the leaching characteristics of asphalt mixture with BOF slag, which has a few limitations. In this article, the leaching characteristics of heavy metals were investigated through the column leaching test device self-designed in the laboratory. The factors that influence the leaching of heavy metals were evaluated. The experimental results indicate that high-basicity BOF slag that has high content of free calcium oxide (f-CaO) can effectively inhibit the leaching of heavy metals from asphalt mixture. Copper and nickel have no leaching risk in neutral and weakly acidic conditions. However, zinc and lead in asphalt mixture with medium-basicity BOF slag have a risk of causing environmental implication in long-term leaching process. Moreover, covering of asphalt inhibits the leaching of f-CaO and hinders the contact between heavy metals and the leachant at the same time. The conclusions of this article provide a theoretical basis for the green application of BOF slag as an asphalt pavement material. [ABSTRACT FROM AUTHOR]