Search

Purpose: To investigate the therapeutic effect of combination of oxaliplatin and vascular intervention in patients with advanced cervical cancer (ACC), and its influence on the prognosis of patients.Methods: One hundred ACC patients were selected and equally assigned to control (oxaliplatin) and combination or study (oxaliplatin plus vascular intervention) groups. The patients in control group received oxaliplatin, while those in study group were treated with oxaliplatin combined with vascular intervention. Clinical efficacy, levels of vascular endothelial growth factor (VEGF), vascular endothelial growth factor receptor-2 (VEGFR-2), fibroblast growth factor-2 (FGF-2), BFGF and platelet-derived growth factor (PDGF) before and after therapy, and survival rate at 3, 6, 12 and 18 months after therapy were determined compared between the two groups. The prognostic factors were analyzed with logistic factor analysis.Results: The clinical efficacy and survival rate at 3, 6, 12 and 18 months after therapy in the combination group were higher when compared with those of the control group (p < 0.05). After therapy, the levels of VEGF, VEGFR-2, FGF-2, BFGF and PDGF were lower in the combination group than in control group. Age, short-term efficacy and basic diseases were identified as the influencing factors for the prognosis of patients with advanced cervical cancer (p < 0.05).Conclusion: The combination of oxaliplatin and vascular intervention significantly improved clinical treatment efficacy and survival rate in ACC patients. Age, short-term efficacy and basic diseases affected the prognosis of patients.

Microvascular protection is the main mechanism of metformin against diabetic complications. Cardiac microvascular endothelial cells (CMECs) are the basic component of cardiac microvessels, and they suffer from oxidative stress and mitochondrial dysfunction under type 2 diabetes mellitus (T2DM). Translocase of the outer mitochondrial membrane 70 (Tom70) improves mitochondrial dysfunction, but its role in the hearts of T2DM patients remains unclear. The purpose of this study was to demonstrate the protective effect of metformin on diabetic cardiac microvascular injury and to identify the role of Tom70 in this effect. T2DM mice were established by multiple intraperitoneal injections of low-dose streptozotocin and 12-week high-fat feeding. CMECs were isolated and cultured with normal glucose (NG), high glucose (HG), and HG plus high fat (HG-HF) media. The results indicated that long-term metformin treatment partly reversed cardiovascular complication and mitigated cardiac microvascular injury in T2DM. In addition, exposure to HG-HF led to CMEC damage, aggravated oxidative stress, aggravated mitochondrial dysfunction, and reduced mitochondrial Tom70 expression, whereas upregulation of Tom70 significantly ameliorated these injuries. Furthermore, metformin treatment promoted Tom70 expression and effectively reversed CMEC injury induced by HG-HF. However, all of these effects were interrupted after Tom70 was knocked down. In conclusion, T2DM damages microvascular integrity by activating a cycle of decreased Tom70 expression, mitochondrial dysfunction, and reactive oxygen species (ROS) overload in CMECs. However, metformin suppresses oxidative stress, relieves mitochondrial dysfunction, and promotes the expression of Tom70, ultimately ameliorating diabetic microvascular injury and heart complications.

We present a work of manipulating collective unconventional photon blockade (UCPB) and nonreciprocal UCPB (NUCPB) in a cavity-driven system composed of an asymmetrical single-mode cavity and two interacting identical two-level atoms (TLAs). When the atoms do not interact directly, the frequency and intensity restrictions of collective UCPB can be specified, and a giant NUCPB exists due to the splitting of optimal atom–cavity coupling strength in proper parameter regime. However, if a weak atom–atom interaction which provides a new and feeble quantum interference pathway to UCPB is taken into account, two restrictions of UCPB are combined complexly, which are rigorous to be matched simultaneously. Due to the push-and-pull effect induced by weak dipole–dipole interaction, the UCPB regime is compressed more or less. NUCPB is improved as a higher contrast is present when the two complex UCPB restrictions are matched, while it is suppressed when the restrictions are mismatched. In general, whether NUCPB is suppressed or promoted depends on its working parameters. Our findings show a prospective access to produce giant quantum nonreciprocity by a couple of weakly interacting atoms.

We improve the nonreciprocal unconventional photon blockade (UCPB) in an asymmetrical single-mode cavity with two asymmetrical arranged two-level atoms (TLAs) where cavity and atom spatial symmetry breakings are involved in. In order to get direction-dependent UCPB in asymmetrical system, we deduce two restrictions of frequency and intensity through the steady solution of the cavity QED system analytically. The former restriction is exactly the same as that of a single-atom case, and the latter restriction combined with both spatial asymmetries. Controllable UCPB in this model shows an improving nonreciprocal UCPB with wider operating regime which is promoted by two asymmetrical arranged atoms. The most innovation of this work is that the contributions of two spatial symmetry breakings are figured out clearly and they play different roles in nonreciprocal UCPB. The cavity spatial symmetry breaking and weak nonlinearity are essential to quantum nonreciprocity, while the atoms spatial symmetry is not and it only can promote such nonreciprocal UCPB. Our findings show a prospective access to manipulate quantum nonreciprocity by a couple of atoms.

Ca 3 Nb 2 O 8 :Sm 3+ phosphor is synthesized by solid-state reaction method in air. Host Ca 3 Nb 2 O 8 emits blue light with excitation 260 and 314 nm, and its emission band peaking at ∼460 nm is attributed to the 3 T 1,2 → 1 A 1 transations in [Nb 2 O 8 6− ] group. Ca 3 Nb 2 O 8 :Sm 3+ phosphor with excitation 314 nm shows a systematically tunable emission by adjusting Sm 3+ ion concentration, and only emits reddish-orange light with excitation 407 nm. Excitation band indicates that Ca 3 Nb 2 O 8 :Sm 3+ phosphor may be effectively excited by (∼407 nm) near ultraviolet light-emitting diode chip. The optimal Sm 3+ ion concentration is ∼5 mol% in Ca 3 Nb 2 O 8 :Sm 3+ phosphor. Emission intensity of Ca 3 Nb 2 O 8 :Sm 3+ phosphor may be increased ∼1.4 times by co-doping Li + ions as charge compensator and fluxing agent roles. The experimental results will contribute to studying novel Sm 3+ -doped luminescent materials.

A double perovskite Sr 2 ZnMoO 6 :Mn 4+ (SZM:Mn 4+ ) phosphor is synthesized by high-temperature solid-state reaction method in air. Emission band peaking at ∼705 nm of SZM:Mn 4+ phosphor in the range of 650–790 nm is attributed to the 2 E → 4 A 2 transition of Mn 4+ ion with activated different lattice vibration modes. Three excitation bands in the range of 210–610 nm are assigned to the O 2− → Mn 4+ charge transfer and the 4 A 2 → ( 4 T 1 , 2 T 2 , and 4 T 2 ) transition of Mn 4+ ion. The optimal Mn 4+ ion concentration is ∼0.8 mol% in SZM:Mn 4+ phosphor. Fluorescence lifetime of SZM:Mn 4+ phosphor decreases from ∼132 μs to 108 μs with increasing Mn 4+ ion concentration in the range of 0.2–1.0 mol%. Time-resolved spectra and fluorescence lifetime data indicate that luminescent center is caused by Mn 4+ ion. The luminous mechanism of SZM:Mn 4+ phosphor is explained by Tanabe-Sugano energy level diagram of Mn 4+ ion. The results are useful to understand the influences of the neighboring coordination environment around Mn 4+ and host crystal structure to the luminescence properties of Mn 4+ ion and develop other novel Mn 4+ -doped materials.

We present a new and interesting physical phenomenon of optical negative differential transmission (ONDT, whose output intensity decreases with the increasing of input field intensity for an arbitrary optical system) in present BEC-cavity coupling system which pumped by a strong light and probed by a weak light. Theoretical results show that the transmission of the probe can be suppressed or promoted greatly by the pump due to optical nonlinearity and the Stokes/anti-Stokes scattering. To our most interest, two kinds of ONDT respectively induced by the nonlinear incoherent light-controlling and the nonlinear coherent interference have been uncovered, which have promising prospect in producing hyper-stable light source since it provides an unusual negative feedback.

The present study aimed to investigate the protective effect of Xuebijing injection (XBJ) on lung injury in heat-stroke rats and the underlying mechanisms. In total, 54 rats were randomly assigned to non-thermal, saline vehicle and XBJ groups. The rectal temperature (Tc), mean arterial pressure (MAP) and respiratory rate (RR) of the rats were recorded. The time-point of heat stroke and the time of survival were assessed, and indicators of arterial blood gas were regularly measured from 0 to 60 min. The concentration of tumor necrosis factor-α (TNF-α), interleukin-1β (IL-1β) and IL-10 was also determined. At the end of the experiment, lung tissue was harvested for histopathological analysis. Inducible nitric oxide synthase (iNOS) and superoxide dismutase (SOD) expression was measured by immunohistochemistry. Terminal deoxynucleotidyl transferase-mediated dUTP nick-end labeling was used to measure apoptosis. XBJ pretreatment prolonged the decline of clinical characteristics, as demonstrated by increases in Tc, MAP, RR and indicators in arterial blood gas in rats under heat stress. The time until heat stroke and the survival time in the Saline group were shorter than in rats treated with XBJ. The expression of iNOS in lung tissue and the concentration of TNF-α, IL-1β and IL-10 in the bronchoalveolar lavage fluid of rats treated with saline was higher than in rats with XBJ pre-treatment. Contrarily, SOD expression in rats treated with saline was decreased compared with that in rats treated with XBJ. Moreover, the apoptotic rate in the lung tissues of rats with saline treatment was higher than that in rats treated with XBJ. In conclusion, XBJ delayed the development of heat stroke and increased the survival time in rats under heat-stress by ameliorating pulmonary failure and acute lung injury. The underlying mechanisms of this effect may be the reduction of inflammatory cytokines as well as attenuation of oxidative stress and apoptosis by XBJ.

To compare glucose metabolism and chemosensitivity between recurrence within the irradiation field and metastases outside the irradiation field in the same patient using (18)F-fluorodeoxyglucose (FDG) positron emission tomography/computed tomography images (PET/CT).The (18)F-FDG PET/CT images of 43 cancer patients with both local recurrence (in-field) and distal metastases (out-field) after initial treatments were reviewed. 23 patients after definitive radiotherapy/chemoradiotherapy and 20 patients after radical surgery were assigned to a radiation group and surgery group, respectively. The tumor maximal diameter on CT and PET images (D CT and D PET), maximal SUV (SUVmax), and mean SUV (SUVmean) were measured. All the patients were administered chemotherapy, and 17 patients from the radiation group and 10 patients from the surgery group underwent PET/CT scanning within 1-2 months after the treatment. The changes in D CT, D PET, SUVmax and SUVmean for each lesion were calculated and compared between in-field and out-field tumors for both groups.In the surgery group, no significant difference was found in tumor size or FDG uptake between the local recurrence and metastases. In the radiation group, both SUVmax (7.03 ± 3.48) and SUVmean (4.33 ± 1.67) of the in-field tumors were lower than those (8.45 ± 4.34 and 5.36 ± 2.51, respectively, P 0.05) of out-field tumors. Moreover, the response extent of in-field tumors was lower than that of out-field tumors in the radiation group (P 0.05). However, in the surgery group, there was no difference in the response extent (tumor size and SUVs) between the local recurrence and metastases (P 0.05).The recurrence within the irradiation field and metastases outside the irradiation field in the same patient do not share the same biological characteristics or treatment response, with inferior glucose metabolism and chemosensitivity seen in locally recurrent tumors.

Due to the development of information technology, physics 3D animation multimedia has been introduced to physics teaching process. In order to match the modernization of physics teaching, new digital teaching platform for physics has been developed up by our group. The digital platform contains two individual parts. One is development system platform which can be used to generate physics 3D animation, and the other is presentation system platform which has been designed to present physics 3D animation. The new digital teaching platform is an open and efficient system and it can communicate with 3DMAX and Matlab program. The digital platform enriched college physics teaching resource and it has been employed to 18 university of China since 2009. Statistics showed that it can stir up students' interesting and it is convenient for physics teachers to explain physics concept. Furthermore, digital platform is easy to use and convenient to control teaching process physics teachers.

A new phenolic glycoside, 2'-hydroxy-4',6'-di-O-beta-D-glucopyranosyl-butyrrophenone (1), was isolated from the aerial parts of Solidago canadensis. The structure was elucidated on the basis of spectroscopic methods.