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29 results on '"Xing, Chunlei"'

7. A portable on-demand therapeutic nitric oxide generation apparatus: New strategy for diabetic foot ulcers

Author

Bian, Huihui, primary, Wang, Junjie, additional, Shan, Xiaodong, additional, Li, Xiuqing, additional, Wang, Yongjin, additional, Sun, Rui, additional, Wang, Chongxian, additional, Lv, Juan, additional, Xing, Chunlei, additional, Hui, Chunlei, additional, Zhang, Dinglei, additional, Zhang, Chenxi, additional, Zhang, Yuyan, additional, Zhao, Yangbo, additional, Tian, Chenguang, additional, Gao, Yuanqing, additional, and Su, Li, additional

Published
2023
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15. An Acid-Sensitive Bone Targeting Delivery System Carrying Acacetin Prevents Osteoporosis in Ovariectomized Mice.

Author

Sun, Xiaochen, Song, Chenyu, Zhang, Chenxi, Xing, Chunlei, Lv, Juan, Bian, Huihui, Lv, Nanning, Chen, Dagui, Dong, Xin, Liu, Mingming, and Su, Li

Subjects
BONE resorption, OSTEOPOROSIS, OSTEOPOROSIS in women, RAPAMYCIN, MICE, CANCELLOUS bone, METABOLIC disorders
Abstract

One effective treatment for postmenopausal osteoporosis is to inhibit osteoclasts and subsequent bone resorption. In our study, we demonstrated that acacetin, a flavone with potential therapeutic effects in infections, cancers, and several metabolic disorders, inhibited osteoclast differentiation and bone resorption in vitro. For improving the efficacy of acacetin in vivo, we developed an acid-sensitive bone-targeting delivery system composed of an acid-sensitive linker (N-ε-maleimidocaproic acid hydrazide, EMCH) for ensuring an effective release of acacetin at the site of action and a hydrophilic aspartic acid hexapeptide ((Asp)6, D6) as the effective bone targeting agent. Our results revealed that Acacetin-EMCH-D6 specifically bound to the bone surface once administrated in vivo, prolonged the retention time in bone and released acacetin at the osteoclastic bone resorption sites where the acidity is higher. We further demonstrated that, in ovariectomy-induced osteoporosis mice, treatment with Acacetin-EMCH-D6 inhibited osteoclast formation and increased trabecular bone mass. On the contrary, neither acacetin nor EMCH-D6 with the same dosage alone showed significant anti-osteoporosis effects in vivo. Mechanistically, targeted delivery of acacetin to the bone resorption sites by Acacetin-EMCH-D6 inhibited autophagy through activating PI3K/AKT/mTOR pathway in osteoclasts, while the activation of autophagy by rapamycin partially reversed the inhibitory effects of acacetin in vitro and in vivo. In summary, our study, for the first time, showed that the acid-sensitive bone-targeting delivery system carrying acacetin was effective for the treatment of postmenopausal osteoporosis. Thus, targeted delivery of acacetin using Acacetin-EMCH-D6 to bone resorption sites is a promising therapy for osteoporosis. [ABSTRACT FROM AUTHOR]

Published
2023
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23. The Fracture Behavior in the Vicinity of Interface Based on the Digital Speckle Experiment

Author

Xing Chunlei, Zhang Deshi, Jiao jian, Dong Kangxing, Wang Suling, and Shao Chongquan

Subjects
Speckle pattern, Computer simulation, Interface (computing), Fracture (geology), Mechanical engineering, Geotechnical engineering, Geology
Abstract

Rock stratification develops widely in unconventional reservoirs, and it increases the non-uniform of the reservoir on vertical. The interfacial slip deformation can alter the fracture shape when it encounters the weak stratification or the natural fractures, so the rock stratification play an important role in the fracture propagation. In this paper, the crack extension experiment about the interface is established through the three-point bending. The digital speckle measurement technology was used in order to observe the change of the strain field, near the interface layer, in the process of cracks through the interface. At the same time, based on the maximum circumferential stress criterion, an interfacial slip model has been developed, and the extended finite element method which can reveal the distribution of stress and strain on the interface has been used in the numerical realization of the model. The numerical results of the strain field agree well with those of experiments. The experiment and numerical simulation results show that when a crack propagates the interface, the crack will break through the interface, or crack kink in the interface, or crack extend along the interface. The reason of the crack deflection, when a crack goes through the interface, is that the crack tip occurs blunt, and the crack length does not increase while the width increases. The tip blunt causes the interfacial shear strain which can turn the direction of the maximum circumferential stress. The crack deflection angle is affected extremely by the interface strength. The weaker the interface is, the greater of crack tip blunt is and the bigger the shear strain of the interface is, which cause the crack deflection angle increase. Based on the above analysis, it indicates that the blunt of crack tip in the interface is the mechanical cause of the crack to change direction extension. The weak bedding is the important factor causing the complexity of unconventional reservoir fracture morphology. This can be used as one of the standards to evaluate the fracturing effect of unconventional reservoir.

Published
2016

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