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1. Clinical Manifestations of Hepatitis E

Author

You, Shaoli, Zhu, Bing, Xin, Shaojie, Crusio, Wim E., Series Editor, Dong, Haidong, Series Editor, Radeke, Heinfried H., Series Editor, Rezaei, Nima, Series Editor, Steinlein, Ortrud, Series Editor, Xiao, Junjie, Series Editor, and Wang, Youchun, editor

Published
2023
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2. Predicting the survival benefit of liver transplantation in HBV-related acute-on-chronic liver failure: an observational cohort study

Author

Li, Peng, Liang, Xi, Luo, Jinjin, Li, Jiaqi, Xin, Jiaojiao, Jiang, Jing, Shi, Dongyan, Lu, Yingyan, Hassan, Hozeifa Mohamed, Zhou, Qian, Hao, Shaorui, Zhang, Huafen, Wu, Tianzhou, Li, Tan, Yao, Heng, Ren, Keke, Guo, Beibei, Zhou, Xingping, Chen, Jiaxian, He, Lulu, Yang, Hui, Hu, Wen, Ma, Shiwen, Li, Bingqi, You, Shaoli, Xin, Shaojie, Chen, Yu, and Li, Jun

Published
2023
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4. THU-078 Extra-hepatic organ failure in ACLF patients is associated with poor survival and limited curative therapy-results from AARC cohort

Author

Choudhury, Ashok Kumar, primary, Arora, Vinod, additional, Rela, Mohd., additional, Jothimani, Dinesh, additional, Al-Mahtab, Mamun, additional, Devarbhavi, Harshad, additional, Eapen, CE, additional, Goel, Ashish, additional, Yaghi, Cesar, additional, Ning, Qin, additional, Chen, Tao, additional, Duan, Zhongping, additional, Hamid, Saeed Sadiq, additional, Jafri, Wasim, additional, Shukla, Akash, additional, Tan, Soek-Siam, additional, Kim, Dong Joon, additional, Saraya, Anoop, additional, Hu, Jinhua, additional, Sood, Ajit, additional, Goyal, Omesh, additional, Sahoo, Manoj, additional, Lee, Guan-Huei, additional, Treeprasertsuk, Sombat, additional, Thanapirom, Kessarin, additional, Mandot, Ameet, additional, Shah, Samir, additional, Lesmana, Laurentius A., additional, Ghazinyan, Hasmik, additional, V G, Mohan Prasad, additional, Dokmeci, A. Kadir, additional, Sollano, Jose, additional, Abbas, Zaigham, additional, Shrestha, Ananta, additional, Lau, George, additional, Payawal, Diana, additional, Shiha, Gamal, additional, Duseja, Ajay Kumar, additional, Taneja, Sunil, additional, Padaki, Nagaraja Rao, additional, Kulkarni, Anand, additional, Karim, Md. Fazal, additional, Dhiman, Radha Krishan, additional, Mishra, Ajay, additional, Alam, Shahinul, additional, Yokosuka, Osamu, additional, Chowdhury, Dr. Debashis, additional, Kedarisetty, Chandan, additional, Saigal, Dr Sanjiv, additional, Arora, Anil, additional, Kumar, Ashish, additional, Yattoo, Ghulam Nabi, additional, Koshy, Abraham, additional, Kumar, Ajay, additional, Elbasiony, Mohammed, additional, Rathi, Pravin, additional, Maharshi, Sudhir, additional, Dayal, V.M., additional, Jha, Ashish Kumar, additional, Kalista, Kemal Fariz, additional, Gani, Rino, additional, Yuen, Man-Fung, additional, Singh, Virendra, additional, Singh, Ayaskant, additional, Violeta, Sargsyan, additional, Huang, Chien-Hao, additional, Mukewar, Saurabh, additional, Xin, Shaojie, additional, Bhavani, Ruveena, additional, Panackel, Charles, additional, Dadhich, Sunil, additional, Sachdeva, Sanjeev, additional, Behera, Sanatan, additional, Maji, Prabir, additional, Kamani, Lubna, additional, Saithanyamurthi, Hemamala Venugopal, additional, Varghese, Dr. Joy, additional, Parikh, Pathik, additional, Javed, P, additional, Saraf, Neeraj, additional, Choudhary, Narendra S., additional, Roy, Akash, additional, Goenka, Mahesh, additional, Kalal, Chetan, additional, Devadas, Krishnadas, additional, Adali, Gupse, additional, Silva H, Janaka De, additional, Omata, Masao, additional, Sharma, Manoj, additional, and Sarin, Shiv Kumar, additional

Published
2024
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5. THU-052 Therapeutic plasma-exchange improves short-term survival in patients with ACLF admitted to intensive care unit with organ failures-a multinational AARC data analysis

Author

Maiwall, Rakhi, primary, Rao Pasupuleti, Samba Siva, additional, Choudhury, Ashok Kumar, additional, Arora, Vinod, additional, Rela, Mohd., additional, Jothimani, Dinesh, additional, Al-Mahtab, Mamun, additional, Devarbhavi, Harshad, additional, Eapen, CE, additional, Goel, Ashish, additional, Yaghi, Cesar, additional, Ning, Qin, additional, Chen, Tao, additional, Jia, Jidong, additional, Duan, Zhongping, additional, Hamid, Saeed Sadiq, additional, Subhan, Amna, additional, Jafri, Wasim, additional, Shukla, Akash, additional, Tan, Soek-Siam, additional, Kim, Dong Joon, additional, Saraya, Anoop, additional, Hu, Jinhua, additional, Sood, Ajit, additional, Goyal, Omesh, additional, Midha, Vandana, additional, Sahoo, Manoj, additional, Lee, Guan-Huei, additional, Treeprasertsuk, Sombat, additional, Thanapirom, Kessarin, additional, Mandot, Ameet, additional, Shah, Samir, additional, Lesmana, Laurentius A., additional, Ghazinyan, Hasmik, additional, V G, Mohan Prasad, additional, Dokmeci, A. Kadir, additional, Sollano, Jose, additional, Abbas, Zaigham, additional, Shrestha, Ananta, additional, Lau, George, additional, Payawal, Diana, additional, Shiha, Gamal, additional, Duseja, Ajay Kumar, additional, Taneja, Sunil, additional, Verma, Nipun, additional, Padaki, Nagaraja Rao, additional, Kulkarni, Anand, additional, Sharma, Mithun, additional, Karim, Md. Fazal, additional, Dhiman, Radha Krishan, additional, Mishra, Ajay, additional, Alam, Shahinul, additional, Yokosuka, Osamu, additional, Chowdhury, Debashis, additional, Kedarisetty, Chandan, additional, Saigal, Sanjiv, additional, Arora, Anil, additional, Kumar, Ashish, additional, Koshy, Abraham, additional, Kumar, Ajay, additional, Elbasiony, Mohammed, additional, Rathi, Pravin, additional, Maharshi, Sudhir, additional, Dayal, V.M., additional, Jha, Ashish Kumar, additional, Kalista, Kemal Fariz, additional, Gani, Rino, additional, Yuen, Man-Fung, additional, Singh, Virendra, additional, Singh, Ayaskant, additional, Violeta, Sargsyan, additional, Huang, Chien-Hao, additional, Mukewar, Saurabh, additional, Xin, Shaojie, additional, Bhavani, Ruveena, additional, Panackel, Charles, additional, Dadhich, Sunil, additional, Sachdeva, Sanjeev, additional, Behera, Sanatan, additional, Maji, Prabir, additional, Kamani, Lubna, additional, Saithanyamurthi, Hemamala Venugopal, additional, Varghese, Dr. Joy, additional, Parikh, Pathik, additional, Javed, P, additional, Saraf, Neeraj, additional, Choudhary, Narendra S., additional, Roy, Akash, additional, Goenka, Mahesh, additional, Kalal, Chetan, additional, Devadas, Krishnadas, additional, De Silva H, Janaka, additional, and Sarin, Shiv Kumar, additional

Published
2024
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7. Impact of Onset Time, Number, Type, and Sequence of Extrahepatic Organ Failure on Prognosis of Acute-on-chronic Liver Failure

Author

Qiu, Shaotian, primary, Zhang, Qian, additional, Hu, Jiaxuan, additional, Wang, Lewei, additional, Chen, Rui, additional, Cao, Yingying, additional, Liu, Fang, additional, Yu, Zhenjun, additional, Zhao, Caiyan, additional, Zhang, Liaoyun, additional, Ren, Wanhua, additional, Xin, Shaojie, additional, Chen, Yu, additional, Duan, Zhongping, additional, and Han, Tao, additional

Published
2024
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14. Complications constitute a major risk factor for mortality in hepatitis B virus-related acute-on-chronic liver failure patients: a multi-national study from the Asia–Pacific region

Author

Chen, Tao, Yang, Zhongyuan, Choudhury, Ashok Kumar, Al Mahtab, Mamun, Li, Jun, Chen, Yu, Tan, Soek-Siam, Han, Tao, Hu, Jinhua, Hamid, Saeed S., Huei, Lee Guan, Ghazinian, Hasmik, Nan, Yuemin, Chawla, Yogesh K., Yuen, Man-Fung, Devarbhavi, Harshad, Shukla, Akash, Abbas, Zaigham, Sahu, Manoj, Dokmeci, A. K., Lesmana, Laurentias A., Lesmana, Cosmas Rinaldi A., Xin, Shaojie, Duan, Zhongping, Guo, Wei, Ma, Ke, Zhang, Zhongwei, Cheng, Qiuyu, Jia, Jidong, Sharma, B. C., Sarin, Shiv Kumar, and Ning, Qin

Published
2019
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16. AARC score determines outcomes in patients with alcohol-associated hepatitis: a multinational study

Author

Rakhi Maiwall, Samba Siva Rao Pasupuleti, Ashok Choudhury, Dong Joon kim, Ajit Sood, Omesh Goyal, Vandana Midha, Harshad Devarbhavi, Anil Arora, Ashish Kumar, Manoj Kumar Sahu, Sudhir Maharshi, Ajay Kumar Duseja, Virendra Singh, Sunil Taneja, P. N. Rao, Anand Kulkarni, Hasmik Ghazinian, Saeed Hamid, C. E. Eapen, Ashish Goel, Ananta Shreshtha, Samir Shah, Jinhua Hu, V. G. Mohan Prasad, Nan Yuemin, Xin Shaojie, R. K. Dhiman, Tao Chen, Qin Ning, Charles Panackel, Madunil A. Niriella, Thupten Kelsang Lama, Soek-Siam Tan, A. Kadir Dokmeci, Akash Shukla, Manoj Kumar Sharma, and Shiv Kumar Sarin

Subjects
Hepatology
Abstract

Acute-on-chronic liver failure (ACLF) is a severe form of alcoholic hepatitis (SAH). We aimed to study the natural course, response to corticosteroids (CS), and the role of the Asian Pacific Association for the Study of Liver (APASL) research consortium (AARC) score in determining clinical outcomes in AH patients.Prospectively collected data from the AARC database were analyzed.Of the 1249 AH patients, (aged 43.8 ± 10.6 years, 96.9% male, AARC score 9.2 ± 1.9), 38.8% died on a 90 day follow-up. Of these, 150 (12.0%) had mild-moderate AH (MAH), 65 (5.2%) had SAH and 1034 (82.8%) had ACLF. Two hundred and eleven (16.9%) patients received CS, of which 101 (47.87%) were steroid responders by day 7 of Lille's model, which was associated with improved survival [Hazard ratio (HR) 0.15, 95% CI 0.12-0.19]. AARC-ACLF grade 3 [OR 0.28, 0.14-0.55] was an independent predictor of steroid non-response and mortality [HR 3.29, 2.63-4.11]. Complications increased with degree of liver failure [AARC grade III vs. II vs I], bacterial infections [48.6% vs. 37% vs. 34.7%; p 0.001); extrahepatic organ failure [66.9% vs. 41.8% vs. 35.4%; p 0.001] respectively. The AARC score better discriminated 90-day mortality. Harrell's C-index was 0.72 compared to other scores.Nearly 4 of 5 patients with AH present with ACLF. Such patients have a higher risk of infections, organ failures, lower response to CS, and higher mortality. Patients with AH and ACLF with AARC grade 3 should be considered for an early liver transplant.

Published
2022

27. Dynamic assessments of hepatic encephalopathy and ammonia levels predict mortality in acute-on-chronic liver failure

Author

Dong Joon Kim, Ashok Choudhury, Guan H Lee, Pratima Rao, Ashok Kumar, Mamun Al Mahtab, Ajit Sood, George K. K. Lau, Diana A. Payawal, AS Butt, Jinhua Hu, Harshad Devarbhavi, Shiv Kumar Sarin, Manoj Kumar Sahu, Ashish Goel, Wasim Jafri, Soek Siam Tan, Qin Ning, Nipun Verma, V G Mohan Prasad, Ramesh Kumar, Vandana Midha, Ananta Shresta, Ayaskanta Singh, Sombat Treeprasertsuk, Akash Shukla, Nan Yuemin, A. Kadir Dokmeci, Han Tao, R. K. Dhiman, Jose D. Sollano, H. Ghazinyan, Sunil Taneja, Saeed Hamid, Duan Zhongping, Ajay Duseja, Anil Arora, Laurentius A. Lesmana, CE Eapen, Anand V. Kulkarni, Virender Singh, Samir Shah, Omesh Goyal, and Xin Shaojie

Subjects
Liver Cirrhosis, medicine.medical_specialty, Cirrhosis, Bilirubin, Systemic inflammation, Severity of Illness Index, Gastroenterology, Sepsis, chemistry.chemical_compound, Ammonia, Internal medicine, medicine, Humans, Hepatic encephalopathy, Creatinine, Hepatology, business.industry, Acute-On-Chronic Liver Failure, Prognosis, medicine.disease, Transplantation, chemistry, Hepatic Encephalopathy, medicine.symptom, business
Abstract

We evaluated the dynamics of hepatic encephalopathy (HE) and ammonia estimation in acute-on-chronic liver failure (ACLF) patients due to a paucity of evidence. ACLF patients recruited from the APASL-ACLF Research Consortium (AARC) were followed up till 30 days, death or transplantation, whichever earlier. Clinical details, including dynamic grades of HE and laboratory data, including ammonia levels, were serially noted. Of the 3009 ACLF patients, 1315 (43.7%) had HE at presentation; grades I–II in 981 (74.6%) and grades III–IV in 334 (25.4%) patients. The independent predictors of HE at baseline were higher age, systemic inflammatory response, elevated ammonia levels, serum protein, sepsis and MELD score (p

Published
2021

29. Survival benefit-based priority of liver transplantation in HBV-related acute-on-chronic liver failure

Author

Li, Peng, primary, Liang, Xi, additional, Luo, Jinjin, additional, Li, Jiaqi, additional, Xin, Jiaojiao, additional, Jiang, Jing, additional, Shi, Dongyan, additional, Lu, Yingyan, additional, Hassan, Hozeifa Mohamed, additional, Zhou, Qian, additional, Hao, Shaorui, additional, Zhang, Huafeng, additional, Wu, Tianzhou, additional, Li, Tan, additional, Yao, Heng, additional, Ren, Keke, additional, Guo, Beibei, additional, Zhou, Xingping, additional, Chen, Jiaxian, additional, He, Lulu, additional, Yang, Hui, additional, Hu, Wen, additional, Ma, Shiwen, additional, Li, Bingqi, additional, You, Shaoli, additional, Xin, Shaojie, additional, Chen, Yu, additional, and Li, Jun, additional

Published
2022
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32. Acute variceal bleeding portends poor outcomes in patients with acute-on-chronic liver failure: a propensity score matched study from the APASL ACLF Research Consortium (AARC)

Author

Sanchit, Sharma, Samagra, Agarwal, Anoop, Saraya, Ashok, Choudhury, Mamun Al, Mahtab, Mohd Shahinul, Alam, Sanjiv, Saigal, Dong Joon, Kim, C E, Eapen, Ashish, Goel, Qin, Ning, Harshad, Devarbhavi, Virendra, Singh, Akash, Shukla, Saeed, Hamid, Jinhua, Hu, Soek-Siam, Tan, Anil, Arora, Manoj Kumar, Sahu, Mohd, Rela, Dinesh, Jothimani, P N, Rao, Anand, Kulkarni, Hashmik, Ghaznian, Guan Huei, Lee, Duan, Zhongping, Ajit, Sood, Omesh, Goyal, Laurentius A, Lesmana, Rinaldi C, Lesmana, Sombat, Treeprasertsuk, Nan, Yuemin, Samir, Shah, Han, Tao, V M, Dayal, Xin, Shaojie, Fazal, Karim, Zaigham, Abbas, Jose D, Sollano, Kemal Fariz, Kalista, Ananta, Shreshtha, Diana, Payawal, Masao, Omata, Shiv Kumar, Sarin, and Jin Mo, Yang

Subjects
Male, Hepatitis, Alcoholic, Acute-On-Chronic Liver Failure, Humans, Female, Esophageal and Gastric Varices, Gastrointestinal Hemorrhage, Prognosis, Propensity Score
Abstract

Limited data exist regarding outcomes of acute variceal bleeding (AVB) in patients with acute-on-chronic liver failure (ACLF), especially in those with hepatic failure. We evaluated the outcomes of AVB in patients with ACLF in a multinational cohort of APASL ACLF Research Consortium (AARC).Prospectively maintained data from AARC database on patients with ACLF who developed AVB (ACLF-AVB) was analysed. This data included demographic profile, severity of liver disease, and rebleeding and mortality in 6 weeks. These outcomes were compared with a propensity score matched (PSM) cohort of ACLF matched for severity of liver disease (MELD, AARC score) without AVB (ACLF without AVB).Of the 4434 ACLF patients, the outcomes in ACLF-AVB (n = 72) [mean age-46 ± 10.4 years, 93% males, 66% with alcoholic liver disease, 65% with alcoholic hepatitis, AARC score: 10.1 ± 2.2, MELD score: 34 (IQR: 27-40)] were compared with a PSM cohort selected in a ratio of 1:2 (n = 143) [mean age-44.9 ± 12.5 years, 82.5% males, 48% alcoholic liver disease, 55.7% alcoholic hepatitis, AARC score: 9.4 ± 1.5, MELD score: 32 (IQR: 24-40)] of ACLF-without AVB. Despite PSM, ACLF patients with AVB had a higher baseline HVPG than without AVB (25.00 [IQR: 23.00-28.00] vs. 17.00 [15.00-21.75] mmHg; p = 0.045). The 6-week mortality in ACLF patients with or without AVB was 70.8% and 53.8%, respectively (p = 0.025). The 6-week rebleeding rate was 23% in ACLF-AVB. Presence of ascites [hazard ratio (HR) 2.2 (95% CI 1.03-9.8), p = 0.026], AVB [HR 1.9 (95% CI 1.2-2.5, p = 0.03)], and MELD score [HR 1.7 (95% CI 1.1-2.1), p = 0.001] independently predicted mortality in the overall ACLF cohort.Development of AVB confers poor outcomes in patients with ACLF with a high 6-week mortality. Elevated HVPG at baseline represents a potential risk factor for future AVB in ACLF.

Published
2022

33. Cover Image

Author

Wang, Jia‐Bo, primary, Huang, Ang, additional, Wang, Yijin, additional, Ji, Dong, additional, Liang, Qing‐Sheng, additional, Zhao, Jun, additional, Zhou, Guangde, additional, Liu, Shuhong, additional, Niu, Ming, additional, Sun, Ying, additional, Tian, Hui, additional, Teng, Guang‐Ju, additional, Chang, Bin‐Xia, additional, Bi, Jing‐Feng, additional, Peng, Xiao‐Xia, additional, Xin, Shaojie, additional, Xie, Huan, additional, Ma, Xiong, additional, Mao, Yi‐Min, additional, Liangpunsakul, Suthat, additional, Saxena, Romil, additional, Aithal, Guruprasad P., additional, Xiao, Xiao‐He, additional, Zhao, Jingmin, additional, and Zou, Zhengsheng, additional

Published
2022
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38. Corticosteroid plus glycyrrhizin therapy for chronic drug‐ or herb‐induced liver injury achieves biochemical and histological improvements: a randomised open‐label trial

Author

Wang, Jia‐Bo, primary, Huang, Ang, additional, Wang, Yijin, additional, Ji, Dong, additional, Liang, Qing‐Sheng, additional, Zhao, Jun, additional, Zhou, Guangde, additional, Liu, Shuhong, additional, Niu, Ming, additional, Sun, Ying, additional, Tian, Hui, additional, Teng, Guang‐Ju, additional, Chang, Bin‐Xia, additional, Bi, Jing‐Feng, additional, Peng, Xiao‐Xia, additional, Xin, Shaojie, additional, Xie, Huan, additional, Ma, Xiong, additional, Mao, Yi‐Min, additional, Liangpunsakul, Suthat, additional, Saxena, Romil, additional, Aithal, Guruprasad P., additional, Xiao, Xiao‐He, additional, Zhao, Jingmin, additional, and Zou, Zhengsheng, additional

Published
2022
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42. Development and validation of a new prognostic score for hepatitis B virus-related acute-on-chronic liver failure

Author

Li, Jiaqi, primary, Liang, Xi, additional, You, Shaoli, additional, Feng, Tingting, additional, Zhou, Xin, additional, Zhu, Bing, additional, Luo, Jinjin, additional, Xin, Jiaojiao, additional, Jiang, Jing, additional, Shi, Dongyan, additional, Lu, Yingyan, additional, Ren, Keke, additional, Wu, Tianzhou, additional, Yang, Lingling, additional, Li, Jiang, additional, Li, Tan, additional, Cai, Qun, additional, Sun, Suwan, additional, Guo, Beibei, additional, Zhou, Xingping, additional, Chen, Jiaxian, additional, He, Lulu, additional, Li, Peng, additional, Yang, Hui, additional, Hu, Wen, additional, An, Zhanglu, additional, Jin, Xiaojun, additional, Tian, Jin, additional, Wang, Baoju, additional, Chen, Xin, additional, Xin, Shaojie, additional, and Li, Jun, additional

Published
2021
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43. Acute-On-Chronic Liver Failure Defined by Asian Pacific Association for the Study of the Liver Should Include Decompensated Cirrhosis

Author

Xu, Manman, primary, Kong, Ming, additional, Yu, Pengfei, additional, Cao, Yingying, additional, Liu, Fang, additional, Zhu, Bing, additional, Zhang, Yizhi, additional, Lu, Wang, additional, Zou, Huaibin, additional, You, Shaoli, additional, Xin, Shaojie, additional, Duan, Zhongping, additional, Han, Tao, additional, and Chen, Yu, additional

Published
2021
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45. The Chinese Society of Hepatology position statement on the redefinition of fatty liver disease

Author

Nan, Yuemin, primary, An, Jihong, additional, Bao, Jianfeng, additional, Chen, Hongsong, additional, Chen, Yu, additional, Ding, Huiguo, additional, Dou, Xiaoguang, additional, Duan, Zhongping, additional, Fan, Jiangao, additional, Gao, Yanhang, additional, Han, Tao, additional, Han, Ying, additional, Hu, Peng, additional, Huang, Yan, additional, Huang, Yuan, additional, Jia, Jidong, additional, Jiang, Jiaji, additional, Jiang, Ying’an, additional, Li, Jie, additional, Li, Jun, additional, Li, Rongkuan, additional, Li, Shuchen, additional, Li, Wengang, additional, Li, Yufang, additional, Lin, Shumei, additional, Liu, Jingfeng, additional, Liu, Shourong, additional, Lu, Lungen, additional, Lu, Qinghua, additional, Luo, Xinhua, additional, Ma, Xiong, additional, Rao, Huiying, additional, Ren, Hong, additional, Ren, Wanhua, additional, Shang, Jia, additional, Shi, Li, additional, Su, Minghua, additional, Wang, Bingyuan, additional, Wang, Rongqi, additional, Wei, Lai, additional, Wen, Zhili, additional, Wu, Biao, additional, Wu, Jing, additional, Xin, Shaojie, additional, Xing, Huichun, additional, Xu, Jinghang, additional, Yan, Ming, additional, Yang, Jiming, additional, Yang, Jinhui, additional, Yang, Li, additional, Yang, Yongfeng, additional, Yu, Yanyan, additional, Zhang, Liaoyun, additional, Zhang, Lingyi, additional, Zhang, Xinxin, additional, Zhang, Yuguo, additional, Zhang, Yuexin, additional, Zhao, Jingmin, additional, Zhao, Shousong, additional, Zheng, Huanwei, additional, Zhou, Yongjian, additional, Zhou, Yongning, additional, Zhuang, Hui, additional, Zuo, Weize, additional, Xu, Xiaoyuan, additional, and Qiao, Liang, additional

Published
2021
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