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189 results on '"Xin, Jiaojiao"'

4. Predicting the survival benefit of liver transplantation in HBV-related acute-on-chronic liver failure: an observational cohort study

Author

Li, Peng, Liang, Xi, Luo, Jinjin, Li, Jiaqi, Xin, Jiaojiao, Jiang, Jing, Shi, Dongyan, Lu, Yingyan, Hassan, Hozeifa Mohamed, Zhou, Qian, Hao, Shaorui, Zhang, Huafen, Wu, Tianzhou, Li, Tan, Yao, Heng, Ren, Keke, Guo, Beibei, Zhou, Xingping, Chen, Jiaxian, He, Lulu, Yang, Hui, Hu, Wen, Ma, Shiwen, Li, Bingqi, You, Shaoli, Xin, Shaojie, Chen, Yu, and Li, Jun

Published
2023
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12. Plasma thrombomodulin as a candidate biomarker for the diagnosis and prognosis of HBV-related acute-on-chronic liver failure

Author

Zhou, Xingping, primary, Luo, Jinjin, additional, Liang, Xi, additional, Li, Peng, additional, Ren, Keke, additional, Shi, Dongyan, additional, Xin, Jiaojiao, additional, Jiang, Jing, additional, Chen, Jiaxian, additional, He, Lulu, additional, Yang, Hui, additional, Ma, Shiwen, additional, Li, Bingqi, additional, and Li, Jun, additional

Published
2024
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20. ETS2 alleviates acute‐on‐chronic liver failure by suppressing excessive inflammation

Author

He, Lulu, primary, Cai, Qun, additional, Liang, Xi, additional, Xin, Jiaojiao, additional, Shi, Dongyan, additional, Ren, Keke, additional, Li, Yun, additional, Chen, Jiaxian, additional, Sun, Suwan, additional, Guo, Beibei, additional, Yang, Hui, additional, Li, Bingqi, additional, Ma, Shiwen, additional, Luo, Jinjin, additional, Hu, Meiqian, additional, Li, Jiaqi, additional, Hu, Wen, additional, Li, Peng, additional, Yao, Heng, additional, Li, Jun, additional, Chen, Xin, additional, and Jiang, Jing, additional

Published
2023
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21. Orthotopic Transplantation of Functional Bioengineered Livers in Rats

Author

Guo, Beibei, primary, Zhou, Qian, additional, Chen, Jiaxian, additional, Xin, Jiaojiao, additional, Jiang, Li, additional, Yang, Hui, additional, Shi, Dongyan, additional, Ren, Keke, additional, Yang, Genren, additional, Li, Jun, additional, Zhou, Xingping, additional, Li, Peng, additional, Luo, Jinjin, additional, He, Lulu, additional, Hassan, Hozeifa Mohamed, additional, Liang, Xi, additional, Yao, Heng, additional, Ma, Shiwen, additional, Li, Bingqi, additional, Geng, Lei, additional, Wang, Changyong, additional, and Jiang, Jing, additional

Published
2023
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22. Generation and Metabolomic Characterization of Functional Ductal Organoids with Biliary Tree Networks in Decellularized Liver Scaffolds

Author

Chen, Jiaxian, primary, Ma, Shiwen, additional, Yang, Hui, additional, Liang, Xi, additional, Yao, Heng, additional, Guo, Beibei, additional, Chen, Deying, additional, Jiang, Jing, additional, Shi, Dongyan, additional, Xin, Jiaojiao, additional, Ren, Keke, additional, Zhou, Xingping, additional, Li, Yun, additional, Geng, Lei, additional, and Li, Jun, additional

Published
2023
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24. Transcriptomics confirm the establishment of a liver‐immune dual‐humanized mouse model after transplantation of a single type of human bone marrow mesenchymal stem cell.

Author

Sun, Suwan, Yang, Hui, Xin, Jiaojiao, Yao, Heng, Yuan, Lunzhi, Ren, Keke, Jiang, Jing, Shi, Dongyan, Li, Jun, Zhou, Qian, An, Zhanglu, Guo, Beibei, Chen, Jiaxian, He, Lulu, Liang, Xi, Cheng, Tong, and Xia, Ningshao

Subjects
MESENCHYMAL stem cells, LABORATORY mice, LIVER cells, ANIMAL disease models, KUPFFER cells, SEVERE combined immunodeficiency
Abstract

Background and Aims: Human bone marrow mesenchymal stem cells (hBMSCs) are important for developing a dual‐humanized mouse model to clarify disease pathogenesis. We aimed to elucidate the characteristics of hBMSC transdifferentiation into liver and immune cells. Methods: A single type of hBMSCs was transplanted into immunodeficient Fah−/− Rag2−/− IL‐2Rγc−/− SCID (FRGS) mice with fulminant hepatic failure (FHF). Liver transcriptional data from the hBMSC‐transplanted mice were analysed to identify transdifferentiation with traces of liver and immune chimerism. Results: Mice with FHF were rescued by implanted hBMSCs. Human albumin/leukocyte antigen (HLA) and CD45/HLA double‐positive hepatocytes and immune cells were observed in the rescued mice during the initial 3 days. The transcriptomics analysis of liver tissues from dual‐humanized mice identified two transdifferentiation phases (cellular proliferation at 1–5 days and cellular differentiation/maturation at 5–14 days) and ten cell lineages transdifferentiated from hBMSCs: human hepatocytes, cholangiocytes, stellate cells, myofibroblasts, endothelial cells and immune cells (T/B/NK/NKT/Kupffer cells). Two biological processes, hepatic metabolism and liver regeneration, were characterized in the first phase, and two additional biological processes, immune cell growth and extracellular matrix (ECM) regulation, were observed in the second phase. Immunohistochemistry verified that the ten hBMSC‐derived liver and immune cells were present in the livers of dual‐humanized mice. Conclusions: A syngeneic liver‐immune dual‐humanized mouse model was developed by transplanting a single type of hBMSC. Four biological processes linked to the transdifferentiation and biological functions of ten human liver and immune cell lineages were identified, which may help to elucidate the molecular basis of this dual‐humanized mouse model for further clarifying disease pathogenesis. [ABSTRACT FROM AUTHOR]

Published
2023
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27. Survival benefit-based priority of liver transplantation in HBV-related acute-on-chronic liver failure

Author

Li, Peng, primary, Liang, Xi, additional, Luo, Jinjin, additional, Li, Jiaqi, additional, Xin, Jiaojiao, additional, Jiang, Jing, additional, Shi, Dongyan, additional, Lu, Yingyan, additional, Hassan, Hozeifa Mohamed, additional, Zhou, Qian, additional, Hao, Shaorui, additional, Zhang, Huafeng, additional, Wu, Tianzhou, additional, Li, Tan, additional, Yao, Heng, additional, Ren, Keke, additional, Guo, Beibei, additional, Zhou, Xingping, additional, Chen, Jiaxian, additional, He, Lulu, additional, Yang, Hui, additional, Hu, Wen, additional, Ma, Shiwen, additional, Li, Bingqi, additional, You, Shaoli, additional, Xin, Shaojie, additional, Chen, Yu, additional, and Li, Jun, additional

Published
2022
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34. Additional file 1 of Integrative analysis of metabolomics and proteomics reveals amino acid metabolism disorder in sepsis

Author

Chen, Qi, Liang, Xi, Wu, Tianzhou, Jiang, Jing, Jiang, Yongpo, Zhang, Sheng, Ruan, Yanyun, Zhang, Huaping, Zhang, Chao, Chen, Peng, Lv, Yuhang, Xin, Jiaojiao, Shi, Dongyan, Chen, Xin, Li, Jun, and Xu, Yinghe

Abstract

Additional file 1: Figure S1. Quality control (QC) of experimental data. (A) Comparison of the total ion chromatogram (TIC) of QC samples in positive ion mode (left) and negative ion mode (right). (B) Principal component analysis (PCA) of the identified metabolites showing QC samples clustered together both in positive ion mode (left) and negative ion mode (right). Figure S2. Evaluation parameters of the OPLS-DA model in positive ion mode (left) and negative ion mode (right). Figure S3. Venn diagram showing the hub metabolites in positive ion mode (left) and negative ion mode (right). Figure S4. Cluster dendrogram and 16 metabolite coexpression modules defined by dendrogram branch cutting of all identified metabolites of patients with sepsis and normal controls.

Published
2022
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36. Additional file 2 of Integrative analysis of metabolomics and proteomics reveals amino acid metabolism disorder in sepsis

Author

Chen, Qi, Liang, Xi, Wu, Tianzhou, Jiang, Jing, Jiang, Yongpo, Zhang, Sheng, Ruan, Yanyun, Zhang, Huaping, Zhang, Chao, Chen, Peng, Lv, Yuhang, Xin, Jiaojiao, Shi, Dongyan, Chen, Xin, Li, Jun, and Xu, Yinghe

Abstract

Additional file 2: Table S1. Characteristics of enrolled patients with sepsis and NC subjects included in the derivation group.

Published
2022
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38. Transcriptomics reveals immune-metabolism disorder in acute-on-chronic liver failure in rats

Author

Hassan, Hozeifa M, primary, Cai, Qun, additional, Liang, Xi, additional, Xin, Jiaojiao, additional, Ren, Keke, additional, Jiang, Jing, additional, Shi, Dongyan, additional, Lu, Yingyan, additional, Li, Tan, additional, Shang, Yuxin, additional, He, Lulu, additional, Chen, Xi, additional, Sun, Suwan, additional, Li, Peng, additional, Guo, Beibei, additional, Chen, Jiaxian, additional, Yang, Hui, additional, Hu, Wen, additional, Chen, Xin, additional, and Li, Jun, additional

Published
2021
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39. Development and validation of a new prognostic score for hepatitis B virus-related acute-on-chronic liver failure

Author

Li, Jiaqi, primary, Liang, Xi, additional, You, Shaoli, additional, Feng, Tingting, additional, Zhou, Xin, additional, Zhu, Bing, additional, Luo, Jinjin, additional, Xin, Jiaojiao, additional, Jiang, Jing, additional, Shi, Dongyan, additional, Lu, Yingyan, additional, Ren, Keke, additional, Wu, Tianzhou, additional, Yang, Lingling, additional, Li, Jiang, additional, Li, Tan, additional, Cai, Qun, additional, Sun, Suwan, additional, Guo, Beibei, additional, Zhou, Xingping, additional, Chen, Jiaxian, additional, He, Lulu, additional, Li, Peng, additional, Yang, Hui, additional, Hu, Wen, additional, An, Zhanglu, additional, Jin, Xiaojun, additional, Tian, Jin, additional, Wang, Baoju, additional, Chen, Xin, additional, Xin, Shaojie, additional, and Li, Jun, additional

Published
2021
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41. Serum ferritin diagnosis and prediction of hepatitis B virus‐related acute‐on‐chronic liver failure.

Author

Luo, Jinjin, Liang, Xi, Xin, Jiaojiao, Li, Peng, Li, Jiaqi, Jiang, Jing, Wang, Yifan, Lu, Yingyan, and Shi, Dongyan

Subjects
LIVER failure, RECEIVER operating characteristic curves, IMMUNOLOGIC diseases, LIVER diseases, CLINICAL deterioration
Abstract

Early diagnosis and prediction of hepatitis B virus‐related acute‐on‐chronic liver failure (HBV‐ACLF) is important to reduce mortality. This study aimed to assess the diagnostic and predictive value of serum ferritin (SF) in HBV‐ACLF patients. Clinical data from 1905 hospitalized patients with acute deterioration of HBV‐related chronic liver diseases were analyzed to explore the association between SF and ACLF. A co‐expression network based on transcriptomics data for 20 HBV‐ACLF patients was constructed to investigate biological processes related to ferritin. Of 1270 patients in the derivation group, 440 and 830 were diagnosed with and without ACLF, respectively, based on Chinese Group on the Study of Severe Hepatitis B‐ACLF criteria. SF levels showed high diagnostic accuracy (area under the receiver operating characteristic [AUROC]: 0.820) for ACLF at admission. In patients with ACLF, SF was associated with liver and coagulation failure. In patients without ACLF, SF predicted risk for 28‐day progression to ACLF (AUROC: 0.808). A validation group of 635 patients confirmed the above results. Moreover, SF was significantly associated with the immune response based on transcriptomics analysis. SF is a potential diagnostic and predictive marker for HBV‐ACLF and might play a crucial role in immune disorders in HBV‐ACLF. [ABSTRACT FROM AUTHOR]

Published
2023
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42. Serum proteomics reveals disorder of lipoprotein metabolism in sepsis

Author

Liang, Xi, primary, Wu, Tianzhou, additional, Chen, Qi, additional, Jiang, Jing, additional, Jiang, Yongpo, additional, Ruan, Yanyun, additional, Zhang, Huaping, additional, Zhang, Sheng, additional, Zhang, Chao, additional, Chen, Peng, additional, Lv, Yuhang, additional, Xin, Jiaojiao, additional, Shi, Dongyan, additional, Chen, Xin, additional, Li, Jun, additional, and Xu, Yinghe, additional

Published
2021
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44. Functionalized Vascular Structure in Bioengineered Liver Identified with Proteomics

Author

Xi Liang, Xin Jiaojiao, Xingping Zhou, Qian Zhou, Jiaxian Chen, Jing Jiang, Dongyan Shi, Jun Li, Beibei Guo, Keke Ren, and Hozeifa Mohamed Hassan

Subjects
Proteomics, Decellularization, Tissue Scaffolds, Angiogenesis, Chemistry, Biomedical Engineering, Muscle filament sliding, In vitro, Umbilical vein, Basement membrane assembly, Cell biology, Biomaterials, Liver, Human Umbilical Vein Endothelial Cells, Cell adhesion
Abstract

Vascularization has been a major challenge in the development of a bioengineered liver. We aimed to develop a functionalized vascular structure in bioengineered liver and to identify the biological vascularization processes at different time points using proteomics. Decellularized rat liver scaffolds were vascularized with human umbilical vein endothelial cells (HUVECs) for 1, 3, 7, 14, and 21 days. HUVECs adhered to the internal surface and formed a functional barrier structure within 7 days. Vascularized liver scaffolds with biological activity were sustained for more than 21 days in vitro. Proteomics analysis indicated distinct characteristics after 14 days of culture compared with other time points. The biological processes of proteins expressed at days 1, 3, and 7 mainly involved cell adhesion, protein synthesis, and energy metabolism; however, different biological processes associated with muscle contraction and muscle filament sliding were identified at days 14 and 21. Coexpressed proteins at days 14 and 21 participated in 7 biological processes that could be classified as angiogenesis, myogenesis, or vascular function. Furthermore, the validation of related proteins revealed that basement membrane assembly, phenotype plasticity of HUVECs, and the regulation of adherence junctions contribute to the formation of a functionalized vascular structure. The biological vascularization processes at different time points identified with proteomics revealed development characteristics of vascular structure in a bioengineered liver, and at least 14 days of in vitro culture should be recommended for developing a functionalized vascular structure. This study may help to provide a better understanding of the mechanism of vascularization and facilitate the construction of a functional bioengineered liver for future clinical applications.

Published
2021

50. PBMC transcriptomics identifies immune-metabolism disorder during the development of HBV-ACLF

Author

Li, Jiang, primary, Liang, Xi, additional, Jiang, Jing, additional, Yang, Lingling, additional, Xin, Jiaojiao, additional, Shi, Dongyan, additional, Lu, Yingyan, additional, Li, Jun, additional, Ren, Keke, additional, Hassan, Hozeifa Mohamed, additional, Zhang, Jianing, additional, Chen, Pengcheng, additional, Yao, Heng, additional, Li, Jiaqi, additional, Wu, Tianzhou, additional, Jin, Linfeng, additional, Ye, Ping, additional, Li, Tan, additional, Zhang, Huafen, additional, Sun, Suwan, additional, Guo, Beibei, additional, Zhou, Xingping, additional, Cai, Qun, additional, Chen, Jiaxian, additional, Xu, Xiaowei, additional, Huang, Jianrong, additional, Hao, Shaorui, additional, He, Jinqiu, additional, Xin, Shaojie, additional, Wang, Di, additional, Trebicka, Jonel, additional, and Chen, Xin, additional

Published
2021
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