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Two donor–acceptor acridone‐based compounds, namely, 2‐{10‐[4‐(diphenylamino)phenyl]acridin‐9‐ylidene}malononitrile (TPA‐AD‐DCN), C34H22N4, and 2‐{10‐[4‐(9H‐carbazol‐9‐yl)phenyl]acridin‐9‐ylidene}malononitrile (CzPh‐AD‐DCN), C34H20N4, have been synthesized in high yield and their structures determined. TPA‐AD‐DCN and CzPh‐AD‐DCN crystallized in the centrosymmetric space groups P and P21/c, respectively. Both molecules adopt a 'butterfly‐like' configuration of the common part of the structure and differences occur within the substituents on the acridine N atom. A Hirshfeld surface analysis showed that the H...H and C...H/H...C contacts constitute a high percentage of the intermolecular interactions. The optical and electrochemical properties, as well as theoretical calculations, of TPA‐AD‐DCN and CzPh‐AD‐DCN support the structural characterization of these materials. As crystallization‐induced emission materials, TPA‐AD‐DCN and CzPh‐AD‐DCN are anticipated to be of potential use in the construction of promising optoelectronic materials. [ABSTRACT FROM AUTHOR]

Background: Concern of ischemia-reperfusion injury reduces utilization of donor lungs. We hypothesized adding L-alanyl-L-glutamine (L-AG) to preservation solution may protect donor lungs from ischemia-reperfusion injury through its multiple cytoprotective effects., Methods: A lung transplantation cell culture model was used on human lung epithelial cells and pulmonary microvascular endothelial cells, and the effects of adding different concentrations of L-AG on basic cellular function were tested. Rat donor lungs were preserved at 4 °C with 8 mmol/L L-AG for 12 h followed by 4 h reperfusion or monitored for 3 d. Lung function, lung histology, inflammation, and cell death biomarker were tested. Computerized tomography scan was used and metabolomic analysis was performed on lung tissues., Results: Cold preservation with L-AG improved cell viability and inhibited apoptosis in cell culture. Rat donor lungs treated with L-AG during cold storage showed decreased peak airway pressure, higher dynamic compliance and oxygenation ability, reduced lung injury, apoptosis, and oxidative stress during reperfusion. L-AG treatment significantly changed 130 metabolites during reperfusion, with enhanced amino acid biosynthesis and tricarboxylic acid cycle. Furthermore, cold storage with L-AG decreased primary graft dysfunction grade, improved oxygenation, reduced pulmonary atelectasis, sign of infection, and pneumothorax in a rat left lung transplant 3-d survival model., Conclusions: Adding L-AG to cold preservation solution reduced lung injury and alleviated primary graft dysfunction by inhibiting inflammation, oxidative stress, and cell death with modified metabolic activities., Competing Interests: The authors declare no conflicts of interest., (Copyright © 2024 Wolters Kluwer Health, Inc. All rights reserved.)