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Backgroud:In order to analyze the therapeutic effect of holmium laser intervention on patients with complicated kidney stones and the relationship between serum LncRNA TapSAKI, MCP-1,IL-6 and prognosis of patients, the clinical efficacy of holmium laser interventional Minimally Invasive Percutaneous Nephrolithotomy (mPCNL) for patients with complicated kidney stones is investigated.Methods:A total of 116 patients with complicated kidney stones admitted to the Department of Urology of our hospital from June 2020 to June 2021 for surgical intervention are selected. Holmium laser combined with mPCNL and open nephrolithotomy group are established according to different surgical intervention methods, and the differences of serum LncRNA TapSAKI, MCP-1 and IL-6 indexes are observed.Results:Pearson correlation coefficient is used to analyze the correlation between serum LncRNA TapSAKI and MCP-1 and IL-6 in patients with complicated kidney stones. Pearson correlation coefficient analysis shows that serum LncRNA TapSAKI is significantly positively correlated with MCP-1 and IL-6 in patients with complicated kidney stones.Conclusion:It is clearly evident thatHolmium laser combined with mPCNL in the treatment of complicated kidney stones has advantages of high stone clearance rate, reduced risk of complications, and high safety in clinical application.

The adsorption characteristics of Eu(III) on colloidal bentonite particles were investigated by batch experiments as functions of colloid concentration, pH, foreign ions, and temperature. Bentonite colloids displayed remarkable adsorption ability to Eu(III), the Eu(III) adsorption was significantly affected by solution chemistry. The Eu(III) adsorption increased with colloids concentration and pH increasing. Divalent cations (Ca2+, Mg2+ and Sr2+) and anions (Cl− and SO42−) inhibited Eu(III) adsorption, whereas PO43− greatly enhanced Eu(III) adsorption. High temperature was beneficial for Eu(III) adsorption, the adsorption process was a spontaneous endothermic process. The results suggested that colloids could acted as an efficient carrier for Eu(III) transport.

Background: Severe acute respiratory syndrome coronavirus 2 is a highly contagious viral infection, without any available targeted therapies. The high mortality rate of COVID-19 is speculated to be related to immune damage. Methods: In this study, clinical bioinformatics analysis was conducted on transcriptome data of coronavirus infection. Results: Bioinformatics analysis revealed that the complex immune injury induced by coronavirus infection provoked dysfunction of numerous immune-related molecules and signaling pathways, including immune cells and toll-like receptor cascades. Production of numerous cytokines through the Th17 signaling pathway led to elevation in plasma levels of cytokines (including IL6, NF-κB, and TNF-α) followed by concurrent inflammatory storm, which mediates the autoimmune response. Several novel medications seemed to display therapeutic effects on immune damage associated with coronavirus infection. Conclusions: This study provided insights for further large-scale studies on the target therapy on reconciliation of immunological damage associated with COVID-19.

MN1 C-terminal truncation (MCTT) is a rare syndrome; only 27 cases have been reported. We report the first case of an 8-year-old girl with MCTT syndrome complicated with moderate obstructive sleep apnea (OSA).MCTT syndrome was diagnosed by whole-exome sequencing (WES) and validated by Sanger sequencing. The patient received 2 years of treatment with continuous positive airway pressure (CPAP) to relieve sleep apnea and hypoxia, and a reverse sector fan-shaped expander for maxillary expansion.WES revealed a de novo MN1 variant, c.3760CT (p.[Q1254*]). An arachnoid cyst was found in the right occipital brain. The patient presented mild symptoms of classic MCTT syndrome. The patient did not experience hearing loss and only mild intellectual disability. Radiological examinations showed cleft secondary palate, narrow upper arch, narrow upper airway, and mandibular skeletal retrusion. Polysomnography indicated moderate OSA, with an apnea/hypopnea index of 6.8, which decreased to 1 after CPAP during the night. Two-year maxillary expansion widened the upper arch, and the cleft secondary palate became visible. The mandible moved forward spontaneously, resulting in the improvement of profile and upper airway widening. General physical conditions, such as motor delay, muscle weakness, and developmental delay, were significantly improved two years later.In conclusion, we discovered a MN1 variant [NM_002430.2: c.3760CT, p.Q1254*] that causes mild MCTT symptoms compared to other MN1 variants. For patients with MCTT complicated with OSA, multidisciplinary combination therapy can improve maxillofacial development, widen the upper airway and relieve sleep apnea, improving the general physical condition.

Electron-impact single-ionization (EISI) cross sections for W q+ (q = 9, 10) ions have been calculated by using the level-to-level distorted-wave (LLDW) method with emphasis on the contribution of metastable states to the total ionization cross sections. Contributions from direct-ionization (DI) and excitation-autoionization (EA) processes are taken into account. The calculated cross sections include the contributions from both the ground configuration and the long-lived metastable states with lifetimes exceeding 10−6 s. Calculated cross sections are in good agreement with experimental measurements when the influence of metastable states on the total ionization cross section are well considered.

An experimental study of 8.5-22.5 keV-energy C-, O-, and F- ion scattering from an HOPG surface has been performed at a grazing scattering angle. For a given incident angle or impact velocity, the F- fraction is the highest and the C- fraction is the smallest among these three projectiles, which is explained with the order of the electron affinity level of the projectile. Moreover, the unexpected observations are that the F- ion fraction increases monotonically with impact velocity and that the negative-ion fraction increases with the decrease in exit angle. It can be explained by the influence of the effective high work function of HOPG and the production of positive ions at short distances from the surface.

keV-energy Na+ ions are scattered from clean and water covered Cu(1 1 0) surfaces in grazing incidence. For both surfaces the pronounced Na° fractions decrease with incident energy. In particular, the lower Na° fraction has been observed for the water covered Cu(1 1 0) surface. The simple calculations using rate equation are presented to compare with the experimental data. The calculation is in agreement with the experimental data. It indicates that the water covered Cu(1 1 0) surface has the slightly higher work function due to water molecules dissociation and forming hydroxyl groups, so that the neutral fraction on water covered Cu(1 1 0) is lower than that on the clean surface.

In order to move from a carbon-based energy system to a more sustainable one, focus is put on liquid organic hydrogen carrier (LOHC) systems for CO2-free hydrogen storage and release. In this study...

Aluminum hydride (AlH3), an attractive hydrogen storage material, plays an important role in rocket and aerospace industry. The impurities in aluminum hydride may seriously cause the deterioration in its properties and stability. Mixing AlH3 sample with the known content of silicon, we distinguish the elements in AlH3 and determine their concentration by using PIXE, XPS and elemental analyzer. Al, Si, Cl, Ca and Fe were identified by PIXE. XPS technique was used to measure the oxidized product of the mixed silicon. C, H content were obtain from the elemental analyzer. The results of the impurity concentration show the effectiveness of the synergy among these techniques except carbon. The XPS result from the pristine sample shows the concentration of carbon is 6 times larger than the major element Al while the result from the elemental analyzer is only 0.620 wt%. It suggests that the XPS technique is surface-sensitive and not well suited to the determination of the bulk concentration of carbon. The mass fraction ratio of Al to H is μ Al / H = 8.718 27 3 , which indicates that the product partly decomposes.

The optical properties and performance of the two-dimensional photonic crystal (2D PhC) filters at normal incidence were simulated, and the best geometric parameters were obtained with the help of a global optimization program. The honeycomb structure has better performance, including high in-band transmittance, high out-band reflectance, and low parasitic absorption. The power density performance and conversion efficiency can reach 80.6% and 62.5%. Furthermore, the deeper cavity structure and multi-layer structure were designed to improve the performance of the filter. The deeper one can reduce the influence of transmission diffraction, increases the power density performance and conversion efficiency. The multi-layer structure reduces the parasitic absorption significantly and increases the conversion efficiency to 65.5%. These filters have both high efficiency and high power density, avoid the challenge of high-temperature stability faced by emitters, also easier and cheaper to fabricate compared to the 2D PhC emitters. These results suggest that the 2D PhC filters can be used in thermophotovoltaic systems for long-duration missions to improve the conversion efficiency.

We present a theoretical description of negative ion conversion of the grazing scattering of neutral hydrogen atoms on LiF(100) surface. Here, in addition to the capture of a valence band electron near a surface F− site by an incident H atom, the Coulomb repulsive barrier tunneling behavior is also considered to treat the detachment of the affinity electron from the formed H− ion to vacuum through its interaction with the surface F− site. With incorporation of the image-attraction-induced increase on the vertical component of the projectile energy and the collective dielectric screening effect of surrounding anions and cations on the charge of surface F− site which participates in the electron detachment, the image attractive interaction was revealed to obviously increase the electron detachment probability, in turn obviously decreasing the final negative ion yield. Moreover, the sub-eV order of the energy defect between the H− affinity level and the unoccupied image state induced by the potential field of the H− image charge in LiF leads to an additional H− destruction channel in which H− affinity electron transfers to the unoccupied image state without electron emission by a nearly resonant charge transfer manner. A clear picture of this electron loss process is also presented. Our present results well reproduce the experimental observation in the whole velocity range and the high fraction of H− ion yield as an alternative solution can be used on the implantation of ITER device.

Graphene bubbles (GBs) are of significant interest owing to their distinguished electrical, optical, and magnetic properties. GBs can also serve as high-pressure reaction vessels to numerous chemical reactions. However, previous strategies to produce GBs are relatively elaborate and random. Therefore, their potential applications are severely restricted. Here, a facile and effective protocol is proposed to construct position-controllable GBs in liquid nitrogen (LN) with the assistance of laser and graphene wrinkles. Specifically, a film of graphene mounted on a SiO2 substrate (G@SiO2) is subjected to irradiation by a low-power laser in LN and then many GBs emerge from the surface of G@SiO2. Most impressively, the domain where GBs arise is the position of the laser beam spot. Hence, we demonstrated that the high collimation of laser facilitates the position definition of GBs. The microscopic results indicate that some GBs split into three parts when they were subjected to irradiation by an electron. Meanwhile, some GBs degenerate into pores with a diameter of 500 nm when they are exposed to air. To grasp the properties of GBs in depth, the molecular dynamics (MD) simulations are performed, and the corresponding results indicate that temperature has very little impact on the GBs' shape. A phase transition process of the substance inside GBs is also revealed. Moreover, a two-dimensional (2D) solid nitrogen is discovered by MD simulations. The simplicity of our protocol paves the way to engineer high-pressure microreaction vessels and fabricate porous graphene membranes.

Jellium model is well known and used to understand the neutralization of alkali-metal ions on metal surfacesbut we find it cannot explain our experiments for the neutralization of 0.4 keV and 0.8 keV Na+ ions on Al(1 1 1) and Cu(1 1 0) surfaces in grazing incidence. As the exit angle increases neutral fractions on Cu(1 1 0) surface decreases first and then increases which is similar to our previous results at large scattering angles. While for the Al(1 1 1) surface we observe opposite characteristics. This anomalous bell-shaped feature cannot be explained by the Jellium model. One possible explanation is the inner 2p electron promotion at smaller exit angles this may cause the Na* excited states to be generated and produce excess Na+ ions while the similar electronic excitation process is inefficient for the Cu(1 1 0) surface in the present energy range.

We present a simple theoretical model study of negative ion conversion in neutral oxygen atom grazing scattering from a LiF(100) surface. A comparison of the calculated relative contributions of th...

The speciation, conformation, and reactivity of transition metal complexes at the gas–liquid interface are poorly understood, yet the potential is high for observing chemistry unique to this anisot...

It is well known that vacancy (Vac) can trap multiple hydrogen (H) atoms, and many Vac-rhenium (Re) and Vac-osmium (Os) clusters can be formed in tungsten (W) under fusion neutron irradiation, but the behaviors of H in Vac-Re/Os clusters are still unclear. Therefore, in this work, first-principles calculations are used to investigate the effects of transmutation elements of Re and Os on the H trapping ability of vacancy in W. We find that the presence of multiple Re/Os atoms around vacancy can significantly decrease the trapping energy of vacancy on H and the number of H atoms trapped in vacancy in W, thus Re/Os has an inhibiting effect on the growth of H bubble. Furthermore, Os has more prominent influence than Re for H trapping ability of vacancy in W. In addition, compared with VacHm in pure W, the presence of 8 Re atoms around vacancy in W would increase the stability of VacHm for m ≤ 4, but reduce the stability of VacHm for m > 4. Based on those results, we can qualitatively explain the recent experimental phenomenon.

PCV2 is one of the most economically important viral agents in swine worldwide. Recently, PCV3 has been frequently reported, and the co-infection of PCV2 and PCV3 is common in China. In order to explore the distribution, epidemiology and genetic diversity of PCV2 and PCV3, a total of 1,760 clinical tissue samples were randomly collected from 18 different regions in Henan province of China from October 2018 to September 2019 and screened for the presence of PCV2 and PCV3 by a duplex real-time PCR assay. The results showed that the positive rates of PCV2 and PCV3 were 72.90% and 5.17% respectively, and the co-infection rate of the two viruses was 3.64%. PCV2 and PCV3 are prevalent all year round. The prevalence of PCV2 in diseased pigs was 83.98%, higher than that in slaughterhouse pigs, while the prevalence of PCV3 in diseased pigs was 2.16%, slightly lower than that in slaughterhouse pigs. Furthermore, the complete genomes of 14 PCV2 and 3 PCV3 strains were obtained, among which 1 belonged to PCV2a, 5 belonged to PCV2b and 8 belonged to PCV2d. A new variant strain (XX2) might escape the host immune system. The phylogenetic analysis of PCV3 showed high nucleotide identity (98%) between sequences obtained in this study and reference sequences. The results of this study might enrich the epidemiological data of PCV2 and PCV3 in Henan province and provide reference information for the comprehensive prevention and control of PCVAD.

Objective—To understand the daily energy expenditure of military personnel with different measurement method, so as to provide scientific basis for guiding the military personnel’ reasonable energy intake and dietary supply. Methods—67 male military personnel were included in the study. The total energy expenditure (TEE) was assessed by 24-hour life observation method and activity recorder (ActiGraph GT3X+) method. The results of these two different energy expenditure assessment methods were compared by paired t-test. Results—With the 24-hour life observation method the average energy consumption of various actions(ECVA) and TEE-24 were (3672.42 ± 829.78)kcal and (3839.26 ± 834.75) kcal respectively. Using Actigraph GT3X+ to measure their average energy consumption of physical activity(PA) and TEE-Actigraph were (1416.47 ± 615.17) kcal and (3251.68 ± 680.98) kcal respectively, and the mean difference between TEE-24 and TEE-Actigraph was (587.58 ± 540.16) kcal. There is a strong correlation between the measurement results of the two methods(r = 0.764, p < 0.001). Conclusions—The measurement result of activity recorder (ActiGraph GT3X+) method and 24-hour life observation method is highly related. The activity recorder (ActiGraph GT3X+) method is more objective and easier to be implemented for the military personnel. Further comparative studies should be performed to find more objective, accurate, reproducible, and maneuverable methods.

In this study, four mixed juice beverages were evaluated using a fuzzy mathematical approach. The dimensions evaluated included color, aroma, taste and composition. Subjects scored each of these four dimensions. Using the obtained scores, a fuzzy mathematical comprehensive sensory evaluation model was developed. The results showed that the mixture of lemon and grapefruit juice scored the highest, followed by the mixture of pineapple and apple juice, and the mixture of strawberry and guava juice. The mixed juices of cherries and cranberries scored the lowest.

Objective—To study the sensory quality of four kinds of sticky soup food by fuzzy mathematics method. Methods—Adopted the method of fuzzy mathematics with color, status, smell, texture and taste as evaluation factors, and carried out fuzzy mathematics judgment of the sensory quality of four kinds of sticky soup food: cheese purple potato soup, guggen pumpkin soup, cocoa black bean soup and matcha wheat soup. Results—The fuzzy comprehensive sensory evaluation scores of four kinds of sticky soup food from high to low were cheese purple potato soup, guggen pumpkin soup, cocoa black bean soup, matcha wheat soup. Conclusions—The fuzzy mathematics method can reflect the sensory quality of sticky soup food objectively, which provided a reference method for the comprehensive sensory quality evaluation of sticky soup food.

Objective—To study the sensory quality of six kinds of military ready-to-eat meat sticks by fuzzy mathematics method. Methods—Adopted the method of fuzzy mathematics with color, status, smell, texture and taste as evaluation factors, and carried out fuzzy mathematics judgment of the sensory quality of six kinds of military ready-to-eat meat sticks: Orleans pork, sauced pork tenderloin, original beef, black pepper beef, mellow beef and spicy beef. Results—The fuzzy comprehensive sensory evaluation scores of six kinds of military ready-to-eat meat sticks from high to low were original beef, mellow beef, black pepper beef, spicy beef, Orleans pork and sauced pork tenderloin. Conclusions—The fuzzy mathematics method can reflect the sensory quality more objectively and accurately, which provided a reference method for the comprehensive sensory quality evaluation of military ready-to-eat meat sticks.

Objective-To study the dietary changes of Chinese flight personnel in the past 60 years, and to provide a basis for formulating reasonable nutritional intervention measures. Methods-The changes of dietary structure of Chinese pilots from 1963 to 2018 were analyzed by retrospective statistical classification and analysis according to each 10-year-period. It involved a total of 10,327 flight personnel, 68 civil aviation personnel, 10,259 military aviation personnel. Results- The average carbohydrate energy intake ratio is 50.21%, decreasing year by year, and the fat is 34.89%, increasing yearly. The intakes of vitamin B1 and vitamin PP decreased while Vitamin B2 increased. Conclusions-The aircrew have been in a high-fat, low-carbohydrate diet for in the past 60 years, and their total energy intake was high. Therefore, attention should be paid to the long-term potential negative effects of these results on flight occupations. Attention should be paid to the intake of vitamin B1 and PP.