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1. COVID-19 was not associated or trigger disease activity in spondylarthritis patients: ReumaCoV-Brasil cross-sectional data

Author

Marques, Claudia Diniz Lopes, Ribeiro, Sandra Lúcia Euzébio, Albuquerque, Cleandro P., de Sousa Studart, Samia Araujo, Ranzolin, Aline, de Andrade, Nicole Pamplona Bueno, Dantas, Andrea T., Mota, Guilherme D., Resende, Gustavo G., Marinho, Adriana O., Angelieri, Danielle, Andrade, Danieli, Ribeiro, Francinne M., Omura, Felipe, Silva, Nilzio A., Rocha Junior, Laurindo, Brito, Danielle E., Fernandino, Diana C., Yazbek, Michel A., Souza, Mariana P. G., Ximenes, Antonio Carlos, Martins, Ana Silvia S., Castro, Glaucio Ricardo W., Oliveira, Lívia C., Freitas, Ana Beatriz S. B., Kakehasi, Adriana M., Gomides, Ana Paula M., Reis Neto, Edgard Torres, Pileggi, Gecilmara S., Ferreira, Gilda A., Mota, Licia Maria H., Xavier, Ricardo M., and de Medeiros Pinheiro, Marcelo

Published
2022
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2. Maintenance of remission following 2 years of standard treatment then dose reduction with abatacept in patients with early rheumatoid arthritis and poor prognosis

Author

Westhovens, Rene, Robles, Manuel, Ximenes, Antonio Carlos, Wollenhaupt, Jurgen, Durez, Patrick, Gomez-Reino, Juan, Grassi, Walter, Haraoui, Boulos, Shergy, William, Park, Sung-Hwan, Genant, Harry, Peterfy, Charles, Becker, Jean-Claude, and Murthy, Bindu

Subjects
Biomedical and Clinical Sciences, Clinical Sciences, Clinical Trials and Supportive Activities, Autoimmune Disease, Clinical Research, Arthritis, Evaluation of treatments and therapeutic interventions, 6.1 Pharmaceuticals, Inflammatory and immune system, Abatacept, Adult, Antirheumatic Agents, Arthritis, Rheumatoid, Double-Blind Method, Female, Humans, Immunoconjugates, Induction Chemotherapy, Kaplan-Meier Estimate, Maintenance Chemotherapy, Male, Middle Aged, Prognosis, Recurrence, Remission Induction, Treatment Outcome, DMARDs, Disease Activity, Early Rheumatoid Arthritis, Rheumatoid Arthritis, Treatment, Immunology, Public Health and Health Services, Arthritis & Rheumatology, Clinical sciences
Abstract

ObjectivesTo evaluate maintenance of response while reducing intravenous abatacept dose from ~10 mg/kg to ~5 mg/kg in patients with early rheumatoid arthritis (RA) who achieved disease activity score (DAS)28 (erythrocyte sedimentation rate, ESR)

Published
2015

3. Quality of life in spondyloarthritis: analysis of a large Brazilian cohort

Author

Ribeiro, Sandra L.E., Albuquerque, Elisa N., Bortoluzzo, Adriana B., Gonçalves, Célio R., da Silva, José Antonio Braga, Ximenes, Antonio Carlos, Bértolo, Manoel B., Keiserman, Mauro, Menin, Rita, Skare, Thelma L., Carneiro, Sueli, Azevedo, Valderílio F., Vieira, Walber P., Bianchi, Washington A., Bonfiglioli, Rubens, Campanholo, Cristiano, Carvalho, Hellen M.S., Costa, Izaias P., Duarte, Angela L.B. Pinto, Kohem, Charles L., Leite, Nocy H., Lima, Sonia A.L., Meirelles, Eduardo S., Pereira, Ivânio A., Pinheiro, Marcelo M., Polito, Elizandra, Resende, Gustavo G., Rocha, Francisco Airton C., Santiago, Mittermayer B., Sauma, Maria de Fátima L.C., Valim, Valéria, and Sampaio-Barros, Percival D.

Published
2016
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4. Qualidade de vida nas espondiloartrites: análise de uma grande coorte brasileira

Author

Ribeiro, Sandra L.E., Albuquerque, Elisa N., Bortoluzzo, Adriana B., Gonçalves, Célio R., Silva, José Antonio Braga da, Ximenes, Antonio Carlos, Bértolo, Manoel B., Keiserman, Mauro, Menin, Rita, Skare, Thelma L., Carneiro, Sueli, Azevedo, Valderílio F., Vieira, Walber P., Bianchi, Washington A., Bonfiglioli, Rubens, Campanholo, Cristiano, Carvalho, Hellen M.S., Costa, Izaias P., Duarte, Angela L.B. Pinto, Kohem, Charles L., Leite, Nocy H., Lima, Sonia A.L., Meirelles, Eduardo S., Pereira, Ivânio A., Pinheiro, Marcelo M., Polito, Elizandra, Resende, Gustavo G., Rocha, Francisco Airton C., Santiago, Mittermayer B., Sauma, Maria de Fátima L.C., Valim, Valéria, and Sampaio‐Barros, Percival D.

Published
2016
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5. PREVALENCE AND ASSOCIATIONS OF HLA-B27 IN A LARGE MULTIRACIAL COHORT OF THE BRAZILIAN REGISTRY OF SPONDYLOARTHRITIS

Author

Rresende, Gustavo Gomes, primary, Saad, Carla Gonçalves Schahin, additional, Marques, Claudia Diniz Lopes, additional, Ribeiro, Sandra Lucia Euzébio, additional, Rocha, Vítor Florêncio Santos, additional, Lage, Ricardo da Cruz, additional, Malheiro, Olivio Brito, additional, Marinho, Adriana de Oliveira, additional, Gavi, Maria Bernadete de Oliveira, additional, Menin, Rita de Cassia, additional, Golebiovski, Rywka Tenenbaum Medeiros, additional, Carneiro, Jamille Nascimento, additional, Ochtrop, Manuella Lima Gomes, additional, Castro, Glaucio Ricardo Werner de, additional, Fernandes, José Mauro Carneiro, additional, Soares, Andressa Miozzo, additional, Ranza, Roberto, additional, Santos, Mario Sergio Ferreira, additional, Alvarenga, Corina Quental de Menezes, additional, Vieira, Rejane Maria de Abreu, additional, Braz, Alessandra de Sousa, additional, Soares, Maria Roberta Melo Pereira, additional, Yazbek, Michel Alexandre, additional, Ximenes, Antonio Carlos, additional, Machado, Natalia, additional, Bianchi, Washington Alves, additional, Carvalho, Lina Oliveira de, additional, Campanholo, Cristiano Barbosa, additional, Fernandes, Vander, additional, Campos, Ana Paula Beckhauser de, additional, Kohem, Charles Lubianca, additional, Albuquerque, Cleandro Pires de, additional, Ruiz, Danilo Garcia, additional, Meirelles, Eduardo de Souza, additional, Bezerra Neto, Francisco Alves, additional, Assis, Marcos Renato de, additional, Sauma, Maria de Fátima Lobato da Cunha, additional, Keiserman, Mauro Waldemar, additional, Santiago, Mittermayer Barreto, additional, Assad, Rodrigo Luppino, additional, Bonfiglioli, Rubens, additional, Lima, Sonia Maria Alvarenga Anti Loduca, additional, Carneiro, Sueli Coelho da Silva, additional, Pinna, Fabiana Pompeo de, additional, Milanez, Fernanda Manente, additional, Pacheco, Sula Glaucia Lage Drumond, additional, Chiereghin, Adriano, additional, Loures, Marco Antonio Araújo da Rocha, additional, Doreto, Debora Tobaldini Russo, additional, Rocha, Francisco Airton Castro da, additional, Pinheiro, Marcelo de Medeiros, additional, and Barros, Percival Degrava Sampaio, additional

Published
2023
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6. Evaluation of performance of BASDAI (Bath Ankylosing Spondylitis Disease Activity Index) in a Brazilian cohort of 1492 patients with spondyloarthritis: data from the Brazilian Registry of Spondyloarthritides (RBE)

Author

Costa, Izaias Pereira da, Bortoluzzo, Adriana B., Gonçalves, Célio R., Silva, José Antonio Braga da, Ximenes, Antonio Carlos, Bértolo, Manoel B., Ribeiro, Sandra L.E., Keiserman, Mauro, Menin, Rita, Skare, Thelma L., Carneiro, Sueli, Azevedo, Valderílio F., Vieira, Walber P., Albuquerque, Elisa N., Bianchi, Washington A., Bonfiglioli, Rubens, Campanholo, Cristiano, Carvalho, Hellen M.S., Duarte, Angela L.B. Pinto, Kohem, Charles L., Leite, Nocy H., Lima, Sonia A.L., Meirelles, Eduardo S., Pereira, Ivânio A., Pinheiro, Marcelo M., Polito, Elizandra, Resende, Gustavo G., Rocha, Francisco Airton C., Santiago, Mittermayer B., Sauma, Maria de Fátima L.C., Valim, Valéria, and Sampaio-Barros, Percival D.

Published
2015
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7. Avaliação do desempenho do BASDAI (Bath Ankylosing Spondylitis Disease Activity Index) numa coorte brasileira de 1.492 pacientes com espondiloartrites: dados do Registro Brasileiro de Espondiloartrites (RBE)

Author

Costa, Izaias Pereira da, Bortoluzzo, Adriana B., Gonçalves, Célio R., Silva, José Antonio Braga da, Ximenes, Antonio Carlos, Bértolo, Manoel B., Ribeiro, Sandra L.E., Keiserman, Mauro, Menin, Rita, Skare, Thelma L., Carneiro, Sueli, Azevedo, Valderílio F., Vieira, Walber P., Albuquerque, Elisa N., Bianchi, Washington A., Bonfiglioli, Rubens, Campanholo, Cristiano, Carvalho, Hellen M.S., Duarte, Angela L.B. Pinto, Kohem, Charles L., Leite, Nocy H., Lima, Sonia A.L., Meirelles, Eduardo S., Pereira, Ivânio A., Pinheiro, Marcelo M., Polito, Elizandra, Resende, Gustavo G., Rocha, Francisco Airton C., Santiago, Mittermayer B., Sauma, Maria de Fátima L.C., Valim, Valéria, and Sampaio‐Barros, Percival D.

Published
2015
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8. Epidemiologic profile of juvenile-onset compared to adult-onset spondyloarthritis in a large Brazilian cohort

Author

Duarte, Angela P., Marques, Cláudia D.L., Bortoluzzo, Adriana B., Gonçalves, Célio R., Silva, José Antonio Braga da, Ximenes, Antonio Carlos, Bértolo, Manoel B., Ribeiro, Sandra Lúcia E., Keiserman, Mauro, Skare, Thelma L., Carneiro, Sueli, Menin, Rita, Azevedo, Valderilio F., Vieira, Walber P., Albuquerque, Elisa N., Bianchi, Washington A., Bonfiglioli, Rubens, Campanholo, Cristiano, Carvalho, Hellen M.S., Costa, Izaias P., Kohem, Charles L., Leite, Nocy, Lima, Sonia A.L., Meirelles, Eduardo S., Pereira, Ivânio A., Pinheiro, Marcelo M., Polito, Elizandra, Resende, Gustavo G., Rocha, Francisco Airton C., Santiago, Mittermayer B., Sauma, Maria de Fátima L.C., Valim, Valéria, and Barros, Percival D. Sampaio

Published
2014
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9. Perfil epidemiológico da espondiloartrite de início juvenil comparada com a espondiloartrite de início na vida adulta em uma grande coorte brasileira

Author

Duarte, Angela P., Marques, Cláudia D.L., Bortoluzzo, Adriana B., Gonçalves, Célio R., Silva, José Antonio Braga da, Ximenes, Antonio Carlos, Bértolo, Manoel B., Ribeiro, Sandra Lúcia E., Keiserman, Mauro, Skare, Thelma L., Carneiro, Sueli, Menin, Rita, Azevedo, Valderilio F., Vieira, Walber P., Albuquerque, Elisa N., Bianchi, Washington A., Bonfiglioli, Rubens, Campanholo, Cristiano, Carvalho, Hellen M.S., Costa, Izaias P., Kohem, Charles L., Leite, Nocy, Lima, Sonia A.L., Meirelles, Eduardo S., Pereira, Ivânio A., Pinheiro, Marcelo M., Polito, Elizandra, Resende, Gustavo G., Rocha, Francisco Airton C., Santiago, Mittermayer B., Sauma, Maria de Fátima L.C., Valim, Valéria, and Barros, Percival D. Sampaio

Published
2014
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10. Profile of the use of disease modifying drugs in the Brazilian Registry of Spondyloarthritides

Author

Kohem, Charles L., Bortoluzzo, Adriana B., Gonçalves, Célio R., Silva, José Antonio Braga da, Ximenes, Antonio Carlos, Bértolo, Manoel B., Ribeiro, Sandra L.E., Keiserman, Mauro, Menin, Rita, Skare, Thelma L., Carneiro, Sueli, Azevedo, Valderílio F., Vieira, Walber P., Albuquerque, Elisa N., Bianchi, Washington A., Bonfiglioli, Rubens, Campanholo, Cristiano, Carvalho, Hellen M.S., Costa, Izaias Pereira da, Duarte, Angela L.B. Pinto, Leite, Nocy H., Lima, Sonia A.L., Meirelles, Eduardo S., Pereira, Ivânio A., Pinheiro, Marcelo M., Polito, Elizandra, Resende, Gustavo G., Rocha, Francisco Airton C., Santiago, Mittermayer B., Sauma, Maria de Fátima L.C., Valim, Valéria, and Sampaio-Barros, Percival D.

Published
2014
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11. Perfil do uso de drogas modificadoras de doença no Registro Brasileiro de Espondiloartrites

Author

Kohem, Charles L., Bortoluzzo, Adriana B., Gonçalves, Célio R., Silva, José Antonio Braga da, Ximenes, Antonio Carlos, Bértolo, Manoel B., Ribeiro, Sandra L.E., Keiserman, Mauro, Menin, Rita, Skare, Thelma L., Carneiro, Sueli, Azevedo, Valderílio F., Vieira, Walber P., Albuquerque, Elisa N., Bianchi, Washington A., Bonfiglioli, Rubens, Campanholo, Cristiano, Carvalho, Hellen M.S., Costa, Izaias Pereira da, Duarte, Angela L.B. Pinto, Leite, Nocy H., Lima, Sonia A.L., Meirelles, Eduardo S., Pereira, Ivânio A., Pinheiro, Marcelo M., Polito, Elizandra, Resende, Gustavo G., Rocha, Francisco Airton C., Santiago, Mittermayer B., Sauma, Maria de Fátima L.C., Valim, Valéria, and Sampaio-Barros, Percival D.

Published
2014
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12. Enteropathic arthritis in Brazil: data from the Brazilian registry of spondyloarthritis

Author

Resende, Gustavo G., Lanna, Cristina C.D., Bortoluzzo, Adriana B., Gonçalves, Célio R., Sampaio-Barros, Percival D., Silva, José Antonio Braga da, Ximenes, Antonio Carlos, Bértolo, Manoel B., Ribeiro, Sandra L.E., Keiserman, Mauro, Menin, Rita, Skare, Thelma L., Carneiro, Sueli, Azevedo, Valderílio F., Vieira, Walber P., Albuquerque, Elisa N., Bianchi, Washington A., Bonfiglioli, Rubens, Campanholo, Cristiano, Carvalho, Hellen M.S., Costa, Izaias P., Duarte, Angela P., Kohem, Charles L., Leite, Nocy, Lima, Sonia A.L., Meirelles, Eduardo S., Pereira, Ivânio A., Pinheiro, Marcelo M., Polito, Elizandra, Rocha, Francisco Airton C., Santiago, Mittermayer B., Sauma, Maria de Fátima L.C., and Valim, Valeria

Published
2013
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13. Artrite enteropática no Brasil: dados do registro brasileiro de espondiloartrites

Author

Resende, Gustavo G., Lanna, Cristina C.D., Bortoluzzo, Adriana B., Gonçalves, Célio R., Sampaio-Barros, Percival D., Silva, José Antonio Braga da, Ximenes, Antonio Carlos, Bértolo, Manoel B., Ribeiro, Sandra L.E., Keiserman, Mauro, Menin, Rita, Skare, Thelma L., Carneiro, Sueli, Azevedo, Valderílio F., Vieira, Walber P., Albuquerque, Elisa N., Bianchi, Washington A., Bonfiglioli, Rubens, Campanholo, Cristiano, Carvalho, Hellen M.S., Costa, Izaias P., Duarte, Angela P., Kohem, Charles L., Leite, Nocy, Lima, Sonia A.L., Meirelles, Eduardo S., Pereira, Ivânio A., Pinheiro, Marcelo M., Polito, Elizandra, Rocha, Francisco Airton C., Santiago, Mittermayer B., Sauma, Maria de Fátima L.C., and Valim, Valeria

Published
2013
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16. Additional file 1 of COVID-19 was not associated or trigger disease activity in spondylarthritis patients: ReumaCoV-Brasil cross-sectional data

Author

Marques, Claudia Diniz Lopes, Ribeiro, Sandra Lúcia Euzébio, Albuquerque, Cleandro P., de Sousa Studart, Samia Araujo, Ranzolin, Aline, de Andrade, Nicole Pamplona Bueno, Dantas, Andrea T., Mota, Guilherme D., Resende, Gustavo G., Marinho, Adriana O., Angelieri, Danielle, Andrade, Danieli, Ribeiro, Francinne M., Omura, Felipe, Silva, Nilzio A., Rocha Junior, Laurindo, Brito, Danielle E., Fernandino, Diana C., Yazbek, Michel A., Souza, Mariana P. G., Ximenes, Antonio Carlos, Martins, Ana Silvia S., Castro, Glaucio Ricardo W., Oliveira, Lívia C., Freitas, Ana Beatriz S. B., Kakehasi, Adriana M., Gomides, Ana Paula M., Reis Neto, Edgard Torres, Pileggi, Gecilmara S., Ferreira, Gilda A., Mota, Licia Maria H., Xavier, Ricardo M., and de Medeiros Pinheiro, Marcelo

Abstract

Additional file 1. Flowchart of patients with immune-mediated rheumatic diseases enrolled in the ReumaCoV-Brasil study and Spondyloarthritis analysis.

Published
2022
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18. Gender characterization in a large series of Brazilian patients with spondyloarthritis

Author

de Carvalho, Hellen M. S., Bortoluzzo, Adriana B., Gonçalves, Célio R., da Silva, José Antonio Braga, Ximenes, Antonio Carlos, Bértolo, Manoel B., Ribeiro, Sandra L. E., Keiserman, Mauro, Menin, Rita, Skare, Thelma L., Carneiro, Sueli, Azevedo, Valderílio F., Vieira, Walber P., Albuquerque, Elisa N., Bianchi, Washington A., Bonfiglioli, Rubens, Campanholo, Cristiano, Costa, Izaias P., Duarte, Angela P., Gavi, Maria Bernadete O., Kohem, Charles L., Leite, Nocy H., Lima, Sonia A. L., Meirelles, Eduardo S., Pereira, Ivânio A., Pinheiro, Marcelo M., Polito, Elizandra, Resende, Gustavo G., Rocha, Francisco Airton C., Santiago, Mittermayer B., de Fátima L. C. Sauma, Maria, Sampaio-Barros, Percival D., and from the Brazilian Registry on Spondyloarthritis

Published
2012
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19. Three Multicenter, Randomized, Double‐Blind, Placebo‐Controlled Studies Evaluating the Efficacy and Safety of Ustekinumab in Axial Spondyloarthritis

Author

Deodhar, Atul, primary, Gensler, Lianne S., additional, Sieper, Joachim, additional, Clark, Michael, additional, Calderon, Cesar, additional, Wang, Yuhua, additional, Zhou, Yiying, additional, Leu, Jocelyn H., additional, Campbell, Kim, additional, Sweet, Kristen, additional, Harrison, Diane D., additional, Hsia, Elizabeth C., additional, Heijde, Désirée, additional, Ariel, Frederico, additional, Asnal, Cecilia Adma, additional, Berman, Alberto, additional, Citera, Gustavo, additional, Rodriguez, Graciela, additional, Savio, Veronica Gabriela, additional, Bird, Paul, additional, Griffiths, Hedley, additional, Nicholls, David, additional, Rischmueller, Maureen, additional, Zochling, Jane, additional, De Vlam, Kurt, additional, Malaise, Michel, additional, Toukap, Adrien Nzeusseu, additional, Van den Bosch, Filip, additional, Vanhoof, Johan, additional, Bonfiglioli, Rubens, additional, Keiserman, Mauro, additional, Scotton, Antonio Scafuto, additional, Xavier, Ricardo, additional, Ximenes, Antonio Carlos, additional, Atanasov, Assen, additional, Goranov, Ivan, additional, Kazmin, Ivan, additional, Licheva, Rodina Nestorova, additional, Nikolov, Nikolay, additional, Oparanov, Boycho, additional, Stoilov, Rumen, additional, Bessette, Louis, additional, Rodrigues, Jude, additional, Bortilik, Ladislav, additional, Dokoupilova, Eva, additional, Dvoarak, Zdenek, additional, Galatikova, Dagmar, additional, Nemec, Petr, additional, Podrazilova, Lucie, additional, Simkova, Gabriela, additional, Stejfova, Zuzana, additional, Moravcova, Radka, additional, Vitek, Petr, additional, Cantagrel, Alain, additional, Baillet, Athan, additional, Banneville, Beatrice, additional, Combe, Bernard, additional, Breban, Maxime, additional, Nguyen, Minh, additional, Goupille, Philippe, additional, Braun, Juergen, additional, Everding, Andrea, additional, Kekow, Joern, additional, Koenig, Ramona, additional, Rubbert‐Roth, Andrea, additional, Witte, Torsten, additional, Bartha, Attila, additional, Drescher, Edit, additional, Kerekes, Kata, additional, Kovacs, Attila, additional, Pulai, Judit, additional, Rojkovich, Bernadette, additional, Szanto, Sandor, additional, Toth, Edit, additional, Avila, Hilario, additional, Torre, Igancio Garcia, additional, Irazoque, Fedra, additional, Maradiaga, Marco, additional, Pacheco, Cesar, additional, Brzosko, Marek, additional, Dudek, Anna, additional, Jeka, Slawomir, additional, Krogulec, Marek, additional, Kwiatkowska, Brygida, additional, Wiland, Piotr, additional, Wojciechowski, Rafal, additional, Zielinska, Agnieszka, additional, Santos, Helena, additional, Bugrova, Olga, additional, Christyakov, Valery, additional, Gorbunov, Vladimir, additional, Ilivanova, Elena, additional, Zemerova, Elena, additional, Kamalova, Rima, additional, Kameneva, Tatyana, additional, Macievskaya, Galina, additional, Marusenko, Irina, additional, Maslyansky, Alexey, additional, Myasoedova, Svetlana, additional, Myasoutova, Leisan, additional, Nemtsov, Boris, additional, Nesmeyanova, Olga, additional, Plaksina, Tatyana, additional, Pokrovskaya, Tatyana, additional, Polyakova, Svetlana, additional, Rebrov, Andrey, additional, Savina, Liudmila, additional, Smakotina, Svetlana, additional, Stanislav, Marina, additional, Ukhanova, Olga, additional, Vinogradova, Irina, additional, Zonova, Elena, additional, Baek, Han Joo, additional, Kim, Tae‐Hwan, additional, Lee, ChangKeun, additional, Lee, SangHeon, additional, Lee, Sang‐Hoon, additional, Lee, Shin‐Seok, additional, Park, Sung‐Hwan, additional, Song, YeongWook, additional, Suh, Chang‐Hee, additional, Ramos, Juan Amarelo, additional, Blanco, Franciso Javier, additional, Collantes, Eduardo, additional, Diaz, Miguel Consuelo, additional, Vivar, Maria Luz Garcia, additional, Gratacos, Jordi, additional, Juanola, Xavier, additional, Chen, Der‐Yuan, additional, Chen, Hsiang‐Cheng, additional, Chen, Kun‐Hung, additional, Chen, Ying‐Chou, additional, Chiu, Ying‐Ming, additional, Luo, Shue‐Fen, additional, Tsai, Shih‐Tzu, additional, Tseng, Jui‐Cheng, additional, Wei, Cheng‐Chung, additional, Weng, Meng‐Yu, additional, Abrahamovych, Orest, additional, Reshotko, Dmytro, additional, Golovchenko, Oleksandr, additional, Hospodarsky, Ihor, additional, Iaremenko, Oleg, additional, Levchenko, Olena, additional, Dudnyk, Oleksandr, additional, Garmish, Olena, additional, Grishyna, Olena, additional, Protsenko, Galyna, additional, Rekalov, Dmytro, additional, Smiyan, Svitlana, additional, Stanislavchuk, Mykola, additional, Trypilka, Svitlana, additional, Tseluyko, Vira, additional, Turianytsia, Samvel, additional, Vasylets, Viktoriya, additional, Virstyuk, Nataliya, additional, Kleban, Yaroslav, additional, Ciurtin, Coziana, additional, Gaffney, Karl, additional, Gunasekera, Wiranthi, additional, Mackay, Kirsten, additional, Packham, Jon, additional, Sengupta, Raj, additional, Tahir, Hasan, additional, Aelion, Jacob, additional, Bennett, Ralph, additional, Deodhar, Atul, additional, Gonzalez‐Paoli, Julio, additional, Griffin, Robert M., additional, Grisanti, Michael, additional, Mallepalli, Jyothi, additional, Peters, Eric, additional, Schechtman, Joy, additional, and Singhal, Atul, additional

Published
2018
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20. Erratum of “Enteropathic arthritis in Brazil: data from the Brazilian registry of spondyloarthritis”

Author

Resende, Gustavo G., Lanna, Cristina C.D., Bortoluzzo, Adriana B., Gonçalves, Célio R., Sampaio-Barros, Percival D., Silva, José Antonio Braga da, Ximenes, Antonio Carlos, Bértolo, Manoel B., Ribeiro, Sandra L.E., Keiserman, Mauro, Menin, Rita, Skare, Thelma L., Carneiro, Sueli, Azevedo, Valderílio F., Vieira, Walber P., Albuquerque, Elisa N., Bianchi, Washington A., Bonfiglioli, Rubens, Campanholo, Cristiano, Carvalho, Hellen M.S., Costa, Izaias P., Duarte, Angela P., Kohem, Charles L., Leite, Nocy, Lima, Sonia A.L., Meirelles, Eduardo S., Pereira, Ivânio A., Pinheiro, Marcelo M., Polito, Elizandra, Rocha, Francisco Airton C., Santiago, Mittermayer B., Sauma, Maria de Fátima L.C., and Valim, Valeria

Published
2014
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21. Errata de “Artrite enteropática no Brasil: dados do Registro Brasileiro de Espondiloartrites”

Author

Resende, Gustavo G., Lanna, Cristina C.D., Bortoluzzo, Adriana B., Gonçalves, Célio R., Sampaio-Barros, Percival D., Silva, José Antonio Braga da, Ximenes, Antonio Carlos, Bértolo, Manoel B., Ribeiro, Sandra L.E., Keiserman, Mauro, Menin, Rita, Skare, Thelma L., Carneiro, Sueli, Azevedo, Valderílio F., Vieira, Walber P., Albuquerque, Elisa N., Bianchi, Washington A., Bonfiglioli, Rubens, Campanholo, Cristiano, Carvalho, Hellen M.S., Costa, Izaias P., Duarte, Angela P., Kohem, Charles L., Leite, Nocy, Lima, Sonia A.L., Meirelles, Eduardo S., Pereira, Ivânio A., Pinheiro, Marcelo M., Polito, Elizandra, Rocha, Francisco Airton C., Santiago, Mittermayer B., Sauma, Maria de Fátima L.C., and Valim, Valeria

Published
2014
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22. Epidemiologic profile of juvenile-onset compared to adult-onset spondyloarthritis in a large Brazilian cohort

Author

Duarte, Angela P., Marques, Cláudia D.L., Bortoluzzo, Adriana B., Gonçalves, Célio R., Silva, José Antonio Braga da, Ximenes, Antonio Carlos, Bértolo, Manoel B., Ribeiro, Sandra Lúcia E., Keiserman, Mauro, Skare, Thelma L., Carneiro, Sueli, Menin, Rita, Azevedo, Valderilio F., Vieira, Walber P., Albuquerque, Elisa N., Bianchi, Washington A., Bonfiglioli, Rubens, Campanholo, Cristiano, Carvalho, Hellen M.S., Costa, Izaias P., Kohem, Charles L., Leite, Nocy, Lima, Sonia A.L., Meirelles, Eduardo S., Pereira, Ivânio A., Pinheiro, Marcelo M., Polito, Elizandra, Resende, Gustavo G., Rocha, Francisco Airton C., Santiago, Mittermayer B., Sauma, Maria de Fátima L.C., Valim, Valéria, and Barros, Percival D. Sampaio

Abstract

To analyze the clinical and epidemiologic characteristics of juvenile-onset spondyloarthritis (SpA) (< 16 years) and compare them with a group of adult-onset (≥ 16 years) SpA patients.

Published
2024
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23. Maintenance of remission following 2 years of standard treatment then dose reduction with abatacept in patients with early rheumatoid arthritis and poor prognosis.

Author

UCL - SSS/IREC/RUMA - Pôle de Pathologies rhumatismales, UCL - (SLuc) Service de rhumatologie, Westhovens, Rene, Robles, Manuel, Ximenes, Antonio Carlos, Wollenhaupt, Jurgen, Durez, Patrick, Gomez-Reino, Juan, Grassi, Walter, Haraoui, Boulos, Shergy, William, Park, Sung-Hwan, Genant, Harry, Peterfy, Charles, Becker, Jean-Claude, Murthy, Bindu, UCL - SSS/IREC/RUMA - Pôle de Pathologies rhumatismales, UCL - (SLuc) Service de rhumatologie, Westhovens, Rene, Robles, Manuel, Ximenes, Antonio Carlos, Wollenhaupt, Jurgen, Durez, Patrick, Gomez-Reino, Juan, Grassi, Walter, Haraoui, Boulos, Shergy, William, Park, Sung-Hwan, Genant, Harry, Peterfy, Charles, Becker, Jean-Claude, and Murthy, Bindu

Abstract

OBJECTIVES: To evaluate maintenance of response while reducing intravenous abatacept dose from ~10 mg/kg to ~5 mg/kg in patients with early rheumatoid arthritis (RA) who achieved disease activity score (DAS)28 (erythrocyte sedimentation rate, ESR) <2.6. METHODS: This 1-year, multinational, randomised, double-blind substudy evaluated the efficacy and safety of ~10 mg/kg and ~5 mg/kg abatacept in patients with early RA with poor prognosis who had reached DAS28 (ESR) <2.6 at year 2 of the AGREE study. The primary outcome was time to disease relapse (defined as additional disease-modifying antirheumatic drugs, ≥2 courses high-dose steroids, return to open-label abatacept ~10 mg/kg, or DAS28 (C reactive protein) ≥3.2 at two consecutive visits). RESULTS: 108 patients were randomised (~10 mg/kg, n=58; ~5 mg/kg, n=50). Three and five patients, respectively, discontinued, and four per group returned to open-label abatacept. Relapse over time and the proportion of patients relapsing were similar in both groups (31% (~10 mg/kg) vs 34% (~5 mg/kg); HR: 0.87 (95% CI 0.45 to 1.69)). Mean steady-state trough serum concentration for the ~10 mg/kg group was 20.3-24.1 µg/mL, compared with 8.8-12.0 µg/mL for the ~5 mg/kg group. CONCLUSIONS: This exploratory study suggests that abatacept dose reduction may be an option in patients with poor prognosis early RA who achieve DAS28 (ESR) <2.6 after ≥1 year on abatacept (~10 mg/kg). TRIAL REGISTRATION NUMBER: NCT00989235.

Published
2015

24. Errata de “Perfil epidemiológico da espondiloartrite de início juvenil comparada com a espondiloartrite de início na vida adulta em uma grande coorte brasileira”

Author

Duarte, Angela P., primary, Marques, Cláudia D.L., additional, Bortoluzzo, Adriana B., additional, Gonçalves, Célio R., additional, Silva, José Antonio Braga da, additional, Ximenes, Antonio Carlos, additional, Bértolo, Manoel B., additional, Ribeiro, Sandra Lúcia E., additional, Keiserman, Mauro, additional, Skare, Thelma L., additional, Carneiro, Sueli, additional, Menin, Rita, additional, Azevedo, Valderilio F., additional, Vieira, Walber P., additional, Albuquerque, Elisa N., additional, Bianchi, Washington A., additional, Bonfiglioli, Rubens, additional, Campanholo, Cristiano, additional, Carvalho, Hellen M.S., additional, Costa, Izaias P., additional, Kohem, Charles L., additional, Leite, Nocy, additional, Lima, Sonia A.L., additional, Meirelles, Eduardo S., additional, Pereira, Ivânio A., additional, Pinheiro, Marcelo M., additional, Polito, Elizandra, additional, Resende, Gustavo G., additional, Rocha, Francisco Airton C., additional, Santiago, Mittermayer B., additional, Sauma, Maria de Fátima L.C., additional, Valim, Valéria, additional, and Sampaio‐Barros, Percival D., additional

Published
2015
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25. Erratum on “Epidemiologic profile of juvenile-onset compared to adult-onset spondyloarthritis in a large Brazilian cohort”

Author

Duarte, Angela P., primary, Marques, Cláudia D.L., additional, Bortoluzzo, Adriana B., additional, Gonçalves, Célio R., additional, Silva, José Antonio Braga da, additional, Ximenes, Antonio Carlos, additional, Bértolo, Manoel B., additional, Ribeiro, Sandra Lúcia E., additional, Keiserman, Mauro, additional, Skare, Thelma L., additional, Carneiro, Sueli, additional, Menin, Rita, additional, Azevedo, Valderilio F., additional, Vieira, Walber P., additional, Albuquerque, Elisa N., additional, Bianchi, Washington A., additional, Bonfiglioli, Rubens, additional, Campanholo, Cristiano, additional, Carvalho, Hellen M.S., additional, Costa, Izaias P., additional, Kohem, Charles L., additional, Leite, Nocy, additional, Lima, Sonia A.L., additional, Meirelles, Eduardo S., additional, Pereira, Ivânio A., additional, Pinheiro, Marcelo M., additional, Polito, Elizandra, additional, Resende, Gustavo G., additional, Rocha, Francisco Airton C., additional, Santiago, Mittermayer B., additional, Sauma, Maria de Fátima L.C., additional, Valim, Valéria, additional, and Sampaio-Barros, Percival D., additional

Published
2015
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26. Maintenance of remission following 2 years of standard treatment then dose reduction with abatacept in patients with early rheumatoid arthritis and poor prognosis

Author

Westhovens, Rene, primary, Robles, Manuel, additional, Ximenes, Antonio Carlos, additional, Wollenhaupt, Jurgen, additional, Durez, Patrick, additional, Gomez-Reino, Juan, additional, Grassi, Walter, additional, Haraoui, Boulos, additional, Shergy, William, additional, Park, Sung-Hwan, additional, Genant, Harry, additional, Peterfy, Charles, additional, Becker, Jean-Claude, additional, and Murthy, Bindu, additional

Published
2014
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28. Assessment of fatigue in a large series of 1492 Brazilian patients with Spondyloarthritis

Author

Bianchi, Washington A., primary, Elias, Fernanda R., additional, Carneiro, Sueli, additional, Bortoluzzo, Adriana B., additional, Gonçalves, Célio R., additional, da Silva, José Antonio Braga, additional, Ximenes, Antonio Carlos, additional, Bértolo, Manoel B., additional, Ribeiro, Sandra L. E., additional, Keiserman, Mauro, additional, Skare, Thelma L., additional, Menin, Rita, additional, Azevedo, Valderílio F., additional, Vieira, Walber P., additional, Albuquerque, Elisa N., additional, Bonfiglioli, Rubens, additional, Campanholo, Cristiano, additional, Carvalho, Hellen M. S., additional, Costa, Izaias P., additional, Duarte, Angela P., additional, Kohem, Charles L., additional, Leite, Nocy H., additional, Lima, Sonia A. L., additional, Meirelles, Eduardo S., additional, Pereira, Ivânio A., additional, Pinheiro, Marcelo M., additional, Polito, Elizandra, additional, Resende, Gustavo G., additional, Rocha, Francisco Airton C., additional, Santiago, Mittermayer B., additional, Sauma, Maria de Fátima L. C., additional, Valim, Valéria, additional, and Sampaio-Barros, Percival D., additional

Published
2014
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29. II brazilian consensus on antinuclear antibodies in HEp-2 cells : definitions for standardizartion of autoantibody testing against the nucleus (ANA HEp-2), nucleolus, cytoplasm and mitotic apparatus, as wel as its clinical associations

Author

Dellavance, Alessandra, Gabriel Junior, Alexandre, Cintra, Alice F. U., Ximenes, Antonio Carlos, Nuccitelli, Barbara, Taliberti, Ben Hur, Moreira, Caio, von Mühlen, Carlos Alberto, Bichara, Carlos David, Santos, Cláudio Henrique Ramos dos, Yano, Cristiane Mertinez, Mangueira, Cristóvão Luis Pitangueira, Carvalho, Darlene Gonçalves, Bonfá, Eloisa Silva Dutra de Oliveira, Doi, Elvira M., Guimarães, Fabiana Nunes de Carvalho, Araújo, Flávia Ikeda e, Mundim, Hugo Mendonça, Rego, Jozelia, Vieira, Lisiane Ericonio dos Anjos, Poli, Luciana, Andrade, Luís Eduardo Coelho, Callado, Maria Roseli, Mesquita, Mauro Meira, Sugiyama, Mitiko, Slhessarenko, Natasha, Silva, Nilzio Antonio da, Carballo, Orlando Gabriel, Leser, Paulo Guilherme, Francescantonio, Paulo Luiz Carvalho, Jarach, Renata, Xavier, Ricardo Machado, Levy, Roger Abramino, Neves, Suzane P. F., Cruvinel, Wilson de Melo, and Santos, Wilton Silva dos

Subjects
Imunofluorescência, Células tumorais cultivadas, Immunofluorescence, Autoanticorpos, Anticorpos antinucleares, HEp-2 cells, Conferência de consenso, Autoantibodies, ANA
Abstract

Objetivo: O Segundo Consenso Brasileiro de Fator Antinuclear (FAN) em Células HEp-2 ratificou os algoritmos de decisão para leitura dos padrões do FAN na imunofluorescência indireta vistos na primeira edição do Consenso Brasileiro, adicionando ainda um novo algoritmo relacionado com os padrões mistos. Métodos: Tendo em vista a habilidade do teste em detectar autoantígenos nos distintos compartimentos celulares, e não apenas no núcleo, propõe-se novas denominações para este exame laboratorial. Resultados e Conclusões: Como novas denominações algumas sugestões foram igualmente aceitas, dentro do tema “pesquisa de auto-anticorpos contra constituintes do núcleo (FAN HEp-2), nucléolo, citoplasma e aparelho mitótico”. Foram abordadas as principais relevâncias clínicas com os padrões de FAN descritos, facilitando o melhor uso do ensaio pelo médico. Objective: The Second Brazilian Consensus on Antinuclear Antibodies (ANA) in HEp-2 Cells approved and extended the decision trees developed during the First Brazilian Consensus in order to also offer information about mixed patterns of fluorescence. Methods: Since this test elicits reactions not only to nuclear autoimmune antigens but also to different cell compartments, new denominations for the test were approved. Results and Conclusions: These new denominations encompass variations on the “autoantibody testing against the nucleus (ANA HEp-2), nucleolus, cytoplasm, and mitotic apparatus” issue. Furthermore, major clinical associations were described for each immunofluorescent pattern, facilitating the interpretation of laboratory results in the clinical practice.

Published
2003

30. Baixa prevalência das manifestações extra-articulares renais, cardíacas, pulmonares e neurológicas nas espondiloartrites: análise do Registro Brasileiro de Espondiloartrites

Author

Rodrigues, Carlos Ewerton Maia, primary, Vieira, Walber Pinto, additional, Bortoluzzo, Adriana B., additional, Gonçalves, Célio Roberto, additional, Silva, José Antonio Braga da, additional, Ximenes, Antonio Carlos, additional, Bértolo, Manoel B., additional, Ribeiro, Sandra L. E., additional, Keiserman, Mauro, additional, Menin, Rita, additional, Skare, Thelma L., additional, Carneiro, Sueli, additional, Azevedo, Valderílio F., additional, Albuquerque, Elisa N., additional, Bianchi, Washington A., additional, Bonfiglioli, Rubens, additional, Campanholo, Cristiano, additional, Carvalho, Hellen M. S., additional, Costa, Izaias P., additional, Duarte, Angela P., additional, Kohem, Charles L., additional, Leite, Nocy H., additional, Lima, Sonia A. L., additional, Meirelles, Eduardo S., additional, Pereira, Ivânio A., additional, Pinheiro, Marcelo M., additional, Polito, Elizandra, additional, Resende, Gustavo G., additional, Rocha, Francisco Airton C., additional, Santiago, Mittermayer B., additional, Sauma, Maria de Fátima L. C., additional, Valim, Valeria, additional, and Sampaio-Barros, Percival D., additional

Published
2012
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31. Ethnic Influence in Clinical and Functional Measures of Brazilian Patients with Spondyloarthritis

Author

SKARE, THELMA L., primary, BORTOLUZZO, ADRIANA B., additional, GONÇALVES, CÉLIO R., additional, BRAGA da SILVA, JOSÉ ANTONIO, additional, XIMENES, ANTONIO CARLOS, additional, BÉRTOLO, MANOEL B., additional, RIBEIRO, SANDRA L.E., additional, KEISERMAN, MAURO, additional, MENIN, RITA, additional, CARNEIRO, SUELI, additional, AZEVEDO, VALDERÍLIO F., additional, VIEIRA, WALBER P., additional, ALBUQUERQUE, ELISA N., additional, BIANCHI, WASHINGTON A., additional, BONFIGLIOLI, RUBENS, additional, CAMPANHOLO, CRISTIANO, additional, CARVALHO, HELLEN M.S., additional, COSTA, IZAIAS P., additional, DUARTE, ANGELA P., additional, GAVI, MARIA BERNADETE O., additional, KOHEM, CHARLES L., additional, LEITE, NOCY H., additional, LIMA, SONIA A.L., additional, MEIRELLES, EDUARDO S., additional, PEREIRA, IVÂNIO A., additional, PINHEIRO, MARCELO M., additional, POLITO, ELIZANDRA, additional, RESENDE, GUSTAVO G., additional, ROCHA, FRANCISCO AIRTON C., additional, SANTIAGO, MITTERMAYER B., additional, SAUMA, MARIA de FÁTIMA L.C., additional, and SAMPAIO-BARROS, PERCIVAL D., additional

Published
2011
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34. Consenso Brasileiro de Espondiloartropatias: espondilite anquilosante e artrite psoriásica diagnóstico e tratamento - primeira revisão

Author

Sampaio-Barros, Percival D., primary, Azevedo, Valderílio Feijó, additional, Bonfiglioli, Rubens, additional, Campos, Wesley R., additional, Carneiro, Sueli Coelho da Silva, additional, Carvalho, Marco Antonio P., additional, Gonçalves, Célio Roberto, additional, Hilário, Maria Odete E., additional, Keiserman, Mauro W., additional, Leite, Nocy H., additional, Mallmann, Karen, additional, Meirelles, Eduardo de Souza, additional, Vieira, Walber P., additional, and Ximenes, Antonio Carlos, additional

Published
2007
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35. Consenso Brasileiro de Espondiloartropatias: outras espondiloartropatias diagnóstico e tratamento - primeira revisão

Author

Sampaio-Barros, Percival D., primary, Azevedo, Valderílio Feijó, additional, Bonfiglioli, Rubens, additional, Campos, Wesley R., additional, Carneiro, Sueli Coelho da Silva, additional, Carvalho, Marco Antonio P., additional, Gonçalves, Célio Roberto, additional, Hilário, Maria OdeteE., additional, Keiserman, Mauro W., additional, Leite, Nocy H., additional, Mallmann, Karen, additional, Meirelles, Eduardo de Souza, additional, Vieira, Walber P., additional, and Ximenes, Antonio Carlos, additional

Published
2007
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36. Ethnic Influence in Clinical and Functional Measures of Brazilian Patients with Spondyloarthritis.

Author

Skare, Thelma L., Bortoluzzo, Adriana B., Gonçalves, Célio R., da Silva, Jose Antonio Braga, Ximenes, Antonio Carlos, Bértolo, Manoel B., Ribeiro, Sandra L. E., Keiserman, Mauro, Menin, Rita, Carneiro, Sueli, Azevedo, Valderilio E, Vieira, Walber P., Albuquerque, Elisa N., Bianchi, Washington A., Bonfiglioli, Rubens, Campanholo, Cristiano, Carvalho, Hellen M. S., Costa, Izaias P., Duarte, Angela P., and Gavi, Maria Bernadete O.

Published
2012
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37. Detection of Chlamydia trachomatis in spondyloarthropathies and rheumatoid arthritis

Author

Fernandez, Rafael Navarrete, Alves, Maria de Fátima Costa, and Ximenes, Antonio Carlos

Subjects
PCR, Espondiloartropatias, DOENCAS INFECCIOSAS E PARASITARIAS [CLINICA MEDICA], Chlamydia trachomatis, Spondyloarthropathies, Artrite reumatóide, Rheumatoid arthritis
Abstract

Introdução: A Chlamydia trachomatis é a bactéria responsável pela doença sexualmente transmissível mais prevalente no mundo. A maioria das infecções em homens e mulheres é assintomática e, quando não diagnosticada e tratada, pode alcançar as articulações e causar artrite, isto sem mencionar outras complicações conhecidas relacionadas ao aparelho reprodutor feminino. Objetivos: Pesquisar o DNA de C. trachomatis no líquido sinovial e urina, em pacientes com espondiloartropatias e artrite reumatóide (AR) e avaliar a presença de anticorpos séricos IgG e IgM anti-C. trachomatis nestes dois grupos de doenças. Identificar o antígeno HLA-B27 em pacientes com espondiloartropatias. Metodologia: A população do estudo consistiu de 15 pacientes com espondiloartropatias: nove com espondiloartropatia indiferenciada (EI) e seis com artrite reativa (ARe) (grupo I) e 15 pacientes com AR (grupo II). O DNA clamidial foi pesquisado em amostras de líquido sinovial e urina de todos eles empregandose a PCR (Amplicor Roche). Os anticorpos IgG e IgM anti-clamidiais foram quantificados por imunofluorescência indireta (IFI), enquanto o HLA-B27 foi tipado em 15 pacientes do grupo I por citometria de fluxo. Os dados sócio-demográficos, de comportamento sexual e presença de sintomas foram obtidos através de questionário na forma de entrevista. Resultados: O DNA da C. trachomatis foi evidenciado apenas em uma amostra de líquido sinovial do grupo I (6,7%), sendo o paciente portador de ARe. Em dois pacientes com AR, o DNA de clamidial foi identificado na urina (13,3%). Os anticorpos IgG anti-clamidiais estavam presentes em oito pacientes da população estudada, três do grupo I (20%) e cinco do grupo II (33,3%). O maior título desse anticorpo (1/256) associou-se com a presença do DNA clamidial na urina de um paciente do grupo II. O anticorpo IgM não foi detectado em nenhuma amostra 14 dos dois grupos. O antígeno HLA-B27 foi positivo em quatro indivíduos do grupo II (26,7%) e sua presença relacionou-se com sacroiliite. Conclusões: Os resultados desse estudo indicam que em portadores de espondiloartropatias e artrite reumatóide, com quadro articular em atividade, a C. trachomatisnão pode ser excluída como agente desencadeador. Introduction: Chlamydia trachomatis is the bacteria responsible for the most prevalent sexually transmitted disease worldwide. Most of the infections in men and women is asymptomatic and when undiagnosed and untreated may reach the joints causing not only arthritis, but also other acknowledged complications related to the female reproductive system. Objective: To investigate C. trachomatis DNA in the urine and synovial fluid from patients with spondyloarthropathies (SpA) and rheumatoid arthritis (RA) and evaluate serum anti-C. trachomatisIgG and IgM antibodies. Methods: The population consisted of 15 patients with spondyloarthropathies, being nine with undifferentiated spondyloarthropathy (US) and six with reactive arthritis (ReA) (group I), and 15 patients with rheumatoid arthritis (RA) (group II). The chlamydial DNA was assessed in synovial fluid and urine samples of all patients by Amplicor PCR. The anti-chlamydial IgG and IgM antibodies were quantified through indirect imunofluorescence (IIF), while 15 patients of group I were typed for HLA-B27 by the use of flow citometry. Social demographical data and all information on sexual behavior and presence of symptoms were collected through a (questionnaire in the form of) an interview. Results: C. trachomatis DNA was found in only one synovial fluid sample from patient with ReA (6,7%). In two patients with RA, chlamydial DNA was identified in the urine sample (13,3%). The anti-chlamydial IgG antibodies were present in eight patients of the population studied; being three patients from group I (20%), and five from group II (33,3%). The greatest titer of this antibody 1/256 was associated with the presence of chlamydial DNA in a patient from group II. The IgM antibody was not detected in any of the samples from both groups. Four individuals from group II (26,7%) were HLA-B27 positive and its presence was 16 related to sacroiliitis. Conclusion: The results in this study show that in patients with spondyloarthropathies and rheumatoid arthritis, presenting a picture of articular activity one might not exclude C. trachomatisas the triggering agent.

Published
2004

38. [Evaluation of performance of BASDAI (Bath Ankylosing Spondylitis Disease Activity Index) in a Brazilian cohort of 1,492 patients with spondyloarthritis: data from the Brazilian Registry of Spondyloarthritides (RBE)].

Author

da Costa IP, Bortoluzzo AB, Gonçalves CR, da Silva JA, Ximenes AC, Bértolo MB, Ribeiro SL, Keiserman M, Menin R, Skare TL, Carneiro S, Azevedo VF, Vieira WP, Albuquerque EN, Bianchi WA, Bonfiglioli R, Campanholo C, Carvalho HM, Duarte AL, Kohem CL, Leite NH, Lima SA, Meirelles ES, Pereira IA, Pinheiro MM, Polito E, Resende GG, Rocha FA, Santiago MB, Sauma Mde F, Valim V, and Sampaio-Barros PD

Subjects
Brazil, Female, Humans, Male, Prospective Studies, Registries, Severity of Illness Index, Spondylitis, Ankylosing diagnosis, Spondylarthritis diagnosis
Abstract

Objective: To analyze the results of the application of the Bath Ankylosing Spondylitis Disease Activity Index (BASDAI) in a large series of Brazilian patients with the diagnosis of SpA and establish its correlations with specific variables into the group., Methods: A common protocol of investigation was prospectively applied to 1492 Brazilian patients classified as SpA according to the European Spondyoarthropathies Study Group (ESSG), attended at 29 referral centers of Rheumatology in Brazil. Clinical and demographic variables, and disease indices (BASDAI, Basfi, Basri, Mases, ASQol) were applicated. The total values of BASDAI were compared to the presence of the different variables., Results: The mean score of BASDAI was 4.20 ± 2.38. The mean scores of BASDAI were higher in patients with the combined (axial + peripheral + entheseal) (4.54 ± 2.38) clinical presentation, compared to the pure axial (3.78 ± 2.27) or pure peripheral (4.00 ± 2.38) clinical presentations (p<0.001). BASDAI also presented higher scores associated with the female gender (p<0.001) and patients who did not practice exercises (p < 0.001). Regarding the axial component, higher values of BASDAI were significantly associated with inflammatory low back pain (p<0.049), alternating buttock pain (p<0.001), cervical pain (p<0.001) and hip involvement (p<0.001). There was also statistical association between BASDAI scores and the peripheral involvement, related to the lower (p=0.004) and upper limbs (p=0.025). The presence of enthesitis was also associated to higher scores of BASDAI (p=0.040). Positive HLA-B27 and the presence of cutaneous psoriasis, inflammatory bowel disease, uveitis and urethritis were not correlated with the mean scores of BASDAI. Lower scores of BASDAI were associated with the use of biologic agents (p<0.001)., Conclusion: In this heterogeneous Brazilian series of SpA patients, BASDAI was able to demonstrate "disease activity" in patients with axial as well as peripheral disease., (Copyright © 2014 Elsevier Editora Ltda. All rights reserved.)

Published
2015
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41. Low prevalence of renal, cardiac, pulmonary, and neurological extra-articular clinical manifestations in spondyloarthritis: analysis of the Brazilian Registry of Spondyloarthritis.

Author

Rodrigues CE, Vieira WP, Bortoluzzo AB, Gonçalves CR, da Silva JA, Ximenes AC, Bértolo MB, Ribeiro SL, Keiserman M, Menin R, Skare TL, Carneiro S, Azevedo VF, Albuquerque EN, Bianchi WA, Bonfiglioli R, Campanholo C, Carvalho HM, Costa IP, Duarte AP, Kohem CL, Leite NH, Lima SA, Meirelles ES, Pereira IA, Pinheiro MM, Polito E, Resende GG, Rocha FA, Santiago MB, Sauma Mde F, Valim V, and Sampaio-Barros PD

Subjects
Brazil epidemiology, Cross-Sectional Studies, Humans, Prevalence, Prohibitins, Registries, Retrospective Studies, Spondylarthritis diagnosis, Heart Diseases epidemiology, Heart Diseases etiology, Kidney Diseases epidemiology, Kidney Diseases etiology, Lung Diseases epidemiology, Lung Diseases etiology, Nervous System Diseases epidemiology, Nervous System Diseases etiology, Spondylarthritis complications
Abstract

Objective: To describe the extra-articular manifestations (cardiac, renal, pulmonary, and neurological), usually not related to spondyloarthritis (SpA), in a large cohort of Brazilian patients., Materials and Methods: This retrospective study analyzed 1,472 patients diagnosed with SpA and cared for at 29 health care centers distributed in the five major geographic regions in the country, participating in the Brazilian Registry of Spondyloarthritis (BRS). All patients were assessed for the prevalence of major extra-articular manifestations (cardiac, renal, pulmonary, and neurological), classified according to the diagnosis [ankylosing spondylitis (AS), psoriatic arthritis (PsA), reactive arthritis (ReA), arthritis associated with inflammatory bowel disease (IBD), undifferentiated spondyloarthritis (uSpA), and juvenile SpA], and according to the clinical presentation (axial, peripheral, mixed, and enthesitis)., Results: Of the patients with SpA assessed, 963 had AS, 271 PsA, 49 ReA, 48 arthritis associated with IBD, 98 uSpA, and 43 juvenile SpA. Cardiac involvement was reported in 44 patients (3.0%), pulmonary involvement in 19 (1.3%), renal involvement in 17 (1.2%), and neurological involvement in 13 patients (0.9%). Most patients with visceral involvement had AS or PsA, and the mixed (axial + peripheral) and/or predominantly axial clinical form., Conclusion: Cardiac, renal, pulmonary, and neurological extra-articular manifestations are quite infrequent in SpA, ranging from 0.9% to 3% in this large Brazilian cohort, and affected predominantly patients with AS and PsA.

Published
2012

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