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Xiao-Hong Xie,* Fei Wang,* Xin-Qing Lin, Yin-Yin Qin, Zhan-Hong Xie, Jie-Xia Zhang, Ming Ouyang, Cheng-Zhi Zhou State Key Laboratory of Respiratory Disease, National Clinical Research Center of Respiratory Disease, Guangzhou Institute of the Respiratory Health, First Affiliated Hospital of Guangzhou Medical University, Guangzhou Medical University, Guangzhou 510120, People’s Republic of China*These authors contributed equally to this workCorrespondence: Cheng-Zhi ZhouState Key Laboratory of Respiratory Disease, National Clinical Research Center of Respiratory Disease, Guangzhou Institute of the Respiratory Health, First Affiliated Hospital of Guangzhou Medical University, Guangzhou Medical University, Guangzhou, People’s Republic of ChinaTel +86-20-83062830Email zhouchengzhi@gird.cnObjective: The study aimed to analyze the efficacy and safety of combination regimen of anlotinib and S-1 for Chinese patients with EGFR mutation-negative advanced squamous cell lung cancer (SqCLC) with poor performance status (PS,2– 3) after progression of second-line or later-line chemotherapy.Methods: Clinical data of 70 SqCLC patients with PS scores of 2– 3 treated in the First Affiliated Hospital of Guangzhou Medical University between January 1, 2018 to September 31, 2019 who failed second- or more-line treatment were analysed retrospectively. The patients were divided into two treatment groups: anlotinib (12mg) plus S-1 (25mg) combination group and anlotinib (12mg) monotherapy group. The efficacy and adverse reactions of the two groups were compared.Results: In terms of the short-term efficacy, there were no significant differences in objective response rate (ORR) (20.0% vs 10.0%, p = 0.464) and disease control rate (DCR) (75.0% vs 60.0%, p = 0.181) between the two groups. As for the long-term efficacy, there was no significant difference in progression-free survival (PFS) between the two groups (3.87± 0.29 months vs 3.00± 0.24 months, p=0. 11). The overall survival (OS) of patients in the combination group was longer than S1 group (8.07± 0.56 months vs 6.17± 0.42 months, p=0.022).Conclusion: Advanced SqCLC patients with higher PS scores still benefit from anlotinib and S-1 combination regimen, even after they failed second-line or later-line systemic treatment.Keywords: anlotinib, S-1, advanced squamous cell lung cancer, performance status, efficacy

Objective To evaluate the pathogenicity of Exophiala dermatitidis melanin in Galleria mellonella infection model. Methods Melanin of albino strain of Exophiala dermatitidis was restored by co-culture with E. dermatitidis (mel3). The G. mellonella were infected with albino, melanized strtain, and melanin restored albino strain. Survival rate, macromorphological and histopathological changes of larvae were observed under the optimal infection concentration. Results The melanin production was restored in albino strain of Exophiala dermatitidis, and conidia at a concentration of 1×107/mL was the optimal infection concentration. At the end of observation, the albino strain displayed lower survival rate compared to both the melanized stain (χ2=6.11，P=0.013) and melanin restored albino strain (χ2=6.37, P=0.010). However, the survival rates did not differ significantly between melanized and melanin restored albino strain (χ2=0.01，P=0.940). Histopathological examination revealed that the melanized strain and melanin restored albino strain attracted aggregation of more Galleria mellonella hemocytes, forming larger infectious nodules in comparison to albino strains. Conclusions In the infection model of Galleria mellonella, the albino strain shows stronger pathogenicity than the melanized strain. Restoration of melanin of albino strain can reverse the pathogenicity.

The aberrant proliferation and migration of vascular smooth muscle cells (VSMCs) contribute to the development of neointima formation in vascular restenosis. This study aims to explore the function of the long noncoding RNA H19 in neointima formation. A mouse carotid ligation model was established, and human vascular smooth muscle cells (VSMCs) were used as a cell model. lncRNA H19 overexpression promoted VSMC proliferation and migration. Moreover, miR-125a-3p potentially bound to lncRNA H19, and Fms-like tyrosine kinase-1 (FLT1) might be a direct target of miR-125a-3p in VSMCs. Upregulation of miR-125a-3p alleviated lncRNA H19-enhanced VSMC proliferation and migration. Furthermore, rescue experiments showed that enhanced expression of miR-125a-3p attenuated lncRNA H19-induced FLT1 expression in VSMCs. In addition, the overexpression of lncRNA H19 significantly exacerbated neointima formation in a mouse carotid ligation model. In summary, lncRNA H19 stimulates VSMC proliferation and migration by acting as a competing endogenous RNA (ceRNA) of miR-125a-3p. lncRNA H19 may be a therapeutic target for restenosis.

Abstract Background This study investigated the mediating effects of coping strategies and psychological status on the relationship between illness perception and health-related quality of life (HRQoL) among patients with atrial fibrillation (AF). Methods This cross-sectional study enrolled 178 patients with AF who were admitted to a tertiary hospital in Beijing City in mainland from March 2020 and June 2022. Assessments were made for HRQoL using the Short Form Health Survey depressive symptoms using the Patient Health Questionnaire-9, anxiety using the Generalized Anxiety Disorder-7 (GAD-7), illness perception using the Brief Illness Perception Questionnaire (BIPQ), AF symptoms using the Atrial Fibrillation Severity Scale (AFSS), and coping strategies using the Brief-COPE Scale. Results Significant correlations were observed between illness perception, emotional variables, coping strategies, and HRQoL scores. The regression analysis found that BIPQ, GAD, Maladaptive coping and Problem-focused coping are significant predictors of PCS (F = 20.906, R2 = 0.326, p

We report three cases of tinea nigra in children caused by Hortaea werneckii. The patients were all girls, aged 2, 2 and 3 years, respectively. All patients presented with asymptomatic brown or black rash on either one palm or both palms. Dermoscopy showed scattered or overlapping dark brown pigmented granules forming a striated or reticulated structure with clear borders and uniform color. Direct microscopic examination revealed branched, curved, brown septate hyphae. The fungal culture showed black, shiny, yeast-like colonies at early stage, and elevated irregular colonies with flocculent mycelium surrounded by a black edge after 14 days. The strain of Hortaea werneckii was identified by ITS rDNA sequencing. Diagnosis of tinea nigra was confirmed by clinical symptoms and laboratory examinations. All patients were cured with topical antifungal drugs and with no recurrence at 3 months of follow-up.

Swiftly and accurately analyze non-stationary disturbance signals within the power grid， a location and detection method for transient power quality disturbance that combines singular value decomposition （SVD） and improved local mean decomposition （ILMD） is proposed. First， noise information is processed by using ILMD and a fuzzy membership function threshold to mitigate noise interference. Then， a difference signal is formulated， and a sliding window SVD is employed to amplify the disturbance features while further suppressing noise interference. In conclusion， an adaptive threshold truncation-based approach for localizing and detecting transient power quality disturbances is proposed， utilizing the feature-enhanced signal. Simulation analysis and algorithm comparisons confirm that the proposed method exhibits precise location， robust resistance to noise， and low computational complexity. Moreover， it demonstrates excellent performance in detecting zero-crossing and minor disturbances.

Objective Since the collision and compression of the Indo-European continental plates, the Qinghai-Tibetan Plateau has experienced uplift and intra-land deformationSince the collision and compression of the Indo-European continental plates, the Qinghai-Tibetan Plateau has experienced uplift and intra-land deformation. Similarly, the Sichuan-Yunnan block underwent lateral escape and rotationSince the collision and compression of the Indo-European continental plates, the Qinghai-Tibetan Plateau has experienced uplift and intra-land deformation. Similarly, the Sichuan-Yunnan block underwent lateral escape and rotation. Although extensive paleomagnetic studies have been conducted on the rotation of the central and western parts of the Sichuan-Yunnan rhombic block, less attention has been paid to the rotation of its eastern partSince the collision and compression of the Indo-European continental plates, the Qinghai-Tibetan Plateau has experienced uplift and intra-land deformation. Similarly, the Sichuan-Yunnan block underwent lateral escape and rotation. Although extensive paleomagnetic studies have been conducted on the rotation of the central and western parts of the Sichuan-Yunnan rhombic block, less attention has been paid to the rotation of its eastern part. This study employs fluvial geomorphology, which is highly sensitive to mass rotation, to investigate the rotation and uplift in the Laoyingshan region, situated in the eastern part of the Sichuan-Yunnan block. Methods A 30 m resolution digital elevation model (DEM) was used to identify and analyze 22 basins in the study area. Four geomorphological parameters were examined: local topographic relief ratio, longitudinal profile, normalized steepness index, and basin azimuth. Results (1) According to regional topographic relief, the low-relief area in the Laoyingshan region is mainly located near the Sijia River and the Baizai River on the western side, whereas the high-relief area is mainly found near the Dabai River and the Gongshan River on the eastern side of the Laoyingshan. The relief around the Dabai and Gongshan Rivers was greater than that around the Sijia River on the western side of Laoyingshan. (2) The normalized steepness index in the Laoyingshan area gradually decreased from north to south. The high-value areas are primarily located near Awang and Jinyuan, corresponding to the east and west branches of the Xiaojiang Fault. In contrast, the low-value areas were mainly distributed at the top of the Laoyingshan and south of the Baozai River in the study area. (3) The results of the river longitudinal profile indicated that the average surface uplift of the area was approximately 358 m. (4) Based on the results of the watershed azimuth angle, the Laoyingshan area underwent a counterclockwise rotation of approximately 15°. Conclusion The analysis suggests that since the Late Miocene, the western region of the Sichuan-Yunnan block, located west of the Yuanmou Fault, has experienced fewer effects from strike-slip faults and has predominantly undergone clockwise rotation. Conversely, the eastern region of the Sichuan-Yunnan block, influenced by strike-slip faults, underwent counterclockwise rotation with differential uplift. [ Significance] The fluvial geomorphological index outlines the tectonic rotation of the eastern Sichuan-Yunnan block.

【Objective】With the development of the sixth generation mobile communication technology, the inter-carrier interference in the traditional Orthogonal Frequency Division Multiplexing (OFDM) system makes the channel estimation performance insufficient to provide highly reliable communication, and Orthogonal Time-Frequency Space (OTFS) system can effectively solve the problem of communication system reliability degradation caused by fast time variability and Doppler effect, which has received wide attention in recent years.【Methods】In order to effectively meet the channel estimation performance requirements of OTFS systems, this paper uses an Optimized Generalized Complex Exponential (OGCE) Basis Expansion Model (BEM) to calculate the channel impulse response as a time-invariant basis function with basis function coefficients, which can effectively fit fast time-varying channels in high-speed mobile communication scenarios. The OGCE-BEM improves the spectral leakage by more intensive sampling and reduces the error of the high-frequency basis model by adding correction coefficients to reduce the error of the HF-based model.【Results】The simulation results show that the proposed algorithm is suitable for high-speed mobile communication scenarios with more reasonable design of the basis function. The estimation method has lower mean square error than the fixed forgetting factor, and the channel estimation results are more accurate. Compared with Least Square (LS), BEM-LS and BEM-Linear Minimum Mean Square Error (LMMSE) channel estimation methods, the performance of mean square error is significantly improved.【Conclusion】It can be seen that the channel estimation algorithm based on OGCE-BEM can effectively reduce the number of unknown parameters to be estimated and improve the accuracy of channel estimation.

Hydrogels have indeed achieved significant advancements, yet their clinical translation has been hampered by their inherent limitations in wet adhesion properties. Furthermore, the design of adhesive hydrogels that can resist postoperative adhesions remains an intricate challenge. In this study, we introduce a Janus hydrogel (JGP) that offers a novel approach to address these challenges. The JGP hydrogel has two asymmetrical sides, consisting of an adhesion layer (AL) and an anti-adhesion layer (AAL). Specifically, the AL incorporates three key components: N-[tris(hydroxymethyl)methyl]acrylamide (THMA), acrylic acid (AAc), and the acrylic acid N-hydroxysuccinimide ester (AAc-NHS). By drying the AL, it has a rapid water absorption capability. The abundance of hydroxyl and carboxyl groups in the AL enables the formation of robust hydrogen bonds with tissues, thereby achieving superior adhesive properties. Additionally, the synergistic effect of THMA's tridentate hydrogen bonding and the covalent bonding formed by AAc-NHS with tissue ensures long-lasting wet adhesion. To realize the anti-adhesion function, one side of the AL was immersed in a solution of [2-(methacryloyloxy)ethyl]dimethyl-(3-sulfopropyl)ammonium hydroxide (SBMA), which undergoes crosslinking to form the AAL. A comprehensive series of tests have confirmed that the JGP hydrogel exhibits exceptional mechanical properties, efficient and enduring adhesion, excellent biocompatibility, and degradability. Moreover, it possesses remarkable hemostatic properties and robust anti-abdominal adhesion characteristics.

Pelvic exenteration is often required for primary rectal cancer beyond total mesorectal excision (PRC-bTME) and locally recurrent rectal cancer (LRRC). Some patients with radical resection can achieve long-term survival, but they need to face risks, such as huge surgical trauma, serious perioperative complications, permanent loss of organ function and decline in quality of life. Preoperative evaluation of PRC-bTME and LRRC should emphasize multidisciplinary collaboration and develop individualized diagnosis and treatment strategies. The principles of function preservation and risk-benefit balance in surgery oncology should be followed, and R0 resection should be emphasized. Perioperative complications, surgical trauma and organ function loss should be minimized to achieve the best quality control and balance point. This consensus was formulated by the Colorectal Cancer Committee of the Chinese Medical Doctor Association and the Gastrointestinal Surgery Committee of China International Exchange and Promotive Association for Medical and Health Care. The draft was formed based on the summary of domestic and foreign research progress and expert experience. After discussion, review and modification by experts, an anonymous voting was conducted for each major opinion, and in-depth verification was carried out according to the principles of evidence-based medicine. Finally, the Chinese expert consensus on the pelvic exenteration with primary rectal cancer beyond total mesorectal excision planes and locally recurrent rectal cancer (2023 edition) was formed. This consensus mainly summarizes the indications and contraindications of pelvic exenteration (PE) for PRC-bTME and LRRC, preoperative diagnosis and evaluation, perioperative treatment, as well as the resection scope, surgical methods, reconstruction of related organs, safety and complications of PE, postoperative follow-up and other issues, in order to provide guidance for PE in patients with PRC-bTME and LRRC.

In order to provide nursing staff with optimal exercise interventions for preventing lymphedema in patients with breast cancer, the AGREE II score, the systematic review tool, the literature evaluation criteria and the evidence grading system of the Joanna Briggs Institute (JBI) Center for Evidence-Based Health Care were used to evaluate the included Based on the guidelines, systematic reviews, and expert consensus, 6 people independently evaluated the quality of the literature, and combined with the judgment of personnel with relevant evidence-based nursing knowledge, the qualified literature was evaluated and the evidence grade was assessed. The included research documents are 2 relevant evidence summaries; 1 guideline; 1 expert consensus; 16 systematic reviews, ranging from exercise contraindications, pre-exercise assessment and testing, exercise intensity, exercise safety, exercise programs, precautions, Eight aspects of health education were summarized and analyzed. This article summarizes the exercise intervention measures and management experience for preventing lymphedema in breast cancer patients, providing a basis for nursing staff to guide breast cancer patients to implement exercise intervention measures, thereby effectively preventing the occurrence of lymphedema.

Objective To compare the short-term efficacy of unilateral biportal endoscopic lumbar interbody fusion (ULIF) and minimally invasive surgery transforaminal lumbar interbody fusion (MIS-TLIF) in the treatment of lumbar spinal stenosis. Methods Clinical data of 87 patients with lumbar spinal stenosis from April 2020 to June 2022 were retrospectively analyzed. Among them, 43 cases were treated with ULIF (ULIF group) and 44 cases were treated with MIS-TLIF (MIS-TLIF group). The surgical time, intraoperative blood loss, postoperative ambulation time, drainage tube removal time, hospital stay, postoperative complications, visual analog scale (VAS) scores for back and leg pain, as well as Oswestry disability index (ODI) were compared between the two groups. Results Compared with the MIS-TLIF group, the ULIF group had a longer surgical time, with statistically significant difference (P＜0.05). There was no significant difference in intraoperative blood loss, postoperative ambulation time, drainage tube removal time and hospital stay between the two groups (P＞0.05). Two cases in the ULIF group and one case in the MIS-TLIF group experienced cerebrospinal fluid leakage postoperatively, but there were no other complications in either group. There was no statistically significant difference in the incidence of complications between the two groups (P＞0.05). Both groups were followed up for 12 months. The fusion rate in the ULIF group was significantly higher than that in the MIS-TLIF group at 6 months (81.4% vs 59.1%, χ2=5.163, P＜0.05) and 12 months (90.7% vs 68.2%, χ2=6.179, P＜0.05) after surgery. Conclusion For patients with lumbar spinal stenosis, ULIF can achieve similar efficacy to MIS-TLIF, while providing higher decompression efficiency, greater surgical instrument flexibility, and more thorough intervertebral space treatment. However, ULIF has a longer surgical time.

The sodium-cooled fast reactor uses liquid metal sodium as the coolant, and the entire external and internal refueling operations are carried out in a fully enclosed environment, and the operation process of the components is not visible. To ensure the correctness of the sodium-cooled fast reactor components, the design converted the component number into a two-dimensional DataMatrix (DM) code and marked it on the head position of the component through direct identification technology (DPM). An industrial advanced and reliable code reading device (reader) was installed on the new component transfer equipment (new component loader). When the new component was put into the reactor, the code was automatically recognized by the reader, and the component code was converted into a component number and transmitted to the fuel operation monitoring system through communication. The monitoring system compared it with the component numbers in the refueling plan to determine whether the transported new components were correct, improving the reliability and safety of component operations. To determine the size and depth of component codes, 16 component codes consisting of 4 sizes and 4 depths were provided as the test sample library based on the engineering site conditions. In order to determine the optimal component code from the experimental sample library, combined with the engineering site conditions, four main factors affecting the determination of component code were analyzed and summarized through enumeration method: installation angle of code reading equipment, offset angle, component type, and component movement speed. Since these four factors had no interaction with each other, a single factor experimental plan was determined that each experiment only changed one influencing factor, and the rest were fixed as fixed values, which were constant factors. There are a total of 7 tests: control rod assembly code reading test, fuel rod assembly code reading test, reader installation angle code reading test, control rod coding offset angle test, fuel rod coding offset angle test, control rod coding motion test, and fuel rod coding motion test. The judgment basis for each experiment is that the average reading time and maximum reading time of the code reader are less than 500 ms, and the success rate of reading is 100%. Through the first two experiments, the experimental sample library was preliminarily optimized, and then the optimized sample library was used for testing the installation angle of the code reader to screen out the optimal installation angle. Then, the sample library was further streamlined and optimized through encoding offset angle experiments, and finally, the optimal component encoding was determined through encoding motion experiments.

Abstract Using polyaspartic acid (PAsp) and bentonite (BT) as the main raw materials, a new type of degradable soil water retaining agent (PAsp-AA/BT) was synthesized by microwave radiation. The optimum synthesis conditions and comprehensive properties of PAsp-AA/BT were discussed and the structure and surface characteristics of PAspsp-AA/BT were characterized by FTIR, SEM, XRD and TGA in the paper. The results showed that the optimum synthesis conditions of PAsp-AA/BT were as follows: the dosages of polyaspartic acid (PAsp), bentonite (BT), initiator potassium persulfate, crosslinking agent N,N′-methylene bisacrylamide was 5, 3, 0.3, 0.03%, respectively, the neutralization degree of acrylic acid was 75%, and the microwave power was 490W. Under this condition, the absorption ratio of the synthesized PAspsp-AA/BT in deionized water and 0.9% NaCl solution was 953 and 164 g/g, respectively. The synthesized PAsp-AA/BT had a high water absorption rate, good water retention and repeated water absorption, and the degradation rate in soil within 30 days reached 32.75%, with good degradation effect. The analysis of SEM, FT-IR, XRD and TGA showed that: the surface of PAsp-AA/BT was rough and had obvious pore structure, which was conducive to the diffusion of water molecules; polyaspartic acid, bentonite and acrylic acid were polymerized; the cross-linking structure was formed between polyaspartic acid, bentonite and acrylic acid; the product of PASP-AA/BT had good thermal stability. This study provides a new soil water retaining agent, which is helpful for the better development of soil water retaining agent research.

AIM: To explore the current status, research hotspots, and trends of global uveitis research to provide a theoretical basis and references for researchers in the field of uveitis, and promote further development in this area.METHODS: Relevant literatures on uveitis were retrieved from the China National Knowledge Infrastructure(CNKI)database, Wanfang database, and Web of Science core collection database since their establishment until 24 August 2023. The country/publishing institutions, research authors, high-frequency keywords, and burst keywords were visual analyzed by using software such as GraphPad Prism 9, CiteSpace 6.2. R2, and VOSviewer.RESULTS: Research teams for uveitis have been formed in various countries globally. The top three countries in terms of publications are the United States of America(7 585 papers), the United Kingdom(2 412 papers)and Germany(1 679 papers). The top three foreign institutions in terms of publications are Harvard University, Oregon Health & Science University, and Moorfields Eye Hospital, while the top three domestic institutions are Affiliated Eye Hospital of Shandong University of Traditional Chinese Medicine, Chongqing Medical University, and Zhongshan Ophthalmic Center, Sun Yat-sen University. The analysis of high-frequency keywords and burst keywords in Chinese and English shows that research hotspots mainly focus on exploring pathogenesis and different treatment methods for uveitis. The research hotspots related to uveitis treatment are transitioning to molecular biology-related research topics, such as molecular biological signaling pathways(NF-κB signaling pathway with a strength value of 22.89), biological agents(adalimumab with a strength value of 32.21), and tumor necrosis factor(with a strength value of 48.44). Related research is also expanding to basic experiments on relevant rats.CONCLUSIONS: In recent years, the research hotspots and trends of global uveitis mainly focus on precise diagnosis, pathogenesis, and more effective treatment methods. It is important for more scholars to dedicate themselves to uveitis-related research in the future to make breakthroughs and progress in the field. More large-scale and multicenter clinical studies on uveitis can provide high-quality research evidence.

Objective The MS 6.8 earthquake that struck Luding County, Sichuan Province, on September 5, 2022, and its aftershocks have drawn widespread attention, especially concerning the potential risks of induced seismicity associated with the construction of high-dam reservoirs in regions with high seismic intensity. Previous studies have explored the possible link between reservoirs and seismic activity, without reaching a definitive conclusion. This study aims to assess the impact of water storage in the Dagangshan Reservoir on the surrounding strata and its correlation with recent seismic events. Methods Numerical simulation methods were employed using high-precision digital elevation model (DEM) data, fault data, and reservoir water level information to develop a three-dimensional poroelastic finite element numerical model extending from the surface to a depth of 25 km. By analyzing the hydrogeological conditions, lithology of rock masses, and groundwater dynamic changes, this study evaluated the seismic hazard risk of major faults, such as the Moxi Fault, and calculated variations in Coulomb stress and strata pore pressure at the hypocenter during the occurrence of the earthquake. Results The study indicates that, during the MS 6.8 Luding earthquake on September 5, 2022, the pore pressure at the epicenter reached 5 kPa, and the Coulomb stress increased by 3.6 kPa, suggesting that the impoundment of the Dagangshan Reservoir contributed to an increased risk along the Moxi Fault on the northwestern side of the reservoir. Using the source parameters of the MS 5.6 aftershock that occurred on January 26, 2023, it was observed that the impoundment caused a change in Coulomb stress at the epicenter of -0.69 kPa and a pore pressure of approximately 0.32 kPa. It is evident that the reservoir impoundment had a relatively minor impact on the fault activity where the MS 5.6 aftershock occurred and even exhibited a certain inhibitory effect. Moreover, seismic activity was mainly concentrated in two areas on the western side of the reservoir, with both the seismicity and expected magnitudes in these regions reflecting a higher risk of earthquakes. Conclusion This study demonstrates a correlation between the impoundment activities of the Dagangshan Reservoir and the occurrence of the Luding County earthquake and its aftershocks. The spatial distribution characteristics of the earthquakes align with the geological stress adjustment patterns following the reservoir impoundment, which played a promotive role in the occurrence of the MS 6.8 main shock, leading to an increased risk of earthquakes in the Moxi Fault region. This finding is significant for understanding the mechanisms of reservoir-induced earthquakes, subsequent aftershock analyses, and earthquake disaster prevention and mitigation efforts. Significance The results of this study provide new insights into the complex relationship between reservoir water storage and seismic events. This study offers a scientific basis for future assessments of seismic risks of reservoir design and operation, contributing to improved accuracy in earthquake early warnings and efficiency in disaster prevention and mitigation efforts.

Highlights MVOH/rGO cathode with dual defect of Mg2+ pre-intercalation defect (P-Mgd) and surface oxygen defect (Od) is prepared. The dual defect of Od and P-Mgd in MVOH/rGO lamellar structure effectively enhances Mg2+ migration kinetics, structural stability, and electronic conductivity. The Mg foil//MVOH/rGO full cell achieves an ultralong lifespan of 850 cycles at 0.1 A g−1 and powers an orange light-emitting diode.

Abstract Mg‐ion batteries (MIBs) are promising next‐generation secondary batteries, but suffer from sluggish Mg2+ migration kinetics and structural collapse of the cathode materials. Here, an H2O‐Mg2+ waltz‐like shuttle mechanism in the lamellar cathode, which is realized by the coordination, adaptive rotation and flipping, and co‐migration of lattice H2O molecules with inserted Mg2+, leading to the fast Mg2+ migration kinetics, is reported; after Mg2+ extraction, the lattice H2O molecules rearrange to stabilize the lamellar structure, eliminating structural collapse of the cathode. Consequently, the demo cathode of Mg0.75V10O24·nH2O (MVOH) exhibits a high capacity of 350 mAh g−1 at a current density of 50 mA g−1 and maintains a capacity of 70 mAh g−1 at 4 A g−1. The full aqueous MIB based on MVOH delivers an ultralong lifespan of 5000 cycles The reported waltz‐like shuttle mechanism of lattice H2O provides a novel strategy to develop high‐performance cathodes for MIBs as well as other multivalent‐ion batteries.

ObjectiveTo investigate the current status of first aid knowledge among middle-aged and elderly residents aged 50 and above in a community in Shanghai， in order to provide reference for improving the self-rescue and mutual aid capabilities of middle-aged and elderly residents.MethodsA multi-stage stratified random sampling method was used to conduct a survey on 335 residents aged 50 and above in a community in Shanghai using a self-made survey questionnaire. The current situation and related factors of emergency knowledge level of residents aged 50 and above in the community were comprehensively analyzed.ResultsFirst aid knowledge level of 335 residents aged 50 and above was low， and the rate of high cognitive level was only 24.18%. Univariate analysis showed that male residents had a higher awareness rate than female residents （P=0.044）， while residents aged 70 and above and 60‒ had lower awareness rates than residents aged 50‒ （P

Cylindrical vector beams (CVBs) hold considerable promise as high-capacity information carriers for multiplexing holography due to their mode orthogonality. In CVB holography, phase holograms are encoded onto the wave-front of CVBs with different mode orders while preserving their independence during reconstruction. However, a major challenge lies in the limited ability to manipulate the spatial phase and polarization distribution of CVBs independently. To address this challenge, we propose a spin-decoupled phase modulation strategy by leveraging the propagation and geometric phase of composite phase metasurfaces. By exploiting the polarized Poincaré sphere, we show that CVBs can be decomposed into two circularly polarized components with orthogonal polarization states and conjugate phase distributions. This decomposition enables independent control of the phase and polarization distributions of CVBs by modulating the initial phase and phase difference of these two components. Consequently, two holograms with discrete spatial frequency distributions that carry opposite helical phases are encoded to modulate the wave-front of CVBs by the metasurface consisting of Si nanopillars. This allows for us to achieve successful four-channel CVB multiplexing holography. Benefiting from the non-dispersive nature of geometric phase, this metasurface exhibits a broad operating band spanning the entire visible light spectrum (443 nm–633 nm). These suggest that our proposed method offers comprehensive control over the spatial phase and polarization of CVBs, thereby holding significant potential for advancing their application in holography.

Objective: To solve the technical problems in the design and analysis of the core parts of the mold open-closing mechanism related rod. Methods: The motion and force analysis of mold open-closing mechanism with an electric eight-bar was described in detail by using the analytical method. Results： Based on the example calculation, the relationship curve between the displacement of the slider and the crank angle was obtained, and the variation law of velocity and acceleration was further deduced. Meanwhile, the theoretical clamping force, the changing trend and the characteristics of each member force in the sheet extrusion process were analyzed. Conclusion: The method solves the implemented analysis of the electric eight-bar linkage mechanism without the need for professional software, shortening the design and prototyping cycles.

Topological edge state (TES) has emerged as a significant research focus in photonics due to its unique property of unidirectional transmission. This feature provides immunity to certain structural disorders or perturbations, greatly improving the robustness of photonic systems and enabling various applications such as optical isolation and topological lasers. Nevertheless, most of current researches focus on the fixed generated TES with no means to control, leaving untapped potential for manipulating the TES through specific methods. In this work, we propose a topological Su–Schriffer–Heeger (SSH) waveguides-lattice scheme that enables the controllable TES without changing the topological phase of the system. Light is selectively localized at the edges of the SSH waveguide lattice, which is determined by the special waveguide modes. Eventually, achieving an effective mode splitter. To validate our proposal, we further demonstrate such mode-controlled TES with a fabricated on-chip device in experiment. The experimentally tested results confirm a successful separation of the waveguide modes with the mode extinction ratio of approximately 10 dB in each channel near the wavelength of 1550 nm. This scheme presents a promising approach for manipulating the TES in photonic systems, thereby facilitating the design of optical controllable topological photonic devices.

Platelet elevation is a rare manifestation in the peripheral blood of patients with chronic myeloid leukemia (CML). In this paper, we report for the first time a case of CML combined with cerebral hemorrhage manifested by abnormally elevated platelets. The patient had elevated platelets in the peripheral blood, showed normal coagulation function, and underwent intracranial hematoma removal due to cerebral hemorrhage. After the operation, bleeding from the operated area and other systems occurred, and the patient was diagnosed as having accelerated CML after combining bone marrow biopsy and genetic testing. His condition was controlled after administration of flumatinib through a jejunal tube. Based on this patient's experience, the feasibility ofadministering flumatinib via a jejunostomy tube was determined, which is the first report of its kind in China and abroad.This article summarizes the diagnosis and treatment process of this patient, with the aim of providing a warning and reference for clinicians.

AIM: To investigate the preoperative ocular symptoms and the characteristics of asymptomatic ocular surface abnormalities in hospitalized patients with primary pterygium.METHODS: Cross-sectional study. Hospitalized patients diagnosed with primary pterygium and scheduled to receive pterygium excision surgery at the Xiamen Eye Center of Xiamen University from August 2022 to October 2022 were enrolled. Ocular surface disease index questionnaire(OSDI), six examinations including non-invasive tear film break-up time, Schirmer I test, tear meniscus height, lid margin abnormality, meibomian gland dropout and tear film lipid layer thickness, and anterior segment optical coherence tomography(AS-OCT)were performed and statistically analyzed.RESULTS: A total of 178 cases(178 eyes), with a mean age of 54.39±10.75 years old, were recruited, including 75 males(42.1%)and 103 females(57.9%). The average values of ocular surface parameters in these patients included OSDI: 11.47±9.69, tear film break-up time: 7.10±3.86 s; tear meniscus height: 0.16±0.07 mm, Schirmer I test values: 14.39±7.29 mm/5 min, and pterygium thickness: 504.74±175.87 μm. Totally 161 eyes(90.4%)presented with abnormal lid margin, 44 eyes(24.7%)presented with meibomian gland dropout score ≥4, 52 eyes(29.2%)presented with low lipid layer thickness. In the 6 objective examinations, abnormalities in at least 4 of these tests were found in 85.4% of eyes. Pterygium morphology was classified into four grades: 10 eyes(5.6%)of grade Ⅰ, 93 eyes(52.2%)of grade Ⅱ, 60 eyes(33.7%)of grade Ⅲ, and 15 eyes(8.4%)of grade Ⅳ. In patients with a higher grade of pterygium, the tear film break-up time was lower, and the proportion of abnormal lid margin was also significantly higher(P

Aiming at the contradiction between the rapidity requirement of online calculation of transient stability preventive control and the computational complexity of time-domain equations, a stacking ensemable learning driven optimization method for power system transient stability preventive control was proposed. Firstly, a transient stability estimator based on a stacking ensemble deep belief network was constructed to replace the nonlinear differential algebraic equation solution process required for transient stability determination. Secondly, the trained transient stability estimator was used as a transient stability constraint discriminator, which was embedded in the iterative optimization process of the Aptenodytes Forsteri optimization algorithm. Finally, with the goal of minimizing the cost of preventive control, a stacking ensemble learning driven power system transient stability preventive control optimization algorithm was established. The algorithm realized the efficient judgment of transient stability constraints in preventive control, and improved the decision-making level of preventive control for power generation rescheduling. Based on the IEEE39 bus system, the proposed preventive control method was verified by experiments. The results show that the method has achieved good results in both evaluation accuracy and calculation efficiency.

Abstract Background Atrial fibrillation (AF) often leads to an impaired Health-Related Quality of Life (HRQoL) in many patients. Moreover, psychological factors such as depression, anxiety, and illness perception have been found to significantly correlate with HRQoL. This study aims to evaluate the long-term effectiveness of Cognitive Behavioral Therapy (CBT) in enhancing HRQoL and mitigating psychological distress among AF patients. Methods Employing a prospective, open design with pseudo-randomization, this study encompassed pre-tests, post-treatment evaluations, and a 6-month follow-up. A total of 102 consecutive patients diagnosed with paroxysmal AF were initially enrolled. Out of these, 90 were assigned to two groups; one to receive a 10-week CBT treatment specifically focusing on anxiety, and the other to receive standard care. Outcome measures were evaluated using tools such as the Item Short Form Health Survey (SF-12), General Anxiety Disorder-7 (GAD-7), Patient Health Questionnaire-9 (PHQ-9), University of Toronto Atrial Fibrillation Severity Scale (AFSS), and Brief Illness Perception Questionnaire (BIPQ). These assessments were conducted at pre-treatment, post-treatment, and at the 6-month follow-up mark. We explored the effectiveness of CBT using Generalized Estimating Equations (GEE). Results Our analysis revealed a notable improvement in the CBT group relative to the control group. All metrics displayed consistent improvement across a 6-month duration. At the 6-month checkpoint, the CBT group exhibited a more favorable SF-12 Mental Component Score (MCS) (50.261 ± 0.758 vs. 45.208 ± 0.887, p

The combination of few-shot learning and graph neural networks can effectively solve the issue of extracting more useful information from limited data. However, most graph-based few-shot models only consider the global feature information extracted by the backbone during the construction process, while ignoring the dependency information hidden within the features. Additionally, the essence of graph convolution is the filtering of graph signals, and the majority of graph-based few-shot models construct fixed, single-property filters to process these graph signals. Therefore, in this paper, we propose an Adaptive Filtering Graph Convolutional Neural Network (AFGN) for few-shot classification. AFGN explores the hidden dependency information within the features, providing a new approach for constructing graph tasks in few-shot scenarios. Furthermore, we design an adaptive filter for the graph convolution of AFGN, which can adaptively adjust its strategy for acquiring high and low-frequency information from graph signals based on different few-shot episodic tasks. We conducted experiments on three standard few-shot benchmarks, including image recognition and fine-grained categorization. The experimental results demonstrate that our AFGN performs better compared to other state-of-the-art models.

This study employed the finite element method to investigate the biaxial stretching deformation mechanism of polyamide 6 (PA6) Film. First, the PA6 film was subjected to biaxial stretching experiments under various conditions. Then, a three-dimensional finite element model of PA6 film was established. The biaxial stretching experiments of PA6 films under various conditions were simulated by the established finite element model. The results show that the biaxial stretching of the films under various conditions exhibited a transition from elastic deformation to plastic deformation. Meanwhile, as the stretching ratio increases, the more uniform stress and strain distribution on the film surface can be found in the stress and strain contour diagrams. The stress and strain distributions were found to be largely consistent under various annealing temperatures. However, lower stretching rates resulted in higher internal stress intensity, making the films more resistant to biaxial stretching. The findings of this study provide a theoretical reference for a deeper understanding of the deformation mechanisms of PA6 films during the biaxial stretching process.

Introduction: The 2019 coronavirus disease (COVID-19) pandemic has reshaped oncology practice, but the impact of anti-angiogenic drugs on the severity of COVID-19 in patients with non-small cell lung cancer (NSCLC) remains unclear. Patients and Methods: We carried out a retrospective study involving 166 consecutive patients with NSCLC who were positive for COVID-19, aiming to determine the effects of anti-angiogenic drugs on disease severity, as defined by severe/critical symptoms, intensive care unit (ICU) admission/intubation, and mortality outcomes. Risk factors were identified using univariate and multivariate logistic regression models. Results: Of the participants, 73 had been administered anti-angiogenic drugs (termed the anti-angiogenic therapy (AT) group), while 93 had not (non-AT group). Comparative analyses showed no significant disparity in the rates of severe/critical symptoms (21.9% vs 35.5%, P = 0.057), ICU admission/intubation (6.8% vs 7.5%, P = 0.867), or death (11.0% vs 9.7%, P = 0.787) between these two groups. However, elevated risk factors for worse outcomes included age ≥ 60 (odds ratio (OR): 2.52, 95% confidence interval (CI): 1.07-5.92), Eastern Cooperative Oncology Group performance status of 2 or higher (OR: 21.29, 95% CI: 4.98-91.01), chronic obstructive pulmonary disease (OR: 7.25, 95% CI: 1.65-31.81), hypertension (OR: 2.98, 95% CI: 1.20-7.39), and use of immunoglobulin (OR: 5.26, 95% CI: 1.06-26.25). Conclusion: Our data suggests that the use of anti-angiogenic drugs may not exacerbate COVID-19 severity in NSCLC patients, indicating their potential safe application even during the pandemic period.

The large-scale integration of distributed photovoltaics （DPVs） has a profound impact on the secure and stable operation of distribution networks. Analysis and assessment on DPV hosting capacity can effectively assist in its rational planning and utilization. To this end， an method for analyzing the DPV hosting capacity interval is proposed to calculate the maximum DPV integration capacity in distribution networks under uncertainties. Firstly， the DPV output uncertainties are quantified by means of nonparametric kernel density estimation based on the historical data， and the DPV output interval is calculated by Newton-Raphson method. Secondly， a DPV hosting capacity interval analysis model for distribution networks considering safe operation constraints is established， which is then decomposed into an optimistic submodel and a pessimistic submodel based on interval analysis theory. Then， to reduce the difficulty of model solution， the pessimistic sub-model is simplified by the equivalence transformation， and the two sub-models are solved separately to obtain the interval solution. Finally， simulation analysis is carried out in the improved 15-node distribution system and a distribution network in Lishui， Zhejiang Province. The results verify the effectiveness and practicality of the proposed method.

Objective To evaluate the diagnostic value of skeletal muscle biopsy in asymptomatic and pauci‑symptomatic hyperCKemia. Methods and Results A total of 146 patients with asymptomatic or pauci ‑ symptomatic hyperCKemia diagnosed in Peking University First Hospital from July 2020 to February 2023 were selected, and skeletal muscle biopsy was performed. About 72.60% (106/146) had histological changes, including muscular dystrophy (n = 73), inflammatory or necrotizing myopathy (n = 16), other myopathy (n = 15), and neurogenic skeletal muscle damage (n = 2). The positive rate of pathological diagnosis was 50.68% (74/146), including muscular dystrophy 82.43% (61/74), inflammatory myopathy 8.11% (6/74) and metabolic myopathy 9.46% (7/74). The positive rate of etiological diagnosis was 85.62% (125/146), including muscular dystrophy 67.20% (84/125), inflammatory myopathy 13.60% (17/125), metabolic myopathy 7.20% (9/125) and other causes 12% (15/125). Compared with different subgroups, the proportion of pathological changes (χ2 = 14.043, P = 0.000; χ2 = 12.740, P = 0.000), the positive rate of pathological diagnosis (χ2 = 10.641, P = 0.001; χ2 = 25.530, P = 0.000) and etiological diagnosis (Fisher's exact probability: P = 0.001; χ2 = 10.811, P = 0.001) in the significantly elevated creatine kinase (CK) level group and the adolescent group was significantly higher than those in the mildly elevated CK level group and the adult group. The positive rate of pathological diagnosis in the asymptomatic group was higher than the pauci‑symptomatic group (χ2 = 4.792, P = 0.029). There were significant differences in the etiological ratio between the mildly elevated CK level group and the significantly elevated CK level group (Fisher's exact probability: P = 0.000), the adolescent group and the adult group (χ2 = 86.149, P = 0.000), and the asymptomatic group and the pauci ‑ symptomatic group (χ2 = 20.608, P = 0.000). Conclusions Skeletal muscle biopsy was important in etiological diagnosis of asymptomatic and pauci‑symptomatic hyperCKemia. Muscular dystrophy is a common cause of asymptomatic and pauci‑symptomatic hyperCKemia.

Abstract Structural search and feature extraction are a central subject in modern materials design, the efficiency of which is currently limited, but can be potentially boosted by machine learning (ML). Here, we develop an ML-based prediction-analysis framework, which includes a symmetry-based combinatorial crystal optimization program (SCCOP) and a feature additive attribution model, to significantly reduce computational costs and to extract property-related structural features. Our method is highly accurate and predictive, and extracts structural features from desired structures to guide materials design. We first test SCCOP on 35 typical compounds to demonstrate its generality. As a case study, we apply our approach to a two-dimensional B-C-N system, which identifies 28 previously undiscovered stable structures out of 82 compositions; our analysis further establishes the structural features that contribute most to energy and bandgap. Compared to conventional approaches, SCCOP is about 10 times faster while maintaining a comparable accuracy. Our framework is generally applicable to all types of systems for precise and efficient structural search, providing insights into the relationship between ML-extracted structural features and physical properties.

Variations in local strain, defect densities, and composition of hybrid metal-halide perovskites have been reported to create heterogeneous energy landscapes in thin films, which impact charge-carrier diffusion and recombination dynamics. Here, we employ one- and two-photon transient absorption spectroscopy to selectively probe the dynamics of charge carriers from surface and bulk regions of methylammonium lead bromide thin films. Differences in the transient absorption spectra indicate that an energy gradient of approximately 100 meV is formed between the higher band-gap surface and lower band-gap bulk regions. Thus, during their lifetime, photoexcited carriers move away from the surface to recombine in the bulk, where our experiments detect long-lived charge populations despite the significant band splitting that has conventionally been assumed to inhibit efficient radiative recombination. Supported by first-principles calculations, we demonstrate that bright emission can still arise from the bulk with states that occupy a wide range of momenta in the vicinity of the band extrema, which show strong dipole transitions. Our results report that photoexcitations in the hybrid perovskites avoid defect-rich surface regions, and that particularly strong emission is generated from accumulated excitation populations in the bulk.

This paper studies the coupling of the five links of ADDIE and the five essential elements of the ideological and political classroom teaching model. Secondly, based on the ADDIE model, the curriculum system of “analysis - design - development - implementation - evaluation” of ideological and political courses is established. It is found that the five modules of ADDIE are closely related to the five core elements. Each link of ideological and political revolution is divided into several specific sub-units. Analyzing the ADDIE model of “ideological and political” curriculum reform can effectively mobilize students’ enthusiasm. This paper has specific reference value to the teaching practice of ideological and political courses in colleges and universities. The conclusion of this paper has a particular reference value for preparing and exploring curriculum thinking in universities.

Glucocorticoid-induced osteoporosis (GIOP), one of the most common and serious adverse effects associated with glucocorticoid administration, manifests as decreased bone formation and increased bone resorption, eventually culminating in bone loss. Galangin (GAL) is a flavonoid extracted from the medicinal herbal galangal that possesses a variety of pharmacological activities and can inhibit osteoclastogenesis. However, the effects of GAL on GIOP remain unclear. Our study aims to explore the effects of GAL on GIOP in mice and the underlying mechanism. Our results show that GAL markedly mitigates the severity of dexamethasone (Dex)-induced osteoporosis in mice and potentiates osteogenic differentiation in mouse bone marrow-derived mesenchymal stem cells (BMSCs). Furthermore, GAL also significantly counteracts Dex-mediated suppression of osteogenic differentiation and autophagy in human BMSCs. GAL augments PKA/CREB-mediated autophagic flux in BMSCs and the bones of osteoporotic mice. GAL-mediated osteogenic differentiation in Dex-treated BMSCs is significantly decreased by the PKA inhibitor H89 and autophagy inhibitor 3-methyladenine. Collectively, our data indicate that GAL can ameliorate GIOP, partly by augmenting the mineralization of BMSCs by potentiating PKA/CREB-mediated autophagic flux, highlighting its potential therapeutic use in treating glucocorticoid-related osteoporosis.

Predictive analysis of the job market before the employment of college graduates provides a direction to improve the quality of college students’ employment and better articulates the enrollment, training, and employment of colleges and universities. This paper utilizes the missing value filling algorithm and the ADASYN algorithm to preprocess the collected data related to the job market and graduates. Based on the HMIGW algorithm, a data feature selection method is proposed, and the feature collection is obtained after the feature selection process of each data series. Then, the XGBoost algorithm is used to predict and analyze the employment market trend. It was found that the accuracy of the model in analyzing and predicting the dynamics of employment market trends among college graduates reached 97.105% on average. After predicting the employment trend of graduates of a certain major in college S, it is found that the proportion of graduates who enter the Internet industry to work between 2020 and 2030 is relatively high, and the overall employment change trend of the agriculture and forestry job market is large. This paper can provide college graduates with a reference for choosing a career, and the predicted employment market trend can provide support for the development of employment guidance in colleges and universities. In future research, we can consider expanding the scope of the study and optimizing the prediction model.

BackgroundBurnout is common among nurses and can lead to negative outcomes of medical care. This study aimed to explore the effectiveness of Balint groups to reduce burnout in head nurses in a Chinese hospital.MethodsThis was a randomized controlled trial with a pre- and post-test. A total of 80 head nurses were randomly assigned to either a Balint group (n = 40) or a control group (n = 40). Participants participated in Balint group for a period of 3 months. Participants in both groups completed the Maslach Burnout Inventory-Human Services Survey and the General Self-Efficacy Scale at the beginning and end of the study. Balint group members also completed the Group Climate Questionnaire-Short Form.ResultsIn the Balint group, 33 participants attended all Balint groups, while the 40 participants in the control group had no intervention. Analysis of variance with repeated measures demonstrated a statistically significant difference on the Maslach Burnout Inventory subscale of sense of personal achievement (F = 9.598, p = 0.003) between the Balint and control groups. However, there were no significant differences between the groups on the subscales of emotional exhaustion (F = 0.110, p = 0.740) and depersonalization (F = 0.75, p = 0.387), and the General Self-Efficacy Scale (F = 0.709, p = 0.403).ConclusionsBalint groups helped reduce burnout among head nurses in terms of personal achievement.

This paper proposes a teaching innovation based on cognitive mapping to address the current problem of dull music teaching in colleges and universities. The combination of BERT-weighted sentence vectors and IDCNN is used to label music topics in cognitive mapping, while music emotion labeling is achieved using BiGRU-Attention. The above music labeling is integrated into the construction of a teaching-oriented cognitive map, and a learning path planning method based on the RippleNet algorithm is proposed under the cognitive map. The teaching effect under the application of cognitive mapping was evaluated in terms of basic literacy and emotional expression after verifying the applicability of the learning path using DCG indicators. As a whole, the student’s basic music literacy improved by an average of 5.16 points in the first stage and by an average of 7.67 points in the whole stage analyzed. The fastest improvement was in Sample 22, which improved by 9.9 points in the first stage and another 3.7 points in the second stage. Learning path planning with the help of cognitive mapping is feasible in the reform of music teaching in colleges and universities.