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Your search keyword '"Xie, Yuqiao"' showing total 19 results
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19 results on '"Xie, Yuqiao"'

1. Restoring thalamocortical circuit dysfunction by correcting HCN channelopathy in Shank3 mutant mice

Author

Guo, Baolin, Liu, Tiaotiao, Choi, Soonwook, Mao, Honghui, Wang, Wenting, Xi, Kaiwen, Jones, Carter, Hartley, Nolan D., Feng, Dayun, Chen, Qian, Liu, Yingying, Wimmer, Ralf D., Xie, Yuqiao, Zhao, Ningxia, Ou, Jianjun, Arias-Garcia, Mario A., Malhotra, Diya, Liu, Yang, Lee, Sihak, Pasqualoni, Samuel, Kast, Ryan J., Fleishman, Morgan, Halassa, Michael M., Wu, Shengxi, and Fu, Zhanyan

Published
2024
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4. High‐precision single‐event transient hardened comparator with the sensitive node transient detection feedback latch technique.

Author

Xie, Yuqiao, Xu, Tao, Liu, Zhongyang, Qiu, Guoji, Bi, Dawei, Hu, Zhiyuan, Zhang, Zhengxuan, and Zou, Shichang

Subjects
*COMPARATOR circuits, *ASTROPHYSICAL radiation, *SPACE environment
Abstract

This paper comprehensively perfects the sensitive node transient detection feedback latch (SNTDFL) technique, subsequently conceptualizes an ideal hardening structure for the pre‐amplification stage, and proposes a radiation hardened by design (RHBD) strategy to cope with the severe single‐event transient (SET) effects of high‐precision voltage comparators in a space radiation environment. Analysis and verification results show that the hardening strategy exhibits excellent SET hardening performance, which can not only detect extremely small transient voltage disturbances at sensitive nodes but also effectively resist transient current pulses of various intensities generated by SETs. Compared with an unhardened high‐precision comparator, the proposed one, hardened with a hybrid strategy of SNTDFL and triple modular redundancy (TMR) techniques, can greatly preserve the original electrical properties and remarkably improve the tolerance of SET with little overhead. In addition, the proposed high‐precision comparator significantly reduces static power consumption compared with the one hardened with the TMR technique alone and has a smaller area overhead. [ABSTRACT FROM AUTHOR]

Published
2024
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5. Restoring the Function of Thalamocortical Circuit Through Correcting Thalamic Kv3.2 Channelopathy Normalizes Fear Extinction Impairments in a PTSD Mouse Model

Author

Xiao, Haoxiang, primary, Xi, Kaiwen, additional, Wang, Kaifang, additional, Zhou, Yongsheng, additional, Dong, Baowen, additional, Xie, Jinyi, additional, Xie, Yuqiao, additional, Zhang, Haifeng, additional, Ma, Guaiguai, additional, Wang, Wenting, additional, Feng, Dayun, additional, Guo, Baolin, additional, and Wu, Shengxi, additional

Published
2023
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7. CB1R dysfunction of inhibitory synapses in the ACC drives chronic social isolation stress-induced social impairments in male mice

Author

Guo, Baolin, primary, Xi, Kaiwen, additional, Mao, Honghui, additional, Ren, Keke, additional, Xiao, Haoxiang, additional, Hartley, Nolan D., additional, Zhang, Yangming, additional, Kang, Junjun, additional, Liu, Yingying, additional, Xie, Yuqiao, additional, Zhou, Yongsheng, additional, Zhu, Yuanyuan, additional, Zhang, Xia, additional, Fu, Zhanyan, additional, Chen, Jiang-Fan, additional, Hu, Hailan, additional, Wang, Wenting, additional, and Wu, Shengxi, additional

Published
2023
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8. Restoring the Function of Thalamocortical Circuit Through Correcting Thalamic Kv3.2 Channelopathy Normalizes Fear Extinction Impairments in a PTSD Mouse Model.

Author

Xiao, Haoxiang, Xi, Kaiwen, Wang, Kaifang, Zhou, Yongsheng, Dong, Baowen, Xie, Jinyi, Xie, Yuqiao, Zhang, Haifeng, Ma, Guaiguai, Wang, Wenting, Feng, Dayun, Guo, Baolin, and Wu, Shengxi

Subjects
EQUALIZERS (Electronics), MACHINE learning, LABORATORY mice, POST-traumatic stress disorder, ANIMAL disease models
Abstract

Impaired extinction of fear memory is one of the most common symptoms in post‐traumatic stress disorder (PTSD), with limited therapeutic strategies due to the poor understanding of its underlying neural substrates. In this study, functional screening is performed and identified hyperactivity in the mediodorsal thalamic nucleus (MD) during fear extinction. Furthermore, the encoding patterns of the hyperactivated MD is investigated during persistent fear responses using multiple machine learning algorithms. The anterior cingulate cortex (ACC) is also identified as a functional downstream region of the MD that mediates the extinction of fear memory. The thalamocortical circuit is comprehensively analyzed and found that the MD‐ACC parvalbumin interneurons circuit is preferentially enhanced in PTSD mice, disrupting the local excitatory and inhibitory balance. It is found that decreased phosphorylation of the Kv3.2 channel contributed to the hyperactivated MD, primarily to the malfunctioning thalamocortical circuit. Using a lipid nanoparticle‐based RNA therapy strategy, channelopathy is corrected via a methoxylated siRNA targeting the protein phosphatase 6 catalytic subunit and restored fear memory extinction in PTSD mice. These findings highlight the function of the thalamocortical circuit in PTSD‐related impaired extinction of fear memory and provide therapeutic insights into Kv3.2‐targeted RNA therapy for PTSD. [ABSTRACT FROM AUTHOR]

Published
2024
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11. Reversal of hyperactive higher-order thalamus attenuates defensiveness in a mouse model of PTSD

Author

Xi, Kaiwen, primary, Xiao, Haoxiang, additional, Huang, Xin, additional, Yuan, Ziduo, additional, Liu, Mingyue, additional, Mao, Honghui, additional, Liu, Haiying, additional, Ma, Guaiguai, additional, Cheng, Zishuo, additional, Xie, Yuqiao, additional, Liu, Yang, additional, Feng, Dayun, additional, Wang, Wenting, additional, Guo, Baolin, additional, and Wu, Shengxi, additional

Published
2023
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15. The safety of pericardiocentesis in patients under antithrombotic therapy: A single-center experience

Author

Zhu, Yuansong, Zhang, Chengxiang, Xie, Yuqiao, Sasmita, Bryan Richard, Xiang, Zhenxian, Jiang, Yi, Gong, Ming, Wang, Yaxin, Chen, Siyu, Luo, Suxin, and Huang, Bi

Subjects
Cardiology and Cardiovascular Medicine
Abstract

ObjectiveThis study aimed to analyze the characteristics of patients with pericardial effusion requiring pericardiocentesis and to evaluate the safety of pericardiocentesis without discontinuation of anticoagulant or antiplatelet drugs.MethodsWe performed a retrospective study of patients undergoing pericardiocentesis in our hospital between 2012 and 2022. Patients were categorized into the Antithrombotic Group if they had used any antiplatelet or anticoagulant drugs on the day of pericardiocentesis; otherwise they were categorized into the Non-antithrombotic Group. All procedures were performed by experienced cardiologists with echocardiographic guidance. Bleeding events were defined using the National Institutes of Health scale of adverse events.ResultsA total of 501 consecutive patients were identified and 70 cases were under antithrombotic drugs (Antithrombotic Group). Patients in Antithrombotic Group were older, had more comorbidities, presented with lower platelet counts and prolonged activated partial thromboplastin time (all p < 0.05). Malignancy was the most common etiology for pericardial effusion in both groups (28.6% in Antithrombotic Group and 54.7% in Non-antithrombotic Group) and tuberculosis was the second etiology in the Non-antithrombotic Group (21.9%), while procedure-related effusion (17.1%) accounted for the second cause in the Antithrombotic Group. Two patients in the Antithrombotic Group had mild oozing at the puncture site that resolved without interventions (2.9 vs. 0%, p = 0.019), and no bleeding events higher than Grade 1 occurred in either group.ConclusionAlthough antiplatelet or anticoagulant drugs may put patients undergoing pericardiocentesis at theoretically higher risk of bleeding, our study demonstrated that they are not associated with increased major bleeding complications.

Published
2022

18. Flame Synthesis of Spring-Like Nanocarbon and Its Application in Flexible Free-Standing Mattress-Like Supercapacitor Electrode

Author

Nian Wang, Linsheng Huang, Dong Liang, Sun Liangwu, Limin Ruan, Ning Wei, Wei Zeng, Xu Chao, and Xie Yuqiao

Subjects
Supercapacitor, Materials science, Renewable Energy, Sustainability and the Environment, 02 engineering and technology, Spring (mathematics), 010402 general chemistry, 021001 nanoscience & nanotechnology, Condensed Matter Physics, 01 natural sciences, 0104 chemical sciences, Surfaces, Coatings and Films, Electronic, Optical and Magnetic Materials, Electrode, Materials Chemistry, Electrochemistry, Composite material, 0210 nano-technology
Published
2017

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