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Your search keyword '"Xie, Yehua"' showing total 23 results
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23 results on '"Xie, Yehua"'

2. Population pharmacokinetic analysis of sirolimus in Japanese pediatric and adult subjects receiving tablet or granule formulations

Author

Miyazaki, Taichi, Hayashi, Daichi, Nozawa, Akifumi, Yasue, Shiho, Endo, Saori, Ohnishi, Hidenori, Asada, Ryuta, Kato, Mototoshi, Fujino, Akihiro, Kuroda, Tatsuo, Maekawa, Takanobu, Fumino, Shigehisa, Kawakubo, Naonori, Tajiri, Tatsuro, Shimizu, Kenji, Sanada, Chihiro, Hamada, Izumi, Ishikawa, Yuko, Hasegawa, Mayumi, Patel, Kashyap, Xie, Yehua, and Ozeki, Michio

Published
2024
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9. Research and Application of Internet of Things Edge Autonomy Technology Based on Microservice in Power Pipe Gallary

Author

Xie Yehua, Hongkun Liu, Shucai Sun, Haichao Ji, and Jiang Tao

Subjects
MQTT, Power transmission, Remote operation, Electric power system, Computer science, business.industry, Information sharing, Reliability (computer networking), Enhanced Data Rates for GSM Evolution, business, Maintenance engineering, Computer network
Abstract

With the rapid development of power internet of things and the continuous improvement of the State Grid Company's requirements for the safe operation of the station, there are more and more monitoring systems for power transmission and transformation pipe gallary in engineering application. The information between multiple systems is relatively isolated. The workload of the operation and maintenance personnel increases dramatically, and the operation safety risk increases accordingly. In order to improve the perception ability, remote operation and maintenance level of the station, it is necessary to study a kind of management platform for information sharing. Based on mqtt protocol and using microservice architecture, the design makes function module plug-and-play possible. An edge autonomy technology of IOT is proposed to integrate intelligent substation and internet of things which can improve the high reliability of the system operation and ensure the security and stability of the power system.

Published
2020

15. Scheme and research of realizing regional substation by using private cloud technology

Author

Zhu Chenpeng, Sun Shucai, and Xie Yehua

Subjects
Scheme (programming language), Information and Communications Technology, business.industry, Computer science, Process (engineering), Mode (statistics), Cloud computing, Internet of Things, business, Telecommunications, Realization (systems), computer, computer.programming_language
Abstract

In recent years, the technology of Internet of things and information communication technology have developed rapidly. With the construction of intelligent substation, the intelligent level of main equipment is constantly improving, and the power data network is constantly improving, which provides the basic conditions for the realization of regional private cloud. In this paper, the concept, advantages, implementation scheme, construction process and advanced application of regional substation are proposed. And the application mode and scenario are discussed.

Published
2019

16. 18.2: Invited Paper:Single‐emitter 638nm laser diode with 4W continuous wave power

Author

Xie, Yehua, Qiu, Yuzhen, Ho, James, Wang, Weimin, Kuang, Langxing, Liu, Wenbin, and Hu, Martin

Abstract

High‐power red laser diodes are essential light sources for display applications. In this paper, we report the design, fabrication and characterization of single‐emitter 638nm laser diode with 4 W continuous wave power. The saturation and COD power of this 110um stripe width LD exceeds 4.0 W and 6.3 W at heatsink temperature of 20°C, respectively. At the operation power of 1 W, the Wall‐Plug efficiency can reach 38.3% and 41.8% for the continuous and pulsed wave with duty of 33.3%. The characteristics temperature T0 and T1 for this device is 62 K and 114K.

Published
2021
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20. Population pharmacokinetic modeling of cefadroxil renal transport in wild-type and Pept2 knockout mice.

Author

Xie, Yehua, Shen, Hong, Hu, Yongjun, Feng, Meihua Rose, and Smith, David E.

Subjects
*BETA lactam antibiotics, *PHARMACOKINETICS, *DRUG interactions, *RENAL tubular transport, *XENOBIOTICS
Abstract

1. Cefadroxil is a broad-spectrum β-lactam antibiotic that is widely used in the treatment of various infectious diseases. Currently, poor understanding of the drug's pharmacokinetic profiles and disposition mechanism(s) prevents determining optimal dosage regimens and achieving ideal antibacterial responses in patients. In the present retrospective study, we developed a population pharmacokinetic model of cefadroxil in wild-type and Pept2 knockout mice using the nonlinear mixed effect modeling (NONMEM) approach. 2. Cefadroxil pharmacokinetics were best described by a two-compartment model, with both saturable and nonsaturable elimination processes to/from the central compartment. Through this modeling approach, pharmacokinetic parameters in wild-type and Pept2 knockout mice were well estimated, respectively, as follows: volume of central compartment V1 (3.43 versus 4.23 mL), volume of peripheral compartment V2 (5.98 versus 8.61 mL), intercompartment clearance Q (0.599 versus 0.586 mL/min) and linear elimination rate constant K10 (0.111 versus 0.070 min−1). Moreover, the secretion kinetics (i.e. Vm1 = 17.6 nmoL/min and Km1 = 37.1 µM) and reabsorption kinetics (i.e. Vm2 = 15.0 nmoL/min and Km2 = 27.1 µM) of cefadroxil were quantified in kidney, for the first time, under in vivo conditions. 3. Our model provides a unique tool to quantitatively predict the dose-dependent nonlinear disposition of cefadroxil, as well as the potential for transporter-mediated drug interactions. [ABSTRACT FROM AUTHOR]

Published
2016
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23. Role and Relevance of PEPT1 in Intestinal Absorption and Pharmacokinetics of 5-Aminolevulinic Acid.

Author

Xie, Yehua

Subjects
PEPT1, 5-Aminolevulinic acid, Intestinal permeability, Pharmacokinetics, PepT1 knockout mice, Intestinal absorption
Abstract

Peptide transporter 1 (PepT1), a member of the proton-coupled oligopeptide transporter family, is known to transport di-/tri-peptides and peptidomimetics across biological membranes. Due to its abundant expression in small intestine, broad substrate specificity and high transport capacity, PepT1 is considered an ideal oral drug delivery target and plays a pivotal role in transporting numerous pharmacological compounds. The therapeutic agent 5-aminolevulinic acid (5-ALA) is widely applied in photodynamic therapy and fluorescence diagnosis for the treatment of various cancers and non-malignant diseases. In this project, experimental results from in situ perfusion and in vivo pharmacokinetic studies in wildtype and PepT1 knockout mice offer a deeper understanding of the PepT1-mediated intestinal absorption of 5-ALA. The effective permeability of 5-ALA was evaluated as a function of drug concentration, potential inhibitors and regional segments of the intestines using in situ perfusions. The results from in situ perfusions indicated that PepT1 accounted for approximately 90% of 5-ALA permeability in mouse small intestine. The differential segmental permeability of 5-ALA was consistent with PepT1 expression along the intestinal segments, in which high permeabilities were observed in the duodenum, jejunum and ileum of wildtype mice with little permeability in colon. In contrast, the residual permeability of 5-ALA in the duodenum, jejunum, and ileum of PepT1 knockout mice was only about 10% of that in wildtype mice and similar to that of colon permeability. The contribution of other transporters, including the amino acid transporter PAT1, in mediating the intestinal permeability of 5-ALA was minor at best. After oral administration (0.2 and 2 micro mol/g) of 5-ALA, the maximum plasma concentration (Cmax) and area under the plasma concentration-time curve (AUC) of 5-ALA were decreased approximately 2-fold in PepT1 knockout mice as compared to wildtype mice. The tissue distribution results after 0.2 micro mol/g 5-ALA oral dose and intravenous pharmacokinetic study (0.01 micro mol/g) revealed that PepT1 had marginal, if any, effect on the in vivo disposition of 5-ALA. In conclusion, research in this dissertation project offered solid evidence in defining the significant role of PepT1 on the intestinal absorption and systemic exposure of 5-ALA after oral dosing.

Published
2015

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