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[Objective] Jiaojia-type gold deposit is a new type of gold mine discovered by Shandong geologists in northwestern Jiaodong in the 1960s, and its output is controlled by regional tectonic fracture zones. Pyrite sericitized alteration generally occurred during the ore-forming period, which is characterized by a large scale, distinct alteration zones, concentration of mineralization, simple morphology of the ore body, relatively uniform grade, and simple mineral combinations. The deposit has gone through 12 years of exploration and scientific research, from discovery to establishment. [Methods] This new type of gold deposit has been rapidly promoted since its establishment and has achieved fruitful prospecting results in China. Deep exploration achievements of the Jiaojia-type gold deposit have been coming up in the Jiaodong area since the 21st century. [Results] The accumulated gold resource reserves submitted have been 3617.12 tons by 2020, which has helped the Jiaodong area become the third largest gold cluster in the world, and gold reserves of China have risen to the second rink in the world. Research on the Jiaojia-style gold mine has also made considerable progress, with the age of mineralization accurately limited to 126~120 Ma and formation occurring under a strong regional extension background. The source of mineralization material has multiple origins, with the Archean tholeiite being the initial source rock of gold-bearing minerals. The ore-forming process is divided into four stages, and the “thermo-extension”metallogenic theory and the step metallogenic model are proposed. The metallogenic depth is about 5~10 km, and the post-metallogenic denudation thickness is 5.2±1.2 km, with the deposits well preserved. [Conclusion] The metallogenic prediction study concluded that the total gold resources in the three major metallogenic zones of Sanshandao, Jiaojia, and Zhaoping in the northwestern Jiaozhou area were 7258~10150 tons of metal at a depth of 5000 m, which demonstrates the immense potential of the deeper part of the Jiaojia-type gold deposits for exploration. A set of key exploration techniques was summarized for different exploration stages, from shallow to deep. [Significance] These studies enriched the metallogenic theory of the Jiaojia-type gold deposit, making the metallogenic prediction results highly accurate, reliable, and effective in guiding the gold exploration in the Jiaodong peninsula.

Crisaborole is a nonsteroidal phosphodiesterase-4 (PDE-4) inhibitor approved for topical treatment of atopic dermatitis in patients aged >= 2 years. For example, in alopecia areata (AA), multiple loci have been associated with AA, including HLA, ULBP1, CTLA4, and IL-2/IL-21, although the exact cause and pathophysiology of alopecia areata have not been determined. Dupilumab is another culprit drug, which may have led to localized hypertrichosis because localized hypertrichosis at the injection site of dupilumab has been reported.[2] Crisaborole was the most likely culprit drug to cause localized hypertrichosis in this child. [Extracted from the article]