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8. Testing for sufficient follow-up in censored survival data by using extremes

Author

Xie, Ping, Escobar-Bach, Mikael, and Van Keilegom, Ingrid

Subjects
Statistics - Methodology
Abstract

In survival analysis, it often happens that some individuals, referred to as cured individuals, never experience the event of interest. When analyzing time-to-event data with a cure fraction, it is crucial to check the assumption of `sufficient follow-up', which means that the right extreme of the censoring time distribution is larger than that of the survival time distribution for the non-cured individuals. However, the available methods to test this assumption are limited in the literature. In this article, we study the problem of testing whether follow-up is sufficient for light-tailed distributions and develop a simple novel test. The proposed test statistic compares an estimator of the non-cure proportion under sufficient follow-up to one without the assumption of sufficient follow-up. A bootstrap procedure is employed to approximate the critical values of the test. We also carry out extensive simulations to evaluate the finite sample performance of the test and illustrate the practical use with applications to leukemia and breast cancer datasets., Comment: 16 pages, 2 figures and 4 tables are added

Published
2023

9. Evaluation of College English Teaching Quality Based on AHP and GWO-ELM

Author

Sun, Kailing, Xie, Ping, Wang, Qian, Cheng, Zhenhua, Akan, Ozgur, Editorial Board Member, Bellavista, Paolo, Editorial Board Member, Cao, Jiannong, Editorial Board Member, Coulson, Geoffrey, Editorial Board Member, Dressler, Falko, Editorial Board Member, Ferrari, Domenico, Editorial Board Member, Gerla, Mario, Editorial Board Member, Kobayashi, Hisashi, Editorial Board Member, Palazzo, Sergio, Editorial Board Member, Sahni, Sartaj, Editorial Board Member, Shen, Xuemin, Editorial Board Member, Stan, Mircea, Editorial Board Member, Jia, Xiaohua, Editorial Board Member, Zomaya, Albert Y., Editorial Board Member, Zhang, Yinjun, editor, and Shah, Nazir, editor

Published
2024
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10. Application of Artificial Intelligence Technology in Learning App Evelopment

Author

Xie, Ping, Palaoag, Thelma D., Sun, Kailing, Akan, Ozgur, Editorial Board Member, Bellavista, Paolo, Editorial Board Member, Cao, Jiannong, Editorial Board Member, Coulson, Geoffrey, Editorial Board Member, Dressler, Falko, Editorial Board Member, Ferrari, Domenico, Editorial Board Member, Gerla, Mario, Editorial Board Member, Kobayashi, Hisashi, Editorial Board Member, Palazzo, Sergio, Editorial Board Member, Sahni, Sartaj, Editorial Board Member, Shen, Xuemin, Editorial Board Member, Stan, Mircea, Editorial Board Member, Jia, Xiaohua, Editorial Board Member, Zomaya, Albert Y., Editorial Board Member, Zhang, Yinjun, editor, and Shah, Nazir, editor

Published
2024
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11. Research on One-Key Sequence Control Automatic Test Technology Based on Digital Simulation

Author

Liu, Jie, Fu, Tinggang, Ji, Haiqiang, Xie, Ping, Chen, Dong, Liu, Jiahao, Li, Yunjie, Angrisani, Leopoldo, Series Editor, Arteaga, Marco, Series Editor, Chakraborty, Samarjit, Series Editor, Chen, Shanben, Series Editor, Chen, Tan Kay, Series Editor, Dillmann, Rüdiger, Series Editor, Duan, Haibin, Series Editor, Ferrari, Gianluigi, Series Editor, Ferre, Manuel, Series Editor, Hirche, Sandra, Series Editor, Jabbari, Faryar, Series Editor, Jia, Limin, Series Editor, Kacprzyk, Janusz, Series Editor, Khamis, Alaa, Series Editor, Kroeger, Torsten, Series Editor, Li, Yong, Series Editor, Liang, Qilian, Series Editor, Martín, Ferran, Series Editor, Ming, Tan Cher, Series Editor, Minker, Wolfgang, Series Editor, Misra, Pradeep, Series Editor, Mukhopadhyay, Subhas, Series Editor, Ning, Cun-Zheng, Series Editor, Nishida, Toyoaki, Series Editor, Oneto, Luca, Series Editor, Panigrahi, Bijaya Ketan, Series Editor, Pascucci, Federica, Series Editor, Qin, Yong, Series Editor, Seng, Gan Woon, Series Editor, Speidel, Joachim, Series Editor, Veiga, Germano, Series Editor, Wu, Haitao, Series Editor, Zamboni, Walter, Series Editor, Tan, Kay Chen, Series Editor, Hu, Cungang, editor, and Cao, Wenping, editor

Published
2024
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12. Combining Cache and Refresh to Optimize SSD Read Performance Scheme

Author

Chen, Jinli, Li, Peixuan, Xie, Ping, Goos, Gerhard, Founding Editor, Hartmanis, Juris, Founding Editor, Bertino, Elisa, Editorial Board Member, Gao, Wen, Editorial Board Member, Steffen, Bernhard, Editorial Board Member, Yung, Moti, Editorial Board Member, Li, Chao, editor, Li, Zhenhua, editor, Shen, Li, editor, Wu, Fan, editor, and Gong, Xiaoli, editor

Published
2024
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23. Pharmacological suppression of the OTUD4/CD73 proteolytic axis revives antitumor immunity against immune-suppressive breast cancers

Author

Zhu, Yueming, Banerjee, Anupam, Xie, Ping, Ivanov, Andrey A., Uddin, Amad, Jiao, Qiao, Chi, Junlong Jack, Zeng, Lidan, Lee, Ji Young, Xue, Yifan, Lu, Xinghua, Cristofanilli, Massimo, Gradishar, William J., Henry, Curtis J., Gillespie, Theresa W., Bhave, Manali Ajay, Kalinsky, Kevin, Fu, Haian, Bahar, Ivet, Zhang, Bin, and Wan, Yong

Subjects
Proteolysis -- Analysis -- Health aspects, Immunosuppression -- Analysis -- Health aspects, Health care industry
Abstract

Despite widespread utilization of immunotherapy, treating immune-cold tumors remains a challenge. Multiomic analyses and experimental validation identified the OTUD4/CD73 proteolytic axis as a promising target in treating immune-suppressive triple negative breast cancer (TNBC). Mechanistically, deubiquitylation of CD73 by OTUD4 counteracted its ubiquitylation by TRIM21, resulting in CD73 stabilization inhibiting tumor immune responses. We further demonstrated the importance of TGF-[beta] signaling for orchestrating the OTUD4/CD73 proteolytic axis within tumor cells. Spatial transcriptomics profiling discovered spatially resolved features of interacting malignant and immune cells pertaining to expression levels of OTUD4 and CD73. In addition, ST80, a newly developed inhibitor, specifically disrupted proteolytic interaction between CD73 and OTUD4, leading to reinvigoration of cytotoxic [CD8.sup.+] T cell activities. In preclinical models of TNBC, ST80 treatment sensitized refractory tumors to anti-PD-LI therapy. Collectively, our findings uncover what we believe to be a novel strategy for targeting the immunosuppressive OTUD4/CD73 proteolytic axis in treating immune-suppressive breast cancers with the inhibitor ST80., Introduction Despite the widespread utilization of immunotherapy, the poor clinical response by immune-suppressive tumors is an emerging challenge in use of current immune checkpoint inhibitors. Triple negative breast cancers (TNBCs) [...]

Published
2024
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24. T cells sustain antitumor response by mediating crosstalk between adenosine A2A receptor and glutathione/GPX4

Author

Chen, Siqi, Fan, Jie, Xie, Ping, Ahn, Jihae, Fernandez, Michelle, Billingham, Leah K., Miska, Jason, Wu, Jennifer D., Wainwright, Derek A., Fang, Deyu, Sosman, Jeffrey A., Wan, Yong, Zhang, Yi, Chandel, Navdeep S., and Zhang, Bin

Subjects
Oncology, Experimental -- Physiological aspects, Lipid peroxidation -- Physiological aspects, T cells -- Physiological aspects, Cancer -- Care and treatment -- Research, Health care industry
Abstract

Antitumor responses of [CD8.sup.+] T cells are tightly regulated by distinct metabolic fitness. High levels of glutathione (GSH) are observed in the majority of tumors, contributing to cancer progression and treatment resistance in part by preventing glutathione peroxidase 4-dependent (GPX4-dependent) ferroptosis. Here, we show the necessity of adenosine A2A receptor (A2AR) signaling and the GSH/GPX4 axis in orchestrating metabolic fitness and survival of functionally competent [CD8.sup.+] T cells. Activated [CD8.sup.+] T cells treated ex vivo with simultaneous inhibition of A2AR and lipid peroxidation acquire a superior capacity to proliferate and persist in vivo, demonstrating a translatable means to prevent ferroptosis in adoptive cell therapy. Additionally, we identify a particular cluster of intratumoral [CD8.sup.+] T cells expressing a putative gene signature of GSH metabolism (GMGS) in association with clinical response and survival across several human cancers. Our study addresses a key role of GSH/GPX4 and adenosinergic pathways in fine-tuning the metabolic fitness of antitumor [CD8.sup.+] T cells., Introduction Glutathione (GSH) is the most abundant antioxidant that maintains cellular redox homeostasis. De novo synthesis of GSH is coordinated by the sequential actions of glutaminase, [gamma]-glutamate-cysteine ligase, and GSH [...]

Published
2024
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26. Type-I-interferon signaling drives microglial dysfunction and senescence in human iPSC models of Down syndrome and Alzheimer’s disease

Author

Jin, Mengmeng, Xu, Ranjie, Wang, Le, Alam, Mahabub Maraj, Ma, Ziyuan, Zhu, Sining, Martini, Alessandra C, Jadali, Azadeh, Bernabucci, Matteo, Xie, Ping, Kwan, Kelvin Y, Pang, Zhiping P, Head, Elizabeth, Liu, Ying, Hart, Ronald P, and Jiang, Peng

Subjects
Biochemistry and Cell Biology, Biological Sciences, Aging, Dementia, Stem Cell Research - Induced Pluripotent Stem Cell, Acquired Cognitive Impairment, Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD), Intellectual and Developmental Disabilities (IDD), Down Syndrome, Stem Cell Research, Neurosciences, Genetics, Stem Cell Research - Induced Pluripotent Stem Cell - Human, Alzheimer's Disease, Pediatric, Brain Disorders, Neurodegenerative, Aetiology, 2.1 Biological and endogenous factors, Neurological, Congenital, Alzheimer Disease, Amyloid beta-Peptides, Animals, Humans, Induced Pluripotent Stem Cells, Interferons, Mice, Microglia, Alzheimer's disease, Down syndrome, human induced pluripotent stem cells, microglia, senescence, synaptic pruning, type I interferon, Medical and Health Sciences, Developmental Biology, Biological sciences, Biomedical and clinical sciences
Abstract

Microglia are critical in brain development and Alzheimer's disease (AD) etiology. Down syndrome (DS) is the most common genetic developmental disorder and risk factor for AD. Surprisingly, little information is available on the impact of trisomy of human chromosome 21 (Hsa21) on microglial functions during DS brain development and in AD in DS. Using induced pluripotent stem cell (iPSC)-based organoid and chimeric mouse models, we report that DS microglia exhibit an enhanced synaptic pruning function, which alters neuronal synaptic functions. In response to human brain tissue-derived pathological tau, DS microglia undergo cellular senescence and exhibit elevated type-I-interferon signaling. Mechanistically, knockdown of Hsa21-encoded type I interferon receptors, IFNARs, rescues the DS microglial phenotypes both during brain development and in response to pathological tau. Our findings provide in vivo evidence that human microglia respond to pathological tau by exhibiting dystrophic phenotypes. Targeting IFNARs may improve DS microglial functions and prevent senescence.

Published
2022

37. Acceleration of DNA Replication of Klenow Fragment by Small Resisting Force

Author

Liu, Yu-Ru, Wang, Peng-Ye, Li, Wei, and Xie, Ping

Subjects
Condensed Matter - Soft Condensed Matter
Abstract

DNA polymerases are an essential class of enzymes or molecular motors that catalyze processive DNA syntheses during DNA replications. A critical issue for DNA polymerases is their molecular mechanism of processive DNA replication. We have previously proposed a model for chemomechanical coupling of DNA polymerases, based on which the predicted results have been provided about the dependence of DNA replication velocity upon the external force on Klenow fragment of DNA polymerase I. Here, we performed single molecule measurements of the replication velocity of Klenow fragment under the external force by using magnetic tweezers. The single molecule data verified quantitatively the previous theoretical predictions, which is critical to the chemomechanical coupling mechanism of DNA polymerases. A prominent characteristic for the Klenow fragment is that the replication velocity is independent of the assisting force whereas the velocity increases largely with the increase of the resisting force, attains the maximum velocity at about 3.8 pN and then decreases with the further increase of the resisting force.

Published
2021
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39. PCSK9 inhibitor added to high-intensity statin therapy to prevent cardiovascular events in patients with acute coronary syndrome after percutaneous coronary intervention: a randomized, double- blind, placebo-controlled, multicenter SHAWN study

Author

Wu, Zhi-Ming, Kan, Jing, Ye, Fei, You, Wei, Wu, Xiang-Qi, Tian, Nai-Liang, Lin, Song, Ge, Zhen, Liu, Zhi-Zhong, Li, Xiao-Bo, Gao, Xiao-Fei, Chen, Jing, Wang, Yan, Wen, Shang-Yu, Xie, Ping, Cong, Hong-Liang, Liu, Li-Jun, Zeng, He-Song, Zhou, Lei, Liu, Fan, Zheng, Yong-Hong, Li, Rui, Ji, Hong-Lei, Zhou, Sheng-Hua, Zhao, Shou-Ming, Qian, Xue-Song, Luo, Jun, Wang, Xin, Zhang, Jun-Jie, and Chen, Shao-Liang

Published
2024
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46. Intravascular ultrasound-guided versus angiography-guided percutaneous coronary intervention in acute coronary syndromes (IVUS-ACS): a two-stage, multicentre, randomised trial

Author

Li, Xiaobo, Ge, Zhen, Kan, Jing, Anjum, Muhammed, Ye, Fei, Gao, Xiaofei, Jalal, Anjum, Xie, Ping, Tao, Ling, Chen, Xiang, Khan, Hamid S, Javed, Asim, Shao, Yibin, Guo, Xiaomei, Li, Feng, Saghir, Tahir, Mengal, Naeem, Nie, Shaoping, Qu, Hong, Qian, Xuesong, Yang, Song, Chen, Jing, Gao, Dasheng, Liu, Lijun, Wang, Mingliang, Chen, Lianglong, Liu, Fan, Xu, Tan, Liu, Yinwu, Gill, Badar Ul Ahad, Yang, Qing, Guo, Nin, Wen, Shangyu, Cong, Hongliang, Hong, Lang, Sheiban, Imad, Raza, Afsar, Wei, Yongyue, Chen, Feng, Mintz, Gary S, Zhang, Jun-Jie, Stone, Gregg W, Chen, Shao-Liang, Khan, Hamid Sharif, and Guo, Ning

Published
2024
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47. Ticagrelor alone versus ticagrelor plus aspirin from month 1 to month 12 after percutaneous coronary intervention in patients with acute coronary syndromes (ULTIMATE-DAPT): a randomised, placebo-controlled, double-blind clinical trial

Author

Li, Xiaobo, Ge, Zhen, Kan, Jing, Anjum, Muhammed, Ye, Fei, Gao, Xiaofei, Jalal, Anjum, Xie, Ping, Tao, Ling, Chen, Xiang, Khan, Hamid S, Javed, Asim, Shao, Yibin, Guo, Xiaomei, Li, Feng, Saghir, Tahir, Mengal, Naeem, Nie, Shaoping, Qu, Hong, Qian, Xuesong, Yang, Song, Chen, Jing, Gao, Dasheng, Liu, Lijun, Wang, Mingliang, Chen, Lianglong, Liu, Fan, Xu, Tan, Liu, Yinwu, Gill, Badar Ul Ahad, Yang, Qing, Guo, Nin, Wen, Shangyu, Cong, Hongliang, Hong, Lang, Sheiban, Imad, Raza, Afsar, Wei, Yongyue, Chen, Feng, Mintz, Gary S, Zhang, Jun-Jie, Stone, Gregg W, Chen, Shao-Liang, Mohydin, Bilal S, Gao, Fentang, Shao, Yibing, Wang, Yan, Zeng, Hesong, and Khan, Hamid Sharif

Published
2024
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