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158 results on '"Xie, Hai-Lun"'

9. Comprehensive prognostic effects of systemic inflammation and Insulin resistance in women with breast cancer with different BMI: a prospective multicenter cohort

Author

Ruan, Guo-Tian, Xie, Hai-Lun, Hu, Chun-Lei, Liu, Chen-An, Zhang, He-Yang, Zhang, Qi, Wang, Zi-Wen, Zhang, Xi, Ge, Yi-Zhong, Lin, Shi-Qi, Tang, Meng, Song, Meng-Meng, Zhang, Xiao-Wei, Liu, Xiao-Yue, Zhang, Kang-Ping, Yang, Ming, Yu, Kai-Ying, Wang, Kun-Hua, Hu, Wen, Deng, Li, Cong, Ming-Hua, and Shi, Han-Ping

Published
2023
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10. AIWW: a new nutrition-screening tool for the oncologic population

Author

Ge, Yi-Zhong, Fu, Zhen-Ming, Zhang, Qi, Song, Meng-Meng, Ruan, Guo-Tian, Zhang, Xi, Zhang, Xiao-Wei, Li, Xiang-Rui, Zhang, Kang-Ping, Tang, Meng, Liu, Xiao-Yue, Yang, Ming, Liu, Tong, Xie, Hai-Lun, Zhang, He-Yang, Wang, Zi-Wen, Hu, Chun-Lei, Lin, Shi-Qi, Zhang, Rui, Xu, Hong-Xia, Li, Wei, Song, Chun-Hua, Liu, Ming, Chen, Jun-Qiang, Wang, Kun-Hua, Bo, Li, Cong, Ming-Hua, Li, Zeng-Ning, Guo, Zeng-Qin, Wang, Xiao-Bin, Wang, Bin-Yan, Xu, Benjamin, Qin, Xian-Hui, Xu, Xi-Ping, Barazzoni, Rocco, Yao, Qing-Hua, Weng, Min, Shen, Xian, and Shi, Han-Ping

Published
2023
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17. Geriatric Nutritional Risk Index Combined with Calf Circumference Can be a Good Predictor of Prognosis in Patients Undergoing Surgery for Gastric or Colorectal Cancer

Author

Zheng, Xin, primary, Shi, Jin-Yu, additional, Wang, Zi-Wen, additional, Ruan, Guo-Tian, additional, Ge, Yi-Zhong, additional, Lin, Shi-Qi, additional, Liu, Chen-An, additional, Chen, Yue, additional, Xie, Hai-Lun, additional, Song, Meng-Meng, additional, Liu, Tong, additional, Yang, Ming, additional, Liu, Xiao-Yue, additional, Deng, Li, additional, Cong, Ming-Hua, additional, and Shi, Han-Ping, additional

Published
2024
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19. Prognostic value of systemic inflammation and for patients with colorectal cancer cachexia

Author

Ruan, Guo‐Tian, primary, Xie, Hai‐Lun, additional, Yuan, Kai‐Tao, additional, Lin, Shi‐Qi, additional, Zhang, He‐Yang, additional, Liu, Chen‐An, additional, Shi, Jin‐Yu, additional, Ge, Yi‐Zhong, additional, Song, Meng‐Meng, additional, Hu, Chun‐Lei, additional, Zhang, Xiao‐Wei, additional, Liu, Xiao‐Yue, additional, Yang, Ming, additional, Wang, Kun‐Hua, additional, Zheng, Xin, additional, Chen, Yue, additional, Hu, Wen, additional, Cong, Ming‐Hua, additional, Zhu, Li‐Chen, additional, Deng, Li, additional, and Shi, Han‐Ping, additional

Published
2023
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20. Association between the Dietary Inflammatory Index and All-Cause Mortality in Adults with Obesity

Author

Zheng, Xin, primary, Ge, Yi-Zhong, additional, Ruan, Guo-Tian, additional, Lin, Shi-Qi, additional, Chen, Yue, additional, Liu, Chen-An, additional, Xie, Hai-Lun, additional, Song, Meng-Meng, additional, Liu, Tong, additional, Wang, Zi-Wen, additional, Shi, Jin-Yu, additional, Zhang, He-Yang, additional, Yang, Ming, additional, Liu, Xiao-Yue, additional, Deng, Li, additional, and Shi, Han-Ping, additional

Published
2023
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22. The Relationship Between Different Fatty Acids Intake and the Presence of Depression: A Population-Based Study

Author

zheng, xin, primary, liu, tong, additional, Lin, Shi-Qi, additional, Liu, Chen-An, additional, Chen, Yue, additional, Ruan, Guo-Tian, additional, Ge, Yi-Zhong, additional, Xie, Hai-Lun, additional, Song, Meng-Meng, additional, Shi, Jin-Yu, additional, Wang, Zi-Wen, additional, Yang, Ming, additional, Liu, Xiao-Yue, additional, Zhang, He-Yang, additional, Deng, Li, additional, and Shi, Han-Ping, additional

Published
2023
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23. Association between C-reactive protein-albumin-lymphocyte (CALLY) index and overall survival in patients with colorectal cancer: From the investigation on nutrition status and clinical outcome of common cancers study

Author

Yang, Ming, primary, Lin, Shi-Qi, additional, Liu, Xiao-Yue, additional, Tang, Meng, additional, Hu, Chun-Lei, additional, Wang, Zi-Wen, additional, Zhang, Qi, additional, Zhang, Xi, additional, Song, Meng-Meng, additional, Ruan, Guo-Tian, additional, Zhang, Xiao-Wei, additional, Liu, Tong, additional, Xie, Hai-Lun, additional, Zhang, He-Yang, additional, Liu, Chen-An, additional, Zhang, Kang-Ping, additional, Li, Qin-Qin, additional, Li, Xiang-Rui, additional, Ge, Yi-Zhong, additional, Liu, Yu-Ying, additional, Chen, Yue, additional, Zheng, Xin, additional, and Shi, Han-Ping, additional

Published
2023
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24. The prognostic value of the combination of body composition and systemic inflammation in patients with cancer cachexia

Author

Xie, Hai‐Lun, primary, Ruan, Guo‐Tian, additional, Wei, Lishuang, additional, Zhang, Qi, additional, Ge, Yi‐Zhong, additional, Song, Meng‐Meng, additional, Zhang, Xi, additional, Lin, Shi‐qi, additional, Liu, Xiao‐yue, additional, Zhang, Xiao‐Wei, additional, Li, Xiang‐Rui, additional, Zhang, Kang‐Ping, additional, Hu, Chun‐Lei, additional, Yang, Ming, additional, Tang, Meng, additional, Song, Chun‐Hua, additional, Cong, Ming‐Hua, additional, Weng, Min, additional, Li, Zeng‐Ning, additional, Li, Wei, additional, Wang, Kun‐Hua, additional, and Shi, Han‐Ping, additional

Published
2023
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26. The Effect of Platelets to Lymphocyte Ratio on Overall Survival in Gastrointestinal Cancer Patients Undergoing Surgery

Author

Zheng, Xin, primary, Shi, Jin-Yu, additional, Ruan, Guo-Tian, additional, Ge, Yi-Zhong, additional, Lin, Shi-Qi, additional, Liu, Chen-An, additional, Chen, Yue, additional, Xie, Hai-Lun, additional, Song, Meng-Meng, additional, Zhang, Qi, additional, Liu, Tong, additional, Yang, Ming, additional, Liu, Xiao-Yue, additional, Deng, Li, additional, and Shi, Han-Ping, additional

Published
2023
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27. Additional file 1 of Muscle distribution in relation to all-cause and cause-specific mortality in young and middle-aged adults

Author

Liu, Chen-An, Liu, Tong, Ge, Yi-Zhong, Song, Meng-Meng, Ruan, Guo-Tian, Lin, Shi-Qi, Xie, Hai-Lun, Shi, Jin-Yu, Zheng, Xin, Chen, Yue, Shen, Liuyi, Deng, Li, and Shi, Han-Ping

Abstract

Additional file 1: TableS1. Clinical characteristics of participants grouped by sex-specific ofdifferent regional lean mass. Table S2. Clinical characteristics of participants grouped bysex-specific of total lean mass in the INSCOC cohort. Table S3.Comparison of discrimination of all-cause mortality with different lean mass inmen. Table S4. Comparison of discrimination of all-cause mortality withdifferent lean mass in women. Table S5. Hazards ratio (95% CI) forcause-specific mortality of lean mass. Table S6. Additional analyses. Table S7. The relationshipbetween total lean mass and prognosis of patients with cancer in the INSCOCcohort. FigureS1. Flow chart of research design (NHANES and INSCOCcohort). Figure S2. Kaplan-Meier Curves of sex-specific quintiles of leanmass. Figure S3. The relationship betweenlean mass and all-cause mortality in different sexes. Figure S4 Therelationship between lean mass and all-cause mortality in young and middle-agedparticipants.

Published
2023
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28. Inflammatory geriatric nutritional risk index stratified the survival of older adults with cancer sarcopenia

Author

Ruan, Guo‐Tian, primary, Xie, Hai‐Lun, additional, Zhang, He‐Yang, additional, Zhang, Qi, additional, Zhang, Xi, additional, Ge, Yi‐Zhong, additional, Hu, Chun‐Lei, additional, Tang, Meng, additional, Song, Meng‐Meng, additional, Zhang, Xiao‐Wei, additional, Yang, Ming, additional, Yu, Kai‐Ying, additional, Gong, Yi‐Zhen, additional, Deng, Li, additional, and Shi, Han‐Ping, additional

Published
2022
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29. Association between systemic inflammation and water composition and survival in colorectal cancer

Author

Lin, Shi-Qi, primary, Xie, Hai-Lun, additional, Ge, Yi-Zhong, additional, Ruan, Guo-Tian, additional, Zhang, Qi, additional, Song, Meng-Meng, additional, Zhang, He-Yang, additional, Zhang, Xi, additional, Li, Xiang-Rui, additional, Tang, Meng, additional, Shen, Xian, additional, Song, Chun-Hua, additional, Li, Wei, additional, and Shi, Han-Ping, additional

Published
2022
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30. Association of systemic inflammation and low performance status with reduced survival outcome in older adults with cancer

Author

Ruan, Guo-Tian, primary, Xie, Hai-Lun, additional, Zhang, He-Yang, additional, Zhang, Qi, additional, Deng, Li, additional, Wang, Zi-Wen, additional, Zhang, Xi, additional, Ge, Yi-Zhong, additional, Hu, Chun-Lei, additional, Tang, Meng, additional, Song, Meng-Meng, additional, Zhang, Xiao-Wei, additional, Liu, Tong, additional, Li, Xiang-Rui, additional, Zhang, Kang-Ping, additional, Yang, Ming, additional, Gong, Yi-Zhen, additional, Chen, Yong-Bing, additional, Yu, Kai-Ying, additional, Cong, Ming-Hua, additional, Pan, Lei, additional, Tang, Wei-Zhong, additional, Wang, Kun-Hua, additional, and Shi, Han-Ping, additional

Published
2022
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31. Novel Diagnostic and Prognostic Tools for Lung Cancer Cachexia: Based on Nutritional and Inflammatory Status

Author

Liu, Chen-An, Zhang, Qi, Ruan, Guo-Tian, Shen, Liu-Yi, Xie, Hai-Lun, Liu, Tong, Tang, Meng, Zhang, Xi, Yang, Ming, Hu, Chun-Lei, Zhang, Kang-Ping, Liu, Xiao-Yue, and Shi, Han-Ping

Subjects
Cancer Research, Oncology
Abstract

BackgroundCachexia is one of the most common complications affecting lung cancer patients that seriously affects their quality-of-life and survival time. This study aimed to analyze the predictors and prognostic factors of lung cancer cachexia as well as to develop a convenient and accurate clinical prediction tool for oncologists.MethodsIn this multicenter cohort study, 4022 patients with lung cancer were retrospectively analyzed. The patients were randomly categorized into training and verification sets (7:3 ratio). Univariate and multivariate logistic regression analyses were performed to determine the risk factors of cachexia in patients with lung cancer. Cox regression analysis was applied to determine independent prognostic factors in the patients with lung cancer cachexia. Meanwhile, two nomograms were established and evaluated by time-dependent receiver operating characteristic curve, calibration curve, and decision curve analysis (DCA).ResultsStage, serum albumin, ALI, anemia, and surgery were independent risk factors for cachexia in patients with lung cancer. Patients with lung cancer cachexia have a shorter survival time. Sex, stage, serum albumin, ALI, KPS score, and surgery served as independent prognostic factors for patients with lung cancer cachexia. The area under the curves (AUCs) of diagnostic nomogram in the training and validation sets were 0.702 and 0.688, respectively, the AUCs of prognostic nomogram in the training set for 1-, 3-, and 5-year were 0.70, 0.72, and 0.75, respectively, while in the validation set the AUCs were 0.71, 0.75, and 0.79, respectively. The calibration curves and DCA of the two nomograms were consistent and the clinical benefit rate was high.ConclusionCachexia brings an additional economic burden and worsens the prognosis of lung cancer patients. The two nomograms can accurately screen and predict the probability of occurrence of cachexia in lung cancer and the prognosis of patients with lung cancer cachexia, and guide clinical work.

Published
2022

32. A Novel Systemic Inflammation Prognostic Score to Stratify Survival in Elderly Patients With Cancer

Author

Ruan, Guo-Tian, primary, Xie, Hai-Lun, additional, Deng, Li, additional, Ge, Yi-Zhong, additional, Zhang, Qi, additional, Wang, Zi-Wen, additional, Zhang, Xi, additional, Zhang, He-Yang, additional, Tang, Meng, additional, Song, Meng-Meng, additional, Zhang, Xiao-Wei, additional, Yang, Ming, additional, Pan, Lei, additional, Wang, Kun-Hua, additional, Cong, Ming-Hua, additional, Gong, Yi-Zhen, additional, Wang, Meng-Yan, additional, and Shi, Han-Ping, additional

Published
2022
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33. A Novel Inflammation and Insulin Resistance Related Indicator to Predict the Survival of Patients With Cancer

Author

Ruan, Guo-Tian, primary, Xie, Hai-Lun, additional, Zhang, He-Yang, additional, Liu, Chen-An, additional, Ge, Yi-Zhong, additional, Zhang, Qi, additional, Wang, Zi-Wen, additional, Zhang, Xi, additional, Tang, Meng, additional, Song, Meng-Meng, additional, Zhang, Xiao-Wei, additional, Yang, Ming, additional, Chen, Yong-Bing, additional, Yu, Kai-Ying, additional, Deng, Li, additional, Gong, Yi-Zhen, additional, Hu, Wen, additional, Wang, Kun-Hua, additional, Cong, Ming-Hua, additional, and Shi, Han-Ping, additional

Published
2022
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34. Inflammatory geriatric nutritional risk index stratified the survival of older adults with cancer sarcopenia.

Author

Ruan, Guo‐Tian, Xie, Hai‐Lun, Zhang, He‐Yang, Zhang, Qi, Zhang, Xi, Ge, Yi‐Zhong, Hu, Chun‐Lei, Tang, Meng, Song, Meng‐Meng, Zhang, Xiao‐Wei, Yang, Ming, Yu, Kai‐Ying, Gong, Yi‐Zhen, Deng, Li, and Shi, Han‐Ping

Subjects
*OLDER people, *CANCER patients, *SARCOPENIA, *PHYSICAL activity, *OVERALL survival
Abstract

Background: Aging is accompanied by muscle loss. In older adults with cancer sarcopenia (OACS), systemic inflammation, reduced food intake, and reduced physical activity led to a poor prognosis. This study was to investigate the prognostic ability of the inflammatory Geriatric Nutritional Risk Index (GNRI), which combines patient's inflammation, diet status, and physical activity status to predict overall survival of OACS. Methods: This prospective multi‐center study enrolled 637 OACS, with an average age of 72.78 ± 5.98 years, of which 408 (64.1%) were males. We constructed the Inflammatory Functional Prognostic Index (IFPI) of OACS based on inflammatory GNRI scores, reduced food intake, and reduced physical activity. According to the IFPI, OACS was divided into high‐, moderate‐, and low‐risk groups. Univariate and multivariate survival analyses analyzed the prognostic ability of the clinical parameters. Results: Compared with OACS with a high GNRI score, the 1‐, 3‐, and 5‐year hazard ratios (95% confidence interval) of OACS with a low GNRI score was 1.816 (1.076–3.063), 1.678 (1.118–2.518), and 1.627 (1.101–2.407), respectively. This result was consistent with that of the calibration curve. The subgroup analysis showed that the low GNRI score had a significant positive relation with patients with gastrointestinal cancer (Pinteraction < 0.001). Notably, the survival analysis of IFPI showed that the mortality risk of moderate‐ and high‐risk patients was 1.722‐and 2.509‐fold higher, respectively, than that of low‐risk patients. Conclusion: The GNRI score was a short‐term and long‐term inflammatory prognostic indicator for OACS. The IFPI score could improve patient survival prediction. [ABSTRACT FROM AUTHOR]

Published
2023
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35. Prognostic Roles of Glucose to Lymphocyte Ratio and Modified Glasgow Prognosis Score in Patients With Non-small Cell Lung Cancer

Author

Yang, Ming, primary, Zhang, Qi, additional, Ge, Yi-Zhong, additional, Tang, Meng, additional, Hu, Chun-Lei, additional, Wang, Zi-Wen, additional, Zhang, Xi, additional, Song, Meng-Meng, additional, Ruan, Guo-Tian, additional, Zhang, Xiao-Wei, additional, Liu, Tong, additional, Xie, Hai-Lun, additional, Zhang, He-Yang, additional, Zhang, Kang-Ping, additional, Li, Qin-Qin, additional, Li, Xiang-Rui, additional, Liu, Xiao-Yue, additional, Lin, Shi-Qi, additional, and Shi, Han-Ping, additional

Published
2022
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36. Systemic inflammation with sarcopenia predicts survival in patients with gastric cancer

Author

Liu, Yu-Ying, primary, Ruan, Guo-Tian, additional, Ge, Yi-Zhong, additional, Li, Qin-Qin, additional, Zhang, Qi, additional, Zhang, Xi, additional, Tang, Meng, additional, Song, Meng-Meng, additional, Zhang, Xiao-Wei, additional, Li, Xiang-Rui, additional, Zhang, Kang-Ping, additional, Yang, Ming, additional, Hu, Chun-Lei, additional, Liu, Tong, additional, Xie, Hai-Lun, additional, Liu, Xiao-Yue, additional, Lin, Shi-Qi, additional, Weng, Min, additional, Yao, Qing-Hua, additional, Wang, Zheng-Ping, additional, Cong, Ming-Hua, additional, and Shi, Han-Ping, additional

Published
2022
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40. Association Between Systemic Inflammation and Malnutrition With Survival in Patients With Cancer Sarcopenia—A Prospective Multicenter Study

Author

Ruan, Guo-Tian, primary, Ge, Yi-Zhong, additional, Xie, Hai-Lun, additional, Hu, Chun-Lei, additional, Zhang, Qi, additional, Zhang, Xi, additional, Tang, Meng, additional, Song, Meng-Meng, additional, Zhang, Xiao-Wei, additional, Liu, Tong, additional, Li, Xiang-Rui, additional, Zhang, Kang-Ping, additional, Yang, Ming, additional, Li, Qin-Qin, additional, Chen, Yong-Bing, additional, Yu, Kai-Ying, additional, Braga, Marco, additional, Cong, Ming-Hua, additional, Wang, Kun-Hua, additional, Barazzoni, Rocco, additional, and Shi, Han-Ping, additional

Published
2022
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42. Association of Systemic Inflammation and Overall Survival in Elderly Patients with Cancer Cachexia – Results from a Multicenter Study

Author

Ruan, Guo-Tian, primary, Yang, Ming, additional, Zhang, Xiao-Wei, additional, Song, Meng-Meng, additional, Hu, Chun-Lei, additional, Ge, Yi-Zhong, additional, Xie, Hai-Lun, additional, Liu, Tong, additional, Tang, Meng, additional, Zhang, Qi, additional, Zhang, Xi, additional, Zhang, Kang-Ping, additional, Li, Xiang-Rui, additional, Li, Qin-Qin, additional, Chen, Yong-Bing, additional, Yu, Kai-Ying, additional, Cong, Ming-Hua, additional, Wang, Kun-Hua, additional, and Shi, Han-Ping, additional

Published
2021
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43. Evaluation and Validation of the Prognostic Value of Serum Albumin to Globulin Ratio in Patients With Cancer Cachexia: Results From a Large Multicenter Collaboration

Author

Xie, Hai-Lun, primary, Zhang, Qi, additional, Ruan, Guo-Tian, additional, Ge, Yi-Zhong, additional, Hu, Chun-Lei, additional, Song, Meng-Meng, additional, Song, Chun-Hua, additional, Zhang, Xi, additional, Zhang, Xiao-Wei, additional, Li, Xiang-Rui, additional, Zhang, Kang-Ping, additional, Liu, Tong, additional, Yang, Ming, additional, Tang, Meng, additional, Xu, Hong-Xia, additional, and Shi, Han-Ping, additional

Published
2021
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44. Association of Systemic Inflammation and Overall Survival in Elderly Patients with Cancer Cachexia – Results from a Multicenter Study

Author

Ruan,Guo-Tian, Yang,Ming, Zhang,Xiao-Wei, Song,Meng-Meng, Hu,Chun-Lei, Ge,Yi-Zhong, Xie,Hai-Lun, Liu,Tong, Tang,Meng, Zhang,Qi, Zhang,Xi, Zhang,Kang-Ping, Li,Xiang-Rui, Li,Qin-Qin, Chen,Yong-Bing, Yu,Kai-Ying, Cong,Ming-Hua, Wang,Kun-Hua, Shi,Han-Ping, Ruan,Guo-Tian, Yang,Ming, Zhang,Xiao-Wei, Song,Meng-Meng, Hu,Chun-Lei, Ge,Yi-Zhong, Xie,Hai-Lun, Liu,Tong, Tang,Meng, Zhang,Qi, Zhang,Xi, Zhang,Kang-Ping, Li,Xiang-Rui, Li,Qin-Qin, Chen,Yong-Bing, Yu,Kai-Ying, Cong,Ming-Hua, Wang,Kun-Hua, and Shi,Han-Ping

Abstract

Guo-Tian Ruan,1– 3,&ast; Ming Yang,1– 3,&ast; Xiao-Wei Zhang,1– 3,&ast; Meng-Meng Song,1– 3 Chun-Lei Hu,1– 3 Yi-Zhong Ge,1– 3 Hai-Lun Xie,1– 3 Tong Liu,1– 3 Meng Tang,1– 3 Qi Zhang,1– 3 Xi Zhang,1– 3 Kang-Ping Zhang,1– 3 Xiang-Rui Li,1– 3 Qin-Qin Li,1– 3 Yong-Bing Chen,1– 3 Kai-Ying Yu,1– 3 Ming-Hua Cong,4 Kun-Hua Wang,5 Han-Ping Shi1– 3 1Department of Gastrointestinal Surgery, Beijing Shijitan Hospital, Capital Medical University, Beijing, 100038, People’s Republic of China; 2Department of Clinical Nutrition, Beijing Shijitan Hospital, Capital Medical University, Beijing, 100038, People’s Republic of China; 3Beijing International Science and Technology Cooperation Base for Cancer Metabolism and Nutrition, Beijing, 100038, People’s Republic of China; 4Comprehensive Oncology Department, National Cancer Center/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100038, People’s Republic of China; 5Department of Surgery, The First Affiliated Hospital of Kunming Medical University, Kunming, 650000, People’s Republic of China&ast;These authors contributed equally to this workCorrespondence: Han-Ping ShiDepartment of Gastrointestinal Surgery and Beijing Shijitan Hospital, Capital Medical University, 10 Tie Yi Road, Beijing, 100038, People’s Republic of ChinaTel +86-10- 6392 6985Fax +86-10 -6392 6325Email shihp@ccmu.edu.cnBackground: Systemic inflammation and cachexia are associated with adverse clinical outcomes in elderly patients with cancer. The survival outcomes of elderly patients with cancer cachexia (EPCC) with high inflammation and a high risk of mortality are unknown. This study aimed to investigate the impact of high inflammation on the prognosis of EPCC patients with high mortality.Patients and Methods: This multicenter cohort study included 746 EPCC (age > 65 years) with a mean age of 72.00 ± 5.24 years, of whom 489 (65.5%) were male. The cut-off value

Published
2021

46. The Perspective of Diagnostic and Prognostic Values of Lipoxygenases mRNA Expression in Colon Adenocarcinoma

Author

Ruan,Guo-Tian, Gong,Yi-Zhen, Zhu,Li-Chen, Gao,Feng, Liao,Xi-Wen, Wang,Xiang-Kun, Zhu,Guang-Zhi, Liao,Cun, Wang,Shuai, Yan,Ling, Xie,Hai-Lun, Zhou,Xin, Liu,Jun-Qi, Shao,Meng-Nan, and Gan,Jia-Liang

Subjects
OncoTargets and Therapy
Abstract

Guo-Tian Ruan1 ,* Yi-Zhen Gong1 ,* Li-Chen Zhu,2 Feng Gao,1 Xi-Wen Liao,3 Xiang-Kun Wang,3 Guang-Zhi Zhu,3 Cun Liao,1 Shuai Wang,1 Ling Yan,1 Hai-Lun Xie,1 Xin Zhou,3 Jun-Qi Liu,3 Meng-Nan Shao,4 Jia-Liang Gan1 1Department of Colorectal and Anal Surgery, The First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi Zhuang Autonomous Region, People’s Republic of China; 2Department of Immunology, School of Preclinical Medicine, Guangxi Medical University, Nanning, Guangxi Zhuang Autonomous Region, People’s Republic of China; 3Department of Hepatobiliary Surgery, The First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi Zhuang Autonomous Region, People’s Republic of China; 4Life Sciences Institute, Guangxi Medical University, Nanning, Guangxi Zhuang Autonomous Region, People’s Republic of China*These authors contributed equally to this workCorrespondence: Jia-Liang GanDepartment of Colorectal and Anal Surgery, The First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi Zhuang Autonomous Region, People’s Republic of ChinaEmail gjl5172@163.comBackground: This study was mainly to explore and study the potential application of lipoxygenases (ALOX) family genes in the diagnostic and prognostic values of colon adenocarcinoma (COAD).Methods: Data sets related to the ALOX genes of COAD were obtained from The Cancer Genome Atlas and the University of California, Santa Cruz Xena browser. Then, the relevant biological information was downloaded from the public data platform. Finally, the bioinformatics technologies and clinical verification were employed to comprehensively analyze the potential values of ALOX genes.Results: The Pearson correlation analysis indicated that there were correlations among ALOXE3, ALOX5, ALOX12, and ALOX12B. The diagnostic receiver operating characteristic (ROC) curves suggested that ALOXE3 and ALOX12 had significant diagnosis in COAD: ALOXE3; P< 0.001, area under curve (AUC) 95%CI:=0.818 (0.773– 0.862) and ALOX12; P< 0.001, AUC 95%CI=0.774 (0.682– 0.807). Besides, the verification study indicated that ALOX12 had a diagnostic value in COAD. Finally, our multivariate survival analysis and comprehensive prognosis of ALOX genes in COAD suggested that the ALOXE3 and ALOX12 were associated with COAD overall survival: ALOXE3; P=0.025, HR 95%CI=1.765 (1.074– 2.901), ALOX12; P=0.046, HR 95%CI=1.680 (1.009– 2.796), and the low expression of ALOXE3 and ALOX12 had a favorable prognosis of COAD (all P< 0.05); on the contrary, the high regulation of them increased the risk of death.Conclusion: In our study, we observed that the mRNA expressions of ALOX genes were associated with the diagnosis and prognosis of COAD. The results of the diagnostic analysis suggested that ALOX12 might have a diagnosis value in COAD. Besides, our comprehensive prognosis analysis indicated that ALOXE3 combined ALOX12 might serve as potential prognosis biomarkers for COAD.Keywords: mRNA, colon adenocarcinoma, diagnostic, prognostic, The Cancer Genome Atlas, lipoxygenases

Published
2020

48. Distinct diagnostic and prognostic values of γ‑aminobutyric acid type A receptor family genes in patients with colon adenocarcinoma

Author

Yan, Ling, primary, Gong, Yi‑Zhen, additional, Shao, Meng‑Nan, additional, Ruan, Guo‑Tian, additional, Xie, Hai‑Lun, additional, Liao, Xi‑Wen, additional, Wang, Xiang‑Kun, additional, Han, Quan‑Fa, additional, Zhou, Xin, additional, Zhu, Li‑Cheng, additional, Gao, Feng, additional, and Gan, Jia‑Liang, additional

Published
2020
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50. The Prognostic Utility of the Triceps Skinfold Thickness Albumin Index in Colorectal Cancer Patients with Cachexia.

Author

Liu, Xiao-Yue, Lin, Shi-Qi, Ruan, Guo-Tian, Zheng, Xin, Chen, Yue, Zhang, He-yang, Liu, Tong, Xie, Hai-Lun, and Shi, Han-Ping

Abstract

AbstractPurposeMethodsResultsConclusionsTo develop a simple and convenient inflammation-nutrition-adiposity biomarker to complement the TNM staging system, further assess the prognosis of patients with colorectal cancer cachexia.This study was a multi-centre cohort study. The triceps skinfold thickness-albumin index (TA) was calculated by combining the triceps skinfold thickness (TSF) and serum albumin levels. Kaplan–Meier analysis and Cox proportional risk regression models were used to assess the relationship between the TA and all-cause mortality. Internal validation was carried out.We included 1025 patients with colorectal cancer cachexia, 61.2% of whom were male, with a mean age of 58.91 (12.45) years. As the TA increased, overall mortality decreased in female patients (hazard ratio [HR], 0.95) but not in male patients (HR, 0.99). Multivariate Cox analysis showed that patients in the normal TA group had a significantly lower risk of death than those in the low TA group (HR, 0.53, 95% CI, 0.40–0.72). Patients with a normal TA had a lower risk of malnutrition, poor quality of life, and poor short-term prognosis than those with a low TA.TA index enables clinicians to assess the prognosis of patients as early as possible to improve the survival of patients with colorectal cancer cachexia. [ABSTRACT FROM AUTHOR]

Published
2024
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