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Your search keyword '"Xie, Chun ‐ Feng"' showing total 30 results
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30 results on '"Xie, Chun ‐ Feng"'

7. Corrigendum to “Low-dose phthalates promote breast cancer stem cell properties via the oncogene ΔNp63α and the Sonic hedgehog pathway” [Ecotoxicol. Environ. Saf. 252 (2023) 114605]

Author

Cao, Wan-shuang, primary, Zhao, Meng-jiu, additional, Chen, Yue, additional, Zhu, Jian-yun, additional, Xie, Chun-feng, additional, Li, Xiao-ting, additional, Geng, Shan-shan, additional, Zhong, Cai-yun, additional, Fu, Jin-yan, additional, and Wu, Jie-shu, additional

Published
2023
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8. Stilbenoids

Author

Shen, Tao, Xie, Chun-Feng, Wang, Xiao-Ning, Lou, Hong-Xiang, Ramawat, Kishan Gopal, editor, and Mérillon, Jean-Michel, editor

Published
2013
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12. Using Integrated Bioinformatics Analysis to Identify Abnormally Methylated Differentially Expressed Genes in Hepatocellular Carcinoma

Author

Chen,Qing-Lian, Yan,Qian, Feng,Kun-Liang, Xie,Chun-Feng, Fang,Chong-Kai, Wang,Ji-Nan, Liu,Li-Hua, Li,Ya, Zhong,Chong, Chen,Qing-Lian, Yan,Qian, Feng,Kun-Liang, Xie,Chun-Feng, Fang,Chong-Kai, Wang,Ji-Nan, Liu,Li-Hua, Li,Ya, and Zhong,Chong

Abstract

Qing-Lian Chen,1,2,* Qian Yan,1,* Kun-Liang Feng,1,2,* Chun-Feng Xie,1,2,* Chong-Kai Fang,1,2 Ji-Nan Wang,1,2 Li-Hua Liu,2,3 Ya Li,3 Chong Zhong2,3 1Guangzhou University of Chinese Medicine, Guangzhou, 510405, People’s Republic of China; 2Department of Hepatobiliary Surgery, The First Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, 510405, People’s Republic of China; 3Lingnan Medical Research Center, Guangzhou University of Chinese Medicine, Guangzhou, 510405, People’s Republic of China*These authors contributed equally to this workCorrespondence: Chong ZhongDepartment of Hepatobiliary Surgery, The First Affiliated Hospital of Guangzhou University of Chinese Medicine, 16 Airport Road, Guangzhou, 510405, People’s Republic of ChinaTel +86-20-36596301Email zhongchong1732@gzucm.edu.cnObjective: For the identification of abnormally methylated differentially expressed genes (MDEGs) in hepatocellular carcinoma (HCC), this study integrated four microarray datasets to investigate the fundamental mechanisms of tumorigenesis.Methods: We obtained the expression (GSE76427, GSE57957) and methylation (GSE89852, GSE54503) profiles from Gene Expression Omnibus (GEO). The abnormally MDEGs were identified by using R software. We used the clusterProfiler package for the functional and pathway enrichment analysis. The String database was used to build the protein–protein interaction (PPI) network and visualize it in Cytoscape. MCODE was employed in the module analysis. Additionally, Gene Expression Profiling Interactive Analysis (GEPIA) and The Cancer Genome Atlas (TCGA) were employed to validate results. Lastly, we used cBioPortal software to examine the hub genetic alterations.Results: We identified 162 hypermethylated, down-regulated genes and 190 hypomethylated, up-regulated genes. Up-regulated genes with low methylation were enriched in biological processes, such as keratinocyte proliferation, and calcium

Published
2021

14. Phenethyl isothiocyanate inhibits colorectal cancer stem cells by suppressing Wnt/β-catenin pathway

Author

Chen, Yue, primary, Li, Yuan, additional, Wang, Xiao-qian, additional, Meng, Yu, additional, Zhang, Qi, additional, Zhu, Jian-yun, additional, Chen, Jia-qi, additional, Cao, Wan-shuang, additional, Wang, Xue-qi, additional, Xie, Chun-feng, additional, Li, Xiao-ting, additional, Geng, Shan-shan, additional, Wu, Jie-shu, additional, Zhong, Cai-yun, additional, and Han, Hong-yu, additional

Published
2018
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16. Curcumin Suppresses Lung Cancer Stem Cells via Inhibiting Wnt/β-catenin and Sonic Hedgehog Pathways

Author

Zhu, Jian-Yun, primary, Yang, Xue, additional, Chen, Yue, additional, Jiang, Ye, additional, Wang, Shi-Jia, additional, Li, Yuan, additional, Wang, Xiao-Qian, additional, Meng, Yu, additional, Zhu, Ming-Ming, additional, Ma, Xiao, additional, Huang, Cong, additional, Wu, Rui, additional, Xie, Chun-Feng, additional, Li, Xiao-Ting, additional, Geng, Shan-Shan, additional, Wu, Jie-Shu, additional, Zhong, Cai-Yun, additional, and Han, Hong-Yu, additional

Published
2017
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29. microRNAs carried by exosomes promote epithelial-mesenchymal transition and metastasis of liver cancer cells.

Author

Chen QL, Xie CF, Feng KL, Cui DY, Sun SL, Zhang JC, Xiong CM, Huang JH, and Chong Z

Abstract

In this study, transforming growth factor-β1 treatment effectively induced epithelial-mesenchymal transition (EMT) of SMMC-7721 cells, and the expression and function of microRNAs (miRNAs) were determined to understand the processes involved in liver cancer metastasis. Nanoparticle tracking analysis and western blotting were performed to identify exosomes. Transwell and MTS assays were used to assess cell migration and proliferation, respectively. Immunofluorescence microscopy was used to identify the metastasis of exosomes in cells. High-throughput sequencing was used to identify mRNAs and miRNAs in cells and exosomes, respectively. The identified differentially expressed miRNAs (DEmis) were further confirmed using quantitative real-time polymerase chain reaction. An miRNA-target mRNA interaction network was constructed using Cytoscape&#95;V2&#95;8&#95;3. SPSS version 16.0 software with one-way analysis of variance was used for statistical analysis. P < 0.05 was considered statistically significant. The overall size of exosomes in EMT SMMC-7721 cells was smaller than that in normal SMMC-7721 cells. Exosomes of EMT SMMC-7721 cells could promote cell migration and invasion in several cell lines. We identified differentially expressed mRNAs (DEms) and DEmis. Among them, a total of 60 and 78 DEms were upregulated and downregulated, respectively, in EMT SMMC-7721 cells compared with those in SMMC-7721 cells. A total of 709 and 123 DEmis were upregulated and downregulated, respectively, in exosomes in EMT SMMC-7721 cells compared with those in SMMC-7721 cells. hsa-miR-24-3p and hsa-miR-21-5p were further selected for knockdown experiments. Exosomes in cells with hsa-miR-24-3p knockdown could effectively inhibit EMT. hsa-miR-24-3p may be one of the most important molecular markers for EMT in liver cancer, which provides novel clues for the mechanisms involved in liver cancer metastasis., Competing Interests: None., (AJTR Copyright © 2020.)

Published
2020

30. (-)-Epigallocatechin-3-Gallate Inhibits Colorectal Cancer Stem Cells by Suppressing Wnt/β-Catenin Pathway.

Author

Chen Y, Wang XQ, Zhang Q, Zhu JY, Li Y, Xie CF, Li XT, Wu JS, Geng SS, Zhong CY, and Han HY

Subjects
Anticarcinogenic Agents pharmacology, Apoptosis drug effects, Catechin pharmacology, Cell Line, Tumor, Cell Proliferation drug effects, Colorectal Neoplasms drug therapy, Humans, Neoplastic Stem Cells drug effects, Tea chemistry, Catechin analogs & derivatives, Colorectal Neoplasms pathology, Wnt Signaling Pathway drug effects
Abstract

The beneficial effects of tea consumption on cancer prevention have been generally reported, while (-)-Epigallocatechin-3-gallate (EGCG) is the major active component from green tea. Cancer stem cells (CSCs) play a crucial role in the process of cancer development. Targeting CSCs may be an effective way for cancer intervention. However, the effects of EGCG on colorectal CSCs and the underlying mechanisms remain unclear. Spheroid formation assay was used to enrich colorectal CSCs from colorectal cancer cell lines. Immunoblotting analysis and quantitative real-time polymerase chain reaction were used to measure the alterations of critical molecules expression. Immunofluorescence staining analysis was also used to determine the expression of CD133. We revealed that EGCG inhibited the spheroid formation capability of colorectal cancer cells as well as the expression of colorectal CSC markers, along with suppression of cell proliferation and induction of apoptosis. Moreover, we illustrated that EGCG downregulated the activation of Wnt/β-catenin pathway, while upregulation of Wnt/β-catenin diminished the inhibitory effects of EGCG on colorectal CSCs. Taken together, this study suggested that EGCG could be an effective natural compound targeting colorectal CSCs through suppression of Wnt/β-catenin pathway, and thus may be a promising agent for colorectal cancer intervention., Competing Interests: The authors declare no conflict of interest.

Published
2017
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