112 results on '"Xiaolan Yan"'
Search Results
2. Maize Dek407 Encodes the Nitrate Transporter 1.5 and Is Required for Kernel Development
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Hongqiu Wang, Xiaolan Yan, Qingguo Du, Pengshuai Yan, Jinjin Xi, Xiaoruo Meng, Xuguang Li, Huijian Liu, Guoqin Liu, Zhongjun Fu, Jihua Tang, and Wen-Xue Li
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maize ,defective kernel ,IAA ,kernel size ,kernel weight ,natural variation ,Biology (General) ,QH301-705.5 ,Chemistry ,QD1-999 - Abstract
The kernel serves as the storage organ and harvestable component of maize, and it plays a crucial role in determining crop yield and quality. Understanding the molecular and genetic mechanisms of kernel development is of considerable importance for maize production. In this study, we obtained a mutant, which we designated defective kernel 407 (dek407), through ethyl methanesulfonate mutagenesis. The dek407 mutant exhibited reduced kernel size and kernel weight, as well as delayed grain filling compared with those of the wild type. Positional cloning and an allelism test revealed that Dek407 encodes a nitrate transporter 1/peptide transporter family (NPF) protein and is the allele of miniature 2 (mn2) that was responsible for a poorly filled defective kernel phenotype. A transcriptome analysis of the developing kernels showed that the mutation of Dek407 altered the expression of phytohormone-related genes, especially those genes associated with indole-3-acetic acid synthesis and signaling. Phytohormone measurements and analysis indicated that the endogenous indole-3-acetic acid content was significantly reduced by 66% in the dek407 kernels, which may be the primary cause of the defective phenotype. We further demonstrated that natural variation in Dek407 is associated with kernel weight and kernel size. Therefore, Dek407 is a potential target gene for improvement of maize yield.
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- 2023
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3. Mechanism for self-compensation in heavily carbon doped GaN
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Zhaohua Shen, Xuelin Yang, Shan Wu, Huayang Huang, Xiaolan Yan, Ning Tang, Fujun Xu, Xinqiang Wang, Weikun Ge, Bing Huang, and Bo Shen
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Physics ,QC1-999 - Abstract
Heavy carbon (C) doping is of great significance for semi-insulating GaN in power electronics. However, the doping behaviors, especially the atomic configurations and related self-compensation mechanisms, are still under debate. Here, with the formation energy as the input parameter, the concentrations of C defects with different atomic configurations are calculated by taking the configurational entropy into account. The result shows that the concentrations of tri-carbon complexes (CNCiCN, where Ci refers to interstitial carbon) and dicarbon complexes (CNCGa) cannot be neglected under heavy doping conditions. The concentration of CNCiCN can even exceed that of CN at sufficiently high doping levels. Especially, we suggest that it is the tri-carbon complex CNCiCN, instead of the commonly expected CGa, that acts as the self-compensation centers in semi-insulating GaN under heavy C doping conditions. The results provide a fresh look on the long-standing problem about the self-compensation mechanisms in C doped GaN.
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- 2023
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4. Genome-wide characterization of PEBP family genes in nine Rosaceae tree species and their expression analysis in P. mume
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Man Zhang, Ping Li, Xiaolan Yan, Jia Wang, Tangren Cheng, and Qixiang Zhang
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PEBP gene family ,Rosaceae species ,Flowering time regulation in perennials ,Gene family evolution ,Floral bud break ,Ecology ,QH540-549.5 ,Evolution ,QH359-425 - Abstract
Abstract Background Phosphatidylethanolamine-binding proteins (PEBPs) constitute a common gene family found among animals, plants and microbes. Plant PEBP proteins play an important role in regulating flowering time, plant architecture as well as seed dormancy. Though PEBP family genes have been well studied in Arabidopsis and other model species, less is known about these genes in perennial trees. Results To understand the evolution of PEBP genes and their functional roles in flowering control, we identified 56 PEBP members belonging to three gene clades (MFT-like, FT-like, and TFL1-like) and five lineages (FT, BFT, CEN, TFL1, and MFT) across nine Rosaceae perennial species. Structural analysis revealed highly conserved gene structure and protein motifs among Rosaceae PEBP proteins. Codon usage analysis showed slightly biased codon usage across five gene lineages. With selection pressure analysis, we detected strong purifying selection constraining divergence within most lineages, while positive selection driving the divergence of FT-like and TFL1-like genes from the MFT-like gene clade. Spatial and temporal expression analyses revealed the essential role of FT in regulating floral bud breaking and blooming in P. mume. By employing a weighted gene co-expression network approach, we inferred a putative FT regulatory module required for dormancy release and blooming in P. mume. Conclusions We have characterized the PEBP family genes in nine Rosaceae species and examined their phylogeny, genomic syntenic relationship, duplication pattern, and expression profiles during flowering process. These results revealed the evolutionary history of PEBP genes and their functions in regulating floral bud development and blooming among Rosaceae tree species.
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- 2021
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5. Integrating Genome-Wide Association Analysis With Transcriptome Sequencing to Identify Candidate Genes Related to Blooming Time in Prunus mume
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Man Zhang, Qingqing Yang, Xi Yuan, Xiaolan Yan, Jia Wang, Tangren Cheng, and Qixiang Zhang
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genome-wide association study ,gene-based association anaysis ,transcriptome sequencing ,co-expression network ,bloom date ,floral bud ,Plant culture ,SB1-1110 - Abstract
Prunus mume is one of the most important woody perennials for edible and ornamental use. Despite a substantial variation in the flowering phenology among the P. mume germplasm resources, the genetic control for flowering time remains to be elucidated. In this study, we examined five blooming time-related traits of 235 P. mume landraces for 2 years. Based on the phenotypic data, we performed genome-wide association studies, which included a combination of marker- and gene-based association tests, and identified 1,445 candidate genes that are consistently linked with flowering time across multiple years. Furthermore, we assessed the global transcriptome change of floral buds from the two P. mume cultivars exhibiting contrasting bloom dates and detected 617 associated genes that were differentially expressed during the flowering process. By integrating a co-expression network analysis, we screened out 191 gene candidates of conserved transcriptional pattern during blooming across cultivars. Finally, we validated the temporal expression profiles of these candidates and highlighted their putative roles in regulating floral bud break and blooming time in P. mume. Our findings are important to expand the understanding of flowering time control in woody perennials and will boost the molecular breeding of novel varieties in P. mume.
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- 2021
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6. The genetic architecture of floral traits in the woody plant Prunus mume
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Qixiang Zhang, He Zhang, Lidan Sun, Guangyi Fan, Meixia Ye, Libo Jiang, Xin Liu, Kaifeng Ma, Chengcheng Shi, Fei Bao, Rui Guan, Yu Han, Yuanyuan Fu, Huitang Pan, Zhaozhe Chen, Liangwei Li, Jia Wang, Meiqi Lv, Tangchun Zheng, Cunquan Yuan, Yuzhen Zhou, Simon Ming-Yuen Lee, Xiaolan Yan, Xun Xu, Rongling Wu, Wenbin Chen, and Tangren Cheng
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Science - Abstract
Mei (Prunus mume) is a woody tree that produces ornamental blossoms which symbolize spring in East Asia. Here, Zhang et al. resequence wild and domesticated mei to reveal considerable admixture and introgression from other Prunus species and identify loci associated with floral traits.
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- 2018
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7. Comparative Genomic and Transcriptomic Analyses of Family-1 UDP Glycosyltransferase in Prunus Mume
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Zhiyong Zhang, Xiaokang Zhuo, Xiaolan Yan, and Qixiang Zhang
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Prunus mume ,UGT family ,evolutionary divergence ,expression analysis ,hormone ,Biology (General) ,QH301-705.5 ,Chemistry ,QD1-999 - Abstract
Glycosylation mediated by Family-1 UDP-glycosyltransferases (UGTs) plays crucial roles in plant growth and adaptation to various stress conditions. Prunus mume is an ideal crop for analyzing flowering for its early spring flowering characteristics. Revealing the genomic and transcriptomic portfolio of the UGT family in P. mume, a species in which UGTs have not yet been investigated, is therefore important. In this study, 130 putative UGT genes were identified and phylogenetically clustered into 14 groups. These PmUGTs were distributed unevenly across eight chromosomes and 32 tandem duplication and 8 segmental duplication pairs were revealed. A highly conserved intron insertion event was revealed on the basis of intron/exon patterns within PmUGTs. According to RNA-seq data, these PmUGTs were specifically expressed in different tissues and during the bud dormancy process. In addition, we confirmed the differential expression of some representative genes in response to abscisic acid treatment. Our results will provide important information on the UGT family in P. mume that should aid further characterization of their biological roles in response to environmental stress.
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- 2018
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8. Distinguish Abnormal Tensile and Torsional Stresses of Steel Wire Rope Using Magnetoelastic Effect.
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Wei Gao, Donglai Zhang, Xiaolan Yan, Enchao Zhang, and Xin Wang 0107
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- 2023
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9. Crack Detection Method Based on the Poly-Magnetic Probe Structure.
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Enchao Zhang, Donglai Zhang, Wei Gao, Xiaolan Yan, Shimin Pan, and Xin Wang 0107
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- 2023
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10. Fast Quantitative Method to Detect the Cross-Sectional Loss of Wire Rope Defects.
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Donglai Zhang, Enchao Zhang, Shimin Pan, Xiaolan Yan, and Wei Gao
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- 2021
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11. Noncontact Magnetostrictive Torsional Guided Wave Sensors for Small-Diameter Pipes.
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Wei Gao, Donglai Zhang, Enchao Zhang, and Xiaolan Yan
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- 2021
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12. Increasing Detection Resolution of Wire Rope Metallic Cross-Sectional Area Damage Based on Magnetic Aggregation Structure.
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Xiaolan Yan, Donglai Zhang, and Hongpeng Wang
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- 2020
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13. Determination of Natural Frequencies of Pipes Using White Noise for Magnetostrictive Longitudinal Guided-Wave Nondestructive Testing.
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Donglai Zhang, Wei Gao, and Xiaolan Yan
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- 2020
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14. Carrier Capture Dynamics of Deep-Level Defects in Neutron-Irradiated Si With Improved Intracascade Potential
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Jun Liu, Pengdi Li, Qirong Zheng, Chuanguo Zhang, Yonggang Li, Yongsheng Zhang, Gaofeng Zhao, Xiaolan Yan, Bing Huang, and Zhi Zeng
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Nuclear and High Energy Physics ,Nuclear Energy and Engineering ,Electrical and Electronic Engineering - Published
- 2023
15. Position-sensorless for wire rope distance measurement and nondestructive testing.
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Xiaolan Yan, Donglai Zhang, Wei Gao, Enchao Zhang, and Shimin Pan
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- 2017
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16. Molecular epidemiology of Acinetobacter baumannii during COVID-19 at a hospital in northern China
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Xinlin Huang, Nianzhi Ning, Deyu Li, Suming Chen, Liangyan Zhang, Huan Wang, Chunmei Bao, Xiaolan Yang, Boan Li, and Hui Wang
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Acinetobacter baumannii ,Molecular epidemiology ,Resistance mechanisms ,ST540 ,Tn2009 ,Therapeutics. Pharmacology ,RM1-950 ,Infectious and parasitic diseases ,RC109-216 ,Microbiology ,QR1-502 - Abstract
Abstract Background The wide spread of carbapenem-resistance clones of Acinetobacter baumannii has made it a global public problem. Some studies have shown that the prevalence of Acinetobacter baumannii clones can change over time. However, few studies with respect to the change of epidemiological clones in Acinetobacter baumannii during Corona Virus Disease 2019 (COVID-19) were reported. This study aims to investigate the molecular epidemiology and resistance mechanisms of Acinetobacter baumannii during COVID-19. Results A total of 95 non-replicated Acinetobacter baumannii isolates were enrolled in this study, of which 60.0% (n = 57) were identified as carbapenem-resistant Acinetobacter baumannii (CRAB). The positive rate of the bla OXA−23 gene in CRAB isolates was 100%. A total of 28 Oxford sequence types (STs) were identified, of which the most prevalent STs were ST540 (n = 13, 13.7%), ST469 (n = 13, 13.7%), ST373 (n = 8, 8.4%), ST938 (n = 7, 7.4%) and ST208 (n = 6, 6.3%). Differently, the most widespread clone of Acinetobacter baumannii in China during COVID-19 was ST208 (22.1%). Further study of multidrug-resistant ST540 showed that all of them were carrying bla OXA−23 , bla OXA−66 , bla ADC−25 and bla TEM−1D , simultaneously, and first detected Tn2009 in ST540. The bla OXA−23 gene was located on transposons Tn2006 or Tn2009. In addition, the ST540 strain also contains a drug-resistant plasmid with msr(E), armA, sul1 and mph(E) genes. Conclusion The prevalent clones of Acinetobacter baumannii in our organization have changed during COVID-19, which was different from that of China. ST540 strains which carried multiple drug-resistant mobile elements was spreading, indicating that it is essential to strengthen the molecular epidemiology of Acinetobacter baumannii.
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- 2024
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17. Relating Gain Degradation to Defects Production in Neutron-Irradiated 4H-SiC Transistors
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Yingxin Cui, Xiaolan Yan, Shangjie Jin, Bing Huang, Fang Dai, Xuegong Yu, Peng Dong, Lin Zhang, and Ying Zhang
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Nuclear and High Energy Physics ,Materials science ,Silicon ,010308 nuclear & particles physics ,business.industry ,Transistor ,chemistry.chemical_element ,Electron ,01 natural sciences ,law.invention ,chemistry.chemical_compound ,Semiconductor ,Nuclear Energy and Engineering ,chemistry ,law ,0103 physical sciences ,Silicon carbide ,Optoelectronics ,Neutron ,Irradiation ,Electrical and Electronic Engineering ,business ,Technology CAD - Abstract
Wide-gap semiconductor SiC is generally considered as a superior candidate for high-radiation applications, due to its higher displacement energy for both Si and C lattice atoms. In this work, we find that the current gain ( $\beta $ ) of 4H-SiC bipolar junction transistors (BJTs) can severely deteriorate after neutron irradiation. Deep-level transient spectroscopy (DLTS) reveals that two major carrier-killer centers, Z1/2 and EH6/7, were produced in neutron-irradiated devices. Surprisingly, we find that the shallow Z1/2 center can play a dominant role over the deep EH6/7 defects in carrier recombination under high-injection conditions, which contributes to the unusual smaller hole capture cross section than that of the electron one, as indicated by the first-principles calculations. Finally, technology computer aided design (TCAD) simulation confirms that the enhanced carrier recombination from the Z1/2 centers is responsible for the degraded performance of SiC BJTs after irradiation. Our findings not only provide a deep insight into the underlying physics for displacement damage in SiC BJTs, but also are of interest for technological applications field related to high-energy particle irradiation or implantation.
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- 2021
18. Fast Quantitative Method to Detect the Cross-Sectional Loss of Wire Rope Defects
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Wei Gao, Pan Shimin, Enchao Zhang, Xiaolan Yan, and Donglai Zhang
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Materials science ,020208 electrical & electronic engineering ,Flux ,Wire rope ,02 engineering and technology ,Mechanics ,engineering.material ,Signal ,Magnetic flux ,Magnetic field ,Nonlinear system ,Quality (physics) ,0202 electrical engineering, electronic engineering, information engineering ,engineering ,Electrical and Electronic Engineering ,Instrumentation ,Leakage (electronics) - Abstract
The loss of metallic area is the most important factor affecting the quality of wire ropes. Therefore, it is very important to detect the loss of metallic area values of wire rope defects quickly and accurately. At present, the main flux detection approach is one of the most effective methods, and the detection signal is related directly to the metal cross-sectional area of the wire rope. However, when the defect width is less than a specific value, the existence of the leakage magnetic field means that the amount of the magnetic flux change is not only related to the loss of metallic area of the defect but also has a complex nonlinear relationship with the defect width. The resulting calculation is highly complex and means that the loss of metallic area cannot be determined quickly and quantitatively. This article presents an in-depth study of the theoretical basis of magnetic flux detection, analyzes the problems of the main magnetic flux detection method and their causes, and proposes a method to improve main magnetic flux detection using the axial magnetic flux density. Simulation analysis and experimental results show that the method presented in this article can be used to calculate the loss of metallic area values of defects quickly and accurately without the need for complex calculation processes.
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- 2021
19. Noncontact Magnetostrictive Torsional Guided Wave Sensors for Small-Diameter Pipes
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Xiaolan Yan, Donglai Zhang, Enchao Zhang, and Wei Gao
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Materials science ,Guided wave testing ,Acoustics ,020208 electrical & electronic engineering ,Magnetostriction ,02 engineering and technology ,Magnetostatics ,Magnetic field ,Physics::Fluid Dynamics ,Amplitude ,Transducer ,Magnet ,0202 electrical engineering, electronic engineering, information engineering ,Electrical and Electronic Engineering ,Instrumentation ,Excitation - Abstract
The magnetostrictive torsional wave sensors are focused on magnetostrictive patch transducer. These transducers use a material with a high magnetostrictive coefficient on the pipe surface to increase the excitation efficiency for detection. However, this approach loses the noncontact characteristic of the magnetostrictive guided waves. To enable noncontact detection in small-diameter pipes using torsional waves, a magnetostrictive torsional wave sensor with a tile-shaped magnet is designed in this article. By optimizing the structure of the static magnetic field, the circumferential magnetic field of the pipe is enhanced. The amplitude and the signal-to-noise ratio of the guided waves are also improved. The tile-shaped magnet with shoving magnetic structure is used to realize a uniform circumferential magnetic field. A solenoid coil is used to provide the axial dynamic magnetic field to generate the torsional waves that are used to detect the pipes. In this article, the principles of torsional wave sensors are studied first. The static magnetic field results for different structures are then analyzed via simulations. Finally, experiments show that the magnetostrictive torsional wave sensors with the tile-shaped magnets can realize the excitation and detection of torsional waves in pipes, which can be used to detect the locations and sizes of defects in these pipes.
- Published
- 2021
20. Temperature Effect on Charge-state Transition Levels of Defects in Semiconductors
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Shuang Qiao, Yu-Ning Wu, Xiaolan Yan, Bartomeu Monserrat, Su-Huai Wei, and Bing Huang
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Condensed Matter - Materials Science ,Materials Science (cond-mat.mtrl-sci) ,FOS: Physical sciences - Abstract
Defects are crucial in determining the overall physical properties of semiconductors. Generally, the charge-state transition level (TEL), one of the key physical quantities that determines the dopability of defects in semiconductors, is temperature dependent. However, little is known about the temperature dependence of TEL, and, as a result, almost all existing defect theories in semiconductors are built on a temperature-independent approximation. In this article, by deriving the basic formulas for temperature-dependent TEL, we have established two fundamental rules for the temperature dependence of TEL in semiconductors. Based on these rules, surprisingly, it is found that the temperature dependences of TEL for different defects are rather diverse: it can become shallower, deeper, or stay unchanged. This defect-specific behavior is mainly determined by the synergistic or opposing effects between free energy corrections (determined by the local volume change around the defect during a charge-state transition) and band edge changes (which differ for different semiconductors). These basic formulas and rules, confirmed by a large number of state-of-the-art temperature-dependent defect calculations in GaN, may potentially be widely adopted as guidelines for understanding or optimizing doping behaviors in semiconductors at finite temperatures.
- Published
- 2022
21. Sex-dimorphic functions of orexin in neuropsychiatric disorders
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Jinghan Zhang, Kangyu Jin, Bing Chen, Shangping Cheng, Jinfan Jin, Xiaolan Yang, Jing Lu, and Qinghai Song
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Orexin ,Sexual dimorphism ,Psychoneurological disorders ,Science (General) ,Q1-390 ,Social sciences (General) ,H1-99 - Abstract
The orexin system regulates a variety of physiological functions, including the sleep-wake cycle, addiction, foraging behavior, stress and cognitive functioning. Orexin levels in central and peripheral are related to the pathogenesis of many diseases, most notably the narcolepsy, eating disorders, stress-related psychiatric disorders, and neurodegenerative diseases. Recently, it has been reported that the orexin system is distinctly sexually dimorphic, and is strongly associated with neuropsychiatric disorders. In this review, we analyzed advancements in the sex differences in the orexin system and their connection to psychoneurological conditions. Considering the scarcity of research in this domain, more research is imperative to reveal the underlying mechanisms.
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- 2024
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22. Myeloid sarcoma in JAK2-positive myelodysplastic neoplasms with fibrosis: a case report and literature review
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Jiaofeng Bai, Xuan Wang, Ruirui Zheng, Miao He, Yuexia Zhang, Zhichen Zhang, Xiaolan Yang, and Yaozhu Pan
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Medicine (General) ,R5-920 - Abstract
Myeloid sarcoma (MS) occurs in patients with acute myeloid leukemia (AML). In rare cases, MS can represent a form of blast transformation in patients with myeloproliferative neoplasms (MPN), myelodysplastic neoplasms (MDS), or MDS/MPN. The most frequent chromosomal alterations in MS are t(8;21) or inv(16), with other alterations being reported. Cases of MS in Janus kinase 2 (JAK2)-positive MDS with fibrosis are exceedingly rare. Here, we describe such a case. To the best of our knowledge, this is the first report of a JAK2 V617F mutation-positive MDS case occurring concurrently with MS involving the posterior aspect of the left seventh rib. No clear association has been previously demonstrated between the intramedullary AML cytogenetics and extramedullary disease occurrence. Interestingly, samples from the intramedullary MDS and extramedullary mass in this patient presented the same JAK2 V617F mutation. Following a treatment regimen of azacitidine and venetoclax, the patient achieved complete remission. The chest CT scan showed that the seventh posterior rib mass disappeared. This case provides valuable information for the potential future treatment of this disease.
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- 2024
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23. The accuracy evaluation method of baseline estimation algorithms in energy dispersive X‐ray fluorescence spectrum analysis
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Luman Jia, Yi Gu, Yifan Zhang, Xiaolan Yan, Jian Zhang, Liangquan Ge, Qingxian Zhang, and Wang Youjing
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Materials science ,Evaluation methods ,X-ray fluorescence ,Spectrum analysis ,Baseline (configuration management) ,Spectroscopy ,Energy (signal processing) ,Computational physics - Published
- 2020
24. Increasing Detection Resolution of Wire Rope Metallic Cross-Sectional Area Damage Based on Magnetic Aggregation Structure
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Hongpeng Wang, Xiaolan Yan, and Donglai Zhang
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Materials science ,business.industry ,020208 electrical & electronic engineering ,Wire rope ,02 engineering and technology ,engineering.material ,Signal ,Magnetic flux ,Magnetic field ,Magnetic circuit ,Induction coil ,Signal-to-noise ratio ,Optics ,Electromagnetic coil ,0202 electrical engineering, electronic engineering, information engineering ,engineering ,Electrical and Electronic Engineering ,business ,Instrumentation - Abstract
Wire rope is a chain structure, and the strength of the weakest link is the strength of the entire wire rope. The axial resolution of loss of metallic cross-sectional area (LMA) detection using the induction coil is related to the length of the detection probe, which is usually greater than or equal to the length of the probe. Improving the axial resolution is an important technical indicator of the LMA. In this article, through theoretical analysis based on the principle of magnetic aggregation and 3-D transient magnetic field simulation, a particular kind of magnetic aggregation structure used for winding coil is proposed and optimized. Simulation and experimental results show that for wire rope LMA detection adding the proposed magnetic aggregation structure, the defect signals’ signal-to-noise ratio (SNR) is improved and the axial resolution of the LMA is increased to 20 mm. At the same time, the cross-sectional area loss can be quantitatively evaluated by the magnetic flux peak-to-peak value. The difference between the maximum and minimum values of the derivative of the magnetic flux signal can be used to evaluate the defect length.
- Published
- 2020
25. Determination of Natural Frequencies of Pipes Using White Noise for Magnetostrictive Longitudinal Guided-Wave Nondestructive Testing
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Xiaolan Yan, Donglai Zhang, and Wei Gao
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Guided wave testing ,Materials science ,business.industry ,Acoustics ,Modal analysis ,020208 electrical & electronic engineering ,Bandwidth (signal processing) ,02 engineering and technology ,White noise ,Vibration ,Nondestructive testing ,0202 electrical engineering, electronic engineering, information engineering ,Structural health monitoring ,Electrical and Electronic Engineering ,Mechanical wave ,business ,Instrumentation - Abstract
Magnetostrictive guided waves are widely used in nondestructive testing and structural health monitoring of pipes to ensure their integrity. These guided waves are mechanical waves, and if the natural frequencies of the pipe are used as excitation frequencies, the mechanical vibration amplitude can be enhanced, which will then improve the amplitude of the guided waves. Comparison of the various methods to determine the natural frequencies of pipes shows that the white noise signals remain relatively smooth in both time and frequency domains. White noise has a wide bandwidth and uniform energy distribution. It does not require high energy within a short time period, so it is easy to generate. In this article, white noise is used to determine the natural frequencies of pipes. Comparison of the white noise spectra produced by analog and digital circuits shows that the energy spectrum of white noise produced by the analog circuit is high and uniform, so the analog circuit is used as the white noise source and this noise is loaded onto a magnetostrictive sensor. The detected signal spectrum is then analyzed and the frequencies with high power density spectra are determined to be the natural frequencies. The natural frequencies of the pipeline detected using white noise are compared with the results of modal analysis. Simulation results and experimental results demonstrate that the use of white noise allows the natural frequencies of pipes to be determined quickly and accurately. These natural frequencies can be used in magnetostrictive guided-wave nondestructive testing.
- Published
- 2020
26. Identification of carbon location in p-type GaN: Synchrotron x-ray absorption spectroscopy and theory
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Huayang Huang, Xiaolan Yan, Xuelin Yang, Wensheng Yan, Zeming Qi, Shan Wu, Zhaohua Shen, Ning Tang, Fujun Xu, Xinqiang Wang, Weikun Ge, Bing Huang, and Bo Shen
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Physics and Astronomy (miscellaneous) - Abstract
Identifying atomic configurations of impurities in semiconductors is of fundamental interest and practical importance in designing electronic and optoelectronic devices. C impurity acting as one of the most common impurities in GaN, it is believed for a long time that it substitutes at Ga site forming CGa with +1 charge-state in p-type GaN, while it substitutes at N site forming CN with -1 charge-state in n-type GaN. However, by combining x-ray absorption spectroscopy and first-principles simulations, we observed that C is mainly occupying the N site rather than the Ga one in p-GaN. We further reveal that this is due to an H-induced EF-tuning effect. During growth, the existing H can passivate Mg dopants and upshifts the EF to the upper region of bandgap, leading to the CN formation. After the p-type activation by annealing out H, although the EF is pushed back close to the valence band maximum, whereas the extremely large kinetic barrier can prevent the migration of C from the metastable CN site to ground-state CGa site, hence stabilizing the CN configuration. Additionally, the CN with neutral charge-state ([Formula: see text]) in the p-GaN is further observed. Therefore, the real C-related hole-killer in p-type GaN could be CN rather than the commonly expected CGa. Our work not only offers the unambiguous evidence for the C defect formation in p-GaN but also contributes significantly to an in-depth understanding of the C-related hole-killers and their critical role on electrical and optoelectrical properties of p-GaN and even p-AlGaN.
- Published
- 2022
27. Integrating Genome-Wide Association Analysis With Transcriptome Sequencing to Identify Candidate Genes Related to Blooming Time in Prunus mume
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Xi Yuan, Qingqing Yang, Xiaolan Yan, Tangren Cheng, Jia Wang, Qixiang Zhang, and Man Zhang
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0106 biological sciences ,0301 basic medicine ,Germplasm ,Candidate gene ,Plant Science ,transcriptome sequencing ,Biology ,01 natural sciences ,SB1-1110 ,Transcriptome ,03 medical and health sciences ,Prunus ,gene-based association anaysis ,Gene ,Original Research ,Genetic association ,co-expression network ,floral bud ,Genetics ,Molecular breeding ,genome-wide association study ,Phenology ,fungi ,Plant culture ,food and beverages ,Prunus mume ,bloom date ,030104 developmental biology ,010606 plant biology & botany - Abstract
Prunus mume is one of the most important woody perennials for edible and ornamental use. Despite a substantial variation in the flowering phenology among the P. mume germplasm resources, the genetic control for flowering time remains to be elucidated. In this study, we examined five blooming time-related traits of 235 P. mume landraces for 2 years. Based on the phenotypic data, we performed genome-wide association studies, which included a combination of marker- and gene-based association tests, and identified 1,445 candidate genes that are consistently linked with flowering time across multiple years. Furthermore, we assessed the global transcriptome change of floral buds from the two P. mume cultivars exhibiting contrasting bloom dates and detected 617 associated genes that were differentially expressed during the flowering process. By integrating a co-expression network analysis, we screened out 191 gene candidates of conserved transcriptional pattern during blooming across cultivars. Finally, we validated the temporal expression profiles of these candidates and highlighted their putative roles in regulating floral bud break and blooming time in P. mume. Our findings are important to expand the understanding of flowering time control in woody perennials and will boost the molecular breeding of novel varieties in P. mume.
- Published
- 2021
28. Hierarchical ZnO/Si nanowire arrays as an effective substrate for surface-enhanced Raman scattering application
- Author
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Imran Khan, Shengli Huang, Shuping Li, Mengyao Gao, Bing He, Jiayuan Wang, Jinshen Lan, Xiaolan Yan, and Junyong Kang
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Materials science ,Silicon ,Nanowire ,chemistry.chemical_element ,02 engineering and technology ,Substrate (electronics) ,010402 general chemistry ,01 natural sciences ,Crystal ,symbols.namesake ,Materials Chemistry ,Electrical and Electronic Engineering ,Thin film ,Surface plasmon resonance ,Instrumentation ,business.industry ,Metals and Alloys ,021001 nanoscience & nanotechnology ,Condensed Matter Physics ,0104 chemical sciences ,Surfaces, Coatings and Films ,Electronic, Optical and Magnetic Materials ,chemistry ,symbols ,Optoelectronics ,0210 nano-technology ,business ,Raman spectroscopy ,Raman scattering - Abstract
Hierarchical arrays of ZnO/Si nanowires were prepared through very convenient two-step solution method on silicon substrates. The tree-like nanowire structures showed high crystal quality, where well aligned Si nanowires were grown vertical to the substrate surface, whereas uniform assembly of branched ZnO nanowires was grown normal to the Si nanowires (backbones). Raman analysis indicated that among all the specimens having identical chemical compositions and dimensions but different forms (thin films or nanowires), Ag-decorated hierarchical arrays of ZnO/Si nanowires possessed the highest intensity peak in surface enhanced Raman scattering spectra. Such arrays demonstrated exceptional ability of detecting Rhodamine 6 G, limiting to a value as low as 1×10−8 mol/L and an enhancement factor up to 1.5 × 104. Both, experimental designing and band structure analysis indicated that electromagnetic effect of the localized surface plasmon resonance of Ag nanoparticles caused eight times enhancement, whereas chemical effect of hierarchical arrays of ZnO/Si nanowires played a more critical role in the high Raman sensitivity. Our results would be helpful to better understand the enhancement mechanisms and meanwhile, could be extended for further potential applications of hierarchical semiconducting nanowires.
- Published
- 2018
29. Additional file 6 of Genome-wide characterization of PEBP family genes in nine Rosaceae tree species and their expression analysis in P. mume
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Zhang, Man, Li, Ping, Xiaolan Yan, Wang, Jia, Tangren Cheng, and Qixiang Zhang
- Abstract
Additional file 6: Fig. S6. Heatmap of average RSCU scores estimated for different codons in five Rosaceae PEBP gene lineages.
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- 2021
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30. Additional file 1 of Genome-wide characterization of PEBP family genes in nine Rosaceae tree species and their expression analysis in P. mume
- Author
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Zhang, Man, Li, Ping, Xiaolan Yan, Wang, Jia, Tangren Cheng, and Qixiang Zhang
- Abstract
Additional file1: Fig. S1. Phylogenetic trees were constructed using three different algorithms.
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- 2021
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31. Additional file 9 of Genome-wide characterization of PEBP family genes in nine Rosaceae tree species and their expression analysis in P. mume
- Author
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Zhang, Man, Li, Ping, Xiaolan Yan, Wang, Jia, Tangren Cheng, and Qixiang Zhang
- Subjects
fungi ,food and beverages - Abstract
Additional file 9: Fig. S9. Relative expression of PEBP family genes in floral bud, leaf, stem, and root tissues of P. mume.
- Published
- 2021
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32. Additional file 5 of Genome-wide characterization of PEBP family genes in nine Rosaceae tree species and their expression analysis in P. mume
- Author
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Zhang, Man, Li, Ping, Xiaolan Yan, Wang, Jia, Tangren Cheng, and Qixiang Zhang
- Abstract
Additional file 5: Fig. S5. Distribution and collinearity of PEBP family genes within genomes of nine Rosaceae species.
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- 2021
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33. Additional file 4 of Genome-wide characterization of PEBP family genes in nine Rosaceae tree species and their expression analysis in P. mume
- Author
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Zhang, Man, Li, Ping, Xiaolan Yan, Wang, Jia, Tangren Cheng, and Qixiang Zhang
- Abstract
Additional file4: Fig. S4. Inter-genomic synteny blocks between species.
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- 2021
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34. Additional file 3 of Genome-wide characterization of PEBP family genes in nine Rosaceae tree species and their expression analysis in P. mume
- Author
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Zhang, Man, Li, Ping, Xiaolan Yan, Wang, Jia, Tangren Cheng, and Qixiang Zhang
- Abstract
Additional file 3: Fig. S3. Protein sequence alignment of FT and TFL1-like proteins in Arabidopsis and nine Rosaceae species.
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- 2021
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35. Genome-wide characterization of PEBP family genes in nine Rosaceae tree species and their expression analysis in P. mume
- Author
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Xiaolan Yan, Man Zhang, Jia Wang, Qixiang Zhang, Ping Li, and Tangren Cheng
- Subjects
0106 biological sciences ,0301 basic medicine ,Gene family evolution ,PEBP gene family ,Evolution ,Phosphatidylethanolamine Binding Protein ,Genes, Plant ,01 natural sciences ,Genome ,Trees ,03 medical and health sciences ,Negative selection ,Phylogenetics ,Arabidopsis ,Gene duplication ,QH359-425 ,Rosaceae ,Gene ,QH540-549.5 ,Plant Proteins ,Synteny ,Genetics ,Ecology ,biology ,General Medicine ,Floral bud break ,biology.organism_classification ,030104 developmental biology ,Codon usage bias ,Flowering time regulation in perennials ,Research Article ,Rosaceae species ,010606 plant biology & botany - Abstract
Background Phosphatidylethanolamine-binding proteins (PEBPs) constitute a common gene family found among animals, plants and microbes. Plant PEBP proteins play an important role in regulating flowering time, plant architecture as well as seed dormancy. Though PEBP family genes have been well studied in Arabidopsis and other model species, less is known about these genes in perennial trees. Results To understand the evolution of PEBP genes and their functional roles in flowering control, we identified 56 PEBP members belonging to three gene clades (MFT-like, FT-like, and TFL1-like) and five lineages (FT, BFT, CEN, TFL1, and MFT) across nine Rosaceae perennial species. Structural analysis revealed highly conserved gene structure and protein motifs among Rosaceae PEBP proteins. Codon usage analysis showed slightly biased codon usage across five gene lineages. With selection pressure analysis, we detected strong purifying selection constraining divergence within most lineages, while positive selection driving the divergence of FT-like and TFL1-like genes from the MFT-like gene clade. Spatial and temporal expression analyses revealed the essential role of FT in regulating floral bud breaking and blooming in P. mume. By employing a weighted gene co-expression network approach, we inferred a putative FT regulatory module required for dormancy release and blooming in P. mume. Conclusions We have characterized the PEBP family genes in nine Rosaceae species and examined their phylogeny, genomic syntenic relationship, duplication pattern, and expression profiles during flowering process. These results revealed the evolutionary history of PEBP genes and their functions in regulating floral bud development and blooming among Rosaceae tree species.
- Published
- 2020
36. Online nondestructive testing for fine steel wire rope in electromagnetic interference environment
- Author
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Donglai Zhang, Enchao Zhang, Gao Wei, Xiaolan Yan, and Shimin Pan
- Subjects
010302 applied physics ,business.industry ,Electromagnetic environment ,Mechanical Engineering ,Acoustics ,Electrical engineering ,Magnetic flux leakage ,Wire rope ,engineering.material ,Condensed Matter Physics ,01 natural sciences ,Electromagnetic interference ,Magnetic circuit ,Nondestructive testing ,Magnet ,0103 physical sciences ,engineering ,General Materials Science ,Hall effect sensor ,business ,010301 acoustics - Abstract
The diameter of fine steel wire rope (FSWR) is generally a few millimeters. Its magnetic flux leakage (MFL) signal is weak, and the number of magnetic sensors installed for defect detection is limited because of the small diameter. In FSWR production workshops, different kinds of machinery work together, deteriorating the power quality and making the spatial electromagnetic environment complex; the weak MFL is thus interfered with further. It is difficult to carry out online nondestructive testing (NDT) of FSWR in the process of manufacturing. In this paper we present a novel MFL method for FSWR NDT in a strong electromagnetic interference environment. We use a three-dimensional finite element method (FEM) to analyze the MFL signals. A simplified magnetic circuit is presented to excite the FSWR; the circuit comprises two half-sized radial magnetizing ring NdFeB magnets, and because there is no need for a magnetic yoke, the device is simple and light. A single Hall sensor is used to measure the flux leakage field. A stable performance power system is designed for the NDT power supply, which is not only resistant to voltage sags, but also has very low output noise. To enhance the signal-to-noise ratio (SNR) of the MFL defects signal, a signal conditioning and processing circuit are designed to enhance the detectability of signals in MFL data. The novel and small FSWR NDT system realizes on-line testing in an environment of strong electromagnetic interference, and for the experiment with a 1.5-mm-diameter wire rope twisted by 19 wires, the minimum damage of a pit on half of a wire can be identified.
- Published
- 2017
37. Improve the signal to noise ratio and installation convenience of the inductive coil for wire rope nondestructive testing
- Author
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Fei Zhao, Donglai Zhang, and Xiaolan Yan
- Subjects
Astrophysics::High Energy Astrophysical Phenomena ,Acoustics ,Physics::Medical Physics ,Bifilar coil ,02 engineering and technology ,engineering.material ,01 natural sciences ,0103 physical sciences ,0202 electrical engineering, electronic engineering, information engineering ,Astrophysics::Solar and Stellar Astrophysics ,General Materials Science ,010301 acoustics ,business.industry ,Mechanical Engineering ,020208 electrical & electronic engineering ,Electrical engineering ,Magnetic flux leakage ,Wire rope ,Condensed Matter Physics ,Magnetic core ,Coil noise ,Electromagnetic coil ,engineering ,business ,Rogowski coil ,Coil tap - Abstract
Inductive coil is used as the nondestructive testing sensor of a wire rope or a pipe, because of its low cost and high durability. However, the winding structure is complex and difficult to design during the field test. Hundreds or even thousands of turns are needed to improve the signal to noise ratio (SNR) and the data processing is cumbersome. In this paper, based on the theoretical analysis and 3D transient magnetic field simulation, a kind of iron core is presented as coil winding skeleton for the wire rope nondestructive testing. Additional iron core plays a role of magnetism concentration, where the magnetic flux leakage (MFL) path is changed and the MFL of the defect is converged to the core. Therefore, the SNR of the coil which is wound on the iron core is improved, and the coil winding skeleton is simplified with the iron core structure optimization. Meanwhile, the influence of the coil cross-section area on the test result analysis is eliminated, and the influence of the lift-off distance between coil and wire rope on the detection result is also reduced. Finally, it is proved by experiment that the SNR of coil with the iron core proposed in this paper is increased almost six times, which makes it easier for defect analysis.
- Published
- 2017
38. Universal Theory and Basic Rules of Strain-Dependent Doping Behaviors in Semiconductors
- Author
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Xiaolan Yan, and Bing Huang, Pei Li, and Su-Huai Wei
- Subjects
Materials science ,Semiconductor ,Strain (chemistry) ,Condensed matter physics ,business.industry ,Doping ,General Physics and Astronomy ,Universal theory ,business - Abstract
Enhancing the dopability of semiconductors via strain engineering is critical to improving their functionalities, which is, however, largely hindered by the lack of basic rules. In this study, for the first time, we develop a universal theory to understand the total energy changes of point defects (or dopants) with different charge states under strains, which can exhibit either parabolic or superlinear behaviors, determined by the size of defect-induced local volume change (Δ V). In general, Δ V increases (decreases) when an electron is added (removed) to (from) the defect site. Consequently, in terms of this universal theory, three basic rules can be obtained to further understand or predict the diverse strain-dependent doping behaviors, i.e., defect formation energies, charge-state transition levels, and Fermi pinning levels, in semiconductors. These three basic rules could be generally applied to improve the doping performance or overcome the doping bottlenecks in various semiconductors.
- Published
- 2021
39. Pharmacological interventions for the treatment of obstructive sleep apnea syndrome
- Author
-
Jin Liu, Xiaolan Yang, Guangcai Li, and Peijun Liu
- Subjects
OSAS ,pharmacological treatments ,respiratory disorder ,ESS ,CPAP ,Medicine (General) ,R5-920 - Abstract
Obstructive Sleep Apnea Syndrome (OSAS) affects 13–33% of males and 6–9% of females globally and poses significant treatment challenges, including poor adherence to Continuous Positive Airway Pressure (CPAP) and residual excessive sleepiness (RES). This review aims to elucidate the emerging interest in pharmacological treatments for OSAS, focusing on recent advancements in this area. A thorough analysis of extensive clinical trials involving various drugs, including selective dopamine reuptake inhibitors, selective norepinephrine inhibitors, combined antimuscarinic agents, and orexin agonists, was conducted. These trials focused on ameliorating respiratory metrics and enhancing sleep quality in individuals affected by OSAS. The studied pharmacological agents showed potential in improving primary outcomes, notably the apnea-hypopnea index (AHI) and the Epworth sleepiness scale (ESS). These improvements suggest enhanced sleep quality and symptom management in OSAS patients. With a deeper understanding of OSAS, pharmacological interventions are emerging as a promising direction for its effective management. This review provides a comprehensive overview of the current state of drug research in OSAS, highlighting the potential of these treatments in addressing the disorder’s complex challenges.
- Published
- 2024
- Full Text
- View/download PDF
40. Electronic and doping properties of hexagonal silicon carbide with stacking faults induced cubic inclusions
- Author
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Peng Dong, Bing Huang, Pei Li, Jiabin Chen, and Xiaolan Yan
- Subjects
010302 applied physics ,Materials science ,Dopant ,Condensed matter physics ,business.industry ,Band gap ,Doping ,Stacking ,Wide-bandgap semiconductor ,General Physics and Astronomy ,02 engineering and technology ,021001 nanoscience & nanotechnology ,01 natural sciences ,Band offset ,chemistry.chemical_compound ,Semiconductor ,chemistry ,0103 physical sciences ,Silicon carbide ,0210 nano-technology ,business - Abstract
Silicon carbide (SiC) has been considered one of the most important wide bandgap semiconductors for both scientific interest and technological applications. The existence of stacking faults induced inclusions, originated from the “wrong” stacking sequences of Si–C bilayers, is a general feature in SiC. Until now, however, a systematical understanding of the role of cubic inclusions (CIs) in the electronic and doping properties of hexagonal SiC is still lacking, which may prevent further improvement of its electronic performance. In this article, using advanced first-principles calculations, we have systematically studied the stability, electronic structures, and doping properties of hexagonal SiC with CIs. First, we find that the CIs in SiC have rather low formation energies but high kinetic stability. Second, we find that the electronic structures of SiC can be dramatically tuned by the ratio of CIs in SiC. Third, we demonstrate that the CI-induced band offset and the dipole-discontinuity-induced dipole field in the system can give rise to different ground-state doping sites for dopants at their different charge-states, which can consequently result in novel doping-site-dependent charge-state transition levels (CTLs). Meanwhile, the intrinsic dipole field can dramatically enhance the structural relaxation effects during the ionization of the dopants, which can push the CTLs deeper inside the bandgap compared to the case without CIs. Our findings suggest that CIs could play unusual roles in determining the overall electronic and doping properties of SiC and other similar semiconductors.
- Published
- 2021
41. Quantitative method for detecting internal and surface defects in wire rope
- Author
-
Donglai Zhang, Enchao Zhang, and Xiaolan Yan
- Subjects
Surface (mathematics) ,Materials science ,Artificial neural network ,business.industry ,Mechanical Engineering ,Acoustics ,Magnetic flux leakage ,Wire rope ,engineering.material ,Condensed Matter Physics ,Magnetic flux ,Induction coil ,Nondestructive testing ,engineering ,General Materials Science ,Hall effect sensor ,business - Abstract
The detection of internal and external defects in steel wire rope is a very important task. Current nondestructive testing methods cannot distinguish between internal and surface defects, and cannot determine the quantitative characteristics of internal defects. This paper first analyzes the advantages and disadvantages of induction coil magnetic flux detection and Hall sensor-based magnetic flux leakage detection. The problem of simultaneous detection using these two methods is then solved, and a new quantitative detection method is proposed for internal and surface defects in wire rope. Finally, a calculation method that uses a two-step training algorithm to establish two sets of neural networks is proposed. Results from simulations and experiments verify that the proposed method can accurately distinguish between internal and surface defects in wire rope, and can also quantitatively detect the width, cross-sectional loss rate, and depth of the defects.
- Published
- 2021
42. The evolutionary analysis of PEBP Gene Family among Rosaceae tree species
- Author
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Qixiang Zhang, Li Ping, Tangren Cheng, Xiaolan Yan, Jia Wang, and Man Zhang
- Subjects
biology ,Evolutionary biology ,Rosaceae ,Gene family ,biology.organism_classification ,Tree species - Abstract
Phosphatidylethanolamine-binding proteins (PEBPs) are a common gene family found among animals, plants and microbes. Plant PEBP proteins play an important role in regulating flowering time, as well as seed and bud dormancy. PEBP proteins can be divided into three major clades: FLOWERING LOCUS T-like (FT-like), TERMINAL FLOWER1-like (TFL1-like), and MOTHER OF FT AND TFL1-like (MFT-like). Though PEBP family genes have been well studied in Arabidopsis and other model species, their functional role in perennial trees is not fully understood. To characterize the evolution of PEBP genes and their role in flowering control among Rosaceae species, we identified a total of 46 PEBP members in seven Rosaceae species. Sequence and gene structure analysis revealed highly conserved intron/exon distributions and featured motifs among Rosaceae PEBP proteins. Analysis of synonymous/nonsysnonymous substitution rates showed purifying selection constraining divergence within most lineages, while positive selection appears to have driven divergence of FT-like and TFL-like genes from the MFT clade. The expression of PEBP genes varied among different tissues indicating their functional divergence during gene family evolution. Furthermore, by employing a weighted gene co-expression network approach, we inferred a putative FT regulatory module essential for dormancy release and floral induction in P. mume. Our study sheds new light on the evolution of PEBP genes and their functional roles in controlling flowering time among Rosaceae tree species.
- Published
- 2019
43. Nondestructive Testing of Elongated Ferromagnetic Members Based on Extruded Structure
- Author
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Hongpeng Wang, Donglai Zhang, and Xiaolan Yan
- Subjects
010302 applied physics ,Materials science ,Physics::Instrumentation and Detectors ,business.industry ,Acoustics ,Magnetic flux leakage ,Wire rope ,engineering.material ,01 natural sciences ,Magnetic field ,Ferromagnetism ,Magnet ,Nondestructive testing ,0103 physical sciences ,engineering ,business ,010301 acoustics ,Saturation (magnetic) ,Excitation - Abstract
The traditional electromagnetic nondestructive testing probe structure includes magnets and yokes, and forms an excitation circuit with the wire rope. The wire rope is excited to a near-saturation state. The magnetic sensor is used for qualitative or quantitative detection of leakage flux from defects. The yoke is essential in the traditional excitation circuit. However, the use of a yoke in a detection probe of such an excitation mechanism has a large volume and is heavy. Through simulation, we improved the magnetization direction and installation position of the permanent magnets. Without a yoke, the permanent magnets were placed in the direction of co-extrusion. The wire rope was excited to near saturation in the permanent-magnet part. However, there was no excitation in the center of the two permanent magnets. The magnetic sensor was placed in the center of two permanent magnets to pick up the magnetic-flux-leakage signal for nondestructive testing of the steel wire rope. This method simplifies the permanent-magnet magnetization. The excitation probe with the yoke removed was also reduced in volume and weight. Through experimental testing, it was proven that the proposed shoving-magnetic-field structure and the traditional detection structure have the same detection effect.
- Published
- 2019
44. Study of Magnetostrictive Guided Wave Detection of Defects in Steel Strip for Elevator Traction
- Author
-
Wei Gao, Enchao Zhang, Xiaolan Yan, and Donglai Zhang
- Subjects
Materials science ,Guided wave testing ,Elevator ,business.industry ,Acoustics ,Wire rope ,Magnetostriction ,02 engineering and technology ,STRIPS ,engineering.material ,021001 nanoscience & nanotechnology ,01 natural sciences ,law.invention ,Natural rubber ,law ,visual_art ,Nondestructive testing ,0103 physical sciences ,engineering ,visual_art.visual_art_medium ,0210 nano-technology ,business ,010301 acoustics ,Leakage (electronics) - Abstract
The traction technology used for elevators in the current market has gradually changed from wire rope-type to steel strip technology. The traditional nondestructive testing of elevator wire ropes mainly involves manual observation. The steel strip is composed of both rubber and multiple wire ropes. Therefore, manual observation can only detect wear of the rubber surface or wire leakage and cannot detect internal defects in the wire ropes. The wire ropes in the steel strip are thus generally electrified to determine whether or not any of these wire ropes have broken. This approach cannot detect whether the wire ropes contain small defects. In this paper, different modes are designed for magnetostrictive guided wave sensors according to the structural characteristics of elevator steel strips. The different sensor modes are determined by comparing the detection effects of the various sensors. Finally, the magnetostrictive guided wave sensors are used to detect defects in the steel strip. The experiments show that the sensor designed in this paper can detect defects within the steel strip effectively.
- Published
- 2019
45. Indexes of ferroptosis and iron metabolism were associated with the severity of diabetic nephropathy in patients with type 2 diabetes mellitus: a cross-sectional study
- Author
-
Pingping Zhao, Xiaoyu Lv, Zhicong Zhou, Xiaolan Yang, Ying Huang, and Jingfang Liu
- Subjects
type 2 diabetes ,ferroptosis ,GPx4 ,ACSL4 ,iron metabolism ,Diseases of the endocrine glands. Clinical endocrinology ,RC648-665 - Abstract
ObjectiveTo explore the correlations between diabetic nephropathy (DN) and serum levels of glutathione peroxidase 4 (GPX4), acyl-CoA synthetase long-chain family member 4 (ACSL4), iron, transferrin (Tf), and ferritin in patients with type 2 diabetes mellitus (T2DM).MethodsAccording to the urinary albumin excretion rate(UAER) or estimated glomerular filtration rate (eGFR) levels, a total of 123 patients with T2DM were separately divided into normoalbuminuria (NO), microalbuminuria (MI), macroalbuminuria (MA) groups, and G1 (eGFR ≥ 90 mL/min), G2 (eGFR ≤ 60 mL/min to < 90 mL/min), and G3 groups (eGFR< 60 mL/min), with 33 healthy participants as the control (HC). The differences in serum GPX4, ACSL4, iron, Tf, and ferritin levels between groups were compared, and the relationships between these levels were analysed. The independent correlations between UAER or DN severity and serum GPX4, ACSL4, iron, Tf, and ferritin levels were analysed by multiple linear and multinomial logistic regression, respectively.ResultsTo the patients with T2DM, with the increase in UAER levels, GPX4, iron, and Tf levels gradually decreased, whereas ACSL4 levels increased, meanwhile with the decrease in eGFR levels, GPX4 and Tf levels gradually decreased, whereas ACSL4 levels increased. UAER were independently and positively correlated with ACSL4 [β = 17.53, 95% confidence interval (CI; 11.94, 23.13)] and negatively correlated with GPX4 [β = −1.633, 95% CI (−2.77, -0.496)] and Tf [β = −52.94, 95% CI (-95.78, −10.11)].The NO and MI groups were considered as reference groups, respectively. The severity of DN was negatively correlated with serum GPX4 [odds ratio (OR) = 0.925 and 0.902, p =0.015 and 0.001], and Tf (OR = 0.109 and 0.119, p =0.043 and 0.034), and positively correlated with ACSL4 (OR = 1.952 and 1.865, both p
- Published
- 2023
- Full Text
- View/download PDF
46. An omicron-based vaccine booster elicits potent neutralizing antibodies against emerging SARS-CoV-2 variants in adults
- Author
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Tao Li, Deyan Luo, Nianzhi Ning, Xin Wang, Liangyan Zhang, Xiaolan Yang, Deyu Li, Yakun Sun, Wenjing Yu, Wenjin Wei, and Hui Wang
- Subjects
SARS-CoV-2 ,Omicron ,vaccine ,booster ,neutralizing titers ,Infectious and parasitic diseases ,RC109-216 ,Microbiology ,QR1-502 - Abstract
ABSTRACTSARS-CoV-2 Omicron subvariants have become the predominantly strain in most countries. However, the neutralizing activity of the human serum after Omicron-based vaccine booster against different SARS-CoV-2 variants is poorly understood. Here, we developed an update Omicron vaccine (SCoK-Omicron), based on the RBD-Fc fusion protein vaccine (SCoK) and RBD domain of Omicron BA.1. To assess cross-variant neutralizing activity in adults, 25 volunteers that have received three doses of SCoK and 25 volunteers with two doses of CoronaVac (inactive vaccine) were further boosted with a dose updated vaccine (SCoK-Omicron). The results of pseudovirus neutralization assays demonstrated that the booster potently induced the high-level of neutralizing antibody against SARS-CoV-2 Wild type, Delta and Omicron subvariants in adults. Further assays of single point mutations showed that K444T, L452R, N460K, or F486V was key mutations to cause immune evasion. Together, these data suggest that SCOK-Omicron can be used as a booster vaccine candidate in adults receiving subunit protein or inactivated vaccine in response to the epidemic of COVID-19 Omicron subvariants, and the mutation K444T, L452R, N460K, or F486V needs to be considered in future vaccine design.
- Published
- 2023
- Full Text
- View/download PDF
47. First-principles study of electronic and diffusion properties of intrinsic defects in 4H-SiC
- Author
-
Xiaolan Yan, Bing Huang, Lei Kang, Su-Huai Wei, and Pei Li
- Subjects
010302 applied physics ,Materials science ,business.industry ,Wide-bandgap semiconductor ,General Physics and Astronomy ,02 engineering and technology ,021001 nanoscience & nanotechnology ,Kinetic energy ,01 natural sciences ,Crystallographic defect ,Hybrid functional ,Semiconductor ,Chemical physics ,0103 physical sciences ,Power semiconductor device ,Diffusion (business) ,Total energy ,0210 nano-technology ,business - Abstract
As a wide bandgap semiconductor, SiC holds great importance for high temperature and high power devices. It is known that the intrinsic defects play key roles in determining the overall electronic properties of semiconductors; however, a comprehensive understanding of the intrinsic defect properties in the prototype 4H-SiC is still lacking. In this study, we have systematically investigated the electronic properties and kinetic behaviors of intrinsic point defects and defect complexes in 4H-SiC using advanced hybrid functional calculations. Our results show that all the point defects in 4H-SiC have relatively high formation energies, i.e., low defect concentrations even at high growth temperatures. Interestingly, it is found that the migration barriers are very high for vacancies (>3 eV) but relatively low for interstitial defects (∼1 eV) in SiC. Meanwhile, the diffusion energy barriers of defects strongly depend on their charge states due to the charge-state-dependent local environments. Furthermore, we find that VSi in SiC, a key defect for quantum spin manipulation, is unstable compared to the spin-unpolarized VC–CSi complex in terms of the total energy (under p-type conditions). Fortunately, the transformation barrier from VSi to VC–CSi is as high as 4 eV, which indicates that VSi could be stable at room (or not very high) temperature.
- Published
- 2020
48. Substantial Epigenetic Variation Causing Flower Color Chimerism in the Ornamental Tree Prunus mume Revealed by Single Base Resolution Methylome Detection and Transcriptome Sequencing
- Author
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Xiaolan Yan, Kaifeng Ma, Qixiang Zhang, Huitang Pan, Tangren Cheng, and Jia Wang
- Subjects
0301 basic medicine ,Transposable element ,transposon ,ornamental Prunus mume ,Flowers ,Biology ,Chimerism ,Catalysis ,Article ,Epigenesis, Genetic ,Trees ,Inorganic Chemistry ,Transcriptome ,lcsh:Chemistry ,03 medical and health sciences ,Gene Expression Regulation, Plant ,Epigenetics ,Physical and Theoretical Chemistry ,Molecular Biology ,Gene ,lcsh:QH301-705.5 ,Spectroscopy ,Genetics ,Regulation of gene expression ,bisulfate sequencing ,DNA methylation ,Pigmentation ,Organic Chemistry ,fungi ,food and beverages ,General Medicine ,Methylation ,Computer Science Applications ,030104 developmental biology ,Differentially methylated regions ,lcsh:Biology (General) ,lcsh:QD1-999 ,DNA Transposable Elements ,flower color chimera ,comparative epigenomes ,Prunus - Abstract
Epigenetic changes caused by methylcytosine modification participate in gene regulation and transposable element (TE) repression, resulting in phenotypic variation. Although the effects of DNA methylation and TE repression on flower, fruit, seed coat, and leaf pigmentation have been investigated, little is known about the relationship between methylation and flower color chimerism. In this study, we used a comparative methylomic&ndash, transcriptomic approach to explore the molecular mechanism responsible for chimeric flowers in Prunus mume &ldquo, Danban Tiaozhi&rdquo, High-performance liquid chromatography-electrospray ionization mass spectrometry revealed that the variation in white (WT) and red (RT) petal tissues in this species is directly due to the accumulation of anthocyanins, i.e., cyanidin 3,5-O-diglucoside, cyanidin 3-O-glucoside, and peonidin 3-O-glucoside. We next mapped the first-ever generated methylomes of P. mume, and found that 11.29&ndash, 14.83% of the genomic cytosine sites were methylated. We also determined that gene expression was negatively correlated with methylcytosine level in general, and uncovered significant epigenetic variation between WT and RT. Furthermore, we detected differentially methylated regions (DMRs) and DMR-related genes between WT and RT, and concluded that many of these genes, including differentially expressed genes (DEGs) and transcription factor genes, are critical participants in the anthocyanin regulatory pathway. Importantly, some of the associated DEGs harbored TE insertions that were also modified by methylcytosine. The above evidence suggest that flower color chimerism in P. mume is induced by the DNA methylation of critical genes and TEs.
- Published
- 2018
49. Position-sensorless for wire rope distance measurement and nondestructive testing
- Author
-
Wei Gao, Enchao Zhang, Pan Shimin, Xiaolan Yan, and Donglai Zhang
- Subjects
Computer science ,business.industry ,Acoustics ,Low-pass filter ,020208 electrical & electronic engineering ,Wire rope ,02 engineering and technology ,engineering.material ,Signal ,GeneralLiterature_MISCELLANEOUS ,Phase-locked loop ,Nondestructive testing ,Physics::Space Physics ,0202 electrical engineering, electronic engineering, information engineering ,engineering ,Astrophysics::Solar and Stellar Astrophysics ,business ,Slipping ,ComputingMethodologies_COMPUTERGRAPHICS - Abstract
Devices used for nondestructive testing of wire rope often include a guide wheel, which is connected to an encoder to measure the running distance of the wire rope and to provide information about defect positions. However, in use, problems with the guide wheel such as contact jittering, slipping, idling, and bouncing cause encoder pulse loss, which affects the location measurements and quantitative analysis of the defects. Also, the wire rope running at high speed is a safety problem. However, these issues can be avoided by using the unique winding of the wire rope to provide a strand wave signal. Using wave signal processing, the distance traveled by the wire rope can be measured. Then, a phase-locked loop locks and multiplies the frequency of the strand wave signal. The multiple-frequency signal is used as a trigger signal for equal distance sampling of the wire rope. This method not only replaces the use of guide wheels and encoders when the wire rope is running at uniform velocity, but also improves the precision of the positioning and quantitative analysis of defects.
- Published
- 2017
50. Elucidating the molecular mechanisms of ozone therapy for neuropathic pain management by integrated transcriptomic and metabolomic approach
- Author
-
Xiaolan Yang, Chaoming Chen, Keyang Wang, Min Chen, Yong Wang, Zhengping Chen, Wang Zhao, and Shu Ou
- Subjects
ozone therapy ,neuropathic pain ,transcriptomics ,metabolomics ,mechanism of action ,multi-omics ,Genetics ,QH426-470 - Abstract
Introduction: Neuropathic pain remains a prevalent and challenging condition to treat, with current therapies often providing inadequate relief. Ozone therapy has emerged as a promising treatment option; however, its mechanisms of action in neuropathic pain remain poorly understood.Methods: In this study, we investigated the effects of ozone treatment on gene expression and metabolite levels in the brainstem and hypothalamus of a rat model, using a combined transcriptomic and metabolomic approach.Results: Our findings revealed significant alterations in key genes, including DCST1 and AIF1L, and metabolites such as Aconitic acid, L-Glutamic acid, UDP-glucose, and Tyrosine. These changes suggest a complex interplay of molecular pathways and region-specific mechanisms underlying the analgesic effects of ozone therapy.Discussion: Our study provides insights into the molecular targets of ozone treatment for neuropathic pain, laying the groundwork for future research on validating these targets and developing novel therapeutic strategies.
- Published
- 2023
- Full Text
- View/download PDF
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