Search

Background ADHD is associated with deficits in executive functions. Cognitive training is a promising nonpharmacological intervention for ADHD, however, there is insufficient evidence to guide the selection of training for individuals with ADHD. This pilot study aims to investigate the efficacy of executive function training targeting key executive dysfunctions in ADHD, compared with general executive function training which targets other executive functions. Methods A total of 127 subjects (6–12 years) diagnosed with ADHD were allocated to receive one of two different cognitive trainings. ADHD symptoms and cognitive functions were evaluated using parent-rated scales and CANTAB cognitive assessments. All participants were required to complete 48 training sessions within a two-month period. Results 94 out of 127 children completed the required training and assessments. Both ADHD executive function training group and general executive function training group showed significant improvement in ADHD symptoms on the ADHD Rating Scale and in executive function on the assessment of CANTAB. There was no significant difference in improvements between the two groups. Subgroup analysis suggested that children who had ADHD-RS total scores less than or equal to 28 at baseline showed greater improvement following ADHD executive function training. Conclusions This study indicates that cognitive training can improve ADHD symptoms and executive function, with no difference in efficacy between targeted and generalized cognitive training. In addition, individuals with lower symptom severity may benefit more from training targeting key ADHD executive dysfunctions.

The platinum nanowires have been verified to be a promising catalyst to promote the performance of proton exchange membrane fuel cells. In this paper, accurately controlled growth of nanowires in a carbon matrix is achieved for reducing Pt loading. The effects of formic acid concentration and reaction temperature on the morphology and size of the Pt nanowires, as well as their electrochemical performances in a single cell, are investigated. The results showed that the increase in the formic acid concentration results in a volcano trend with the length of Pt nanowires. With increasing reduction temperature, the diameter of Pt nanowires increases while Pt particles evolve from one-dimensional to zero-dimensional up to 40 °C. A mechanism of the Pt nanowires growth is proposed. The optimized Pt nanowires electrode exhibits a power density (based on electrochemical active surface area) 79% higher than conventional Pt/C one. The control strategy obtained contributes to the design and control of novel nanostructures in nano-synthesis and catalyst applications.

Objective Several studies have found that epigallocatechin-3-gallate (EGCG) can alleviate acute radiation-induced esophagitis, inhibit pulmonary inflammation and fibrosis, and reduce the severity of cardiovascular disease. Therefore, this study was aimed at exploring the influence of EGCG on late radiation toxicity in the heart, esophagus, and lungs among patients with locally advanced lung cancer. Methods The patients were divided into an EGCG group and a control group, the groups received EGCG and symptomatic treatment, respectively. The Radiation Therapy Oncology Group/European Organisation for Research and Treatment of Cancer Late Radiation Morbidity Scoring Scheme was used to determine the late toxicity scores. Tumor responses were evaluated by chest computed tomography (CT), based on the Response Evaluation Criteria in Solid Tumors version 1.1. Results We retrospectively analyzed 74 patients treated at our hospital from September 2012 to September 2016 (37 patients received EGCG and 37 received supportive treatment). The late toxicity scores of the EGCG group decreased compared to those of the control group. An obvious clinical significance was observed for the oral EGCG solution in the treatment and prevention of late cardiac, esophageal, and pulmonary toxicity. However, no significant difference was found (P ​> ​0.05). The tumor response rates were similar in the two groups. Moreover, there was no difference in progression-free survival (PFS) between the groups (P ​> ​0.05). Conclusion Oral EGCG solution might alleviate radiation-induced late cardiac, esophageal, and pulmonary toxicity but has no significant effect on the tumor response rate and PFS following radiotherapy.

Background The potential mechanisms underlying cyber victimization and the resulting psychological and physical symptoms remain unclear. Thus, the present study investigated whether Internet addiction mediates the association between peer victimization (e.g., cyberbullying) and psychological and physical symptoms. Furthermore, it was assessed whether physical exercise moderates the hypothetical mediation. Methods 1854 students from 11 middle and high schools in Shenzhen, Guangdong Province, China, were sampled for this study. Psychological and physical symptoms were assessed using the World Health Organization Quality of Life-BREF, while Internet addiction was evaluated using the Internet addiction test by Young. Cyber victimization was measured using a single question. In addition, this study examined whether Internet addiction mediated the association between cyber victimization and both psychological and physical symptoms. Additional work was conducted to test if physical exercise played a moderating role in the mediation hypothesized above. Mediation and moderation were analyzed using PROCESS macro for SPSS. Results Regression analysis showed that both cyber victimization (β = − 0.102, p < 0.05) and Internet addiction (β = − 0.278, p < 0.05) significantly predicted psychological and physical symptoms and demographic variables were controlled. Further mediation analysis suggested that Internet addiction mediated the relationship between cyber victimization and psychological and physical symptoms. The 95% CI (confidence interval) of the direct effect was (− 4.283, − 1.696) and the indirect effect (− 1.904, − 0.820), respectively, excluding zero. Finally, moderation analysis indicated that physical exercise moderated the relationship between Internet addiction and psychological and physical symptoms (p = 0.047). Conclusions Internet addiction plays a mediating role in the association between cyber victimization and both psychological and physical symptoms, Thus, addressing Internet addiction among cyberbullying victims is worthwhile. Furthermore, physical exercise alleviates negative impacts on health and should thus be promoted.

Ovarian cancer is the one of the most deadly gynecologic malignancy among cancer related death in women. However, the treatment for ovarian cancer is still limited. In this study, we aimed to explore the inhibition potential of miR-377-3p in ovarian cancer and explore the mechanism of this effect. Quantitative real-time PCR was used to detect the mRNA or microRNA (miRNA) levels. CCK-8, wound-healing, transwell assay were used to detect cell proliferation, migration and invasion. The protein levels were examined by western blot. The dual luciferase reporter assay was conducted to examine the luciferase activity. Tumor volume was measured and Ki67 was detected via immunohistochemistry. qRT-PCR results showed that miR-377-3p was downregulated in ovarian cancer patients. MiR-377-3p mimics suppressed cell proliferation, migration, invasion and decreased the JAG1 level. However, miR-377-3p inhibitor promoted these appearances. Interestingly, we found JAG1 was a target gene of miR-377-3p. JAG1 overexpression reversed the miR-377-3p-induced inhibition of proliferation and invasion. In addition, miR-377-3p inhibited ovarian cancer tumorigenesis in vivo, indicating by decreased tumor volume and staining of Ki67. The results showed that miR-377-3p inhibited growth and invasion of ovarian cancer cells by targeting JAG1.

Existing diagnosis of the autism spectrum disorder (ASD) heavily depends on the informant’s evaluation of the patient’s behavior, which is both time consuming and labor demanding. In order to develop a rapid diagnostic tool with high accuracy, machine learning (ML) approaches have been proposed to explore the feasibility of identifying ASD with a limited number of features extracted from behavioral evaluation, neuroimaging and kinematic data. Though restricted and repetitive behavior (RRB) is one of the cardinal symptoms of ASD, no study has been conducted to investigate whether restricted kinematic features (RKF) could be used to identify ASD. The present study aimed to address this question. Twenty children with high functioning autism and twenty-three children with typical development (TD) were recruited. They were instructed to perform a motor task that required the execution of the utmost variant movement. Entropy and 95% range of the movement amplitude, velocity and acceleration were computed as indices of RKF. Five ML classifiers were trained and tested including support vector machine (SVM), Linear Discriminant Analysis (LDA), Decision tree (DT), Random forest (RF), and K nearest neighbor (KNN). Results showed that the KNN algorithm ( $k = 1$ ) yielded the highest classification accuracy with four kinematic features (accuracy: 88.37%, specificity: 91.3%, sensitivity: 85%, AUC: 0.8815). Our study demonstrated that RKF could help robustly identify ASD. It is inferred that the application of ML on genetic, neuroimaging, psychological and kinematic features might pose a considerable challenge to the current diagnostic criteria of ASD, and might potentially lead to an automated and objective diagnosis of ASD.

Interpersonal trauma in adolescent is an important public health concern. Depression can be a main consequence of interpersonal trauma, which subsequently results in various negative mental health outcomes. Previous research has investigated the independent effects of interpersonal trauma, interpersonal relationships and physical exercise on the risk of depression. However, the interaction effect of the three factors on depression remains unclear. We aim to investigate the associations between these potential factors and depression in adolescents, and explore the interaction effect of the three aforementioned factors. A cross-sectional study was conducted in Shenzhen, China, in 2017. A total of 1,883 adolescents from 11 middle schools and high schools were recruited. Demographic information, depressive symptoms, physical exercise, interpersonal relationships, interpersonal trauma, and academic record were collected through the use of standardized questionnaires. A linear regression model was performed to explore the association between these variables and depression. Pathway analysis was used to explore the role of potential mediators and moderators. The results showed that interpersonal trauma and poorer interpersonal relationships were significantly associated with depression (p < 0.05). We identified a mediating role of interpersonal relationships in the relationship between interpersonal trauma and depression, and a moderating role of physical exercise between interpersonal trauma and interpersonal relationships. This is the first study to examine the interaction effects of interpersonal trauma, interpersonal relationships and physical exercise on depression in adolescents. The current study therefore provides insights into factors which impact the mental health of adolescents. Through examining these factors one can gain further insight into potential factors associated with depression and therefore then develop more tailored interventions in order to support adolescents' mental well-being.

Background: Internet Addiction is a newly emerging issue for adolescents globally. Previous literature suggested a tangled relationship between Internet Addiction, depressive mood and lower subjective and objective ratings in Quality of Life. However, the independent relationship between Internet Addiction and Quality of Life was less discussed. Method: A cross-sectional study was conducted in Shenzhen adolescents to address the independent associations between Internet Addiction and 4 domains of Quality of Life (physical, psychological, social relation and environmental domains), in order to further guide the prevention and intervention for IA. Associations were calculated using linear regression models before and after the adjustment for the existence of depressive mood and confounding demographic factors. Result: The prevalence of Internet Addiction in Shenzhen was 23.2%. Engaging with Internet Addiction resulted in significant decrease in Quality of Life score in physical domain (B = -0.87, p

// Chuanwang Miao 1, 2, * , Shan Zhu 3, 4, * , Hong Pan 5 , Xiaolan Cao 1, 2 , Shuanghu Yuan 2 and Xudong Hu 2 1 School of Medicine and Life Sciences, University of Jinan-Shandong Academy of Medical Sciences, Jinan, Shandong Province, P.R. China 2 Department of Radiotherapy, Shandong Cancer Hospital Affiliated to Shandong University, Jinan, Shandong Province, P.R. China 3 Department of Head and Neck Radiotherapy, Shandong Provincial Hospital Affiliated to Shandong University, Jinan, Shandong Province, P.R. China 4 Department of Head and Neck Radiotherapy, Shandong Provincial Western Hospital, Jinan, Shandong Province, P.R. China 5 Central Sterile Supply Department, Shandong Cancer Hospital Affiliated to Shandong University, Jinan, Shandong Province, P.R. China * These authors have contributed equally to this work Correspondence to: Xudong Hu, email: drhuxudong@163.com Keywords: chemoradiotherapy (CRT), esophageal squamous cell carcinoma (ESCC), neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), hemoglobin (Hb) Received: June 21, 2017 Accepted: August 17, 2017 Published: September 27, 2017 ABSTRACT Systemic inflammation and hematological markers have prognostic value in patients with esophageal squamous cell carcinoma (ESCC). The objective of this study was to evaluate the neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), combined neutrophil-platelet (CNP) score, and hemoglobin (Hb) to inform treatment decisions and predict outcomes in patients with locally advanced ESCC treated with chemoradiotherapy (CRT). A total of 168 patients with locally advanced ESCC were retrospectively evaluated. Patients were stratified by marker value using a receiver operating characteristic curve analysis to determine the cutoff point. Logistic regression was used to identify markers associated with sensitivity to treatment. Overall survival (OS) was calculated by the Kaplan–Meier method. Multivariate Cox logistic regression modeling was used to assess the influences of OS. Smoking history, tumour site, clinical stage, NLR, PLR, CNP, and Hb ( p ≤ 0.05) were associated with the sensitivity to therapy. In multivariate analysis, a high CNP score was independently associated with poor treatment sensitivity (OR = 2.066, p = 0.021). Univariate analysis revealed that PLR, CNP, and Hb levels were associated with OS, and Cox multivariate analysis found that CNP (HR = 1.47, p = 0.027) and Hb level (HR = 0.44, p = 0.007) were independent predictors of OS. In conclusion, CNP and Hb are inexpensive and universally available prognostic markers in patients with locally advanced ESCC patients. CNP score is a systemic inflammatory marker that predicted sensitivity to CRT.

Restricted and repetitive behavior is one of the two cardinal symptoms of autism, and it might find its root in the neuropsychological trait of “insistence on sameness”. Conceived from the perspective of embodied psychology, our study aimed to investigate whether “restrictedness” might be embodied in the patient’s motor activity. Four patients with high functioning autism (ASD) and five participants of typical development (TD) aged between 6 and 13 years were recruited to perform a horizontal left–right movement with their dominant hand. Instructions were to perform as complex movement as possible by demonstrating variant amplitude and frequency. Entropy of movement amplitude, frequency, and velocity was calculated as indices of movement “restrictedness”. Results demonstrated that the velocity entropy was significantly lower in ASD than in TD (both p < 0.01), indicating a higher level of restrictedness in ASD’s movement. Given the fact that current evaluation of RRB is questionnaire-based, which might be biased by subjective factors of the evaluator, our finding sheds light on potential objective assessment of restrictedness in autism. A discussion on the comparison between our approach and recent method on automatic RRB pattern recognition was formulated.

Ginkgo biloba extract EGb 761 possesses a variety of biological effects and has been proved to be beneficial in Alzheimer's disease. This study aimed to explore the anti-inflammatory mechanisms of EGb 761 on the Aβ1-42-induced BV-2 microglial cells. We analyzed the production and gene expression of proinflammatory cytokines by enzyme-linked immunosorbent assay and qRT-PCR, examined phosphorylation of MAPKs by western blot and measured nuclear factor-κB nuclear translocation. Compared with Aβ1-42-treated group, EGb 761 inhibited release and gene expression of tumor necrosis factor-α and interleukin-1β, suppressed nuclear translocation of nuclear factor-κB and attenuated phosphorylation of p38 MAPK in a concentration-dependent manner, but not ERK and JNK. In summary, the results suggested that EGb 761 could attenuate Aβ1-42-induced neuroinflammatory response.

Background This study examined (a) the relationship that interpersonal problems and depression share with the intensity of mobile phone use and (b) their effects on suicide-related behaviors (SRBs) and self-harming behaviors among adolescents. Methods In this cross-sectional study, adolescents were recruited from 11 middle and high schools in Shenzhen, China. They completed self-reported measures that assessed mobile phone use, their history of SRBs (i.e., suicidal ideation, suicidal planning, and attempted suicide) and self-harming behaviors, depression, and interpersonal problems. Results Interpersonal problems and depression mediated the relationship between high-intensity mobile phone use and the risk for SRBs and self-harming behaviors among Chinese adolescents. Conclusions The findings delineate the pathways through which interpersonal problems and depression increase the risk for SRBs and self-harming behaviors among adolescents who report high-intensity mobile phone use. Future studies should develop interventions that alleviate interpersonal problems and depressive symptoms to reduce the risk for SRBs and self-harming behaviors among adolescents who report high-intensity mobile phone use.

A series of Cu-X (X = W, Mo, Nb, Cr, V, Al) films with similar Cu content (about 50 at.%) were prepared by dual-target co-deposition technique. By using this method, we found that the multilayered structure can be detected in Cu-W, Cu-Mo, Cu-Nb, Cu-V and Cu-Cr films, but not in Cu-Al films. Except for Cu-Al system, the multilayered structures are made up of Cu-rich and X-rich sublayers rather than conventional pure Cu and X layers. Based on our previous work, we further proved that the confocal targets, rotation of sample stage and the existence of diffusion barrier elements are the essential conditions for obtaining the multilayered structure within the films. The formation mechanism of the multilayered structure by co-deposition was discussed. Initially, the multilayered structure is formed by co-sputtering deposition with the sample stage rotation. And the multilayered structure can remain stable and become more prominent with the uphill diffusion of Cu in immiscible systems. However, in miscible systems, because of the interdiffusion and forming intermetallic compounds between Cu and X (such as Al), the initial multilayered structure can be interrupted and disordered. In addition, the morphology of multilayered structure formation also depends on the diffusion barrier abilities of the elements.

Objective: To extract the computed tomography (CT) imaging features of the primary lesions in patients with advanced esophageal squamous cell carcinoma (ESCC) and to study whether these imaging features can predict the short-term outcome after concurrent chemoradiotherapy (CCRT). Methods: From January 2014 to December 2015, a total of 49 patients with locally advanced ESCC who underwent CCRT were analyzed retrospectively. They were randomly categorized into the training and validation groups. Collection of CT imaging of patients before and intermediate stage undergoing radiotherapy. The correlations between imaging characteristics and short-term outcome were analyzed. The accuracy of cutoff value was verified by imaging characteristics of patients in validation group. Result: There were 38 patients in the training group and 11 patients in the validation group. 13 patients in the training group were classified as responders and 25 patients as nonresponders. According to the CT imaging before radiotherapy, there are no significant differences between responders and nonresponders. According to the CT imaging in the middle stage of radiotherapy, responders showed significantly higher Roundness than nonresponders ( P = .004, 95% confidence interval [CI] = 0.0419-0.212). The areas under the ROC curves for the ability to predict significantly tumor response were 0.768 for Roundness ( P = .001, 95% CI = 0.603-0.889). The cutoff value of Roundness is 0.3099. Roundness showed no significant associations with survival parameters. Conclusions: Computed tomography imaging in the middle stage of radiotherapy can predict the short-term outcome of concurrent chemoradiotherapy for patients with locally advanced ESCC but have no predictive effect on the total survival time.

Objective To analyze the mistakes in the application of tuina therapy in the rehabilitation of stroke, in order to elevate the clinical effects in the treatment of stroke by tuina.

To observe the effects of anti-inflammatory of kudiez (KDZ) injection on stroke patients as well as the biomarker changes compared with aspirin. 246 cases were randomized into two groups, aspirin and normal saline were administrated in control group (124 cases); KDZ injection and placebo were administrated in treatment group (122 cases), the national institute of health stroke scale (NIHSS) and serum biomarker (Hscrp/MMP-9/OX-LDL) changes were recorded in Day 1 and 14. The major three biomarkers of the patients declined significantly compared with Day 1 in the study; the PagT test results showed that the KDZ injection was not less than aspirin on anti-platelet aggregations in the study. Aspirin is effective in anti-platelet aggregation; the KDZ injection has the same effort as aspirin. The anti-inflammatory effort may be one of the mechanism of intervention, the platelet aggregation in the infarction process of acute stroke (de Jong et al., 2007). The KDZ injection is effective in preventing further deterioration of infarction through the anti-inflammatory effort in human beings. Key words: China Ixeris, kudiez (KDZ), stroke, inflammatory factors.

OBJECTIVE To study the effect and safety of Kudiezi injection on patients with acute ischemic stroke. METHOD Seven hundreds patients were divided into two groups by central randomization system. The study group, 346 cases, was treated with kudiezi injection plus traditional Chinese medicine (TCM) synthesis rehabilitation project, and the control group, 354 cases, was treated with synthetic rehabilitation project. The patients were treated for 10 to 21 days. Before treatment and at the 7th, 14th and 21th day of treatment, the indexes include NIHSS used for evaluating the neurological deficit degree and the motor function score (Fugl-Meyer) for evaluating motor function were observed. The safety index is defined by adverse observation event and laboratory test. The incidence of adverse events and laboratory tests results were observed before and after treatment at the same time. RESULT Application of generalized estimating equation model, we found that as the treatment time, NIHSS score and FMI score of the two groups showed a trend of improvement. And at the 14th days and 21th days of treatment, compared to the control group the treatment group showed significant statistical difference on the impact of NIHSS and FMI (P

OBJECTIVE To verify the efficacy and safety of post-marketed fleabane injection combined with Dengzhan Shengmai capsules in the treatment of ischemic stroke (IS). METHOD A multicentre, prospective, practical, randomized controlled study was carried out to compare the efficacy and safety of Dengzhan group (n = 343) and western medicine group (n = 335), appling "clinical study central stochastic system". The treatment of Dengzhan group is using fleabane injection in acute stage and Dengzhan Shengmai capsules in convalescence. The primary indexes of effect evaluation are the important outcome events in 360 days' follow-up, including mortality, recurrence, disability and quality of life to reflect the effect of clinical study. The indexes of safety evaluation involve laboratory examination results and incidence of adverse events. RESULT After 360 days' follow-up, 4 people died of IS in Dengzhan group, and the mortality rate of which is 1.17%, while 16 died in Western medicine group (WM group), and the mortality rate is 4.78%, suggesting that the mortality rate of Dengzhan group is significantly lower than WM group (P