Search

Non-small cell lung cancer (NSCLC) is a malignant cancer worldwide. Long non-coding RNAs (lncRNAs) have emerged as key players in the development and progression of NSCLC, and may be potential biomarkers of NSCLC. Here, we investigated the clinical significance of lncRNA oxidative stress responsive serine rich 1 antisense RNA 1 (OSER1-AS1) in peripheral blood of patients with NSCLC. OSER1-AS1 in peripheral blood of patients with lung squamous cell carcinoma (LUSC), lung adenocarcinoma (LUAD), and healthy subjects was detected, and the clinical diagnostic efficacy was analyzed. The correlation between OSER1-AS1 expression and clinicopathological features in patients with LUSC and LUAD was analyzed. The downstream mechanism of OSER1-AS1 was explored. The area under the ROC curve of lncRNA OSER1-AS1 and miR-1298-5p/CHSY3 in LUSC and LUAD was compared using the MedCalc analysis. OSER1-AS1 was low in peripheral blood of patients with LUSC and LUAD. The area under the ROC curve for predicting LUSC was 0.800. The area under the ROC curve for predicting LUAD was 0.728. In LUSC and LUAD, OSER1-AS1 deficiency was associated with tumor node metastasis stage, lymph node metastasis, distal metastasis, and poor prognosis. miR-1298-5p was highly expressed, while chondroitin sulfate synthase 3 (CHSY3) was lowly expressed in patients with LUSC and LUAD. miR-1298-5p had target relations with OSER1-AS1 and CHSY3. lncRNA OSER1-AS1 had a higher diagnostic value in patients with NSCLC than miR-1298-5p and CHSY3. Overall, low expression of OSER1-AS1 in peripheral blood of NSCLC patients has high clinical significance, which provides a certain reference value for NSCLC early diagnosis.

The yield stress of mud is the basis for analyzing the flow and desilting of debris flow. Nanyang expansive soil mud was used as experimental materials, and the rheological curves of mud with different solid volume concentrations were obtained by using the stress scanning rheological experiment of Antonpa mcr702 rheometer. For Nanyang expansive soil slurry with different solid volume concentration, the change process of shear stress with shear rate is analyzed. According to the experimental results, the rheological process of Nanyang expansive soil slurry is divided into three stages: stress growth, stress attenuation and stress stability. The slurry concentration has obvious influence on the dynamic and static shear stress of mud.

The stretchability and stretch-induced structural evolution of organic solar cells (OSCs) are pivotal for their collapsible, portable, and wearable applications, and they are mainly affected by the complex morphology of active layers. Herein, a highly ductile conjugated polymer P(NDI2OD-T2) was incorporated into the active layers of high-efficiency OSCs based on nonfullerene small molecule acceptors to simultaneously investigate the morphological, mechanical, and photovoltaic properties and structural evolution under stretching of ternary blend films with various acceptor contents. The structural robustness of the blend films was indicated by their stretch-induced structural evolution, which was monitored in real-time by a combination of in-situ wide/small angle X-ray scattering. We found that adding the soft P(NDI2OD-T2) can enhance the stretchability and structural robustness of ternary blend films by increasing entangled chains and tie chains to dissipate strain. Furthermore, the stretchability of the ternary blends can be superbly predicted by the three-dimensional equivalent box model. This work provides instructive insight and guidance for designing stretchable electronics and predicting the stretchability of multi-component blends. This article is protected by copyright. All rights reserved.

BackgroundThis study aimed to explore the level and changes in handgrip strength among preclinical Alzheimer’s disease (AD) and AD patients and to evaluate the association between handgrip strength and cognitive function.MethodsA total of 1431 participants from the memory clinic of Shanghai JiaoTong University Affiliated Sixth People’s Hospital and community were enrolled in the final analysis, including 596 AD, 288 mild cognitive impairment (MCI), and 547 normal individuals (NC). All participants received a comprehensive neuropsychological assessment. Mini-Mental State Examination (MMSE), Montreal Cognitive Assessment-Basic (MoCA-BC), and the Chinese version of Addenbrooke’s Cognitive Examination III (ACE-III-CV) were used as cognitive tests. The receiver operating characteristic curve (ROC) was plotted to assess the power of handgrip strength as a screening measure to discriminate AD and MCI.ResultsThe results showed that handgrip strength in the MCI group was significantly lower than that of NC group, and the AD group had a further decline (bothP ). Multivariate logistic regression was performed with the handgrip strength quartiles, and the results showed that the ORs of AD for increasing levels of handgrip strength were 1.00, 0.58 (0.46–0.78), 0.51 (0.36–0.73), and 0.50 (0.35–0.68), showing a decreasing trend (Pfor trend<0.01). The ROC curve demonstrated that the handgrip strength cutoff points for the identification of AD were 16.8 and 20.7 kg among the female participants above and under 70 yrs and 24.4 and 33.3 kg for the male participants above and under 70 yrs, respectively. Similarly, for the identification of MCI, cutoff points were 17.5 and 21.9 kg for females above 70 yrs and under 70 yrs, and 25.8 and 36.2 kg for males above 70 yrs and under 70 yrs, respectively.ConclusionsOur study provided the further knowledge on the relationship between noncognitive features and cognition in populations with differing cognitive status, revealed that the stronger handgrip strength was associated with better performances on cognitive function. It can be speculated that handgrip strength can help early recognition of Chinese AD patients.

BackgroundThis study aimed to explore the level and changes of handgrip strength in pre-clinical Alzheimer’s disease (AD) and AD participates, and to evaluate the association between handgrip strength and cognitive function.Methods1431 participants from the memory clinic of Shanghai JiaoTong University Affiliated Sixth People’s Hospital and community were enrolled into the final analysis, included 596 AD, 288 mild cognitive impairment (MCI), and 547 normal individuals (NC). All participants received a comprehensive neuropsychological assessment. Mini-mental state examination (MMSE), montreal cognitive assessment-Basic (MoCA-BC), and the Chinese version of the Addenbrooke’s cognitive examination (ACE-III-CV) were used as cognitive tests. The receiver operating characteristic curve (ROC) was plotted to assess the power of the handgrip strength as a screening measure to discriminate AD and MCI.ResultsThe results showed that participants with lower handgrip strength had lower MMSE, MoCA-BC, and ACE-III-CV scores (P ). Handgrip strength in the mild cognitive impairment (MCI) group was significantly lower than that of normal individuals (NC), and the AD group had a further decline (both P). Multivariate logistic regression was performed with the handgrip strength quartiles, the results showed ORs of AD for increasing levels of handgrip strength were 1.00, 0.58 (0.46–0.78), 0.51 (0.36–0.73), and 0.50 (0.35–0.68), showing a decreasing trend (Pfor trend < 0.001). The receiver operating characteristic curve demonstrated that the handgrip strength cut-off points for identification of AD were16.8 kg and 20.7 kg among the female participates above and under 70 yrs, 24.4 kg and 33.3 kg for the male participates above and under 70 yrs, respectively.ConclusionsStronger handgrip strength was associated with better performances on cognitive function, handgrip strength could be an early predictor of cognitive impairment in the Chinese population. The current study provides a foundation for non-cognitive features as early predictors of cognitive impairment, researches on the association between frailty and cognition will be further developed in the future.

Background and AimLow cardiac output syndrome (LCOS) is a serious postoperative complication, affecting the prognosis of patients underwent heart valve replacement (HVR). We aim to create a nomogram to predict LCOS after HVR in cardiac valvular disease patients.MethodsWe performed a retrospective review of 500 cardiac valvular disease patients underwent HVR from 2016 to 2020 in our department. Univariate analysis evaluated the associations between clinical/echocardiographic parameters and LCOS. Independent t-test or Mann–Whitney U‐test: for continuous variables. Fisher's exact test or χ2 test: for categorical variables. Variables with a P

Background Cerebral embolism after lobectomy is a life-threatening complication during the early postoperative period. However, it is unclear if cerebral embolism can develop after segmentectomy. Case presentation We experienced a case of a 37-year-old man who demonstrated early symptom of acute ischemic stroke in early postoperative period after right upper posterior segmentectomy and performed intra-arterial mechanical thrombectomy (IAMT) successfully. Conclusions Long and irregular pulmonary vein stump (PVS) and endothelial injury caused by surgical procedure may lead to cerebral embolism after segmentectomy. We believe that doing preoperative pulmonary vascular assessment and using appropriate surgical procedure may reduce the rate of cerebral embolism.

Background: Previous studies reported subjective cognitive decline (SCD) linked to underlying the biomarker of early AD pathology. There is a lack of studies on whether structural brain changes and how cerebral morphology in association with verbal and visuospatial episodic memory performance.Method: We combined VBM and SBM analysis for evaluating structural alterations in gray matter atrophy and cortical thickness among individuals with SCD, MCI, AD and normal controls and investigated the associations between cerebral morphology and AVLT-H, BVMT-R performance in the whole samples and SCD, respectively. Results: No significant regional gray matter volume atrophy and cortical thickness differences were found between SCD and normal controls. We found that immediate recall in verbal learning performance was significantly correlated with the loss of bilateral hippocampus volume in SCD group, furthermore, attention capacity (SDMT) was positively correlated with bilateral hippocampus atrophy and AVLT-IR in individuals with pre-MCI cognitive status.Conclusions: Our results found hippocampal atrophy links much closer with verbal memory than visuospatial memory and immediate recall in verbal learning test was probably the primary deficit and maybe influenced by the attention capacity.

To investigate the abnormal ground pressures and roof control problem in fully mechanized repeated mining of residual coal after room and pillar mining, the roof fracture structural model and mechanical model were developed using numerical simulation and theoretical analysis. The roof fracture characteristics of a repeated mining face were revealed and the ground pressure law and roof supporting conditions of the repeated mining face were obtained. The results indicate that when the repeated mining face passes the residual pillars, the sudden instability causes fracturing in the main roof above the old goaf and forms an extra-large rock block above the mining face. A relatively stable “Voussoir beam” structure is formed after the advance fracturing of the main roof. When the repeated mining face passes the old goaf, as the large rock block revolves and touches gangue, the rock block will break secondarily under overburden rock loads. An example calculation was performed involving an integrated mine in Shanxi province, results showed that minimum working resistance values of support determined to be reasonable were respectively 11,412 kN and 10,743 kN when repeated mining face passed through residual pillar and goaf. On-site ground pressure monitoring results indicated that the mechanical model and support resistance calculation were reasonable. Keywords: Residual coal after room and pillar mining, Repeated mining, Fully mechanized caving face, Roof control, Support resistance

Understanding the influence of water and temperature on the mechanical behaviors of coal measure rocks is important for deep coal resource exploitation. Using an electro-hydraulic servo-controlled testing system (MTS816) with a self-designed thermostatic water tank, a series of water absorption experiments and uniaxial compression experiments were performed on mudstone and sandstone samples that were immersed in water under different temperature conditions (from 25 to 95 °C). The water absorption characteristics at different temperatures and the effect of water and temperature on the mechanical strength, deformation and failure mode of the samples under uniaxial compression were systematically analyzed. In addition, computerized tomography (CT) scanning was used to examine the microstructural changes in the mudstone and sandstone before and after water saturation at different water temperatures. The results from the water absorption tests show that the water content of the mudstone and sandstone samples kept increasing with immersion time until a saturated state was reached, with the trend generally following an exponential law. The higher water temperature allowed additional water absorption in the saturated mudstone, but less water absorption in the saturated sandstone. The mechanical tests suggest that the presence of water can significantly reduce the mechanical properties of the coal measure rocks. Decreases in the uniaxial compressive strength (UCS) of 76.0 and 38.9 % and the elastic modulus of 68.1 and 48.5 % were observed in the mudstone and sandstone, respectively, because of water saturation at room temperature. Moreover, the water-weakening effect was sensitive to water temperature, and as the water temperature increased from 25 to 95 °C, the UCS and elastic modulus decreased linearly in the saturated mudstone by 53.8 and 70.4 %, respectively, and increased linearly in the saturated sandstone by 21.3 and 20.2 %, respectively. The increasing water temperature also promoted a transition in the saturated mudstone from brittle to ductile behavior, but it had a negligible effect on the failure mode of the saturated sandstone. The CT scanning tests demonstrated that new fractures are produced inside the mudstone after water saturation and that the increasing temperature can exacerbate such water-induced damage. However, no obvious fractures were observed in the CT images of the sandstone at room temperature or at high water temperatures, and the water-induced damage in the sandstone appeared as the micro-fractures at a scale below the CT resolution.

This paper investigates a novel anti-disturbance speed tracking control problem for permanent magnet synchronous motor (PMSM) systems with unknown mismatched disturbances. In order to realise the rejection and compensation for load torque, a cascaded PMSM system is constructed by using a coordinate transformation such that the load disturbances become matched with respect to the virtual control input. By combining disturbance observer with proportional-integral feedback control structure, a composite speed controller is proposed on this basis to ensure the PMSM system stability, and convergence of the tracking error of angular velocity to zero. The favourable observation performance for the load torque and its derivative can also be achieved simultaneously. Meanwhile, the [Formula: see text] performance index is used to further optimise the robustness of the PMSM system. Finally, the effectiveness of the proposed control scheme is verified by simulations for the PMSM system with monotonous disturbances and harmonic disturbances respectively.

In this study, a microscale visualization test system for rock fracture grouting was developed to perform in-situ, dynamic, and visual observational studies of the microscopic behaviour of grout particle filtration during grouting. A series of laboratory grouting tests of ordinary cement (OC) grout and microfine cement (MC) grout were carried out under various fracture aperture conditions using this testing system. The curves of the macroscopic grouting pressure and grout weight changes during grouting, as well as visual images of the microscopic filtration of the grout particles, were obtained. For a large fracture aperture, the grouting processes of both the OC and MC grouts can be divided into three stages, namely, the pressurization stage (stage I), the constant pressure stage (stage II), and the depressurization stage (stage III), whereas the grouting processes under the medium and small fracture aperture conditions consisted of only stages I and II. Almost no filtration of either the OC or MC grouts occurred at the fracture inlet under the large fracture aperture condition. By contrast, under the medium and small fracture aperture conditions, the OC and MC grout particles began to accumulate at the fracture inlet in the pressurization stage (stage I), rapidly forming a semi-circular arch-shaped filter cake and increasing in thickness. The filter cake formed by the OC grout was more stable than that formed by the MC grout. Quantitative measurement and analysis of the microscopic images of the grout particle filtration showed that the thicknesses of the filter cakes formed by the OC and MC grouts increased rapidly with time, and with an increase in the fracture aperture, the filter cakes formed by both grout types initiated later, and the rate of increase in the filter cake thickness gradually decreased. Finally, a new method for evaluating the penetrability and filtration characteristics (i.e., bmin and bcrit values) of grout based on microscopic images of grout particle filtration was proposed.

Die empirische Untersuchung konkretisiert, differenziert, erweitert bzw. modifiziert die theoriebasierten Vorannahmen aus Kapitel 3 - des didaktischen Konzeptes fur BNE (s. Kap. 5.1.3, 5.3.1) bzw. der ganzheitlichen Implementierungsstrategie fur BNE in Schulen (s. Kap. 5.4, 5.5.4 bis 5.5.6). Durch die Governance-Analyse wird besonders darauf aufmerksam gemacht, dass das aktuelle chinesische Schulsystem nicht mehr nur hierarchisch organisiert wird, sondern es wird durch verschiedene Koordinationsmechanismen und mit komplexen Formen der Handlungskoordination organisiert und verandert und kann als Mehrebenensystem bezeichnet werden (s. Kap. 5.5.3).

Das BNE-Konzept orientiert sich an dem von den Vereinten Nationen global propagierten politischen Leitbild einer nachhaltigen Entwicklung. Bildung wird dabei als ein wichtiges Instrument fur das Erreichen einer nachhaltigen Entwicklung gesehen. Hierbei ist die Konkretisierung von BNE kontextspezifisch.

Bezugnehmend auf die leitende Fragestellung, wie der Lehrer den Unterricht gestaltet, um Schulerpartizipation im Sinne von BNE zu fordern, und auf der Basis des ausgefuhrten Forschungsstands in Kapitel 2 werden die theoriebasierten Vorannahmen der BNE-Implementierung uber Schulerpartizipation im chinesischen Grundschulkontext in diesem Kapitel spezifiziert. Zuerst werden die drei Faktoren des ganzheitlichen Ansatzes der BNE-Implementierung des chinesischen UNE-SCO-BNE-Projekts (Shi 2004a; Shi 2009) genauer erklart (s. Kap. 3.1). Anschliesend werden die Elemente des didaktischen Konzeptes fur BNE in Anlehnung an das Konzept von Kunzli (2007) mit der Perspektive der Schulerpartizipation beschrieben (s. Kap. 3.2).

Durch die Kategorienbildung wurde das Material systematisiert und strukturiert. In diesem Kapitel werden die Ergebnisse der kategorienbasierten inhaltsanalytischen Auswertung dargestellt. In den Kapiteln 5.1 und 5.2 geht es um die fallbasierende Beschreibung der BNE-Implementierung der zwei Schulen. Anschliesend werden im Kapitel 5.3 die schulische und unterrichtliche BNE-Implementierung vor dem Hintergrund der theoretischen Vorannahmen zwischen den zwei Schulen und Lehrern miteinander verglichen.

The stabilization of roadways in soft rock under high stress has always been a major concern for deep underground coal mines. This paper describes a case study focusing on the stability of a soft-rock roadway in Yuandian coal mine in Anhui Province, China. The Beiyi main return roadway in this mine was primarily supported by U-steel support; however, considerable deformation and severe failures occurred. Therefore, a new support design, the yielding bolt - grouting support design, was proposed based on the physical and mechanical parameters, in situ stress measurements, and the failure characteristics of the roadway. The mechanics of the yielding bolt - grouting support was analysed and compared to the normal bolt - grouting support. A field experiment was conducted in a 100 m long section of the roadway. The monitoring results showed that compared with the old support, the new support design reduced the deformations of roof, floor, and rib by 41.4%, 56.1%, and 64.7% respectively, and the maximum deformation rate decreased from 15.12 mm/d to 9.28 mm/d. This case study indicates that the yielding bolt - grouting support design is an effective method to support roadways in soft rock under high stress.

During the operation of the electrified railway, the location of the train through the Neutral-Zone area will appear obvious electromagnetic disturbance phenomenon. In this paper, by analyzing the circuit structure of the Neutral-Zone, the circuit simulation model is constructed and the data of the disturbance voltage is obtained. The data is measured on the cable of the EMU and the simulation results are confirmed. At the same time, Through the construction of the analog discharge platform to study the phenomenon of off-line arc generated electromagnetic disturbance, get the real discharge data, get the real discharge data. Finally, through the electromagnetic simulation software, the arc net off-line equivalent antenna radiation simulation modeling, And the spectrum distribution of electromagnetic disturbance is analyzed.

A core-cladding-mode interferometer is fabricated by splicing a single-mode fiber to an endlessly single-mode photonic crystal fiber (ESM-PCF). The optimum collapsed length of ESM-PCF is investigated to ensure a higher order cladding mode of ESM-PCF to be excited, serving as a sensing beam. At the end of ESM-PCF, a spherical end-facet with big radius is proposed to ensure from where the higher order cladding mode is to be reflected and then it interferes with the core mode serving as a reference beam. Such a device has an enhanced refractive index sensitivity of ~ 199 nm/RIU, offering potentials in biological and chemical applications.

A magnetic sensor utilizing long-period fiber grating (LPFG) written by high frequency CO2 laser pulses in a D-shaped fiber and the magneto-optical effect of magnetic fluid is proposed. Because of the high evanescent field of the grating structure in D-shaped fiber, by immersing the LPFG with a period of 685 μm into a water-based magnetic fluid within a capillary tube, the redshift as high as 33.5 nm of the resonant wavelength of the grating is observed when the external magnetic-field intensity is 189.7 mT, resulting in a sensitivity of 176.4 pm/mT. The hysteresis effect is observed and explained by the characters of magnetic fluid. Such kind of sensors would find potential applications in magnetic sensing fields.

This paper discusses the fault diagnosis problem for a class of non-Gaussian stochastic processes with unknown fault. By using the spline function and T-S model simultaneously, the probability density function (PDF) control problem can be transformed into the control problem of T-S fuzzy weight dynamics. In this framework, an adaptive fuzzy filter based on output PDF is designed to estimate the size of system fault. Meanwhile, in order to solve the bounded problem of the fault, an adaptive projection algorithm is applied into adjust the estimated value for the fault. As a result, the satisfactory stability and fault diagnosis ability can be guaranteed by rigorous theoretical proof.

In this paper, a novel proportional-integral (PI) rotor position tracking controller-based linear matrix inequality (LMI) technique is designed for the permanent magnet synchronous motor (PMSM) system. Different from the results on structure control for PMSM, the PI-type gain parameters can be obtained by solving a series of LMIs instead of by manual debugging repeatedly. As a result, more control requirements for PMSM system including stability, position tracking, and robustness can be guaranteed based on systemic analysis method. Moreover, when considering the motor model without position sensor, a reduced-order Luenberger observer is constructed to estimate the rotor position.

This paper presented a case study of the failure mechanisms and support design for deep composite soft rock roadway in the Yangcheng Coal Mine of China. Many experiments and field tests were performed to reveal the failure mechanisms of the roadway. It was found that the surrounding rock of the roadway was HJS complex soft rock that was characterized by poor rock quality, widespread development of joint fissures, and an unstable creep property. The major horizontal stress, which was almost perpendicular to the roadway, was 1.59 times larger than the vertical stress. The weak surrounding rock and high tectonic stress were the main internal causes of roadway instabilities, and the inadequate support was the external cause. Based on the failure mechanism, a new support design was proposed that consisted of bolting, cable, metal mesh, shotcrete, and grouting. A field experiment using the new design was performed in a roadway section approximately 100 m long. Detailed deformation monitoring was conducted in the experimental roadway sections and sections of the previous roadway. The monitoring results showed that deformations of the roadway with the new support design were reduced by 85–90% compared with those of the old design. This successful case provides an important reference for similar soft rock roadway projects.