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Background Many breast cancer clinical trials with PARPi have been completed or are currently carried out, either by monotherapy or combined with chemotherapy. We aim to assess the efficacy and safety of PARPi in breast cancer patients as compared to chemotherapy. Methods A comprehensive literature search of PubMed, EMBASE, CENTRAL, conference meetings and clinical trial registry was performed. The primary outcomes were progression-free survival (PFS), overall survival (OS), overall response rate (ORR). The secondary outcome was safety profile. The comparative effects were measured using hazard ratio (HR) or relative risk (RR) with 95% confidence interval. Subgroup analyses were conducted based on types of intervention and baseline characteristics of patients. Results Six RCTs (n = 1953) were included. Two RCTs were recognized as high risk. PARPi was associated with an improved PFS (HR, 0.65; 95% CI, 0.56–0.74), OS (HR, 0.86; 95% CI, 0.73–1.01), and a higher ORR (RR, 1.38; 95% CI, 1.05–1.82). PARPi, however, significantly increased risk of grade 3–4 thrombocytopenia (RR, 1.63; 95% CI, 1.06–2.52). Monotherapy was observed with lower risk of disease progression and higher ORR rate than combination therapy, 0.56 to 0.65 and 2.21 to 1.05, respectively. For patients without prior platinum treatment, PARPi significantly improved PFS (HR, 0.64; 95% CI, 0.52–0.79). Conclusions PARPi was observed with a significantly improved efficacy in aspects of PFS and ORR, but also higher risk of grade 3–4 thrombocytopenia as compared to chemotherapy. PARPi was a better choice for patients who had not received previous platinum treatment., Highlights • PARPi showed improved efficacy in PFS and ORR. • PARPi presented higher risk of grade 3–4 thrombocytopenia. • PARPi is better for patients who had not received prior platinum treatment.

Based on the engineering education professional certification, this paper analyses the importance and particularity of the electrical basic course of building electrical and intelligent specialty, and puts forward some suggestions for the reform of the electrical basic course. Based on the certification of engineering education specialty, this paper analyses the importance and particularity of the electrical basic course of building electrical and intelligent specialty, and puts forward some suggestions for the reform of the electrical basic course. Suggestions include the establishment of electrics basic course group, the revision of teaching syllabus, the innovation and improvement of curriculum system, the renewal of teaching content, the transformation of teaching concepts, the improvement of teaching methods and means, the strengthening of practice, the improvement of students' practical ability and the improvement of assessment methods.

Quadrotor UAV is a kind of aircraft which is widely used in both military and civil fields. The research on its control method is a hot topic in current research. This paper presents an output feedback H control method based on parameter uncertainty. The feasible solutions of the controllers satisfying the performance requirements are obtained in the form of linear matrix inequalities (LMIs). This method can also suppress the interference of external environment when the parameters change, and the system also has good performance.

According to the complicated condition and special dynamic performance of the Ducted Fan UAV, a nonlinear multiple input and multiple output control method is designed. This method is based on the sliding mode adaptive theory. Introducing the integral term, this method can work without the derivative value of the tracked signal; even the derivative doesnt exist or cannot be got. The adaptive control can identify the uncertain parameters and external disturbance, and adjust the controllers parameters real-time. Using a low-pass filter can effectively inhibit the chattering phenomenon in sliding mode control system. The Ducted Fan UAV attitude is controlled by this method. The simulation results show that this method has strong robustness and good tracking performance.

This paper deals with the aerodynamic modeling of a small ducted fan UAV and the problem of attitude stabilization when the parameter of the vehicle is varied. The main aerodynamic model of the hovering flight UAV is first presented. Then, an attitude control is designed from a linearization of the dynamic model around the hovering flight, which is based on theH∞output feedback control theory withD-stability. Simulation results show that such method has good robustness to the attitude system. They can meet the requirements of attitude control and verify further the feasibility of such a control strategy.

This paper studies the robust fault-tolerant control problem of the linear uncertain system in actuator failures. Using linear matrix inequalities, a H-inf state feedback fault tolerant control method which can meet the regional pole constraints is proposed. This method has integrity to the actuator. It is applied to attitude control system of the ducted fan UAV. The simulation results shows that this method has good robustness for the ducted fan UAV's attitude control system when actuator is under the condition of performance degradation. Meanwhile closed-loop poles can be placed at a prescribed disk region.