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Neuroglioma is the most common primary malignant tumor in neurosurgery. Due to its short survival period and high patient mortality rate, neuroglioma is a major challenge in clinics. Elucidating the pathogenic mechanisms and associated molecular targets of neuroglioma can therefore benefit diagnosis and treatment of glioma. Previous studies have established the role of microRNA (miR)‑26b in various tumors, including breast cancer, lymphoma and glioma. Its function and mechanism in neuroglioma, however, remains to be elucidated. In the present study, in vitro cultured U87 glioma cells were randomly divided into miR‑26b mimic, miR‑26b inhibitor and respective control (NC) groups. MTT assay was performed to detect the effect of miR‑26b on cell proliferation, while a cell invasion assay detected its effects on cell invasion. Caspase‑3 activity was also quantified to test cell apoptosis, followed by reverse transcription-quantitative polymerase chain reaction and western blotting to detect the variation of Bcl‑2 expression under the effect of miR‑26b. miR‑26b mimics transfection upregulated its expression in U87 cells, which had significantly reduced Bcl‑2 mRNA and protein expression levels and higher casapse3 activity, and inhibited cell proliferation and invasion compared with the control group. The transfection of miR‑26b inhibitor, in contrast, facilitated U87 cell proliferation and invasion, inhibited caspase‑3 activity and elevated Bcl‑2 mRNA/protein expression. In conclusion, miR‑26 could facilitate apoptosis and inhibit proliferation/invasion of neuroglioma cells via downregulating Bcl‑2 expression and potentiating caspase-3 activity.

This study reported the synthesis of nanoscale zero-valent iron (nZVI) by rheological phase reaction method in the presence of sodium (CMC). The synthesized CMC coated nZVI (CMC-nZVI) was then characterized with x-ray diffraction (XRD) and transmission electron microscope (TEM) and was tested for the removal of chloroform from simulated groundwater. The investigated parameters in the uptake experiments included different adsorbents, initial concentrations of chloroform and different water flow. The results show that:(1) the prepared CMC-nZVI has good stability and dispersibility; (2) when the concentration of chloroform is 0.1 mg/L, the dosage of CMC-Fe0 is 0.01 g, the removal rate of chloroform is 91.2%;(3)The reaction follows the first-order kinetic reaction equation, and the apparent reaction rate constant increases with decreasing the concentration of chloroform.

An integrated Eulerian–Lagrangian method has been proposed to simulate liquid jet in supersonic flow. The carrier fluid surrounding the liquid droplets is described by multicomponent Navier–Stokes equations based on stationary (Eulerian) Cartesian grid, and the Lagrangian-discrete droplet method is employed to represent the behavior of atomized droplets in this work. A total of three classic breakup models, Taylor analogy breakup model, Reitz wave model, and Kelvin–Helmholtz/Rayleigh–Taylor hybrid model, are discussed under supersonic conditions, and model predictions are compared to experimental data through multiple perspectives quantitatively. More accurate predictions of liquid penetration, as well as droplet size distribution, can be achieved for specific conditions with Kelvin–Helmholtz/Rayleigh–Taylor hybrid model comparing to other breakup models. Additionally, a statistical injection model has been introduced to depict droplet dispersion in the near-nozzle region. The probability density function is utilized to predict the size and position of the injected droplet, and the four commonly used probability density functions, uniform, chi-squared, Nukiyama–Tanasawa, and Rosin–Rammler, are analyzed. The influence of statistical representation of injection condition is discussed. The simulation results indicate that the random components in the velocity and droplet size of the injected droplets have a significant impact on the structure of the liquid jet in high-speed flow.

Three types of wrappped nanoscale zero-valent iron (W-nZVI) with different coatings including agar, starch, and carboxyl methyl cellulose, were synthesized using a rheological phase reaction method. The structure and morphology of W-nZVI particles were characterized by scanning electron microscopy and transmission electron microscopy. Batch degradation experiments exhibited that W-nZVI dosage, initial trichloroethylene (TCE) concentration and solution pH had significant effects on TCE dechlorination. Experimental results proved that the highest dechlorination efficiency was obtained within 320 minutes for 10 mg/L of TCE at the optimal pH of 5.0 and W-nZVI dosage of 0.5 g/L. Kinetic study revealed that TCE dechlorination by W-nZVI in aqueous solution obeyed the quasi-first-order reaction kinetics. The product after the reaction could be easily separated by the permanent magnet for re-use.

A miniaturized spatial temperature gradient CE system with automated sample introduction for DNA mutation detection was established. Continuous electrokinetic sample injection was achieved by combining an automated slotted-vial array sample introduction device to the spatial temperature gradient CE system. The temperature gradient was produced by a radiative heating system with a single graphite block heater, and the stability of the temperature gradient was investigated. The temperature variation of each measure point was 0.12-0.21% RSD (n = 7) within 6 h. A 14-cm Teflon AF-coated silica capillary was used both as the separation channel and as the liquid-core waveguide tube of fluorescence signal. Under a temperature gradient from 54.8 to 59.5°C, a low range control mutation standard (209 bp) was separated within 4 min with only 5.6 nL sample consumption. Automated continuous sample introducing and changing were realized with a carryover of 3.3%. Utility of the system was further demonstrated by detecting K-ras gene mutations in paraffin tissue sections from two colorectal cancer patients.

The interaction effect between jet and control surface in supersonic and hypersonic flow is one of the key problems for advanced flight control system. The flow properties of exhaust jet secondary combustion in a hypersonic compression ramp flow field were studied numerically by solving the Navier–Stokes equations with multi-species and combustion reaction effects. The analysis was focused on the flow field structure and the force amplification factor under different jet conditions. Numerical results show that a series of different secondary combustion makes the flow field structure change regularly, and the temperature increases rapidly near the jet exit.

A numerical method of aerodynamic heating with material thermal ablation effects for hypersonic half-sphere is presented. A surface material ablation model is provided to analyze the ablation effects on aero-thermal properties and structural heat conduction for thermal protection system (TPS) of hypersonic vehicles. To demonstrate its capability, applications for thermal analysis of hypersonic vehicles using carbonaceous ceramic ablators are performed and discussed. The numerical results show the high efficiency and validation of the method developed in thermal characteristics analysis of hypersonic aerodynamic heating.

A novel extrusion driving protocol was developed based on micro-fabricated polydimethylsiloxane (PDMS) pneumatic valves. High efficiency liquid transfer was performed by using entirely overlapping control channels and fluid channels. A 0.5-s time is sufficient for the transfer of 9 μL sample solution between two chambers in the microchip with a nitrogen pressure of 70 kPa. The driving method was used in a microfluidic polymerase chain reaction (PCR) system, and rapid cycling of the PCR mixture in a closed loop was achieved. The amplification of DNA was demonstrated via both three-stage and two-stage PCR thermal cycling on the microchips resulting in significant reduction of the PCR time. The amplifications of 144-bp and 200-bp DNA fragments were achieved within 24 min using a three-stage protocol with 30 thermal cycles, and 130-bp DNA fragments within 12 min by using 20 thermal cycles in the two-stage system, compared to about 2 h in benchtop PCR with the same number of thermal cycles.

An improved automated continuous sample introduction system for microfluidic capillary electrophoresis (CE) is described. A sample plate was designed into gear-shaped and was fixed onto the shaft of a step motor. Twenty slotted reservoirs for containing samples and working electrolytes were fabricated on the "gear tooth" of the plate. A single 7.5-cm long Teflon AF-coated silica capillary serves as separation channel, sampling probe, as well as liquid-core waveguide (LCW) for light transmission. Platinum layer deposited on the capillary tip serves as the electrode. Automated continuous sample introduction was achieved by scanning the capillary tip through the slots of reservoirs. The sample was introduced into capillary and separated immediately in the capillary with only about 2-nL gross sample consumption. The laser-induced fluorescence (LIF) method with LCW technique was used for detecting fluorescein isothiocyanate (FITC)-labeled amino acids. With electric-field strength of 320 V/cm for injection and separation, and 1.0-s sample injection time, a mixture of FITC-labeled arginine and leucine was separated with a throughput of 60/h and a carryover of 2.7%.

The mechanism of stress generation and propagation by detonation loading in five separate independent advance of ore breaking patterns is discussed in the paper. An elastic numerical model was developed using ANSYS/LS-DYNA 3D Nonlinear Dynamic Finite Element Software. In this package ANSYS is the preprocessor and LS-DYNA is the postprocessor. Numerical models in the paper to actual were 1:10 and the element mesh was dissected in scanning mode utilizing the symmetry characteristics of the numerical model. Five different advance rates were studied. Parameters, such as the time required to maximum stress, the action time of the available stress, the maximum velocity of the nodes, the stress penetration time, the magnitude of the stress peak and the time duration for high stress were numerically simulated. The 2.2 m advance appeared optimum from an analysis of the simulation results. The results from numerical simulation have been validated by tests with physical models.

A theoretical study of the response of hole mobility and thermal velocity, both relevant for short channel devices, to [110] uniaxial stress in Si up to 4 GPa of both tension and compression has been conducted. The strained-Si bandstructure was calculated using the kmiddotp method. Effective masses, thermal velocities, and scattering rates were calculated from the bandstructure as a function of stress. Mobilities were then calculated via full band Monte Carlo simulations. Calculated mobilities match experimental and theoretical data from prior work addressing lower degrees of stress. Large increases in both carrier thermal velocities and mobilities were found. In the high-stress regime between 1 and 2 GPa, mobilities exhibit a strong superlinear dependence, and compressive stress becomes more favorable for increasing both mobilities and thermal velocities in pMOS. Improvements in both thermal velocity and mobility finally only begin to rolloff toward apparent saturation as we push the stress toward 4 GPa in these simulations

The coated nanoscale zero-valent iron (coated CMC-Fe0) was synthesized with cheap and environment friendly CMC as the coating agent using rheological phase reaction. The sample was characterized by means of XRD, SEM, TEM and N2 adsorption-stripping and used to study reductive dechlorination of TCE. The experimental results indicated that the removal rate of TCE was about 100% when the CMC-Fe0 dosage was 6 g x L(-1), the initial TCE concentration was 5 mg x L(-1) and the reaction time was 40 h. The TCE degradation reaction of coated CMC-Fe0 followed a pseudo-first-order kinetic model. Finally, the product could be simply recovered.

In this paper, we perform fullband Monte Carlo simulations of nanoscale strained Ge bulk pMOSFETs with compressive strain in the strained Ge layer. We consider transport in the presence of phonon, ionized impurity, surface roughness scattering and impact ionization. Quantum confinement in the inversion layer is taken into account in the form of a modified potential. Strained Gedevices gave higher drive current when compared with unstrained Ge devices for the device structures studied.

In this work we perform full-band Monte Carlo simulations of nanoscale Ge bulk PMOSFETs with ultrathin ( κ dielectrics and investigate the importance of remote Coulomb and remote surface roughness scattering in these devices. In addition to these remote scattering mechanisms, transport is considered in the presence of phonon, ionized impurity, surface roughness scattering and impact ionization. Quantum confinement in the inversion layer is taken into account in the form of a modified potential. We show that the experimentally observed data on the dependence of mobility on the thickness of the high- κ dielectric can be accurately modeled via scattering by remote surface roughness at the gate-dielectric interface and remote Coulomb scattering due to fixed charges in the dielectric. The parameters in the remote scattering mechanisms are fitted by matching Monte Carlo data with those obtained from experiments on the dependence of mobility on the thickness of the dielectric. For a gate overdrive, ( V g − V t ), of 1.0 V, remote scattering mechanisms seem to decrease the saturation current by as much as 15% in these devices. We also show that at the high vertical fields (∼1 MV/cm) in these experimental devices, remote scattering mechanisms can substantially reduce the mobility for oxide thicknesses below 5 nm.

In this paper, we perform fullband Monte Carlo simulations of Ge bulk nand pMOSFETs and compare them with their Si counterparts. We consider transport in the presence of phonon, ionized impurity, surface roughness scattering, and impact ionization. Quantum confinement in the inversion layer is taken into account in the form of a modified potential. Germanium devices gave higher drive current when compared with Si devices for the device structures studied. Consistent with the arguments of Lundstrom, the performance enhancement of Ge MOSFETs lies between that which would be expected based on the higher mobility alone, and the much smaller advantage, if any, offered in the ballistic limit where transport is governed by thermal injection velocities from the source.

A new two-dimensional full-band Monte Carlo simulator, "Monte Carlo University of Texas" (MCUT) is introduced and described in this paper. MCUT combines some of the best features of semiclassical MC device simulation including full-band structure and flexibility of scattering processes, with generality of material composition and the ability to address degeneracy breaking among energy valleys and the associated effects on scattering and transport due to quantum confinement and strain effects. The latter capability derives from extension of a prior crystal-momentum-independent self-consistent Poisson-Schro/spl uml/dinger-based quantum corrected potential, to a valley dependent quantum correction via, in part, a new modeling concept of "effective strain" within the full-band structure code. Low field mobility simulation results for large tensile strained-Si channel nMOSFETs and unstrained-Si channel nMOSFETs device are compared with other simulation methods and experimental data to demonstrate the effectiveness of the approach, and the abilities to simulate high-field transport and transport in devices of a few 10s of nanometer channel lengths are briefly demonstrated.

We discuss the continuous variable entanglement swapping using the Wigner function. The sufficient inseparability criterion for continuous variable systems is used to analyse the quantum correlation. Perfect teleportation can be obtained by increasing the degree of squeezing on the entanglement source. Entanglement swapping occurs for any nonzero squeezing in both of the two initial sources if optimal gain is obtained.

We propose a scheme to generate three-particle entangled state from sources of nonmaximally entangled pure states.

In this paper we present a non-destructive Bell discrimination scheme on photons maximally entangled in polarization with the help of a nonlinear device, a Fock filter. Moreover, the scheme is generalized to 2n-partite Greenberger-Horne-Zeilinger bases.

Volume compensation (VC) achieved in (Lu, Nd):YAl3(BO3)4 (YAB) crystal codoped with Lu3+ and Nd3+ ions is described. The lattice parameters, spectral properties and laser performances of the VC (Lu, Nd):YAB and single-doped Nd:YAB (NYAB) crystals are measured and compared. The results indicate that the laser performances of NYAB crystal can be greatly improved by the VC doping.

To investigate the influential factors and establish culture method for G. uralensis callus.To study the possible effective factors of culture condition by comparing with different explants, light, plant hormones and its ratio.The hypocotyl was the best among different explants, its inducing ratios was 94%, and the callus occurred earliest. When the calluses were inoculated on MS + 6 - BA (1.0-2.0) mg/L + NAA (0.5-1.0) mg/L, adventitious buds formed. 2,4-D could induce non-embryogenic callus, the compounding proportions of 6 - BA and NAA could induce embryogenic callus. Light influenced induction and growth of callus.Different explants, components of hormone and light are the influencial factors of callus induction and growth of G. uralensis.

An automated nanoliter sample introduction system was combined to a liquid-core waveguide (LCW)-based microfluidic CE system for high-throughput analysis of DNA fragments. The main component of the sample introduction system was a motor-driven plate, on which a circular array of bottom-slotted vials containing sample/buffer solutions was placed. A 7 cm-long LCW capillary served as both the sample probe and separation channel. The inlet terminal of the capillary could pass through the slots of the vials for electrokinetic sample introduction, and the capillary outlet was immersed in the solution of a reservoir, behind which a PMT facing directly to the outlet was positioned. A diode laser was used as excitation source for LCW LIF detection. Performance of the system was demonstrated through the separation of DNA fragments. Baseline separation was achieved for all 11 fragments of PhiX174-HaeIII digest DNA with a throughput of 33/h. Theoretical plate number for 603 bp fragment was 7.3x10(6)/m, corresponding to a plate height 0.14 microm. The detection limitation for 603 bp fragment was 0.4 ng/microL with a precision of 2.2% RSD for the peak height. Automated sample changing and introduction were achieved with only 0.3 nL gross sample consumption for each cycle.

Retention elements were added in the removable reverse headgear appliances in order to achieve better treatment effects of skeletal Class III malocclusion.Eighteen patients who needed treatments with reverse headgear appliances were randomly and equally divided into two groups with traditional type of retention elements (T group) and modified type of retention elements (M group) respectively. For the modified type appliances, an adams clasp was added in the position of central incisors on the basis of the traditional type. The minimum dislocating force for both types was measured with the same forcemeter in the first and second visit, respectively. The occurrence of dislocation caused by traction was recorded during the visits of the first three months.The M group showed significantly greater retention than the T group. The minimum dislocating force for M group was larger in the first and second visit (P0.01, P0.001). Furthermore, during the first three months, two times of dislocation occurred in M group while it was nine times for T group, indicating great difference in retention (P0.05).Adding an adams clasp in the position of upper central incisors could effectively prevent the downward dislocation of the appliance when traction force was applied. Accordingly, the therapeutic efficacy was greatly improved.

To demonstrate the vasodilatation activity of the coumarin-containing Angelica dahurica var. formosana and to further analyze active components in the herb extracts.(1) The vasodilatation effects induced by different extracts (cyclohexane, ethyl acetate, acetone, methanol, 95 % ethanol and water) of Angelica dahurica var. formosana on mouse thoracic aorta pre-contracted with phenylephrine were investigated. (2) The amount of imperatorin and isoimperatorin in each extract was measured by high-performance liquid chromatography. (3) The vasodilatation effects of imperatorin and isoimperatorin on mouse thoracic aorta were compared using the same in vitro method. (4) The vasodilatation mechanism of imperatorin in the mouse thoracic aorta pre-contracted with phenylephrine was studied using the methods of denuded endothelium, NG-nitro-L-arginine methylester (L-NAME, a nitric oxide synthase inhibitor), and propranolol.(1) The cyclohexane and ethyl acetate extracts of Angelica dahurica var. formosana decreased the maximal response of phenylephrine-induced mouse thoracic aorta contraction dose-dependently, with 50% inhibiting concentration (IC(50)) values of 35.3+/-12.4 mg/L and 40.5+/-12.0 mg/L, respectively. The vasodilatation effect of imperatorin and isoimperatorin was dose-dependent. (2) The cyclohexane extract, showing the strongest vasodilatation effect, possessed the highest contents of imperatorin (4.09%) and isoimperatorin (0.27%, w/w). There was a correlation between the vasodilatation activity and the contents of imperatorin and isoimperatorin in the extracts. (3) The vasodilatation effect of imperatorin was about 4-fold stronger than that of isoimperatorin. (4) The vasodilatation effect of imperatorin was signifificantly attenuated to 24.88%+/-4.06% in the denuded endothelium group compared with the intact endothelium group. And 1 mmol/L L-NAME reduced the imperatorin-induced vasorelaxation by 32.18 %+/-11.29 %.The principal effective component of Angelica dahurica var. Formosana was found to be imperatorin. Imperatorin-induced vasodilatation is at least partially regulated by nitric oxide, and has no correlation to beta-receptor.

A technique for temperature control and measurement in microfluidic systems was developed. The technique is easy to be implemented in an analytical lab and the experimental setup is relatively simple and inexpensive. The parts for temperature measurement include a CCD camera, a fluorescence microscope and an image acquisition card. The spatial distribution and the temporal variation of temperature in microfluids were measured. The method is non-invasive and the spatial and temporal resolutions were 0. 8 microm and 40 ms, respectively a thermal control device was built using indium-tin-oxide (ITO) coated glass as heater, taking advantage of its transparent quality. The temperature could be controlled with a precision of +/-0.1 degrees C. The image processing procedure was optimized and the efficacy of the method was demonstrated.

In this work we perform full-band Monte Carlo simulations of nanoscale Ge bulk PMOSFETs with ultrathin (

A miniaturized CE system has been developed for fast DNA separations with sensitive fluorimetric detection using a rectangle type light-emitting diode (LED). High sensitivity was achieved by combining liquid-core waveguide (LCW) and lock-in amplification techniques. A Teflon AF-coated silica capillary on a compact 6x3 cm baseplate served as both the separation channel for CE separation and as an LCW for light transmission of fluorescence emission to the detector. An electronically modulated LED illuminated transversely through a 0.2 mm aperture, the detection point on the LCW capillary without focusing, and fluorescence light was transmitted to the capillary outlet. To simplify the optics and enhance collection of light from the capillary outlet, an outlet reservoir was designed, with a light transmission window, positioned directly in front of a photomultiplier tube (PMT), separated only by a high pass filter. Automated sample introduction was achieved using a sequential injection system through a split-flow interface that allowed effective release of gas bubbles. In the separation of a phiX174 HaeIII DNA digest sample, using ethidium bromide as labeling dye, all 11 fragments of the sample were effectively resolved in 400 s, with an S/N ratio comparable to that of a CE system with more sophisticated LIF.

A reflective flow cell was developed and coupled to a sequential injection system and optical fiber photometric detection system based on emitting diode light source. A multistrand bifurcated optical fiber was coupled with incident light, detector and flow cell. Optical fibers were used to carry light from the electronics unit to a reflective flow-through cell and back. The liquid flow path through the cell is linear with a large exit aperture such that bubbles are not trapped in the optical path. The optical arrangement is such that the incident light crosses the liquid flow orthogonally and is reflected back to the receiver fiber. This arrangement reduces the reflective index sensitivity by an order of magnitude relative to a conventional flow cell. The cell showed good immunity to refractive index and air bubble effects. The chromogenic reaction of chloride ion with mercury thiocyanate-iron(III) was used as a model reaction to optimize the experiment system and check the optical system. The reflectance of the reaction was monitored with blue emitting diode. The linear range was 0-100 mg x L(-1) Cl-. A detection limit (3sigma) of 1.2 mg x L(-1), precision of 1.5% (n = 11), and a throughput of 30 samples per hour were achieved.

As device dimensions are being scaled to their ultimate limits, channel mobility engineering seems to offer one of the best prospects of improved performance of metal oxide semiconductor field effect transistors (MOSFETs). In fact, new materials, such as Ge, with higher effective mobilities of electrons (2times) and holes (4times) than in Si are already being explored to increase the drive currents in MOSFETs. In addition, by straining the Ge channels, it is possible to further increase the mobilities of the holes. However, how this advantage in mobility translates to improved drive current in the short-channel length MOSFETs is not completely clear. For example, in the ballistic limit, it is thermal velocity that matters (Lundstrom, 1997) and these are comparable for Si and Ge. Although, there have been reports from some experimental and theoretical (in the ballistic limit) studies of the mobility and drive current enhancements of unstrained and strained Ge channel MOSFETs over Si MOSFETs, no Monte Carlo simulation taking into account full band structure, scattering, non local field effects, etc., has so far been been performed. The aim of this work was to perform a full band Monte Carlo simulation study of unstrained Ge bulk N- and P- MOSFETs and strained Ge bulk PMOSFETs and compare with their Si counterparts. Since biaxial strain along the (100) plane in Ge does not break the degeneracy of the conduction band L valleys of Ge, we have not considered strained Ge NMOSFETs

In order to fully understand hepatitis c virus (HCV) genotype 3b, 1a, 2b and 6a infection in China, We built HCV 5'-noncoding region (5'-NCR) of different genotypes and subtypes.The classification HCV into variable genotypes (subtypes) was carried on by programs A, B and C A. Using a combination of three restriction endonuclease BHH' (BsrB I, Hae II, Hinf I) digestions at the same time. The distinct genotypes were classified into 5 groups: genotype 1 (1a, 1b), 6a, 2 (2a, 2b), genotype 3 (3a, 3b), genotype4 (4a). B. With regard to genotype 1, we could distinguish subtype 1a from 1b using BstU I digestion. C. Using restriction endonuclease Hae III, genotype 2a, 2b, 3b, 4a, 6a are differentiated respectively.(1) HCV genotype 1a, 1b, 2a, 2b, 3a, 3b, 4a, 6a are fully discriminated by comparison with the genotypes regular samples. (2) Of the 93 patients, HCV genotype distribution in China was 66.67% for 1b, 18.28% for 2a, 3.23% for 1b/2b, 3b, 2b respectively. 2.15% for 2a/2b, 1b/2a respectively. 1.08% for 1a.This research indicated that adoption of HCV 5'-NCR A B C restriction endonuclease digestions techniques, might be sensitive and efficient to detect HCV and discriminate HCV genotype (subtypes) 1a to 6a.

To compare the therapeutic effect and indication between standard large trauma craniotomy and routine craniotomy.There were 97 patients in the standard large trauma craniotomy group and 110 patients in the routine craniotomy group. The mortality, postoperative ICP (intracranial pressure), ratio of pupil rebound, complication and results of six month follow-up after operation were compared between the two groups.Fifteen patients (15.6%) died in the standard large trauma craniotomy group and 30 (27.7%) in the routine craniotomy group. The postoperative mean ICP was 3.75 kPa+/-1.89 kPa in the standard large trauma craniotomy group and 5.11 kPa+/-1.57 kPa in the routine craniotomy group. The pupil rebound was found in 47 patients (61.0%) in the standard large trauma craniotomy group and in 41 patients (46.1%) in the routine craniotomy group (P0.01). The rate of complication was lower in the standard large trauma craniotomy group, but no obvious difference in long-term therapeutic effect was found between the two groups.Standard large trauma craniotomy can attenuate brain hernia and the mortality of the patients with acute subdural hematoma. The incidence of complication can also be decreased. But the long term life quality of the patients can not be improved.

Using the previously shared Einstein-Podolsky-Rosen pairs, a proposal which can be used to distribute a quantum key and identify the user's identification simultaneously is presented. In this scheme, two local unitary operations and the Bell state measurement are used. Combined with quantum memories, a cryptographic network is proposed. One advantage is no classical communication is needed, which make the scheme more secure. The secure analysis of this scheme is shown., Revtex, 9 pages, no figure, accepted for publication by Phys. Lett. A