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BACKGROUND: Long non-coding RNA (LncRNA) TUG1 plays a critical role in the development of human cancers. This study explored whether TUG1 is involved in the cytotoxicity of dendritic cells and cytokine-induced killer cells (DCs-CIK), an immunotherapy approach, in neuroblastoma. METHODS: A TUG1 expression plasmid was transfected into DCs. Neuroblastoma SK-N-SH cells were incubated with CIK cells, DCs-CIK cells, and TUG1-overexpressing DCs-CIK cells, with or without irradiation. SK-N-SH cell viability, colony formation, migration, and apoptosis were analyzed using CCK-8, colony formation assay, transwell assay, and flow cytometry, respectively. Production of IL-12, IL-2 and IFN-γ in the supernatants was determined using ELISA. A dual luciferase activity assay was performed to confirm the molecular interactions between TUG1 and miR-204. Tumor-bearing mice were established by injection of SK-N-SH cells followed by stimulation with CIK cells, DC-CIK cells, and TUG1-overexpressing DCs-CIK cells. RESULTS: Compared to CIK alone or DC-CIK therapy, overexpression of TUG1 significantly suppressed tumor cell proliferation, colony formation, and migration of neuroblastoma cells. Moreover, upregulation of TUG1 robustly induced apoptosis and altered key molecules associated with apoptosis and epithelial-mesenchymal transition. Contents of IL-12, IL-2 and IFN-γ were dramatically elevated in the supernatants in the coculturing system upon transfection with TUG1. In addition, TUG1 was found to be act as miR-204 sponge. Furthermore, in vivo experiments demonstrated that upregulation of TUG1 potentiated the antitumor activity of DC-CIK immunotherapy. CONCLUSION: Overexpression of TUG1 promotes DC maturation and enhances CIK cytotoxicity, suggesting that TUG1 may be a novel target for enhancing DC-CIK based immunotherapy for neuroblastoma.

The synergic coordination of trz, en, and PW9 resulted in a {Ni30} cluster substituted POM, [Ni(trz)3]2@[Ni30(H2O)16]POM, that was discovered as the SBU of four frameworks which served as heterogeneous catalysts for HERs.

A simple and effective method to reduce the lifetime of a thermally activated delayed fluorescence material with a factor of over three orders of magnitude.

Despite their scarcity due to synthetic challenges, supertetrahedron-based metal–organic frameworks (MOFs) possess intriguing architectures, diverse functionalities, and superb properties that make them in-demand materials. Employing a new window-space-directed assembly strategy, a family of mesoporous zeolitic MOFs have been constructed herein from corner-shared supertetrahedra based on homometallic or heterometallic trimers [M3(OH/O)(COO)6] (M3 = Co3, Ni3 or Co2Ti). These MOFs consisted of close-packed truncated octahedral cages possessing a sodalite topology and large β-cavity mesoporous cages (∼22 Å diameter) connected by ultramicroporous apertures (∼5.6 Å diameter). Notably, the supertetrahedron-based sodalite topology MOF combined with the Co2Ti trimer exhibited high thermal and chemical stability as well as the ability to efficiently separate acetylene (C2H2) from carbon dioxide (CO2)., A series of supertetrahedron (ST)-based sodalite (sod)-topology zeolitic MOFs specimens ST-sod-MOFs featuring ultramicroporous square windows and a mesoporous sodcage have been synthesized via a window-space-directed assembly approach.

Porous transition metal hydroxide (M(OH)2, M = Ni or Co) nanosheet/Ni foam electrodes were prepared by a facile electrodeposition method. The catalytic activities of the as-prepared porous electrodes for the electrooxidation of benzyl alcohol were investigated in NaOH aqueous solution. It was found that the Ni(OH)2 nanosheet/Ni foam electrode exhibited a superior current density to the obtained Co(OH)2 nanosheet/Ni foam electrode for the electrooxidation of benzyl alcohol, in which the Ni(OH)2 nanosheet electrode required an extremely low potential of ∼1.33 V vs. RHE to achieve a current density of 100 mA cm−2. The results of the durability test revealed that it exhibited an outstanding stability for the electrooxidation of benzyl alcohol. Moreover, the electrooxidation of benzyl alcohol for the green synthesis of benzoic acid with the simultaneous generation of hydrogen could be easily implemented in a two-electrode configuration by using noble-metal-free catalysts. When benzyl alcohol was fully oxidized, the optimized selectivity of benzoic acid and the faradaic efficiency for the electrooxidation of BnOH could reach 96% and 95%, respectively.

Alkaline water electrolysis can be a feasible choice for large-scale hydrogen production using noble-metal-free electrocatalysts. A bipolar membrane-based decoupled electrolysis system is construct...

A RuO2–TiO2/Ti electrode modified with LaCoO3 was successfully fabricated by thermal decomposition and its electrochemical properties were evaluated by cyclic voltammetry (CV), electrochemical impedance spectroscopy (EIS), and stability tests. In contrast with an unmodified RuO2–TiO2/Ti electrode, the LaCoO3–RuO2–TiO2/Ti electrode displays a more uniform layer with smaller microparticles. This electrode also displays higher OER performance with lower overpotential (289 mV vs. 348 mV) at a current density of 10 mA cm−2 and lower Tafel slope (87 mV dec−1 vs. 104 mV dec−1) than the unmodified RuO2–TiO2/Ti electrode. The modified LaCoO3–RuO2–TiO2/Ti electrode possesses larger current density, higher specific voltammetric charge, and lower charge transfer resistance (Rct) than the unmodified RuO2–TiO2/Ti electrode does in a KOH solution, according to CV and EIS studies. The LaCoO3–RuO2–TiO2/Ti electrode is very stable. The results show that the modified LaCoO3–RuO2–TiO2/Ti electrode presents higher electrocatalytic activity and good stability for OER.

Strong-field phenomena in solids exhibit extreme high-order nonlinear optical effects, which have triggered many theoretical and experimental investigations. However, there is still a lack of highly efficient numerical tools to simulate the relevant phenomena. In this paper, a versatile multiscale numerical tool set is developed for studying high-order nonlinear optical effects in solids, generated by ultrafast strong laser pulses. This tool is based on the tight-binding model approximation of the crystal structure, the related parameters of which are obtained from the density functional theory calculations. And the nonlinear effects are explored by solving the Maxwell equations coupled with the semiconductor Bloch equations. Our numerical tool can provide not only basic electronic structures and optical responses of the crystal, but also the real-time evolution of the macroscopic electromagnetic fields and the current density. The high-performance parallel computing and the interpolation method in our tool make it possible to study the strong-field nonlinear responses and propagation effects on a large spatial and temporal scale. Finally, three theoretical or experimental results published recently are satisfactorily reproduced, showing a good performance of the current toolbox.

BackgroundMyeloperoxidase (MPO) and global registry of acute coronary events (GRACE) risk scores were independently used to predict adverse outcomes in patients with acute coronary syndrome (ACS). However, the relationship between MPO level and GRACE score, and whether the combination of MPO and GRACE can better predict major adverse cardiovascular events (MACEs) in patients with acute non-ST-segment elevation myocardial infarction (NSTEMI), have not been previously investigated.MethodsA prospective cohort of 271 consecutive patients with NSTEMI were enrolled in this study. Plasma MPO levels were measured by ELISA. Baseline demographic and clinical information was collected, and GRACE scores were calculated at admission. The correlation between MPO and MACEs was evaluated with the GRACE score during a 1-year follow-up.ResultsThe results showed that plasma MPO level was correlated with inflammatory indices (including high-sensitivity C-reactive protein (hs-CRP), leukocyte count, neutrophil count, and fibrinogen), N-terminal pro-B type natriuretic peptide (NT-proBNP), and hypersensitive troponin T (hsTNT) levels (All p-values < 0.05), and there was a statistically significant correlation between plasma MPO level and GRACE score (r = 0.22, p < 0.001). The Kaplan-Meier curves showed that patients with higher MPO levels had lower event-free survival (Log-rank P < 0.001). The multivariate Cox model showed MPO was an independent risk factor for 1-year MACEs in patients with NSTEMI (HR: 3.85, 95% CI: 1.4–10.6, p = 0.009). Subgroup analysis showed that MPO was a strong prognostic biomarker, and its prognostic value was more significant in patients with age >65 years and N-terminal pro-B type natriuretic peptide (NT-proBNP) level >1,000 pg/ml. For high-risk patients with GRACE scores, a higher level of MPO has a higher prognostic value.ConclusionElevated plasma MPO levels are associated with high inflammatory status and GRACE scores in patients with NSTEMI. For high-risk patients with GRACE scores, higher MPO levels were more predictive of future MACEs.

A scientific measurement of the amount of tradable water rights forms the premise for reaching an agreement in water rights trading. However, the existing measurement methods, based on water saving potential, still have problems caused by large computation workload and difficult-to-control errors. Conflicts also easily emerge between transferor and transferee during the execution of transaction agreements. This paper proposes a new method for measuring tradable water rights from the perspective of an assessment of the risk of water shortage for the transferor. The following describes the basic idea: An index system is established for the assessment of the water shortage risk of the transferor to identify water shortage risk categories. The impact of the water rights transaction volume on the transferor’s water shortage risk category is analyzed under different incoming water frequencies. The transferor’s water shortage risk threshold is set and a simulated annealing algorithm is designed to calculate the theoretical value of tradable water rights. The following summarizes the innovation of the proposed method: The water resource shortage risk evaluation index of the transferor is constructed based on water resource endowment, water supply, water demand, and water ecological environment of the transferor; then, a risk classification evaluation model of water resource shortage is established and a measurement method of tradable water rights is introduced. Comprehensive analysis of a case analysis of Helan County in the Ningxia Autonomous Region, China, shows that the recommended value of tradable water rights of Helan County is 40 million m3. Various methods are used to calculate the weights of evaluation indexes, which are compared to the measured results of tradable water rights; moreover, the sensitivity of the results is analyzed. The obtained results show that the use of water-saving potential to measure the amount of tradable water rights is feasible.

H2 and O2 were produced at separate times from water electrolysis by using silicotungstic acid as an electron-coupled-proton buffer. It was found that the redox property of silicotungstic acid in water could be regulate by the introduction of organic solvents (acetonitrile, DMF and ethanol). The redox wave of silicotungstic acid at ∼0.02 V vs. RHE moved in the negative direction, which was good for the production of hydrogen. A high yield of hydrogen (∼85%) was obtained in a water-ethanol system (V/V = 1:1), which was higher than that in water (∼45%). And the introduction of ethanol didn’t affect the rate of hydrogen evolution. Moreover, the semihydrogenation of organic compounds could be achieved in the present system under mild conditions. The conversion of phenylacetylene and acetophenone are 97% and 80% under optimum reaction conditions, while the selectivity of styrene and 1-phenylethanol are 80% and 82%, respectively.

A new Keggin-type heteropolyoxometalates compound, {[Cd(DMA)4]2(bibp)(SiW12O40)}n (1), (DMA = N, N-dimethylacetamide, bibp = 4,4′-bis(1-imidazolyl) biphenyl) has been synthesized and characterized by single-crystal X-ray diffraction, IR spectrum, elemental analysis, powder X-ray diffraction, thermogravimetric (TG) analysis and electrochemical analysis. Compound 1 is crystallized in orthorhombic with Pbca space group. The [SiW12O40]4− anions and bibp ligands are linked by coordinated Cd2+ ions alternately into a zigzag-like chain, and the chains are extended into a three-dimensional (3D) framework by the C–H···O hydrogen bonds. The cyclic voltammetry analyses show that compound 1 presences of W-centered reversible redox processes and that 1 has electrocatalytic activities towards the reduction of nitrite.

A sextuple ordered interpenetrated copper-naphthalenediimide network has been constructed by combining the features of porous metal-organic frameworks and π-conjugated supramolecular aggregation. The material exhibits intrinsic semiconductive features with narrow bandgap energy (1.2 eV) and outstanding electron transport. Theoretical calculations combined with experiments indicate that the high electron conduction may originate from π-d coupling and J-aggregation.

A novel sandwich-type polyoxometalate, [NiII4(H2O)2(TiW9O34)2]12−(Ni4Ti2), has been developed for noble-metal-free hydrogen evolution reaction (HER). Employing a simple three-component catalytic system, with triethylamine as sacrificial donor and fluorescein as photosensitizer, Ni4Ti2 exhibits outstanding efficiency in hydrogen evolution upon visible light irradiation. The turnover number (TON) of Ni4Ti2 reaches 2000 in 3 h. Spectral studies reveal that the hydrogen evolution process is mainly a reductive one.

High-order harmonic generation (HHG) is responsible for high-energy photons and isolated attosecond pulses. The plasmonic fields excited by nanostructures exhibit both field enhancement and spatial dependence. And two-dimensional (2D) materials exhibit attractive features for coherent HHG. Here, by using ab initio simulations, we explore the possibility of combining 2D materials and plasmonic fields generated by nanoscale dimers to produce efficient HHG. In our scheme, we find the spatial inhomogeneity of plasmonic fields plays a key role for HHG enhancement in a wide range of the high-energy region, which enables the production of isolated attosecond pulses. By the classical trajectory simulation based on the single-electron approximation, we further analyze and confirm the role of the spatial inhomogeneity. We also investigate the HHG enhancement in bilayer 2D materials and analyze the influences of the stacking forms between two layers. According to our simulation results, different stacking forms will induce distinctive interlayer plasmons which cause significant differences in low-energy harmonics. Our exploration supplies a scheme to generate high-energy photons and ultrashort isolated pulses.

Anionic POMs prefer to bond with positive metal cations instead of neutral or negative organic ligands. Therefore, it is challenging to synthesize POM-based MOFs, let alone bi-POM-based host-guest MOFs. In this work, an unprecedented bi-POM-based host-guest MOF, Na[Ni(enMe)2]4[Ni(enMe)2(H2O)2]2{[Ni6(μ3-OH)3(enMe)3 (SIP)1.5(B-α-PW9O34)]2[H3PNiW11O40]}·5enMe·33H2O (1), with Ni6-capped [PW9O34] as the node of the host framework and Keggin-type [PNiW11O40] units as the guest was synthesized. 1 showed excellent chemical stability towards aqueous solutions of pH 2-12 at both ambient and boiling temperature, providing opportunities for its application in fresh water harvesting from air.

We theoretically investigate the high-order harmonic generation (HHG) of the monolayer hexagonal boron nitride by two-color laser pulses, based on the ab initio time-dependent density-functional theory. We find that the waveform of the two-color laser field can dramatically control the harmonic spectrum. The two-color laser field can enhance the harmonic radiation more efficiently than the monochromatic pulse laser with the same incident energy. We investigate the influence of incident laser pulse parameters on the harmonic radiation, such as the relative phase of the two-color field, the amplitude ratio between component electric fields, and the laser orientation. We show that the HHG spectrum is controlled by both the electric field and the vector potential. The electronic band structure and the laser-matter energy transfer play an important role in determining the laser polarization for optimal HHG in the hBN crystal. Our work supplies a scheme to manipulate HHGs in two-dimensional materials and provides a potential methodology for the generation of intense extreme-ultraviolet pulses.

A new nickel substituted silicotungstate ([Ni4(H2O)2(SiW10O38)2]8−, Ni2SiW10) was builded by NiCl2 and Na10SiW9O34 under mild conditions. It was used as a carbon-free homogeneous catalyst for the efficient visible-light-induced hydrogen production from water splitting with fluorescein sodium and triethanolamine as a photosensitizer and sacrificial electron donor, respectively. The initial rate of the H2 evolution was 239 μmol h−1, corresponding to a turnover frequency of 28 h−1. Further results suggested that a reductive process was dominant in the present system for fluorescein sodium, and the production of H2 came from water splitting.

Under the guidance of our previous achievements, and in order to extend this small molecular library. In current work, other 21 novel structures of thieno[2,3-d]pyrimidines containing isoxazole-moiety (1a-1u) were firstly synthesized and the cytotoxicity to A549, HCT116 and MCF-7 cell lines was evaluated using the MTT method. The results showed that most target compounds exhibited good to excellent cytotoxicity to A549, HCT116 and MCF-7 cell lines, especially 6-Methyl-4-{[3-(4-chlorophenyl)-isoxazol-5-yl-]-methoxy-}-thieno[2,3-d]-pyrimidine (1e) exhibited a broad-spectrum and the most potent cytotoxicity to A549, HCT116 and MCF-7 cell lines (IC50s: 2.79, 6.69 and 4.21×10-3 μM, respectively) as compared with the reference drug gefitinib (IC50s: 17.90, 21.55 and 20.68 μM, respectively). 1e can be seen as the best drug candidates for development of anticancer drugs.

Solution-processed tungsten oxide nanocrystals (WO3 NCs) hybridized with a conductive polymer, polyaniline:poly(styrene sulfonate) (PANI:PSS), are introduced as a hole injection layer (HIL) in organic light-emitting diodes (OLEDs). These devices exhibited much higher current efficiency (CE) and power efficiency (PE) compared to regular devices without HILs and devices using pristine WO3 NCs as HILs. This enhanced device performance is mainly attributed to the facilitated hole injection due to the improvement in the energy level alignment at the interface between the ITO anode and the organic semiconductor layer. Besides, PANI:PSS can efficiently reduce surface defects and enhance the film-forming properties of WO3 NCs without affecting the device conductivity. These results suggest that PANI:PSS–WO3 could be a promising candidate for charge injection layers in optoelectronic devices.

La-doped RuO2?TiO2/Ti coating (TRL) and RuO2?TiO2/Ti coating (TR) were prepared by the sol?gel method and thermal treatment. The products were characterized by X-ray diffraction (XRD) analysis and scanning electron microscopy (SEM). The electrochemical properties were investigated by cyclic voltammetry and polarization measurements in O2 and Cl2 evolution in H2SO4 and NaCl solution. The XRD analysis showed that in both TRL and TR, the particles of the synthesized coatings were of low crystallinity, and that they were mainly formed of two phases, rutile TiO2 and RuO2. SEM confirmed that the surface of TRL and TR coatings had a cracked mud appearance consisting of blocks separated by cracks. The morphology of the TRL coating shows irregular crack blocks, which increased the specific area greatly and provides more active sites. Polarization measurements indicate that the onset potential of chlorine evolution reaction for TRL coating was 1.08 VSCE, which is lower than the value of 1.12 VSCE registered for the TR coating. The onset potentials for oxygen evolution for the two coatings were similar. Cyclic voltammetry shows an improvement of the electrochemical capacity for the La-doped coatings.

A novel tetranuclear Ag(i) complex, [Ag4(μ-DMPTP)2(POP)3][BF4]2 (Ag4N2P3), has been designed to achieve highly efficient thermally activated delayed fluorescence (TADF). Photophysical investigations show that the compound exhibits highly efficient TADF (Φ = 76%) and has a very short ambient-temperature TADF decay time of only 0.65 μs, corresponding to a radiative decay rate of k = Φ/τ = 1.2 × 106 s-1, a value belonging to the fast radiative rates in TADF materials.

Utilizing metal-ligand binding as the driving force, a unique photochromic hydrogel cross-linked by metal ions and π-acidic naphthalene bisimide dyes was obtained by simply mixing a two-phase solution. The mechanism of the coordination-driven self-assembly is elucidated by the morphological, XRD, FT-IR, ESR, UV-Vis and TGA studies and the controlled experiments.

A layer compound, [Cd2(bibp)2.5(DMA)3(DMF) 2 (SiW12O40)]n (1), which was synthesized via a self-assembly procedure by the reaction of silicotungstic acid, cadmium ion and bichelate-bridging ligand (4,4′-bis(imidazolyl)biphenyl, bibp) in the solution of DMF and DMA, has been characterized by IR, elemental analysis, TGA, X-ray single crystal diffractometer and electrochemistry. Single crystal structure analysis shows that the structure for 1 represents hoop-club chains by the cadmium ions and the bibp ligands, extends to layers by the [SiW12O40]4− polyanions and further spreads to 3D by hydrogen bond via the bridge oxygen atoms in [SiW12O40]4− units. The electrochemical investigation shows that compound 1 exhibits POM-based electro-catalytic behavior for the reduction of nitrite.

We present two different hyperentanglement concentration protocols (hyper-ECPs) for two-photon systems in nonlocal polarization-time-bin hyperentangled states with known parameters, including Bell-like and cluster-like states, resorting to the parameter splitting method. They require only one of two parties in quantum communication to operate her photon in the process of entanglement concentration, not two, and they have the maximal success probability. They work with linear optical elements and have good feasibility in experiment, especially in the case that there are a big number of quantum data exchanged as the parties can obtain the information about the parameters of the nonlocal hyperentangled states by sampling a subset of nonlocal hyperentangled two-photon systems and measuring them. As the quantum state of photons in the time-bin degree of freedom suffers from less noise in an optical-fiber channel, these hyper-ECPs may have good applications in practical long-distance quantum communication in the future.

Autosomal dominant polycystic kidney disease (ADPKD) is a common single-gene inherited kidney disease, and also the fourth leading cause of end-stage renal disease (ESRD). Currently, no effective treatment exists to delay ADPKD progression. In recent years, there has been great progress in gene research, diagnosis and treatment of ADPKD. Moreover, clinical trials were conducted using somatostatin analogs and vasopressin receptor antagonists, and resulted in the approval of tolvaptan in treatment of ADPKD in some countries. The relevant research status and developments of ADPKD will be summarized in the present paper focusing on the diagnosis and treatment of the disease. DOI: 10.11855/j.issn.0577-7402.2017.11.16

A novel polyoxometalate (POM)-based inorganic-organic hybrid material constructed from the monolacunary Keggin-type polyoxomolybdates and the multi-nuclear copper clusters, namely, {[Cu8(tz)8(Htz)4(H2O)5][PMo10VIMoVO39]}∙~10H2O (1) (Htz = 1H-tetrazole) has been synthesized under hydrothermal conditions and characterized by single-crystal X-ray diffraction, IR spectra, PXRD analysis. In 1, the six-nuclear copper clusters in the roof shape were bridged by the tz ligands. These clusters are extended into the wave-like layers by the μ2-Htz ligands and the copper atoms in octahedron coordination geometry. The polyoxomolybdate anions act as the eight-connected node to link the layers into a 3D framework. In addition, the magnetic and photocatalytic properties of compound 1 have been investigated.

We identify the contribution of Floquet-Bloch states to the high-order harmonic generation (HHG) in solids by numerically solving the time-dependent Schr\"odinger equation for both a one-dimensional and a two-dimensional model. Results from the single $k$ point and the full Brillouin zone are compared to each other and the symmetry- breaking effect is discussed. We show that the observed phenomena can be explained under the framework of the Floquet-Bloch theory and the strong-field approximation, respectively. Our results indicate that the total yield of the harmonic radiation increases nonmonotonically with the intensity of the driving pulse. After a rough consideration of the focusing volume effects, we find that the yield of the harmonics shows a steplike structure, which is similar to several recent experimental observations. The present work can contribute to a better understanding of the channel-closing effect in the HHG of solids and may provide a way to detect the Floquet-Bloch bands in a laser field.

Metal-free ultralong organic phosphorescence (UOP) materials have attracted significant attention owing to their anomalous photophysical properties and potential applications in various fields. Here, three pyrimidine-based organic luminogens, 9-(pyrimidin-2-yl)-9H-carbazole, 9-(4,6-dimethylpyrimidin-2-yl)-9H-carbazole, and 9-(5-bromopyrimidin-2-yl)-9H-carbazole are designed and synthesized, which show efficient yellow UOP with the longest lifetimes up to 1.37 s and the highest absolute phosphorescence quantum yields up to 23.6% under ambient conditions. Theoretical calculations, crystal structures, and photophysical properties of these compounds reveal that intramolecular hydrogen bonding, intermolecular π-π interactions, and intermolecular electronic coupling are responsible for forming dimers and generating highly efficient UOP. Their efficacy as solid materials for data encryption is demonstrated.

A Ho-MOF ([Ho(SIP)(H2O)5]·3H2O (1), NaH2SIP = monosodium 5-sulfoisophthalic acid) was designed and synthesized for proton conductivity. It showed a proton conductivity of 8.2 × 10−4 S cm−1 at 343 K and 98% relative humidity. Besides, compound 1 showed excellent water and chemical stability as well as reversible dehydration and hydration closely related to the proton conductivity.

For the high-order harmonic generation in solids, we find a distinct and clean interference pattern in the high-energy end of the spectrum which can be interpreted as a Michelson interferometer of the Bloch electron. Our results are achieved by a numerical solution to the time-dependent Schr\"odinger equation of the quasi-electron in solids and can be explained by an analytical model based on the principle of the Michelson interferometry. The present study deepens our understanding of the HHG mechanism in crystalline materials and may find potential applications in imaging of the dispersion relation or topological structure of the energy bands in solids., Comment: 2 figures, 6 pages

The formation of the water rights trading price is an important part of the water rights trading system. In order to continuously and dynamically reflect the social–economic development changes and water resource scarcity, herein, we discuss the dynamic adjustment of the water rights trading price from the perspective of water resource scarcity value analysis. First, we constructed the water resource scarcity evaluation index system from the four dimensions of the water resource natural endowment, the water resource supply, the water resource demand, and the water environment, and then we constructed the water resource scarcity index calculation model of the transferor, the transferee, and the comprehensive water resource scarcity index calculation model of both parties of the trading. Second, by analyzing the 30 comparable water rights trading cases in China since 2016, we established the response function of the water rights trading price to the water resource scarcity index, and then we analyzed the impact mechanism of the water resource scarcity index on the water rights trading price. Third, based on the two factors of “the water resource scarcity value” and “the capital time value,” we constructed a dynamic price adjustment model of water rights trading for different adjustment factors, so as to adjust the water rights trading price scientifically. Finally, we took the water rights trading in Helan County (Helan) of Ningxia Hui Autonomous Region (Ningxia) as an example. The research shows that: (1) During the trading period of water rights in Helan, the water resource scarcity index rises, and the water rights trading price should be increased year-by-year. Additionally, there are certain differences in the water rights trading price changes with the adjustment of different elements. Among them, considering the adjustment of “the water resource scarcity value” element, the water rights trading price of Helan should be increased from 1.0940 to 2.8574 CNY/m³ during the water rights trading period, (2) there are differences in the water rights trading cost under different payment modes, among which the annual payment mode increased the most, i.e., from 2.7350 × 108 to 7.4500 × 108 CNY. This study suggests exerting a regulating effect of the water scarcity value on the water rights trading price, so as to promote the construction of a more equitable and long-term water rights trading market.

// Ying Liu 1, * , Shu Ning Xu 1, * , Yong Shun Chen 2 , Xiao Yuan Wu 1 , Lei Qiao 1 , Ke Li 1 , Long Yuan 3 1 Department of Medical Oncology of Henan Cancer Hospital, Zhengzhou University Affiliated Cancer Hospital, Zhengzhou, Henan, China 2 Department of Radiation Oncology of Henan Cancer Hospital, Zhengzhou University Affiliated Cancer Hospital, Zhengzhou, Henan, China 3 Department of Surgical Oncology of Henan Cancer Hospital, Zhengzhou University Affiliated Cancer Hospital, Zhengzhou, Henan, China * These authors have contributed equally to this work Correspondence to: Ying Liu, email: yaya7207@126.com Keywords: paclitaxel, esophageal squamous cell carcinoma, chemotherapy, single nucleotide polymorphisms, FBW7 Received: December 09, 2015 Accepted: May 17, 2016 Published: May 31, 2016 ABSTRACT Paclitaxel plays a major role in the treatment of advanced esophageal squamous cell carcinoma. However, there is no biomarker that could be used to predict the clinical response of paclitaxel. This work was conducted to investigate the association of genetic polymorphisms in FBW7 and its substrate genes and the clinical response of paclitaxel. Patients with advanced esophageal squamous cell carcinoma were treated with paclitaxel 175 mg/m 2 over 3 hours day 1 and cisplatin 75 mg/m 2 day 1, every 3 weeks. The genotypes of 11 FBW7 and its substrate gene polymorphisms were determined by polymerase chain reaction–restriction fragment length polymorphism (PCR-RFLP) method. Statistical analysis revealed that patients with mTOR rs1057079 AG (OR adjusted : 4.59; 95% CI: 1.78-11.86) genotype had significant correlation with the clinical response of paclitaxel when compared with AA genotype after adjustment for sex, age, and chemotherapy cycle. The median progression-free survival (PFS) of patients with advanced ESCC who received paclitaxel plus cisplatin (TP) as first-line treatment is 14.3 months (95% CI: 9.0-19.60 months). The median PFS (mPFS) of AG genotypes and AA genotypes in mTOR rs1057079 were 17.31 months (95% CI: 15.9-18.67 months) and 9.8 months (95% CI: 8.58-11.02 months) ( p =0.019), respectively.

A cobalt-organic framework (1) consisted of close-packed polyhedral cages is isostructural to CPM-35-Ni. The activated sample (1a) can adsorb high H2 uptake of 88.3 cm3 g− 1 (0.79 wt.%) at 77 K and 1.0 bar. Remarkably, 1a shows high CO2 adsorption capacity and good adsorption selectivity for CO2 over CH4 and N2.

Self-assemble of aqueous solution of the Cu2+/molybdate/glyc-ine system results in {[NaCu6(Gly)8(H2O)2][Mo8O26Cu(Gly)2]2}n·n{NaCu6(Gly)8(H2O)2}·n{Mo8O26[Cu(Gly)(GlyH)(H2O)2]2} 15nH2O 1, which exhibits the 0-D + 1-D supramolecular framework and in which the copper atoms show three kinds of coordination models: (1) in quadrilateral geometry, (2) in square-pyramidal geometry, and (3) in distorted octahedral geometry. The space group of the compound is P–1, with the lattice parameters: α = 89.036(5)°, β = 89.384(4)°, γ = 88.337(5) °, a = 12.559(4) A, b = 14.441 (4)A, c = 23.063(6) A, and Z = 1.