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Cognitive investment theory states that personality can predict individuals’ behavior patterns on one specific activity, and further predict a related ability. Besides, personality itself is predicted by environmental factors throughout individuals’ development. The present research explored if and how parental support predicts singing ability through openness and musical training, using a sample of high school students in mainland China. A measurement tool for acquiring the musical training and singing ability of targeted sample was lacking. Therefore, an adjustment study was conducted, which adjusted the Goldsmiths Musical Sophistication Index–traditional Chinese version adjusted for Taiwanese (GMSI-TC), to obtain a suitable simplified Chinese version for the high school students (GMSI-SC-H). Thus, this research comprised two studies: Study 1 was an adjustment study, and Study 2 was a relation exploration study. Results of Study 1 showed that the GMSI-SC-H possessed acceptable reliability and validity on the general musical sophistication factor, Musical Training, Perceptual Abilities, and Singing Abilities sub-scales. The results of Study 2 showed that two mediating paths from parental support to singing ability were significant. Therefore, the conclusion was that parental support can predict singing ability through openness and musical training in a group of high school students. This research expands our understanding of links between personality and life outcomes.

Objective To evaluate the antitumor capability and to investigate the underlying molecular mechanism of paclitaxel. Methods First, cck‐8 and apoptosis assays were used to determine survival and apoptotic effects of HS 737.T cells under treatment of paclitaxel. Next, RNA‐seq and bioinformatics were used to determine the differentially expressed genes and to analyze the pathway involved. Quantitative real‐time polymerase chain reaction was used to verify the accuracy of some differentially expressed genes (DEG). ClueGO was used to decode and visualize functionally grouped GO terms of differentially expressed genes, and to map the DEG protein–protein interactions (PPI) network. Western blotting was used to check the expression of target genes, the cleavage of Caspase‐3 and PARP1, and the phosphorylation level of p53. Finally, transcriptomics, bioinformatics, and RNAi were used to estimate the antitumor capability and to identify the underlying mechanisms of paclitaxel in GCTB. Results Our data revealed that paclitaxel had significant time‐dependent effects on the viability and induced apoptosis of HS 737.T cells. RNA‐seq and bioinformatics analysis showed that apoptosis, death receptor signaling pathway, TNF signaling pathway, and TP53 regulated transcription of cell death genes pathway were closely associated with paclitaxel in the treatment of GCTB. Western bolt results revealed that paclitaxel induced cleavage of Caspase‐3 and PARP1, and increased the phosphorylation level of p53 in HS 737.T cells. RNAi results showed that the expression level of TP53INP1 was significantly decreased in HS737.T cells (the decrease was more than 70%). In addition, we found that the inhibitory ratios of paclitaxel on HS737.T cells deficient in TP53INP1 were less than in HS737.T cells with empty vector (19.88 and 40.60%, respectively). Hence, our data revealed that TP53INP1 regulated paclitaxel‐driven apoptosis in HS737.T cells. Conclusion Paclitaxel can significantly repress cell proliferation and induce apoptosis of HS 737.T cells through activating Caspase‐3, PARP1, p53, and TP53INP1. Paclitaxel may be an effective drug in the management of GCTB.

Background High incidence of asymptomatic venous thromboembolism (VTE) has been observed in severe COVID‐19 patients, but the characteristics of symptomatic VTE in general COVID‐19 patients have not been described. Objectives To comprehensively explore the prevalence and reliable risk prediction for VTE in COVID‐19 patients. Methods/Results This retrospective study enrolled all COVID‐19 patients with a subsequent VTE in 16 centers in China from January 1 to March 31, 2020. A total of 2779 patients were confirmed with COVID‐19. In comparison to 23,434 non‐COVID‐19 medical inpatients, the odds ratios (ORs) for developing symptomatic VTE in severe and non‐severe hospitalized COVID‐19 patients were 5.94 (95% confidence interval [CI] 3.91–10.09) and 2.79 (95% CI 1.43–5.60), respectively. When 104 VTE cases and 208 non‐VTE cases were compared, pulmonary embolism cases had a higher rate for in‐hospital death (OR 6.74, 95% CI 2.18–20.81). VTE developed at a median of 21 days (interquartile range 13.25–31) since onset. Independent factors for VTE were advancing age, cancer, longer interval from symptom onset to admission, lower fibrinogen and higher D‐dimer on admission, and D‐dimer increment (DI) ≥1.5‐fold; of these, DI ≥1.5‐fold had the most significant association (OR 14.18, 95% CI 6.25–32.18, p = 2.23 × 10−10). A novel model consisting of three simple coagulation variables (fibrinogen and D‐dimer levels on admission, and DI ≥1.5‐fold) showed good prediction for symptomatic VTE (area under the curve 0.865, 95% CI 0.822–0.907, sensitivity 0.930, specificity 0.710). Conclusions There is an excess risk of VTE in hospitalized COVID‐19 patients. This novel model can aid early identification of patients who are at high risk for VTE.

Additional file 1: Fig. S1. (A) Chemical structures of modified GelMA polymer,a-i represented H protons corresponding to 1HNMR spectrum. (B) 1H NMR spectra of Gel-EPL polymers with different EPL modification in D2O. (C) TG analysis indicating high stability of polymers above 300℃. (D) DSC curve of GelMA and modified GelMA polymers. (E) Degradation analysis of under enzymatic digestion with Collagenase Type II (0.2U/ml). (F) A demonstration of the injectability and moldability of GelMA -based hydrogels. Fig. S2. (A) Immunofluorescence staining Col II of chondrocytes with cultured within 3D Gel-EPL/B hydrogels over 1 and 3 days for demonstrating cell metabolic activity and stability of chondrocytes after the gel was irradiated with blue light (405nm) for 1min. (B-C) Proliferation of rBMSCs (C) and chondrocytes (D) cultured with hydrogels at the different time points was assessed by MTT assay.

In the present paper, one new species and two new records of Erythroneurini from Guizhou Province, China are reported. The new species, Seriana bacilla sp. n. is described and illustrated. A key to distinguish all species of the genus is given. Another two species newly recorded from China, Empoascanara gracilis Dworakowska, 1992 and Tautoneura mayarami Mathew & Ramakrishnan, 1996, are redescribed and illustrated.

Yuan, Xiao-Wei, Song, Yue-Hua (2019): One new genus and species of Typhlocybinae (Hemiptera: Cicadellidae) from Southwest China. Zootaxa 4691 (1): 97-100, DOI: https://doi.org/10.11646/zootaxa.4691.1.11

The layered structure graphitic carbon nitride (g-C3N4) makes it possible to form good interfacial contact with metal oxide nanoparticles. In this paper, we obtain the TiO2/g-C3N4 (TC) composite via ultra-sonication and apply it as photoanode materials in dye-sensitized solar cells (DSSCs). The TC photoanodes decrease the energy barrier of electron transport and improve the injection efficiency of photo-generated electrons. Moreover, the g-C3N4 broadens the absorption spectrum of the TiO2 based photoanode to visible region and enhances the light harvesting. As a result, the short-circuit current density (Jsc) and power conversion efficiency (PCE) of DSSCs based on TC photoanode have been considerably increased from 9.75 mA/cm−2 to 11.29 mA/cm−2, 3.87% to 4.51%, compared with pure TiO2 photoanode, enhanced by 15.8% and 16.8%, respectively.

Hollow cubic TiO2 particles were synthesized using cubic Cu2O particles as hard templates, and the hydrolysis of tetrabutyl titanate (TBOT). The products were characterized by powder X-ray diffraction (XRD), scanning electron microscopy (SEM), transmission electron microscopy (TEM), and UV-Vis spectrometer, respectively. The results show that the prepared TiO2 is composed of anatase TiO 2, and has a stronger absorption in the range of 300-400nm wavelengths in its UV-Vis spectroscopy. Experiments were carried out using a methyl orange solution as a model to evaluate the photocatalytic activity of hollow cubic TiO2 particles. The effects of catalyst dosage, initial concentration and pH of methyl orange solution on the degree of photodegradation have been investigated. It’s found that the hollow cubic TiO2 particles have a good photocatalytic property. And the degradation rate of the methyl orange, after methyl orange solution (5mg/L) containing hollow cubic TiO2 particles (0.5g/L) is irradiated by 125W ultraviolet light for 120 minutes, is 95%.

Objective To determine whether primary sclerosing cholangitis (PSC) in childhood is associated with abnormalities in cystic fibrosis transmembrane conductance regulator (CFTR). Study design Subjects with PSC diagnosed in childhood (n = 20) were recruited from Children’s Hospital. Subjects had testing with sweat chloride concentration, nasal transmembrane potential difference, and extensive genetic analysis of the CFTR gene. Disease control subjects consisted of 14 patients with inflammatory bowel disease alone and no liver disease. t Tests were performed to determine statistical significance. Results In the PSC group, CFTR chloride channel function (ΔChloride free + isoproterenol) was markedly diminished at −8.6 ± 8.2 mV (reference range: −24.6 ± 10.4 mV). In contrast, disease control subjects had normal function, at −17.8 ± 9.7 mV (P = .008). Sweat chloride concentration in subjects with PSC was greater than in disease control subjects (20.8 ± 3.4 mmol/L vs 12.0 ± 1.6 mmol/L, P = .045). Comprehensive CFTR genotyping revealed that 5 of 19 (26.3%) subjects with PSC had a CFTR mutation or variant, compared with 6 of 14 (42.9%) disease control subjects. Conclusions There is a high prevalence of CFTR-mediated ion transport dysfunction in subjects with childhood PSC.

A high performance liquid chromatographic method (HPLC) was developed for the chiral separation of six α-aryl tetralone derivatives, using a Chiralpak IC column. The factors influencing the chiral separation including the type and concentration of organic modifier, column temperature and flow rate were investigated. The results showed that high enantiomeric separation can be obtained with isopropanol as modifier for the six compounds. The thermodynamic study indicated that the enantioseparation was enthalpically driven and showed that low column temperature was beneficial to separation. Complete separation of compound I was achieved with a binary solvent mixture of n-hexane-isopropanol (90 :10, v/v) as the recommended mobile phase. The compounds II , II and IV were separated with the mobile phase of the mixture of n-hexane-isopropanol (99:1, v/v) and the compound V was separated with the mixture of n-hexane-isopropanol (85:15, v/v). The compound VI was separated with the mixture of n-hexane-isopropanol (80:20, v/v). The column temperature was 25 °C, and the flow rate was 1. 0 mL/min. The six tetralone derivative enantiomers were separated on a chiral stationary phase of Chiralpak IC by HPLC. The column has high enantiomeric selectivity to the six tetralone derivative enantiomers.

To develop a capillary electrophoresis system for enantiomeric impurity test of repaglinide.An uncoated fused silica capillary (50 μm×50 cm, with an effective length of 41 cm) was used. The running buffer was composed of 30 mmol/L NaH2PO4 and 5 mg/ml carboxymethyl-β-cyclodextrin(pH 3.5).Linear range was 2.00-80.00 μg/ml (correlation coefficient was 0.9993). The average recovery rate was 92.5% to 105.0%.The method is simple, accurate and sensitive and it can be used for determination of enantiomeric impurities in repaglinide tablet.