17 results on '"Xiao-Huang Tu"'
Search Results
2. The comparison between conventional method and perineal-approach-first abdominoperineal resection
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Zhi-Cong Cai, Xiao-Huang Tu, and Chen Lin
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Prone position ,medicine.medical_specialty ,business.industry ,Colorectal cancer ,Abdominoperineal resection ,Medicine ,Surgery ,Perineal approach ,business ,medicine.disease - Published
- 2019
3. Glutamine dipeptide-supplemented parenteral nutrition in patients with colorectal cancer
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Jing-Xiang, Song, Xiao-Huang, Tu, Lie, Wang, and Chen-Jing, Li
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- 2004
- Full Text
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4. High Tumor Vascular Endothelial Growth Factor Expression Is Associated With Poorer Clinical Outcomes in Resected T3 Gastric Adenocarcinoma
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Ruohan Wang, Xiao-huang Tu, Yun Xu, Shao-quan Chen, Qiaojia Huang, Daiyong Wang, Chen Lin, Zaizhong Zhang, Lie Wang, and Jian Gao
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Male ,Vascular Endothelial Growth Factor A ,0301 basic medicine ,medicine.medical_specialty ,Pathology ,VEGF receptors ,Adenocarcinoma ,Gastroenterology ,Disease-Free Survival ,03 medical and health sciences ,chemistry.chemical_compound ,Gastric adenocarcinoma ,0302 clinical medicine ,Stomach Neoplasms ,Internal medicine ,Biomarkers, Tumor ,medicine ,Humans ,Neoplasm Staging ,biology ,business.industry ,Proportional hazards model ,Hazard ratio ,General Medicine ,Middle Aged ,Prognosis ,Immunohistochemistry ,Confidence interval ,Survival Rate ,Vascular endothelial growth factor ,Treatment Outcome ,030104 developmental biology ,chemistry ,030220 oncology & carcinogenesis ,biology.protein ,Biomarker (medicine) ,Female ,Neoplasm Recurrence, Local ,business - Abstract
Objectives: To investigate the clinical and prognostic significance of high vascular endothelial growth factor (VEGF) expression in resected T3 gastric adenocarcinoma (GA). Methods: Data of VEGF expression on 453 patients with resected T3 GA were collected from a single institute in Fuzhou, China. VEGF expression in the resected tumor tissues was evaluated by immunohistochemistry (IHC). Associations between VEGF expression outcomes and prognosis were investigated using by the χ2 test, Kaplan-Meier plus log-rank test, and univariate and multivariate Cox models. Results: In total, 48.6% (220/453) patients had low VEGF expression (IHC score ≤2+). Patients with high VEGF expression (IHC>2+; 233/453, 51.4%) had significantly poorer median recurrence-free survival time (20 vs 55 months, P < .001) and median overall survival time (28 vs 58 months; P < .001) than patients with low VEGF. High VEGF was associated with higher overall recurrence (68.2% vs 51.4%, P = 2.675 × 10−4), poorer overall survival (27.5% vs 47.3%, P = 1.719 × 10−5), and increased risk of recurrence (hazard ratio [HR], 1.71; 95% confidence interval [CI], 1.33-2.19; P = 2.43 × 10−5) and death (HR, 1.80; 95% CI, 1.41-2.3; P = 2.19 × 10−6). Conclusions: High VEGF expression is associated with a higher risk of recurrence and shorter survival in resected T3 GA. These findings may provide a foundation for evaluating VEGF-targeted molecular therapies in T3 GA.
- Published
- 2016
5. Mesenchymal stem cells improve intestinal integrity during severe acute pancreatitis
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Xiao-huang Tu, Wen-sheng Li, Jing-xiang Song, Shao-xiong Huang, and Xiao-Li Yang
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Male ,Taurocholic Acid ,Cancer Research ,Pathology ,medicine.medical_specialty ,genetic structures ,Biology ,Mesenchymal Stem Cell Transplantation ,Systemic inflammation ,Biochemistry ,Rats, Sprague-Dawley ,Andrology ,Genetics ,medicine ,Animals ,Transplantation, Homologous ,Intestinal Mucosa ,Molecular Biology ,Aquaporin 1 ,Tumor Necrosis Factor-alpha ,Mesenchymal stem cell ,Mesenchymal Stem Cells ,medicine.disease ,Immunohistochemistry ,Rats ,Transplantation ,Disease Models, Animal ,Pancreatitis ,Oncology ,Apoptosis ,Acute Disease ,Amylases ,Molecular Medicine ,Acute pancreatitis ,Tumor necrosis factor alpha ,Amine Oxidase (Copper-Containing) ,Diamine oxidase ,medicine.symptom - Abstract
Severe acute pancreatitis (SAP) is an acute inflammatory disease of the pancreas that involves various distant tissues and organs. This study aimed to investigate post-tissue injury repair by mesenchymal stem cells (MSCs) in a rat model of SAP. A total of 54 pathogen-free adult male SD rats were randomly assigned to the groups SAP, SAP + MSCs and sham-operated (SO). SAP was induced by 4% sodium taurocholate, and MSCs were injected via the dorsal penile vein 1 h later. The amylase activity, and tumor necrosis factor (TNF)-α and diamine oxidase (DAO) levels were measured with an enzyme-linked immunosorbent assay (ELISA), while the expression of aquaporin (AQP)-1 was evaluated by immunohistochemical staining. The pathological score of intestinal tissues was also compared among groups. Marked improvement in intestinal necrosis, villi shedding and infiltration of inflammatory cells was observed in the SAP + MSCs group compared to the SAP and SO groups. Amylase, TNF-α, and DAO levels were significantly increased in the SAP + MSCs group. The intestinal expression of AQP-1 was increased at 12 and 24 h post-MSC transplantation compared to the SO group. Rats of the SAP + MSCs group displayed higher pathological scores compared to the SAP group at all time points. Overall, these data showed that MSCs can inhibit systemic inflammation and reduce TNF-α release in a rat model of SAP-induced intestinal injury, suggesting that MSCs exert protective effects on the intestinal barrier during SAP.
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- 2014
6. Protective effect of transplanted bone marrow-derived mesenchymal stem cells on pancreatitis-associated lung injury in rats
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Jing-Xiang Song, Zhong-Dong Zou, Lie Wang, Peng Zhao, and Xiao-Huang Tu
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Male ,Taurocholic Acid ,Cancer Research ,Pathology ,medicine.medical_specialty ,Acute Lung Injury ,Bone Marrow Cells ,Pulmonary Edema ,Inflammation ,Substance P ,Lung injury ,Biology ,Mesenchymal Stem Cell Transplantation ,Severity of Illness Index ,Biochemistry ,Rats, Sprague-Dawley ,Genetics ,medicine ,Animals ,RNA, Messenger ,Lung ,Molecular Biology ,Peroxidase ,Reverse Transcriptase Polymerase Chain Reaction ,Tumor Necrosis Factor-alpha ,Mesenchymal Stem Cells ,Pulmonary edema ,medicine.disease ,Systemic Inflammatory Response Syndrome ,Rats ,Enzyme Activation ,Transplantation ,Disease Models, Animal ,medicine.anatomical_structure ,Pancreatitis ,Oncology ,Amylases ,Molecular Medicine ,Acute pancreatitis ,Tumor necrosis factor alpha ,Inflammation Mediators ,medicine.symptom - Abstract
Severe acute pancreatitis (SAP) is initiated by the premature activation of digestive enzymes within the pancreatic acinar cells, leading to self-digestion and inflammatory responses in pancreatic ductal cells, thus giving rise to systemic inflammatory response syndrome (SIRS). The most common and serious SIRS is pancreatitis-associated lung injury, and inflammatory mediators play an important role in its pathogenesis. Bone marrow-derived mesenchymal stem cells (MSCs) are differentiated into alveolar endothelial cells to replace the damaged alveolar endothelial cells and inhibit inflammatory response in the injured lung tissues. In this study, we aimed to investigate the therapeutic effect of bone marrow-derived MSCs in rats with pancreatitis-associated lung injury. Experimental SAP was induced by a retrograde injection of 5% sodium taurocholate into the biliopancreatic duct of 75 male Sprague-Dawley rats, which were divided into the SAP group (n=25), the MSC group (n=25) and the sham-operated group (n=25) to explore the pathology and function of lung tissues and the regulation of inflammatory mediators. Pulmonary edema was estimated by measuring water content in the lung tissues. Pulmonary myeloperoxidase (MPO) activity was detected using spectrophotometry. Serum amylase was detected using the Automatic Biochemistry Analyzer. Tumor necrosis factor-α (TNF-α) and substance P (SP) mRNA levels were determined by quantitative reverse transcriptase-polymerase chain reaction. Our results showed that serum amylase activity was significantly decreased in the MSC group compared to the SAP group. Pulmonary edema was significantly diminished (p
- Published
- 2012
7. Protective effect of Shenfu injection against intestinal barrier dysfunction and second hit in rats with severe acute pancreatitis
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Zai-zhong Zhang, Xiao-huang Tu, Lie Wang, Li-jun Tang, Zhong-dong Zou, and Yu Wang
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medicine.medical_specialty ,business.industry ,Second hit ,Internal medicine ,Medicine ,Acute pancreatitis ,General Medicine ,business ,medicine.disease ,Gastroenterology ,Surgery - Published
- 2009
8. Safety and efficacy of Qingre Buyi Decoction (清热补益煎剂) in the treatment of acute radiation proctitis: A prospective, randomized and controlled trial
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Xiao-huang Tu, Jian-hua Liu, Lie Wang, Zhong-dong Zou, Zai-zhong Zhang, and Yu Wang
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Qingre buyi ,medicine.medical_specialty ,business.industry ,Treatment outcome ,Decoction ,Acute radiation proctitis ,General Medicine ,Pharmacology ,medicine.disease ,Gastroenterology ,law.invention ,Clinical trial ,Complementary and alternative medicine ,Randomized controlled trial ,law ,Internal medicine ,medicine ,Pharmacology (medical) ,Liver function ,business ,Proctitis - Abstract
Objective To investigate the efficiency, safety, and possible mechanisms of Qingre Buyi Decoction (清热补益煎剂, QBD) in the treatment of acute radiation proctitis (ARP).
- Published
- 2009
9. [Correlation of methylation of CpG island in cystathionine beta synthase promoter and clinicopathological features in colorectal cancer]
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Xiao-huang, Tu, Shao-xiong, Huang, Wen-sheng, Li, and Jing-xiang, Song
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Adult ,Aged, 80 and over ,Male ,Liver Neoplasms ,Cystathionine beta-Synthase ,Adenocarcinoma ,DNA Methylation ,Middle Aged ,Prognosis ,Biomarkers, Tumor ,Humans ,CpG Islands ,Female ,RNA, Messenger ,Neoplasm Grading ,Neoplasm Recurrence, Local ,Colorectal Neoplasms ,Promoter Regions, Genetic ,Aged ,Follow-Up Studies ,Neoplasm Staging - Abstract
To explore the association between methylation of cystathionine-beta-synthase (CBS) promoter and clinicopathological features in colorectal cancer.Bisulfate sequencing PCR, real-time RT-PCR, and immunohistochemistry were used to investigate the methylation of CpG island in CBS promoter of 95 sporadic colorectal cancers. Software SPSS PASW Statistics was used to analyze the data of the hypermethylation levels in the malignant tissues and the correlation with pathological parameters and clinical outcome.Methylation levels in tumor tissue of patients [(64.9 ± 14.3)%]with colorectal cancer were significantly higher than that in normal tissues[(27.5 ± 13.1)%, P0.001]. The CBS mRNA levels in the hypomethylation group (7.22 ± 1.91) were significantly higher than that in the hypermethylation group (2.78 ± 1.12, P0.01). Univariate analysis showed that age, pT stage, pN stage, liver metastases, pTNM stage, and CBS hypermethylation level significantly correlated with the survival and recurrence rates of colorectal cancer patients (All P0.05). Multivariate analysis showed that CBS hypermethylation level and liver metastasis were independent factors significantly correlated with the recurrence rate and overall survival of the patients (All P0.05).Our study indicates that methylation of CpG island in CBS promoter is correlated with the occurrence and progression of colorectal cancer and plays a role in its tumorigenesis. It might serve as a useful marker for early diagnosis, targeted therapy and prediction of prognosis in colorectal cancer.
- Published
- 2013
10. Role of bone marrow-derived mesenchymal stem cells in a rat model of severe acute pancreatitis
- Author
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Jing-Xiang Song, Xian-Wei Guo, Yun-Xia Ma, Lie Wang, Xiao-Jun Xue, Zhong-Dong Zou, Xiao-Huang Tu, and Zhi-Yao Chen
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Male ,Time Factors ,genetic structures ,Systemic inflammation ,Severity of Illness Index ,Rats, Sprague-Dawley ,chemistry.chemical_compound ,Intestinal mucosa ,Malondialdehyde ,Medicine ,Intestinal Mucosa ,Cells, Cultured ,Gastroenterology ,Interleukin ,General Medicine ,Pancreas, Exocrine ,Interleukin-10 ,Interleukin 10 ,medicine.anatomical_structure ,Acute Disease ,Amylases ,Tumor necrosis factor alpha ,medicine.symptom ,Inflammation Mediators ,Deoxycholic Acid ,medicine.medical_specialty ,Brief Article ,Cell Survival ,macromolecular substances ,Mesenchymal Stem Cell Transplantation ,Internal medicine ,Lactate dehydrogenase ,Animals ,Cell Proliferation ,L-Lactate Dehydrogenase ,business.industry ,Interleukin-6 ,Superoxide Dismutase ,Tumor Necrosis Factor-alpha ,Mesenchymal stem cell ,Coculture Techniques ,Rats ,Disease Models, Animal ,Oxidative Stress ,Endocrinology ,chemistry ,Pancreatitis ,Immunology ,Bone marrow ,business - Abstract
AIM: To investigate the role and potential mechanisms of bone marrow mesenchymal stem cells (MSCs) in severe acute peritonitis (SAP). METHODS: Pancreatic acinar cells from Sprague Dawley rats were randomly divided into three groups: non-sodium deoxycholate (SDOC) group (non-SODC group), SDOC group, and a MSCs intervention group (i.e., a co-culture system of MSCs and pancreatic acinar cells + SDOC). The cell survival rate, the concentration of malonaldehyde (MDA), the density of superoxide dismutase (SOD), serum amylase (AMS) secretion rate and lactate dehydrogenase (LDH) leakage rate were detected at various time points. In a separate study, Sprague Dawley rats were randomly divided into either an SAP group or an SAP + MSCs group. Serum AMS, MDA and SOD, interleukin (IL)-6, IL-10, and tumor necrosis factor (TNF)-α levels, intestinal mucosa injury scores and proliferating cells of small intestinal mucosa were measured at various time points after injecting either MSCs or saline into rats. In both studies, the protective effect of MSCs was evaluated. RESULTS: In vitro, The cell survival rate of pancreatic acinar cells and the density of SOD were significantly reduced, and the concentration of MDA, AMS secretion rate and LDH leakage rate were significantly increased in the SDOC group compared with the MSCs intervention group and the Non-SDOC group at each time point. In vivo, Serum AMS, IL-6, TNF-α and MAD level in the SAP + MSCs group were lower than the SAP group; however serum IL-10 level was higher than the SAP group. Serum SOD level was higher than the SAP group at each time point, whereas a significant between-group difference in SOD level was only noted after 24 h. Intestinal mucosa injury scores was significantly reduced and the proliferating cells of small intestinal mucosa became obvious after injecting MSCs. CONCLUSION: MSCs can effectively relieve injury to pancreatic acinar cells and small intestinal epithelium, promote the proliferation of enteric epithelium and repair of the mucosa, attenuate systemic inflammation in rats with SAP.
- Published
- 2012
11. [Protective effect of N-acetylcysteine on the intestinal barrier dysfunction after radiation injury in rats]
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Yu, Wang, Zai-zhong, Zhang, Shao-quan, Chen, Zhong-dong, Zou, Xiao-huang, Tu, and Lie, Wang
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Male ,Rats, Sprague-Dawley ,X-Rays ,Intestine, Small ,Animals ,Dose-Response Relationship, Radiation ,Intestinal Mucosa ,Nitric Oxide ,Radiation Injuries ,Acetylcysteine ,Rats - Abstract
To evaluate the protective effect of N-acetylcysteine (NAC) on the intestinal barrier dysfunction in rats after extensive abdominal radiation with X ray.Twenty-four Spraque-Dawley male rats were divided into normal control group (n=8), radiation group (n=8), and radiation+NAC group (300 mg/kg) (n=8). Radiation injury was induced by X ray with a single dose of 10 Gy. NAC was administered from 4 days before irradiation to 3 days after radiation. Three days after radiation, all the rats were euthanized. The terminal ileum was collected for crypt survival assay and ileal villi count. The tissue samples from mesenteric lymph nodes (MLN), spleen, and liver were harvested under sterile conditions for microbiological analysis and ileum samples were harvested for biochemical analysis. The blood levels of D-lactate, endotoxin and diamine oxidase (DAO) and the ileum samples levels of nitric oxide(NO) were also measured.Rats in radiation+NAC group had a higher survival rate of intestinal crypt [(76.84+/-4.82)% vs (49.64+/-5.48)%, P0.01], higher intestinal villus count [(8.56+/-0.68)/mm vs (4.02+/-0.54)/mm, P0.01], lower NO concentration [(0.48+/-0.12) mumol/g vs (0.88+/-0.16) mumol/g, P0.01], lower levels of D-lactate, endotoxin and DAO (P0.05 or P0.01), and significantly decreased enteric bacteria cultured from mesenteric lymph nodes and other tissues as compared with the radiation group (P0.05 or P0.01).NAC protects the small intestine from radiation-induced injury maybe through the inhibition of NO in rats.
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- 2010
12. [Evaluation of endoscopy-assisted laparoscopic surgery in the treatment of early colon cancer]
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Lie, Wang, Xiao-Huang, Tu, Zai-Zhong, Zhang, Zhong-Dong, Zou, and Yu, Wang
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Adult ,Male ,Colonic Neoplasms ,Humans ,Endoscopy ,Female ,Laparoscopy ,Middle Aged ,Aged ,Retrospective Studies - Abstract
To evaluate the endoscopy-assisted laparoscopic surgery in the treatment of early colon carcinoma.The data of 55 early colon cancer patients, including 30 male, 25 female with mean age of 54 years(ranged 42 to 68), undergone endoscopy-assisted laparoscopic surgery at the colon were reviewed retrospectively.From March 2002 to December 2007, 55 early colon cancer patients were treated with endoscopy-assisted laparoscopic surgery in our institute. In 53 cases, a laparoscopic and endoscopic cooperative bowel segment resection was performed at first. Of these 53 patients, 11 cases then received laparoscopic and endoscopic cooperative radical anatomical resection according to the result of frozen section. Two cases were transferred to open surgery because of small intestinal inflation after endoscopic location. The mean operative time of cooperation was 90 min (55-240 min), and the mean blood loss was 50 ml(10-200 ml). In 51 cases(92.7%), the time for flatus passage was 2 to 3 days. The mean postoperative hospital stay was 5 d(2-15 d). No postoperative complications were found. Follow-up data were obtained by clinical examination and personal communication via telephone. The median follow-up was 42 months(ranged 3-72). Most of the patients were alive except one case died of myocardial infarction during the follow-up period. None of the patients with early colon cancer treated by the cooperative surgery had relapse or metastasis. Two cases of T1N1Mx underwent adjuvant chemotherapy.Endoscopy-assisted laparoscopic surgery offers a minimal-invasive and safe therapeutic approach for early colon cancer. The early colon cancer may be a good indication for endoscopy-assisted laparoscopic surgery when the endoscopic mucosal resection is inadequate.
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- 2009
13. Safety and efficacy of Qingre Buyi Decoction in the treatment of acute radiation proctitis: a prospective, randomized and controlled trial
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Lie, Wang, Zai-zhong, Zhang, Xiao-huang, Tu, Zhong-dong, Zou, Jian-hua, Liu, and Yu, Wang
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Adult ,Male ,Integrative Medicine ,Glutamine ,Silicates ,Anti-Inflammatory Agents ,Pain ,Middle Aged ,Azulenes ,Treatment Outcome ,Gastrointestinal Agents ,Acute Disease ,Humans ,Drug Therapy, Combination ,Female ,Proctitis ,Single-Blind Method ,Sesquiterpenes ,Aged ,Drugs, Chinese Herbal ,Norfloxacin - Abstract
To investigate the efficiency, safety, and possible mechanisms of Qingre Buyi Decoction (QBD) in the treatment of acute radiation proctitis (ARP).This study was a single center, prospective, single blind, randomized, and placebo-controlled clinical trial. A total of 60 patients with ARP was equally and randomly distributed into the control group (conventional treatment) and the combination group (conventional treatment plus QBD). The changes of main Chinese medicine clinical symptoms and signs, including stomachache, diarrhea, mucous or bloody stool before and after treatment, and their adverse reactions were observed after the two-week treatment. Also, D-lactate and diamine oxidase (DAO) levels, hepatic and renal function were measured. Cure rates, effective rates, and recurrence rates were compared between the two groups.The blood levels of both DAO and D-lactate were significantly decreased in the combination group as compared with those in the control group (P0.05 or P0.01). All main clinical symptoms and signs were alleviated more significantly in the combination group (P0.01). The main symptom scores also were significantly decreased after treatment in the control group (P0.01), except those for mucous or bloody stool (P0.05). Compared to the control group, the improvements of stomachache, diarrhea, defecation dysfunction, and stool blood in the combination group were significantly better (P0.05 or P0.01). For the combination group, the curative rate, effective rate, and recurrence rate was 76.67%, 16.67%, and 6.67%, respectively. On the other hand, for the control group, the rate was 53.33%, 16.67%, and 30.00%, respectively. The total curative effect was significantly better in the combination group than in the control group (P0.05). However, the recurrence rate was similar between the two groups (P0.05). The hepatic and renal function remained normal in both groups (P0.05). In addition, no severe adverse event was found in both groups.Addition of QBD to the conventional treatment can effectively alleviate the damage of intestinal mucosal barrier function and improve all main clinical symptoms and signs of the ARP. The combination of conventional treatment with Chinese herbal medicine QBD is effective and safe for ARP.
- Published
- 2008
14. Protective effects of N-acetylcysteine against liver injury in rats with severe acute pancreatitis
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Xiao-huang Tu, Lie Wang, Xiang-Quan Song, Shao-quan Chen, Zai-zhong Zhang, Yu Wang, and Zhong-dong Zou
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Acetylcysteine ,Liver injury ,medicine.medical_specialty ,business.industry ,Internal medicine ,medicine ,Acute pancreatitis ,medicine.disease ,business ,Gastroenterology ,medicine.drug - Published
- 2008
15. Mechanism of thermochemotherapy with 5-fluorocytosine on human colon cancer cell line SW480 transfected cytosine deaminase gene
- Author
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Lie Wang, Xiao-Huang Tu, Jing-Xiang Song, and Cheng-Jin Li
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Human colon cancer ,Chemistry ,Cell culture ,Mechanism (biology) ,Cytosine deaminase ,Transfection ,Molecular biology ,Gene - Published
- 2004
16. “Fast track” rehabilitation after gastric cancer resection: experience with 80 consecutive cases.
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Jing-xiang Song, Xiao-huang Tu, Bing Wang, Chen Lin, Zai-zhong Zhang, Li-ying Lin, and Lie Wang
- Abstract
Background: To evaluate the safety, efficacy and outcomes of fast-track rehabilitation applied to gastric cancer proximal, distal and total gastrectomy. Methods: Eighty consecutive patients undergoing gastric cancer resection performed by a single surgeon, received perioperative multimodal rehabilitation. Demographic and operative data, gastrointestinal function, postoperative hospital stays, surgical and general complications and mortality were assessed prospectively. Results: Of the 80 patients (mean age 56.3 years), 10 (12.5%) received proximal subtotal gastrectomy (Billroth I), 38 (47.5%) received distal (Billroth II), and 32 (40%) received total gastrectomy (Roux-en-Y). Mean operative time was 104.9 minutes and intraoperative blood loss was 281.9 ml. Time to first flatus was 2.8 ± 0.5 postoperative days. Patients were discharged at a mean of 5.3 ± 2.2 postoperative days; 30-day readmission rate was 3.8%. In-hospital mortality was 0%; general and surgical complications were both 5%. Conclusions: Fast-track multimodal rehabilitation is feasible and safe in patients undergoing gastric cancer resection and may reduce time to first flatus and postoperative hospital stays. [ABSTRACT FROM AUTHOR]
- Published
- 2014
- Full Text
- View/download PDF
17. 'Fast track' rehabilitation after gastric cancer resection: experience with 80 consecutive cases
- Author
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Liying Lin, Lie Wang, Xiao-huang Tu, Jing-xiang Song, Zai-zhong Zhang, Chen Lin, and Bing Wang
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Male ,medicine.medical_specialty ,medicine.medical_treatment ,Fast track rehabilitation ,Perioperative Care ,Cancer resection ,Cohort Studies ,Postoperative Complications ,Clinical Protocols ,Gastrectomy ,Stomach Neoplasms ,Internal medicine ,Humans ,Medicine ,Prospective Studies ,Prospective cohort study ,Early Ambulation ,Aged ,Neoplasm Staging ,Hospital stay ,Rehabilitation ,business.industry ,Fast-track surgery ,Gastroenterology ,Cancer ,General Medicine ,Length of Stay ,Middle Aged ,Hepatology ,medicine.disease ,Perioperative treatment ,Surgery ,Treatment Outcome ,Feasibility Studies ,Female ,Morbidity ,Gastric cancer ,business ,Research Article ,Cohort study - Abstract
Background To evaluate the safety, efficacy and outcomes of fast-track rehabilitation applied to gastric cancer proximal, distal and total gastrectomy. Methods Eighty consecutive patients undergoing gastric cancer resection performed by a single surgeon, received perioperative multimodal rehabilitation. Demographic and operative data, gastrointestinal function, postoperative hospital stays, surgical and general complications and mortality were assessed prospectively. Results Of the 80 patients (mean age 56.3 years), 10 (12.5%) received proximal subtotal gastrectomy (Billroth I), 38 (47.5%) received distal (Billroth II), and 32 (40%) received total gastrectomy (Roux-en-Y). Mean operative time was 104.9 minutes and intraoperative blood loss was 281.9 ml. Time to first flatus was 2.8 ± 0.5 postoperative days. Patients were discharged at a mean of 5.3 ± 2.2 postoperative days; 30-day readmission rate was 3.8%. In-hospital mortality was 0%; general and surgical complications were both 5%. Conclusions Fast-track multimodal rehabilitation is feasible and safe in patients undergoing gastric cancer resection and may reduce time to first flatus and postoperative hospital stays.
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