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We present an interface-type memristor utilizing native silicon oxide nanostructures achieved through controlled plasma oxidation engineering at room temperature. This process effectively reduces the concentration of oxygen vacancies on the surface of the native silicon oxide, facilitating oxygen-vacancy-mediated interfacial resistive switching with excellent COMS compatibility and low switching variability (1.03% for C2C and 3.96% for D2D variability). Moreover, this dynamic memristor exhibits favorable nonlinearity and short-term memory (STM) effects, which are crucial properties for the development of memristor-based reservoir computing (RC) systems. Compared with the conventional neural network, the RC system requires fewer trainable weights to achieve an accuracy of 96.7% for the Iris classification task. By the addition of virtual nodes to the reservoir with masks, the accuracy can be further increased to 100%. A simple digit recognition task is also employed, and noisy images that are not included in the original training set can be recognized correctly. These results highlight the great potential of our device for constructing reservoir computing hardware. [ABSTRACT FROM AUTHOR]

Background: The suitability of hepatectomy among patients with multinodular hepatocellular carcinoma (MHCC) beyond the Milan criteria remains controversial. There is a need for a reliable risk stratification tool among these patients for the selection of ideal candidates of curative resection. Purpose: To determine the clinicoradiological prognostic factors for patients with MHCC beyond the Milan criteria to further develop a stratification system. Study Type: Retrospective. Subjects: 176 patients with pathologically confirmed MHCC beyond the Milan criteria. Field Strength/Sequence: The 1.5 T scanner, including T1‐, T2‐, diffusion‐weighted imaging, in/out‐phase imaging, and dynamic contrast‐enhanced imaging. Assessment: Conventional MRI features and preoperative laboratory data including aspartate aminotransferase (AST) and α‐fetoprotein (AFP) were collected and analyzed. Two nomograms incorporating clinicoradiological variables were independently constructed to predict recurrence‐free survival (RFS) and overall survival (OS) with Cox regression analyses and verified with 5‐fold cross validation. Based on the nomograms, two prognostic stratification systems for RFS and OS were further developed. Statistical Tests: The Cohen's kappa/intraclass correlation coefficient, C‐index, calibration curve, Kaplan–Meier curve, log‐rank test. A P value <0.05 was considered statistically significant. Results: AST > 40 U/L, increased tumor burden score, radiological liver cirrhosis and nonsmooth tumor margin were independent predictors for poor RFS, while AST > 40 U/L, AFP > 400 ng/mL and radiological liver cirrhosis were independent predictors for poor OS. The two nomograms demonstrated good discrimination performance with C‐index of 0.653 (95% confidence interval [CI], 0.602–0.794) and 0.685 (95% CI, 0.623–0.747) for RFS and OS, respectively. The 5‐fold cross validation further validated the discrimination capability of the nomograms. Based on the nomogram models, MHCC patients beyond the Milan criteria were stratified into low−/medium−/high‐risk groups with significantly different RFS and OS. Data Conclusion: The proposed MRI‐based prognostic stratification system facilitates the refinement and further subclassification of patients with MHCC beyond the Milan criteria. Evidence Level: 4. Technical Efficacy: 2. [ABSTRACT FROM AUTHOR]

Background: Hepatocellular carcinoma (HCC) has a poor prognosis, often characterized by microvascular invasion (MVI). Radiomics and habitat imaging offer potential for preoperative MVI assessment., Purpose: To identify MVI in HCC by habitat imaging, tumor radiomic analysis, and peritumor habitat-derived radiomic analysis., Study Type: Retrospective., Subjects: Three hundred eighteen patients (53 ± 11.42 years old; male = 276) with pathologically confirmed HCC (training:testing = 224:94)., Field Strength/sequence: 1.5 T, T2WI (spin echo), and precontrast and dynamic T1WI using three-dimensional gradient echo sequence., Assessment: Clinical model, habitat model, single sequence radiomic models, the peritumor habitat-derived radiomic model, and the combined models were constructed for evaluating MVI. Follow-up clinical data were obtained by a review of medical records or telephone interviews., Statistical Tests: Univariable and multivariable logistic regression, receiver operating characteristic (ROC) curve, calibration, decision curve, Delong test, K-M curves, log rank test. A P-value less than 0.05 (two sides) was considered to indicate statistical significance., Results: Habitat imaging revealed a positive correlation between the number of subregions and MVI probability. The Radiomic-Pre model demonstrated AUCs of 0.815 (95% CI: 0.752-0.878) and 0.708 (95% CI: 0.599-0.817) for detecting MVI in the training and testing cohorts, respectively. Similarly, the AUCs for MVI detection using Radiomic-HBP were 0.790 (95% CI: 0.724-0.855) for the training cohort and 0.712 (95% CI: 0.604-0.820) for the test cohort. Combination models exhibited improved performance, with the Radiomics + Habitat + Dilation + Habitat 2 + Clinical Model (Model 7) achieving the higher AUC than Model 1-4 and 6 (0.825 vs. 0.688, 0.726, 0.785, 0.757, 0.804, P = 0.013, 0.048, 0.035, 0.041, 0.039, respectively) in the testing cohort. High-risk patients (cutoff value >0.11) identified by this model showed shorter recurrence-free survival., Data Conclusion: The combined model including tumor size, habitat imaging, radiomic analysis exhibited the best performance in predicting MVI, while also assessing prognostic risk., Evidence Level: 3 TECHNICAL EFFICACY: Stage 2., (© 2024 International Society for Magnetic Resonance in Medicine.)

Background: The number of focal liver lesions (FLLs) detected by imaging has increased worldwide, highlighting the need to develop a robust, objective system for automatically detecting FLLs., Purpose: To assess the performance of the deep learning-based artificial intelligence (AI) software in identifying and measuring lesions on contrast-enhanced magnetic resonance imaging (MRI) images in patients with FLLs., Study Type: Retrospective., Subjects: 395 patients with 1149 FLLs., Field Strength/sequence: The 1.5 T and 3 T scanners, including T1-, T2-, diffusion-weighted imaging, in/out-phase imaging, and dynamic contrast-enhanced imaging., Assessment: The diagnostic performance of AI, radiologist, and their combination was compared. Using 20 mm as the cut-off value, the lesions were divided into two groups, and then divided into four subgroups: <10, 10-20, 20-40, and ≥40 mm, to evaluate the sensitivity of radiologists and AI in the detection of lesions of different sizes. We compared the pathologic sizes of 122 surgically resected lesions with measurements obtained using AI and those made by radiologists., Statistical Tests: McNemar test, Bland-Altman analyses, Friedman test, Pearson's chi-squared test, Fisher's exact test, Dice coefficient, and intraclass correlation coefficients. A P-value <0.05 was considered statistically significant., Results: The average Dice coefficient of AI in segmentation of liver lesions was 0.62. The combination of AI and radiologist outperformed the radiologist alone, with a significantly higher detection rate (0.894 vs. 0.825) and sensitivity (0.883 vs. 0.806). The AI showed significantly sensitivity than radiologists in detecting all lesions <20 mm (0.848 vs. 0.788). Both AI and radiologists achieved excellent detection performance for lesions ≥20 mm (0.867 vs. 0.881, P = 0.671). A remarkable agreement existed in the average tumor sizes among the three measurements (P = 0.174)., Data Conclusion: AI software based on deep learning exhibited practical value in automatically identifying and measuring liver lesions., Technical Efficacy: Stage 2., (© 2024 International Society for Magnetic Resonance in Medicine.)