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Your search keyword '"Xiao, Yousheng"' showing total 143 results
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143 results on '"Xiao, Yousheng"'

9. Biosonar activity of the Indo-Pacific humpback dolphin (Sousa chinensis) near the tunnel section of the world’s longest cross-sea bridge—the Hong Kong-Zhuhai-Macao Bridge—is negatively correlated with underwater noise

Author

An, Xue, primary, Duan, Pengxiang, additional, Li, Weilun, additional, Yuan, Jing, additional, Chen, Yuwei, additional, Fan, Fei, additional, Deng, Xiaojun, additional, Xiao, Yousheng, additional, Chen, Xi, additional, Wang, Ding, additional, Wang, Zhitao, additional, and Wang, Kexiong, additional

Published
2023
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13. METTL14 is decreased and regulates m6A modification of α‐synuclein in Parkinson's disease.

Author

He, Honghu, Zhang, Qinxin, Liao, Jiajia, Lei, Jiang, Luo, Man, Huang, Jianyi, Chen, Meiling, Shen, Yuefei, Wang, Jin, Xu, Pingyi, and Xiao, Yousheng

Subjects
PARKINSON'S disease, ALPHA-synuclein, RNA modification & restriction, MONONUCLEAR leukocytes, RNA methylation, IMMUNOASSAY
Abstract

N6‐methyladenosine (m6A), an emerging modification of messenger RNA, has been implicated in many biological processes. However, its role in Parkinson's disease (PD) remains largely unknown. Here, we investigated the role of m6A modification and its underlying mechanism in PD. First, 86 individuals with PD and 86 healthy controls were recruited from a pilot multicenter cohort. Levels of m6A and its modulators in peripheral blood mononuclear cells of patients with PD and controls were measured using an m6A RNA methylation quantification kit and quantitative real‐time PCR. The underlying mechanism of m6A modification in PD was investigated in vitro through RNA immunoprecipitation assay, RNA stability assay, gene silencing or overexpression, western blot, and confocal immunoassay. The results show that mRNA levels of m6A, METTL3, METTL14, and YTHDF2 in patients with PD were significantly lower than in healthy controls, and METTL14 was the main factor involved in abnormal m6A modification. Area under the curve (AUC) analysis suggests METTL14 may provide excellent diagnostic capability for PD, especially when combined with plasma α‐synuclein (α‐syn). Spearman correlation analysis identified that METTL14 was moderately negatively correlated with plasma α‐syn and the motor function of PD. Mechanistic experiments demonstrated that Mettl14 targets and regulates the expression of the α‐syn gene using its methylation function. Overexpression of Mettl14 dramatically increased m6A modification of α‐syn mRNA and weakened its stability. Further results suggest that α‐syn mRNA was modified by Mettl14 binding of an m6A motif in the coding region of α‐syn mRNA, while the reading protein Ythdf2 was involved in recognizing m6A‐modified α‐syn mRNA. Taken together, our results reveal the potential of METTL14 as a novel diagnostic biomarker for PD and identify modification of pathogenic α‐syn protein by METTL14 via an m6A‐YTHDF2‐dependent mechanism. [ABSTRACT FROM AUTHOR]

Published
2023
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15. CHCHD2 maintains mitochondrial contact site and cristae organizing system stability and protects against mitochondrial dysfunction in an experimental model of Parkinson's disease

Author

Lu, Lin, primary, Mao, Hengxu, additional, Zhou, Miaomiao, additional, Lin, Yuwan, additional, Dai, Wei, additional, Qiu, Jiewen, additional, Xiao, Yousheng, additional, Mo, Mingshu, additional, Zhu, Xiaoqin, additional, Wu, Zhuohua, additional, Pei, Zhong, additional, Guo, Wenyuan, additional, Xu, Pingyi, additional, and Chen, Xiang, additional

Published
2022
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17. Perampanel monotherapy for epilepsy

Author

Wang, Jin, Zhong, Cai, and Xiao, Yousheng

Subjects
Pharmacology (medical)
Abstract

This protocol for a Cochrane Review is out of date and has been withdrawn in order to adhere to Cochrane policy.

Published
2021
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19. Comparing Brain Functional Activities in Patients With Blepharospasm and Dry Eye Disease Measured With Resting-State fMRI

Author

Feng, Changqiang, primary, Jiang, Wenyan, additional, Xiao, Yousheng, additional, Liu, Yang, additional, Pang, Lulu, additional, Liang, Meilan, additional, Tang, Jingqun, additional, Lu, Yulin, additional, Wei, Jing, additional, Li, Wenmei, additional, Lei, Yiwu, additional, Guo, Wenbin, additional, and Luo, Shuguang, additional

Published
2021
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20. Whistle signal variations among three Indo‐Pacific humpback dolphin populations in the South China Sea: a combined effect of the Qiongzhou Strait's geographical barrier function and local ambient noise?

Author

YUAN, Jing, primary, WANG, Zhitao, additional, DUAN, Pengxiang, additional, XIAO, Yousheng, additional, ZHANG, Hongke, additional, HUANG, Zhixiong, additional, ZHOU, Ruichun, additional, WEN, Hua, additional, WANG, Kexiong, additional, and WANG, Ding, additional

Published
2021
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21. Genetic analysis of NUS1 in Chinese patients with Parkinson's disease

Author

Chen, Xiang, primary, Xiao, Yousheng, additional, Zhou, Miaomiao, additional, Lin, Yuwan, additional, Guo, Wenyuan, additional, Huang, Shuxuan, additional, Qiu, Jiewen, additional, Peng, Guoyou, additional, Mo, Mingshu, additional, Li, Zhe, additional, Zhu, Xiaoqin, additional, and Xu, Pingyi, additional

Published
2020
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24. Relationship between variants of 17 newly loci and Parkinson's disease in a Chinese population

Author

Chen, Xiang, primary, Xiao, Yousheng, additional, Guo, Wenyuan, additional, Zhou, Miaomiao, additional, Huang, Shuxuan, additional, Mo, Mingshu, additional, Li, Zhe, additional, Li, Guihua, additional, Liu, Hanqun, additional, Peng, Guoyou, additional, Wu, Zhuohua, additional, Wu, Yijuan, additional, Yang, Chaohao, additional, Pei, Zhong, additional, Chen, Chaojun, additional, and Xu, Pingyi, additional

Published
2019
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26. Acupuncture Modulates the Cerebello-Thalamo-Cortical Circuit and Cognitive Brain Regions in Patients of Parkinson's Disease With Tremor

Author

Li, Zhe, primary, Chen, Jun, additional, Cheng, Jianbo, additional, Huang, Sicong, additional, Hu, Yingyu, additional, Wu, Yijuan, additional, Li, Guihua, additional, Liu, Bo, additional, Liu, Xian, additional, Guo, Wenyuan, additional, Huang, Shuxuan, additional, Zhou, Miaomiao, additional, Chen, Xiang, additional, Xiao, Yousheng, additional, Chen, Chaojun, additional, Chen, Junbin, additional, Luo, Xiaodong, additional, and Xu, Pingyi, additional

Published
2018
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27. Iron promotes α-synuclein aggregation and transmission by inhibiting TFEB-mediated autophagosome-lysosome fusion

Author

Xiao, Yousheng, primary, Chen, Xiang, additional, Huang, Shuxuan, additional, Li, Guihua, additional, Mo, Mingshu, additional, Zhang, Li, additional, Chen, Chaojun, additional, Guo, Wenyuan, additional, Zhou, Miaomiao, additional, Wu, Zhuohua, additional, Cen, Luan, additional, Long, Simei, additional, Li, Shaomin, additional, Yang, Xinling, additional, Qu, Shaogang, additional, Pei, Zhong, additional, and Xu, Pingyi, additional

Published
2018
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38. Association of IGF1 gene polymorphism with Parkinson's disease in a Han Chinese population.

Author

Xiao, Yousheng, Cen, Luan, Mo, Mingshu, Chen, Xiang, Huang, Shuxuan, Wei, Lei, Li, Shaomin, Yang, Xinling, Qu, Shaogang, Pei, Zhong, and Xu, Pingyi

Abstract

Background Accumulating evidence suggests that insulin-like growth factor 1 ( IGF1) plays an important role in Parkinson's disease (PD) pathogenesis. However, it is not clear whether IGF1 polymorphism contributes to PD risk. Methods We performed a case-control study in a Han Chinese population that included 512 sporadic PD cases and 535 matched controls. All participants were genotyped for rs972936 using the Sequenom MassARRAY iPLEX platform. Serum IGF1 levels of 61 de novo, drug-naïve PD patients and 55 age- and sex-matched controls were also measured using an enzyme-linked immunosorbent assay. Results Genotype frequency of rs972936-CC was significantly associated with an increased PD risk ( p = 0.009), especially in males ( p = 0.024) and late-onset patients ( p = 0.013). Serum IGF1 levels were significantly increased in de novo, drug-naïve PD patients compared to controls ( p = 0.036), although they were not correlated with motor dysfunction in PD patients ( p = 0.220). Conclusions The present study shows that rs972936 polymorphism may increase susceptibility to PD, especially in males and late-onset patients. Furthermore, high serum IGF1 levels may be a potential diagnostic biomarker for PD in the Han Chinese population, although they do not correlate with a more severe motor dysfunction. [ABSTRACT FROM AUTHOR]

Published
2017
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