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Your search keyword '"Xiao, Tai-Wu"' showing total 13 results
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13 results on '"Xiao, Tai-Wu"'

1. The outcome and predictive model of allogeneic hematopoietic stem cell transplantation among elderly patients with severe aplastic anemia from the Chinese Blood and Marrow Transplant Registry Group

Author

Xu, Zheng-Li, primary, Xu, Lan-Ping, additional, Zhang, Yi-Cheng, additional, Zhou, Yu-Hong, additional, Jiang, Er-Lie, additional, Zhang, Jian-Ping, additional, Fu, Bin, additional, Ouyang, Gui-Fang, additional, Song, Xian-Min, additional, Zhang, Xue-Jun, additional, Dong, Yu-Jun, additional, Li, Nai-Nong, additional, Wang, Ling, additional, Zhang, Xi, additional, He, Peng-Cheng, additional, Kong, Fan-Sheng, additional, Liu, Hui-Xia, additional, Liu, Li, additional, Liu, Lin, additional, Xiao, Tai-Wu, additional, Xu, Wen-Wei, additional, Xu, Xiao-Jun, additional, Yuan, Guo-Lin, additional, Yi, Hai, additional, Yu, Dan, additional, Yu, Li, additional, and Huang, Xiao-Jun, additional

Published
2024
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9. Knockdown of eukaryotic translation initiation factor 3 subunit D (eIF3D) inhibits proliferation of acute myeloid leukemia cells.

Author

Liu, Guo-zhen, Liu, Ji-zhu, Li, Xiao-qing, Zhang, Li, Li, Shuang-jing, Xiao, Tai-wu, Wang, Jing-xia, Li, Guang-yao, and Liu, Yusen

Abstract

Various eukaryotic translation initiation factors (eIFs) have been implicated in carcinoma development. Eukaryotic translation initiation factor 3 subunit D (eIF3D) has recently been shown to regulate the growth of several types of human cancer cells. However, the function of eIF3D in acute myeloid leukemia (AML) remains unclear. In this study, we investigated the expression of eIF3D in three AML cell lines and a lymphoblast cell line, and found that eIF3D was expressed in all four leukemia cell lines. To explore the role of eIF3D in AML cell proliferation, lentivirus-mediated RNA interference was applied to knock down the expression of eIF3D in U937 cells. The expression of eIF3D was significantly downregulated in U937 cells after eIF3D knockdown, as confirmed by quantitative real-time PCR (qRT-PCR) and Western blot analysis. Knockdown of eIF3D significantly inhibited proliferation of U937 cells. Furthermore, flow cytometry analysis revealed that eIF3D silencing induced cell cycle arrest at the G2/M phase, ultimately leading to apoptosis. Our results indicate that eIF3D plays a key role in the proliferation of AML cells, and suggest that eIF3D silencing might be a potential therapeutic strategy for leukemia. [ABSTRACT FROM AUTHOR]

Published
2018
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11. Effect of a seashell protein Haishengsu on cell growth and expression of apoptosis genes in leukemia K562 cells

Author

Li, Guang-Yao, Liu, Ji-Zhu, Yu, Xiao-Min, Chen, Shuang-Feng, Zhang, Bin, Zhang, Wei-Feng, Xiao, Tai-Wu, Wang, Chun-Bo, Wang, Le-Xin, Li, Guang-Yao, Liu, Ji-Zhu, Yu, Xiao-Min, Chen, Shuang-Feng, Zhang, Bin, Zhang, Wei-Feng, Xiao, Tai-Wu, Wang, Chun-Bo, and Wang, Le-Xin

Abstract

Objectives: To investigate the effect of a seashell protein Haishengsu (HSS), an extract from a shellfish Tegillarca granosa, on cell growth and the expression of apoptosis genes in leukemia K562 cells. Methods: Cultured K562 cells were treated with HSS at various concentrations (10-40mg/L). The cell cycle, cell growth and the expression of apoptosis suppressor gene bcl-2 and apoptosis promoting gene bax were evaluated. Results: HSS, 20mg/L, inhibited cell cycle in the G0/G1 and S phases. HSS, 20mg/L, also inhibited the growth of K562 cells over time. Expression of bcl-2 gene in the HSS 20mg/L (58.8%±4.7%) and HSS 40mg/L group (26.6%±2.1%) were lower than in the control group (91.0±8.7%, P < 0.01). Expression of bax gene in the HSS 20mg/L (77.7±3.6%) and 40mg/L group (90.6±3.7%) were higher than in the control group (10.9±6.6%, P < 0.01). Conclusion: HSS suppresses leukemia K562 cell growth by inhibiting the G0/G1 and S phases of the cell cycle. It also induces apoptosis in these leukemia cells by reducing the expression of apoptosis suppressor gene bcl-2, and increasing the expression of apoptosis promoting gene bax. Further studies are required to investigate the clinical efficacy of HSS in leukemia.

Published
2008

13. The outcome of allogeneic hematopoietic stem cell transplantation among elderly patients with severe aplastic anemia and a predictive model from the Chinese Blood and Marrow Transplant Registry group.

Author

Xu ZL, Xu LP, Zhang YC, Zhou YH, Jiang EL, Zhang JP, Fu B, Ouyang GF, Song XM, Zhang XJ, Dong YJ, Li NN, Wang L, Zhang X, He PC, Kong FS, Liu HX, Liu L, Liu L, Xiao TW, Xu WW, Xu XJ, Yuan GL, Yi H, Yu D, Yu L, and Huang XJ

Subjects
Humans, Aged, Male, Female, Middle Aged, Treatment Outcome, China epidemiology, East Asian People, Hematopoietic Stem Cell Transplantation methods, Anemia, Aplastic therapy, Anemia, Aplastic mortality, Anemia, Aplastic diagnosis, Registries, Transplantation, Homologous
Published
2024
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