19 results on '"Xiao, Jing-Fang"'
Search Results
2. CCL8 secreted by tumor-associated macrophages promotes invasion and stemness of glioblastoma cells via ERK1/2 signaling
- Author
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Zhang, Xiang, Chen, Lu, Dang, Wei-qi, Cao, Mian-fu, Xiao, Jing-fang, Lv, Sheng-qing, Jiang, Wen-jie, Yao, Xiao-hong, Lu, Hui-min, Miao, Jing-ya, Wang, Yan, Yu, Shi-cang, Ping, Yi-fang, Liu, Xin-dong, Cui, You-hong, Zhang, Xia, and Bian, Xiu-wu
- Published
- 2020
- Full Text
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3. A 3D screening approach identifies the compound epitajixanthone hydrate as a new inhibitor of cancer cell growth and invasion
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Yang, Sheng-Xiang, Xiao, Jing-Fang, Liu, Ting-Kai, Huang, Ze-Diao, Li, Xiang, Chen, Ye-Miao, and Yang, Xiao-Long
- Published
- 2020
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4. Zyxin (ZYX) promotes invasion and acts as a biomarker for aggressive phenotypes of human glioblastoma multiforme
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Wen, Xian-Mei, Luo, Tao, Jiang, Yi, Wang, Li-Hong, Luo, Ying, Chen, Qian, Yang, Kaidi, Yuan, Ye, Luo, Chunhua, Zhang, Xiang, Yan, Ze-Xuan, Fu, Wen-Juan, Tan, Yu-Huan, Niu, Qin, Xiao, Jing-Fang, Chen, Lu, Wang, Jiao, Huang, Jia-Feng, Cui, You-Hong, Zhang, Xia, Wang, Yan, and Bian, Xiu-Wu
- Abstract
Glioblastoma multiforme (GBM) is characterized by highly invasive growth, which leads to extensive infiltration and makes complete tumor excision difficult. Since cytoskeleton proteins are related to leading processes and cell motility, and through analysis of public GBM databases, we determined that an actin-interacting protein, zyxin (ZYX), may involved in GBM invasion. Our own glioma cohort as well as the cancer genome atlas (TCGA), Rembrandt, and Gravendeel databases consistently showed that increased ZYXexpression was related to tumor progression and poor prognosis of glioma patients. In vitro and in vivo experiments further confirmed the oncogenic roles of ZYXand demonstrated the role of ZYXin GBM invasive growth. Moreover, RNA-seq and mass-spectrum data from GBM cells with or without ZYXrevealed that stathmin 1 (STMN1) was a potential target of ZYX. Subsequently, we found that both mRNA and protein levels of STMN1were positively regulated by ZYX. Functionally, STMN1not only promoted invasion of GBM cells but also rescued the invasion repression caused by ZYXloss. Taken together, our results indicate that high ZYXexpression was associated with worse prognosis and highlighted that the ZYX-STMN1axis might be a potential therapeutic target for GBM.
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- 2024
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5. Study of Enhanced Depth Imaging Optical Coherence Tomography in Cerebral Autosomal Dominant Arteriopathy with Subcortical Infarcts and Leukoencephalopathy
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Xiao-Jing Fang, Meng Yu, Yuan Wu, Zi-Hao Zhang, Wei-Wei Wang, Zhao-Xia Wang, and Yun Yuan
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Cerebral Autosomal Dominant Arteriopathy with Subcortical Infarcts and Leukoencephalopathy ,Magnetic Resonance Imaging ,Optical Coherence Tomography ,Retinal Vessels ,Medicine - Abstract
Background: Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) is a hereditary small artery disease caused by NOTCH3 gene mutation. We performed enhanced depth imaging optical coherence tomography (EDI-OCT) to evaluate the retinal vessel changes in CADASIL patients and assessed their consonance with brain magnetic resonance imaging (MRI) findings. Methods: Of 27 genetically confirmed patients and an equal number of controls were recruited at the Peking University First Hospital from January 2015 to August 2016. All patients underwent 7T-MRI of the brain. Fazekas score, number of small infarcts and microbleeds were evaluated. All patients and controls underwent EDI-OCT to measure subfoveal choroidal thickness (SFCT), inner and outer diameters as well as arterial and venous wall thickness, and arterial venous ratio of the inner (AVRin) and outer diameters (AVRout). The relation between retinal vessel changes and Fazekas scores, numbers of small infarcts, or microbleeds was analyzed. Paired t-test was used to compare the SFCT and retinal vessel measurement data between patients and controls. Spearman's correlation was used to investigate the correlation between retinal vessel changes and MRI lesions. Results: In CADASIL patients, mean SFCT (268.37 ± 46.50 μm) and mean arterial inner diameter (93.46 ± 9.70 μm) were significantly lower than that in controls (P < 0.001,P = 0.048, respectively). Mean arterial outer diameter (131.74 ± 10.87 μm), venous inner (128.99 ± 13.62 μm) and outer diameter (164.82 ± 14.77 μm), and mean arterial (19.13 ± 1.85 μm) and venous (17.91 ± 2.76 μm) wall thickness were significantly higher than that in controls (P = 0.023,P = 0.004,P < 0.001,P < 0.001, respectively). Arterial inner diameter (rs= −0.39, P= 0.044), AVRin (rs= −0.65,P < 0.001), and AVRout (rs= −0.56, P= 0.002) showed a negative correlation with the number of small infarcts. Venous inner diameter (rs = 0.46, P= 0.016) showed a positive correlation with the number of small infarcts. Venous inner diameter (rs = 0.59, P= 0.002), outer diameter (rs = 0.47, P= 0.017), showed a positive correlation with the number of cerebral microbleeds (CMBs). AVRin (rs= −0.52, P= 0.007) and AVRout (rs= −0.40, P= 0.048) showed a negative correlation with the number of CMBs. Conclusions: Measurement of retinal vessels using EDI-OCT correlates moderately well with MRI parameters. EDI-OCT might be a useful evaluation tool for CADASIL patients.
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- 2017
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6. Compound Heterozygote Mutation of C12orf65 Causes Distal Motor Neuropathy and Optic Atrophy
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Xiao-Jing Fang, Wei Zhang, He Lyu, Zhao-Xia Wang, Wei-Wei Wang, and Yun Yuan
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C12orf65 Protein ,Inherited Peripheral Neuropathy ,Optic Atrophy ,Medicine - Published
- 2017
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7. Current status and potential application of navigated transcranial magnetic stimulation in neurosurgery: a literature review
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Yuanli Zhao, Changyu Lu, Xianzeng Liu, Meige Liu, and Xiao-Jing Fang
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medicine.medical_specialty ,Computer science ,medicine.medical_treatment ,Neurosurgery ,lcsh:Surgery ,Review ,lcsh:RC346-429 ,03 medical and health sciences ,0302 clinical medicine ,Physical medicine and rehabilitation ,Cortex (anatomy) ,medicine ,Speech mapping ,lcsh:Neurology. Diseases of the nervous system ,Navigational system ,Motor mapping ,Human brain ,lcsh:RD1-811 ,Transcranial magnetic stimulation ,Functional mapping ,medicine.anatomical_structure ,Neurology ,030220 oncology & carcinogenesis ,Surgery ,Neurology (clinical) ,Primary motor cortex ,030217 neurology & neurosurgery - Abstract
Transcranial magnetic stimulation (TMS) is a noninvasive neurophysiologic technique that can stimulate the human brain. Positioning of the coil was often performed based merely on external landmarks on the head, meaning that the anatomical target in the cortex remains inaccurate. Navigated transcranial magnetic stimulation (nTMS) combines a frameless stereotactic navigational system and TMS coil and can provide a highly accurate delivery of TMS pulses with the guidance of imaging. Therefore, many novel utilities for TMS could be explored due to the ability of precise localization. Many studies have been published, which indicate nTMS enables presurgical functional mapping. This review aimed to provide a comprehensive literature review on nTMS, especially the principles and clinical applications of nTMS. All articles in PubMed with keywords of “motor mapping,” “presurgical mapping,” “navigated transcranial magnetic stimulation,” and “language mapping” published from 2000 to 2018 were included in the study. Frequently cited publications before 2000 were also included. The most valuable published original and review articles related to our objective were selected. Motor mapping of nTMS is validated to be a trustful tool to recognize functional areas belonging to both normal and lesioned primary motor cortex. It can offer reliable mapping of speech and motor regions at cortex prior to operation and has comparable accuracy as direct electrical cortical stimulation. nTMS is a powerful tool for mapping of motor and linguistic function prior to operation, has high application value in neurosurgery and the treatment of neurological and psychiatric diseases, and has gained increasing acceptance in neurosurgical centers across the world.
- Published
- 2019
8. Stromal PD-1+ tumor-associated macrophages predict poor prognosis in lung adenocarcinoma
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Chen, Lu, primary, Cao, Mian-Fu, additional, Xiao, Jing-Fang, additional, Ma, Qing-Hua, additional, Zhang, Han, additional, Cai, Rui-Li, additional, Miao, Jing-Ya, additional, Wang, Wen-Ying, additional, Zhang, Hua, additional, Luo, Min, additional, Ping, Yi-Fang, additional, Yao, Xiao-Hong, additional, Cui, You-Hong, additional, Zhang, Xia, additional, and Bian, Xiu-Wu, additional
- Published
- 2020
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9. The landscape of immune microenvironment in lung adenocarcinoma and squamous cell carcinoma based on PD‐L1 expression and tumor‐infiltrating lymphocytes
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Chen, Lu, primary, Cao, Mian‐Fu, additional, Zhang, Xiang, additional, Dang, Wei‐Qi, additional, Xiao, Jing‐Fang, additional, Liu, Qing, additional, Tan, Yu‐Huan, additional, Tan, Yao‐Yao, additional, Xu, Yuan‐Yuan, additional, Xu, Sen‐Lin, additional, Yao, Xiao‐Hong, additional, Cui, You‐Hong, additional, Zhang, Xia, additional, and Bian, Xiu‐Wu, additional
- Published
- 2019
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10. Association of maximum standardized uptake value with occult mediastinal lymph node metastases in cN0 non-small cell lung cancer
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Xiao-jing Fang, Jun-yi Zheng, Song Dong, Xue-Ning Yang, Wen-Zhao Zhong, Qiang Nie, Jun-Tao Lin, Ri-Qiang Liao, Yi-Long Wu, and Si-xian Weng
- Subjects
Adult ,Male ,Pulmonary and Respiratory Medicine ,medicine.medical_specialty ,Lung Neoplasms ,Standardized uptake value ,030204 cardiovascular system & hematology ,Sensitivity and Specificity ,03 medical and health sciences ,0302 clinical medicine ,Risk Factors ,Carcinoma, Non-Small-Cell Lung ,Positron Emission Tomography Computed Tomography ,Preoperative Care ,medicine ,Humans ,Stage (cooking) ,Lung cancer ,False Negative Reactions ,Aged ,Neoplasm Staging ,Retrospective Studies ,Aged, 80 and over ,business.industry ,Paratracheal lymph nodes ,Mediastinum ,Cancer ,General Medicine ,Middle Aged ,medicine.disease ,Occult ,medicine.anatomical_structure ,ROC Curve ,Lymphatic Metastasis ,030220 oncology & carcinogenesis ,Mediastinal lymph node ,Lymph Node Excision ,Female ,Surgery ,Radiology ,Cardiology and Cardiovascular Medicine ,business - Abstract
OBJECTIVES The management of non-small cell lung cancer (NSCLC) relies on the tumour-node-metastasis (TNM) stage, and the treatment regimen differs based on the N status. Positron emission tomography-computed tomography (PET-CT) has emerged as a powerful imaging tool for the detection of various cancers with a relatively low false-negative rate. We explored predictors to identify false-negative N2 disease in PET-CT. METHODS A total of 284 consecutive cN0 patients with peripheral NSCLC who underwent PET-CT scans followed by curative intent resections were enrolled as a training set to identify predictors of occult N2 metastases by multivariable analysis. The accuracy and cut-off values for the predictors were calculated using a receiver operating characteristic curve. Clinical and pathological data were analysed retrospectively. An additional 151 patients were collected as a test set to validate the results, including the occult N2 rate and accuracy. RESULTS In total, 8.5% (24/284) PET-CT-diagnosed N0 NSCLC cases had pathologically diagnosed N2 metastases. The SUVmax of the primary tumour was a unique independent risk factor for occult N2 NSCLC [P = 0.003, 95% confidence interval = 0.81-0.96, odds ratio (OR) = 0.88]. Occult N2 metastases occurred more frequently in the subcarinal (16/24) and right lower paratracheal lymph nodes (12/24). Accordingly, we divided the patients into two groups by SUVmax: the occult N2 rates in the SUVmax of
- Published
- 2016
11. Clinical application of 3.0 T intraoperative magnetic resonance combined with multimodal neuronavigation in resection of cerebral eloquent area glioma
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Chang-Yu Lu, Yuanli Zhao, Xiao-Jing Fang, Xiao-Lin Chen, and Xiao-Lei Chen
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Adult ,Male ,medicine.medical_specialty ,Neuronavigation ,Interventional magnetic resonance imaging ,Eloquent Brain Areas ,Observational Study ,Multimodal Imaging ,Neurosurgical Procedures ,030218 nuclear medicine & medical imaging ,Resection ,03 medical and health sciences ,0302 clinical medicine ,Eloquent cortex ,Glioma ,Monitoring, Intraoperative ,medicine ,Humans ,navigated transcranial magnetic stimulation (nTMS) ,medicine.diagnostic_test ,business.industry ,Brain Neoplasms ,intraoperative magnetic resonance image ,Brain ,Magnetic resonance imaging ,General Medicine ,Middle Aged ,medicine.disease ,Magnetic Resonance Imaging ,cerebral eloquent area glioma ,Treatment Outcome ,Female ,Neurosurgery ,Radiology ,multimodal neuronavigation ,business ,030217 neurology & neurosurgery ,Research Article - Abstract
Glioma is the most common tumor among central nervous system tumors; surgical intervention presents difficulties. This is especially the case for gliomas in so-called “eloquent areas,” as surgical resection threatens vital structures adjacent to the tumor. Intraoperative magnetic resonance imaging (iMRI) combined with multimodal neuronavigation may prove beneficial during surgery. This study explored the applicability of 3.0 T high field iMRI combined with multimodal neuronavigation in the resection of gliomas in eloquent brain areas. We reviewed 40 patients with a glioma located in the eloquent brains areas who underwent treatment in the Neurosurgery Department of Peking University International Hospital between December 2015 and August 2017. The experimental group included 20 patients treated using iMRI assistance technology (iMRI group). The remaining 20 patients underwent treatment by conventional neuronavigation (non-iMRI group). Tumor resection degree, preoperative and postoperative ability of daily living scale (Barthel index), infection rate, and operative time were compared between the 2 groups. No difference in infection rate was observed between the 2 groups. However, compared with the non-iMRI group, the iMRI group had a higher resection rate (96.55 ± 4.03% vs 87.70 ± 10.98%, P = .002), postoperative Barthel index (90.75 ± 12.90 vs 9.25 ± 16.41, P = .018), as well as a longer operation time (355.85 ± 61.40 vs 302.45 ± 64.09, P = .011). The use of iMRI technology can achieve a relatively higher resection rate among cases of gliomas in eloquent brain areas, with less incidence of postoperative neurological deficits. Although the operative time using iMRI was longer than that taken to perform conventional navigation surgery, the surgical infection rate in these 2 procedures showed no significant difference.
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- 2018
12. Prenylated Indole Diterpene Alkaloids from a Mine-Soil-Derived Tolypocladium sp.
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Xu, Lu-Lin, primary, Hai, Ping, additional, Zhang, Shuai-Bing, additional, Xiao, Jing-Fang, additional, Gao, Yuan, additional, Ma, Bing-Ji, additional, Fu, Hai-Yan, additional, Chen, Ye-Miao, additional, and Yang, Xiao-Long, additional
- Published
- 2019
- Full Text
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13. The Study on Intangible Culture Heritage Protection Method by Utilizing China's University Libraries
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Xiao-Jing Fang, Hong-Guang Ye, Bin Li, and An-Ding Liu
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Cultural heritage ,Engineering ,Intangible cultural heritage ,business.industry ,Library science ,China ,business - Published
- 2017
14. Study on Causes of Disappearance of Wax Printing Technique in the Central Plains Area during Song Dynasty
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Xiao-Jing Fang, Bin Li, Hong-Guang Ye, and An-Ding Liu
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Wax ,Geography ,visual_art ,visual_art.visual_art_medium ,Archaeology - Published
- 2017
15. The Construction of Augmented Reality Teleoperation System with Force Feedback
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Rongxin Fu, Si Yu Han, Xiao Jing Fang, Xiao Ou Liu, Xin Gao, and Ping Wang
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Engineering ,Telerobotics ,business.industry ,Control (management) ,Control engineering ,General Medicine ,Virtual reality ,Teleoperation ,Augmented reality ,Motion planning ,business ,Robotic arm ,Simulation ,Haptic technology - Abstract
Aiming at the time delay of telecommunication problem and the real-time correction problem in path planning, this paper presents a telerobot system based on augmented reality technology and force feedback technology. The core is the dynamic integration of live streaming video of the remote scene and virtual robot, and applying the force feedback sensing and control technologies to solve robotic arms path planning problem. Experiment proves that the system can basically solve the delay problem and make up for the limitation of merely relying on virtual reality simulation technology.
- Published
- 2014
16. On the dynamics of a certain four-order fractional difference equations.
- Author
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Chang-you Wang, Xiao-jing Fang, and Rui Li
- Subjects
- *
NUMERICAL solutions to difference equations , *RECURSIVE sequences (Mathematics) , *DIFFERENTIAL equations , *ASYMPTOTIC theory of algebraic ideals , *EQUILIBRIUM , *MATHEMATICAL inequalities , *MATHEMATICS theorems , *ITERATIVE methods (Mathematics) - Abstract
This paper is concerned with the following rational recursive sequences xn+1=xn-1xn-1/A+Byn-3,yn+1=yn-1yn-2/C+Dxn-3, n=0,1,---, where the parameters A, B, C, D are positive constants. The initial condition x-3, x-2,x-1,x0, and y-3, y-2,y-1,y0 are arbitrary nonnegative real numbers. We give sufficient conditions under which the equilibrium (0,0) of the system is globally asymptotically stable, which extends and includes corresponding results obtained in the cited references [12-17]. Moreover, the asymptotic behavior of others equilibrium points is also studied. Our approach to the problem is based on new variational iteration method for the more general nonlinear difference equations and inequality skills as well as the linearization techniques. [ABSTRACT FROM AUTHOR]
- Published
- 2017
17. Association of maximum standardized uptake value with occult mediastinal lymph node metastases in cN0 non-small cell lung cancer.
- Author
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Jun-tao Lin, Xue-ning Yang, Wen-zhao Zhong, Ri-qiang Liao, Song Dong, Qiang Nie, Si-xian Weng, Xiao-jing Fang, Jun-yi Zheng, and Yi-long Wu
- Subjects
NON-small-cell lung carcinoma ,FLUORODEOXYGLUCOSE F18 ,POSITRON emission tomography ,COMPUTED tomography ,MULTIVARIATE analysis - Abstract
OBJECTIVES: The management of non-small cell lung cancer (NSCLC) relies on the tumour-node-metastasis (TNM) stage, and the treatment regimen differs based on the N status. Positron emission tomography-computed tomography (PET-CT) has emerged as a powerful imaging tool for the detection of various cancers with a relatively low false-negative rate. We explored predictors to identify false-negative N2 disease in PET-CT. METHODS: A total of 284 consecutive cN0 patients with peripheral NSCLC who underwent PET-CT scans followed by curative intent resections were enrolled as a training set to identify predictors of occult N2 metastases by multivariable analysis. The accuracy and cut-off values for the predictors were calculated using a receiver operating characteristic curve. Clinical and pathological data were analysed retrospectively. An additional 151 patients were collected as a test set to validate the results, including the occult N2 rate and accuracy. RESULTS: In total, 8.5% (24/284) PET-CT-diagnosed N0 NSCLC cases had pathologically diagnosed N2 metastases. The SUV
max of the primary tumour was a unique independent risk factor for occult N2 NSCLC [P = 0.003, 95% confidence interval = 0.81-0.96, odds ratio (OR) = 0.88]. Occult N2 metastases occurred more frequently in the subcarinal (16/24) and right lower paratracheal lymph nodes (12/24). Accordingly, we divided the patients into two groups by SUVmax : the occult N2 rates in the SUVmax of <2.6 and SUVmax of ≥2.6 groups were 1.0% (1/100) and 12.5% (23/184), respectively (P = 0.001). In the test set, the occult N2 incidence rate was 9.3% (14/151), with the highest rates occurring in the subcarinal (9/14) and right lower paratracheal lymph nodes (6/14). In the two groups defined by SUVmax , the occult N2 rates were 4% (2/50) and 11.9% (12/101), respectively. CONCLUSIONS: The SUVmax of the primary tumour was an independent risk factor for occult N2 metastases in NSCLC patients diagnosed as clinical N0 by PET-CT. SUVmax of ≥2.6 of the primary tumour may indicate the risk of N2 metastases, and invasive mediastinal staging techniques or comprehensive therapy should not be ignored in these patients. [ABSTRACT FROM AUTHOR]- Published
- 2016
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18. On the solution for a system of two rational difference equations.
- Author
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Chang-you Wang, Xiao-jing Fang, and Rui Li
- Subjects
- *
DIFFERENCE equations , *NUMERICAL analysis , *DIFFERENCE sets , *MATHEMATICAL equivalence - Abstract
This paper is concerned with the dynamical behavior and the expression of the solution for a system of two rational difference equations xn+1=xn-3/A+Xn-3yn-1, yn+1 =yn-3/B+yn-3xn-1, n=0,1,..., where the parameters A, B and the initial conditions x-3,x-2,x-1,x0,y-3,y-2,y-1,y0 are positive real numbers. [ABSTRACT FROM AUTHOR]
- Published
- 2016
19. Stromal PD-1 + tumor-associated macrophages predict poor prognosis in lung adenocarcinoma.
- Author
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Chen L, Cao MF, Xiao JF, Ma QH, Zhang H, Cai RL, Miao JY, Wang WY, Zhang H, Luo M, Ping YF, Yao XH, Cui YH, Zhang X, and Bian XW
- Subjects
- Adenocarcinoma of Lung genetics, Adenocarcinoma of Lung mortality, Adenocarcinoma of Lung pathology, Animals, Biomarkers, Tumor genetics, Carcinoma, Lewis Lung genetics, Carcinoma, Lewis Lung pathology, Female, Gene Expression Regulation, Neoplastic, Humans, Immunohistochemistry, Lung Neoplasms genetics, Lung Neoplasms mortality, Lung Neoplasms pathology, Macrophages pathology, Male, Mice, Inbred C57BL, Middle Aged, Prognosis, Programmed Cell Death 1 Receptor genetics, Stromal Cells pathology, Adenocarcinoma of Lung immunology, Biomarkers, Tumor analysis, Carcinoma, Lewis Lung immunology, Lung Neoplasms immunology, Macrophages immunology, Programmed Cell Death 1 Receptor analysis, Stromal Cells immunology
- Abstract
Immunotherapies targeting programmed cell death protein 1 (PD-1)/PD-1 ligand (PD-L1) axis have been emerging as a promising therapeutic strategy to treat lung cancer. PD-1 is preferentially expressed by activated T lymphocytes; but whether/how its expression by tumor-associated macrophages (TAMs) in lung adenocarcinoma remains elusive. Herein, we investigate the frequency of PD-1 expression on TAMs in mouse allografts by flow cytometry analysis and evaluate the spatial distribution and clinicopathological significance of PD-1
+ TAMs in 213 cases of human lung adenocarcinoma specimens by immunohistochemical staining. We find the expression of PD-1 by both mouse and human TAMs. Mouse PD-1+ TAMs possess unique transcriptional profile as compared to PD-1- TAMs. Furthermore, PD-1 is preferentially expressed by CD163+ TAMs in the tumor stroma than those in the tumor islets of lung adenocarcinoma. Stromal PD-1+ TAM infiltration is an independent predictor of reduced survival as determined by univariate (P < .001) and multivariate (P = .023) analysis. Moreover, patients with high stromal PD-1+ TAMs but low tumor cell PD-L1 expression have the shortest survival (P = .0001). Our study demonstrates that PD-1+ TAMs have unique gene expression characteristics and PD-1+ TAMs in the tumor stroma is a potential prognostic factor in lung adenocarcinoma, suggesting that a better understanding of PD-1+ TAMs will be beneficial for immunotherapy of lung adenocarcinoma patients., (Copyright © 2020 Elsevier Inc. All rights reserved.)- Published
- 2020
- Full Text
- View/download PDF
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