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The (Mg0.75Zn0.25)TiO3 ceramics with Ta2O5 additive were prepared with solid-state reaction method. Ta2O5 as an additive effectively lowered the sintering temperature to 1100 °C and improved the microstructure of the ceramics. Ta5+ was completely incorporated into the (Mg0.75Zn0.25)TiO3 lattice to form the ilmenite phase (R-3), alongside the emergence of a second phase, MgTi2O5. The increasing content of the second phase caused the cell volume of the main phase to increase. When the Ta2O5 content is less than 5 wt%, the density of the ceramics has the main effect on the εr, while above 5 wt%, the second phase plays a dominant role in the εr of the ceramics. The results showed that when the additive of Ta2O5 is 2 wt%, the ceramics sintered at 1100 °C for 3 h exhibited the excellent microwave dielectric properties of Q × f ~ 108,726 (at 7.9 GHz), εr ~ 18.73 and τf ~ − 59.76 ppm/°C. [ABSTRACT FROM AUTHOR]

Soil moisture content is an important measure of soil health, and high-precision soil moisture trend analysis is essential for understanding regional ecological quality in the context of climate change, flood monitoring, and water cycle processes. However, in the arid regions of Central Asia, where data are severely lacking, obtaining high-spatial-resolution, continuous soil moisture data is difficult due to the scarcity of stations. Moreover, because soil moisture is easily affected by evaporation time, surface morphology, and anthropogenic factors, mature theoretical models or empirical or semiempirical models to measure soil moisture are also lacking. To investigate the distribution and trend of soil moisture in the Ebinur Lake water, in this study, microwave remote sensing and visible remote sensing data were selected as inputs, and the Global Land Data Assimilation System (GLDAS-2.2) data products were downscaled using the GTWR model, which increased the spatial scale from 27,830 m × 27,830 m to 30 m × 30 m. The phenomena involved in the soil moisture change cycle, spatial distribution, temporal variation, and internal randomness distance were analyzed in the study area through wavelet analysis, Theil–Sen trend analysis, the Mann–Kendall (MK) test, and a variogram. This study obtained high-resolution continuous soil moisture data in the arid and data-scarce region in Central Asia, thus broadening the field of multisource remote sensing analysis and providing a theoretical basis for the construction of precision agriculture in northwest China. [ABSTRACT FROM AUTHOR]

The pharmacokinetic behaviours of amoxicillin (AMX) and clavulanic acid (CA) in swine were studied after either an intravenous or oral administration of AMX (10 mg/kg) and CA (2.5 mg/kg). The concentrations of these two medicines in swine plasma were determined using high‐performance liquid chromatographic‐tandem mass spectrometry, and the data were analysed using a noncompartmental model with the WinNonlin software. After intravenous administration, both substances were absorbed rapidly and reached their effective therapeutic concentration quickly. CA was eliminated more slowly compared with AMX. Moreover, the distribution volume of AMX was larger than that of CA, suggesting that AMX could penetrate tissues better. After oral administration of the granular formulation, no significant difference was observed in the mean elimination half‐life value between AMX and CA. The mean maximal plasma concentrations of AMX and CA, reached after 1.14 and 1.32 hr, were 2.58 and 1.91 μg/m, respectively. The mean oral bioavailability of AMX and CA was 23.6% and 26.4%, respectively. After oral administration, the T>MIC50 for three common respiratory pathogens was over 6.12 hr. Therefore, oral administration could be more effective in the clinical therapy of pigs, especially when administered twice daily. [ABSTRACT FROM AUTHOR]

The pharmacokinetic parameters of moxidectin (MXD) after intravenous and pour‐on (topical) administration were studied in sixteen pigs at a single dose of 1.25 and 2.5 mg/kg BW (body weight), respectively. Blood samples were collected at pretreatment time (0 hr) over 40 days. The plasma kinetics were analyzed by WinNonlin 6.3 software through a noncompartmental model. For intravenous administration (n = 8), the elimination half‐life (λZ), the apparent volume of distribution (Vz), and clearance (Cl) were 10.29 ± 1.90 days, 89.575 ± 29.856 L/kg, and 5.699 ± 2.374 L/kg, respectively. For pour‐on administration (n = 8), the maximum plasma drug concentration (Cmax), time to maximum plasma concentration (Tmax), and λZ were 7.49 ng/ml, 1.72, and 6.20 days, respectively. MXD had a considerably low absolute pour‐on bioavailability of 9.2%, but the mean residence time (MRT) for pour‐on administration 10.88 ± 1.75 days was longer than 8.99 ± 2.48 days for intravenous administration. These results showed that MXD was absorbed via skin rapidly and eliminated slowly. The obtained data might contribute to refine the dosage regime for topical MXD administration. [ABSTRACT FROM AUTHOR]