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BackgroundWeb-based smoking cessation interventions can have a public health impact because they are both effective in promoting cessation and can reach large numbers of smokers in a cost-efficient manner. Their potential impact, however, has not been realized. It is still unclear how such interventions promote cessation, who benefits most, and how to improve their population impact. ObjectiveTo examine the effectiveness of a highly promoted Web-based smoking cessation intervention to promote quit behavior over time, identify the most effective features, and understand who is most likely to use those features by using unweighted and weighted analyses to estimate the impact in the broader pool of registered site users. MethodsA sample of 1033 new adult registrants was recruited from a Web-based smoking cessation intervention by using an automated study management system. Abstinence was assessed by self-report through a mixed-mode follow-up (online survey with telephone follow-up for nonrespondents) at 1, 3, and 6 months. Software tracked respondents’ online activity. Generalized estimating equations (GEE) were used to examine predictors of website utilization and how utilization promoted abstinence using unweighted and weighted data. ResultsThe 7-day point prevalence abstinence rates at 6 months ranged from 20.68% to 11.13% in the responder and intent-to-treat samples, respectively. Predictors of abstinence in unweighted analyses included number of visits to the website as well as accessing specific interactive or engaging features. In weighted analyses, only number of visits was predictive of abstinence. Motivation to quit was a key predictor of website utilization, whereas negative partner support decreased the likelihood of increasing visits or accessing engaging features. ConclusionsEngagement is critical to promoting smoking cessation. The next generation of Web-based smoking cessation interventions needs to maximize the initial engagement of all new visitors and work to retain those smokers who proceed to register on the site.

Camptothecin (CPT), an alkaloid, was first discovered from plants and has potent anti-tumor activity. Since then, CPT analogs (namely Irinotecan and Topotecan) have been approved by the FDA for cancer treatments. Curcumin, on the other hand, is a widely used photosensitizer in photodynamic therapy (PDT) treatment. In our previous work, we have reported a straightforward strategy to construct a drug self-delivery system in which two-molecular species Irinotecan and Curcumin can self-assembly into a complex of ion pairs, namely ICN, through intermolecular non-covalent interactions. We found that ICN has slightly better chemotherapy efficacy than its individual components with much fewer side effects. In this paper, we aim to combine the chemotherapy and the PDT of ICN to further improve its anti-tumor performance. The efficient cellular uptake of ICNs was observed by confocal microscopy. Dichloro-dihydro-fluorescein diacetate (DCFH-DA) assay was used to detect the generation of singlet oxygen species. We found that the cell viability was 9% with both chemotherapy and PDT, and 31% with chemotherapy alone for the case with an ICN concentration of 10 μM, which demonstrated that the anti-tumor efficacy against the HT-29 cancer cell line was enhanced substantially with the combination therapy strategy. The study with an in vivo mouse model has further verified that the chemo-PDT dual therapy can inhibit tumor growth by 84% and 18.8% comparing with the control group and the chemotherapy group, respectively. Our results demonstrated that the new strategy using self-assembly and carrier-free nanoparticles with their chemo-PDT dual therapy may provide new opportunities to develop future combinatorial therapy methods in treating cancer.

Insects are the most diverse group of organisms in the animal kingdom, and some species exhibit complex social behaviors. Although research on insect object use is still in its early stages, insects have already been shown to display rich object‐use behaviors. This review focuses on patterns and behavioral flexibility in insect object‐use behavior, and the role of cultural evolution in the development of object‐use behaviors. Object use in insects is not widespread but has been documented in a diverse set of taxa. Some insects can use objects flexibly and display various object‐use patterns. Like mammals and birds, insects use objects in diverse activities, including foraging, predator defense, courtship, and play. Intelligence, pre‐existing manipulative behaviors, and anatomical structure affect innovations in object use. In addition, learning and imitation are the main mechanisms underlying the spread of object‐use behaviors within populations. Given that insects are one of the major animal groups engaging in object use, studies of insect object use could provide general insights into object use in the animal kingdom. [ABSTRACT FROM AUTHOR]

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The purpose of this study is to understand differences in demographics, frequency of tobacco use, and tobacco-related attitudes between youth/young adults who carry tobacco products and those who do not. Carrying tobacco is hypothesized to affect individuals' smoker identity and thereby their tobacco-related attitudes. Carriers are an influential peer group, often serving as social sources of tobacco for others, setting tobacco-related social norms, and advertising tobacco via the packs they carry. Thus, understanding their characteristics and attitudes can aid in the targeting and tailoring of cessation messaging. In this study, 3,927 attendees ages 13 to 24 years at the Vans Warped Tour were surveyed using iPads and asked to photograph any tobacco products they were currently carrying. Current tobacco users were classified as proven carriers (n = 363), unproven carriers (n = 182), or noncarriers (n = 1,426). Carriers (N = 545) were older, were more often White, and used tobacco over twice as often as noncarriers. Results indicated carriers and noncarriers differed significantly on most antitobacco attitudes, with carriers feeling less strongly antitobacco.

Simple Summary: Predatory spider and epigaeic beetle assemblages are major natural enemies (NEs) in agricultural ecosystems. The effects of non-crop natural habitats in supporting predatory NEs are well known for summer crop systems; however, limited attention has been given to summer–winter crop rotation transaction systems and during overwintering periods, especially in small-scale farmland systems. Here, we examine the effect of winter planting regimes and landscape composition on the species diversity and functional diversity of ground predators (spiders and carabids) in eight gradient landscape sites in southern China over two consecutive winters (2019/2020 and 2020/2021). Our work reveal that the spiders were more abundant and had a higher activity density in fallow rice fields (FRs) than oilseed rape fields (OSRs); however, the ground beetles were more abundant in OSRs than that in FRs. The composition of spider assemblages was impacted by semi-natural habitats (SNHs) during overwintering, while ground beetle assemblages were influenced mainly by overwintering planting patterns. The results suggest that different planting regimes and SNHs are a strategic way to enhance these ground predators. To conserve and improve predator diversity during overwintering, we suggest maintaining a diversity of planting regimes and conserving local semi-natural habitats. The rotation patterns of summer rice–winter oil seed rape and summer rice–winter fallow are the main planting regimes in the rice ecosystem in southern China. However, the impact of local rotation patterns and landscape factors on the overwintering conservation of predators in spider and epigaeic beetle assemblages remains poorly understood. Here, we investigate the diversity and density of spiders and beetles over two consecutive winters (2019/2020 and 2020/2021), focusing on the impact of two rotation patterns (rice–fallow and rice–oilseed rape) and surrounding landscape compositions on predator diversity. The main findings of our research were that spiders were more abundant and had a higher activity density in the fallow rice fields (FRs) compared to the oilseed rape fields (OSRs), whereas ground beetles exhibited the opposite pattern. Specifically, fallow rice fields supported small and ballooning spiders (e.g., dominant spider: Ummeliata insecticeps), while OSRs supported larger ground beetles (e.g., dominant beetles: Agonum chalcomus and Pterostichus liodactylus). Moreover, the composition of spider assemblages were impacted by semi-natural habitats (SNHs) during overwintering, while ground beetle assemblages were influenced by overwinter planting patterns. Overall, our results suggest that different planting regimes and preserving semi-natural habitats are a strategic way to enhance species diversity and functional diversity of ground predators. It is, therefore, recommended that to conserve and improve predator diversity during overwintering, land managers and farmers should aim to maintain diverse planting regimes and conserve local semi-natural habitats. [ABSTRACT FROM AUTHOR]

When the index finger is injured or severed with a traumatic thumb amputation, transfer of the injured index finger can restore the function of the thumb. The purpose of this study was to evaluate the result of the transfer of an injured index finger for the traumatic loss of the thumb. A patient had a traumatic amputation at the first metacarpal level with the bone defect of the second metacarpal and proximal part of index finger. She was treated with a pedicled transfer of the injured index finger to the ipsilateral thumb. Postoperative evaluations included thumb range of motion, opposition and pinch function, grasp and pinch strength, sensation, and a patient-rated appearance of the thumb and hand. In result, the blood supply of the transferred traumatic index fingers was normal, and the transferred index fingers survived without complications. The range of motion of the first metacarpophalangeal joint and interphalangeal joint was almost the same as that of a normal thumb. The opposition and pinch function of the thumb was also normal. The patient is able to complete activities of daily living with the new thumb. Nevertheless, the sensation has not yet been completely restored. In conclusion, it is feasible to treat traumatic thumb amputation with the transfer of injured index finger.