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Incorporation of dual functions, i.e., sensing and adsorption, into one single organic-inorganic hybrid material for the detection and removal of toxic permanganate (MnO4-) ions is of great importance, representing a challenging and new task in the design and application of new functional materials. However, most of the reported materials display only one function as either sensing probes or adsorbents. In this work, a fluorescent cuboid mesoporous silica-based hybrid material (SiO2@SFNO) is first prepared by the covalent coupling of a new safranin O-based fluorophore (2,8-dimethyl-5-phenyl-3,7-bis(3-(3-(triethoxysilyl)propyl)ureido)phenazin-5-ium chloride) (SFNO) and newly-made cuboid mesoporous silica, which showed selective dual-functional activities towards MnO4- and green emission at 575 nm with a long-range excitation wavelength that is suitable for bio-imaging application. The design of this SiO2@SFNO material is based on the position of -NHCONH- groups, which are mainly responsible for the strong and selective coordination with MnO4-. SiO2@SFNO is responsive to MnO4- at parts per billion (67 ppb) level; it also displays high adsorption ability (292 mg g-1) to MnO4- in aqueous solutions. The fluorescence responses of MnO4-in vivo (limnodrilus claparedianus and zebrafish) demonstrate the possibility of further application in biology. Interestingly, this SiO2@SFNO material is also capable of monitoring trace amounts of Hg2+ and Cu2+ in living organisms, holding great potential in bio-related applications.

A dicarboxylatopillar[5]arene (DCP5)-based coordination polymer, namely DCP5-EuxTby, with color-tunable emission and capable of nitroaromatic pollutant detection, has been designed and fabricated via a typical metal–ligand coordination approach. Due to its rigid skeleton and electron-rich cavity, DCP5 plays an important role in this multi-color framework, not only as a linker but also as a blue-color fluorescence donor. Intriguingly, the fluorescent color of DCP5-EuxTby can be tuned from green to red simply by mediating the molar ratio of Eu3+ : Tb3+ in the functional system. More importantly, a white-color emitting system, that is, DCP5-Eu1Tb3, is discovered when the ratio of Eu3+ : Tb3+ is 1 : 3, and the white-light emissive DCP5-Eu1Tb3 exhibits good detection performance toward nitroaromatic pollutants in a wide application field. We envision that this work will open a new avenue for the exploration of synthetic macrocycle-based new materials in the construction of new fluorescent sensors and detectors for environmental sustainability and bio-related fields.

A biopolymer-inorganic hybrid system (MSN@PBLGF) is designed and fabricated from mesoporous silica nanoparticles (MSNs) and folic acid (FA)-terminated temperature-sensitive synthetic polypeptide, i.e., poly(γ-benzyl- l -glutamate) (PBLG) derivative, through a thiol-disulfide exchange reaction, where MSNs with high drug loading capacity serve as drug nanocarriers and the biocompatible PBLG biopolymer brushes installed on MSN surface through disulfide bonds endow the system with tumor-specific recognition ability and GSH/temperature dual-stimuli responsiveness. Controlled drug release experiments indicate that DOX can be tightly hosted in the system with limited premature release, but efficiently released in response to an increased concentration of GSH and/or an elevated temperature. Intracellular experiments demonstrate that the DOX-loaded MSN@PBLGF nanohybrid shows outstanding cellular uptake and cell-growth inhibition effects on human lung cancer cell line A549 in comparison with healthy human cells such as hepatocyte cells LO2.

Carboxylatopillar[5]arene-modified Fe3O4 magnetic nanoparticles (CP5-MNPs), with highly controllable particle size distribution, are successfully prepared through a newly developed one-pot solvothermal strategy for the first time. Due to the strong supramolecular host-guest interactions in conjunction with appreciable magnetic responsiveness, CP5-MNPs show excellent adsorption performance and ultrafast adsorption efficiency in the separation and enrichment of organic cationic dyes, including but not limited to methylene blue and crystal violet. Significantly, the excellent dye separation performance of CP5-MNPs demonstrates a strong tolerance towards pH changes and a good resistance to inorganic salts interference. The materials' inherent features of easy recyclability and affordability endow them with great potentials in column adsorption filler for sewage regeneration and environmental purification.

Succinate dehydrogenase inhibitors (SDHIs) have become one of the fastest growing classes of new fungicides since entering the market, and have attracted increasing attention as a result of their unique structure, high activity and broad fungicidal spectrum. The mechanism of SDHIs is to inhibit the activity of succinate dehydrogenase, thereby affecting mitochondrial respiration and ultimately killing pathogenic fungi. At present, they have become popular varieties researched and developed by major pesticide companies in the world. In the review, we focused on the mechanism, the history, the representative varieties, structure–activity relationship and resistance of SDHIs. Finally, the potential directions for the development of SDHIs were discussed. It is hoped that this review can strengthen the individuals’ understanding of SDHIs and provide some inspiration for the development of new fungicides.

Toxicity is one of the most important factors limiting the success of new drug development. In this paper, we built a fast and convenient new method (Carrier protein binding information-toxicity relationship, CPBITR) for predicting drug acute toxicity based on the perspective of binding information with carrier protein. First, we studied the binding information between carbamate pesticides and human serum albumin (HSA) through various spectroscopic methods and molecular docking. Then a total of 16 models were established to clarify the relationship between binding information with HSA and drug toxicity. The results showed that the binding information was related to toxicity. Finally we obtained the effective toxicity prediction model for carbamate pesticides. And the “Platform for Predicting Drug Toxicity Based on the Information of Binding with Carrier Protein” was established with the Back-propagation neural network model. We proposed and proved that it was feasible to predict drug toxicity from this new perspective: binding with carrier protein. According to this new perspective, toxicity prediction model of other drugs can also be established. This new method has the advantages of convenience and fast, and can be used to screen out low-toxic drugs quickly in the early stage. It is helpful for drug research and development.

To predict drug acute toxicity using the binding information with human serum albumin, our research group established a new method (Carrier protein binding information-toxicity relationship, CPBITR). Unfortunately, the previous model had too few data sets which may affect the accuracy and credibility of the model. In this paper, therefore, we measured the binding modes of three carbamate pesticides, Bendiocarb, Butocarboxim and Dioxacarb with human serum albumin (HSA) to supplement the previously modeled training set. Multispectral methods and molecular docking were used to study their binding modes. We built and optimized the previous models with the combined information of three different toxicity pesticides and HSA in order to find better prediction method. The results showed that Back-propagation Artificial Neural Network model has the best fitting effect among these models. In conclusion, the proposed model effectively improves the accuracy and credibility of the existing model. It results in significant predict drug acute toxicity using the binding information with carrier protein and contribute to drug development and research.

Research to determine the production process and recipe of toon cookies, to remove the bitterness of toon, research and analysis of different people for the taste test of toon cookies, to further determine the feasibility of the product. The parsnip leaves are thick, and the leaf buds are very tender, and the young buds and young leaves are fragrant and refreshing, so they can be eaten as a vegetable with a strong fragrance and are much richer in nutrients than other vegetables. One of the additives, erythritol, helps the body's blood sugar balance. Modern medical research shows that the decoction of Tsubaki has obvious apparent and bactericidal effects on Staphylococcus aureus, pneumococcus, dysentery bacillus, typhoid bacillus, Escherichia coli and Pseudomonas aeruginosa.

Studies have shown that high toxicity at all stages of drug development is a major limiting factor in getting a new drug to market. At present, a number of toxicity assay methods have been published in the literature. Most of them rely mainly on the UV spectrometer and manual injection. However, the manual injection has low accuracy of detection results, long detection time, complicated operation, cross-contamination, and inadequate safety factor. Therefore, it is necessary to develop an automatic sampler that is used in combination with a platform for predicting drug toxicity based on carrier protein binding information and an ultraviolet spectrophotometer. The automatic sampler for UV spectroscopy toxicity detection uses the quartz cell gripper to clamp the quartz cell and realizes the precise automatic sample injection function through the position sensor. Through the movement simulation, the whole moving process is smooth and without interference, and the movement position of the quartz cell is accurate. The research and development of the automatic sampler for UV spectroscopy toxicity detection will significantly promote the precise detection of toxicity in the early stage of drug development. The development of UV spectral toxicity detection autosampler will provide hardware support for the precise detection of toxicity in the early stage of drug development. At the same time, it will significantly shorten the drug R&D process and save a lot of R&D expenses for drug R&D.

In order to prevent the further proliferation and spread of RIFA in our country, reduce the serious harm caused by RIFA populations to agricultural and forestry production, human health, public safety and the ecological environment. A new type of trap based on mobile function, obstacle clearance function, energy supply function, signal transmission function and trapping function has been developed. The new remote controlled RIFA trap is improved and upgraded on the basis of the existing traditional traps. The research and development of this trap not only advances the process of emergency trapping of RIFA in my country, but also provides a new way for artificial intelligence to prevent and control RIFA in the future.

A bean-shaped and dual-functionalized organic-inorganic hybrid supramolecular system with a GSH-dependent turn-on fluorescence enhancement property and stimuli-responsive drug delivery function endowed with leaning towerarene-based switches has been constructed for simultaneous tumor inhibition and imaging.

Nanotechnology in agriculture and food industry has attracted significant attention over the past few decades. Benefiting from the introduction of controlled release capability, drug/cargo delivery systems possess great advantages for plants in delivering plant genes, hormones, pesticides, and fertilizers to mediate their growth. Herein, we construct a new smart multi-stimuli responsive hormone delivery system to regulate the release of gibberellin acid (GA3) for plant growth. Hollow mesoporous silica nanoparticles have been utilized as nanocarriers, upon which water soluble carboxylatopillar[5]arene ammonium (WP[5]A) functionalized Fe3O4 nanoparticles (WP[5]A-Fe3O4) are installed as nanovalves via host–guest interactions (WP[5]A-Fe3O4 capped HMSNs are denoted as HMSN/Fe3O4). Bidirectional pH-responsive supramolecular nanovalves have been constructed for the first time, and under acidic or alkaline conditions hormones can be released out from GA3-loaded HMSN/Fe3O4 (GA3-HMSN/Fe3O4) to promote the growth of plants. Interestingly, the GA3-HMSN/Fe3O4 nanoparticles can also respond to other stimuli including 1,4-butanediamine (BDA) and ultrasound. This smart delivery system has been successfully applied in plants like Arabidopsis thaliana (A. thaliana) and cabbages, and our experimental results suggested that the GA3-HMSN/Fe3O4 hybrid nanomaterials can obviously promote the growth of both plants. Therefore, we envision that this magnetic multi-stimuli responsive system will hopefully play an important role in promoting agricultural industry development.

Reversible regulation of membrane microstructures via non-covalent interactions is of considerable interest yet remains a challenge. Herein, we discover a general one-step approach to fabricate supramolecular porous polyelectrolyte membranes (SPPMs) from a single poly(ionic liquid) (PIL). The experimental results and theoretical simulation suggested that SPPMs were formed by a hydrogen-bond-induced phase separation of a PIL between its polar and apolar domains, which were linked together by water molecules. This unique feature was capable of modulating microscopic porous architectures and thus the global mechanical property of SPPMs by a rational design of the molecular structure of PILs. Such SPPMs could switch porosity upon thermal stimuli, as exemplified by dynamically adaptive transparency to thermal fluctuation. This finding provides fascinating opportunities for creating multifunctional SPPMs.

Catalysts with high performance are needed to remove the residual CO in the hydrogen streams in order to avoid poisoning Pt anode of proton exchange membrane fuel cells. We herein prepared the CeO2/xCNTs-CuO catalysts that increase the amount of active sites as well as the concentration and distribution of oxygen vacancies at contact interface based on copper-cerium oxides. The CNTs insert in CuO microsphere with one ends, and the other ends extend out the surface. The CeO2 particles uniformly disperse onto the surface of 20CNTs-CuO support to compose an eggshell structure, and this kind of structure can ensure close interaction between CeO2 and CuO to form long contact perimeter. The CNTs play an improvement role on catalytic performance and resistance against CO2 and H2O via increasing the amount of active sites and the concentration of oxygen vacancies in the CeO2/xCNTs-CuO catalysts. CuO microspheres, and they are also inserted the inside of each microsphere with one ends. The other ends of CNTs extend out and twine with CuO on the surface.

Hybrid fluorescent materials constructed from organic chelating fluorescent probes and inorganic solid supports by covalent interactions are a special type of hybrid sensing platform that has gained much interest in the context of metal ion sensing applications owing to their excellent advantages, recyclability, and solubility/dispersibility in particular, as compared with single organic fluorescent molecules. In recent decades, SiO2 materials and core-shell Fe3 O4 @SiO2 nanoparticles have become important inorganic solid materials and have been used as inorganic solid supports to hybridize with organic fluorescent receptors, resulting in multifunctional fluorescent hybrid systems for potential applications in sensing and related research fields. Therefore, recent progress in various fluorescent-group-functionalized SiO2 materials is reviewed, with a focus on mesoporous silica nanoparticles and core-shell Fe3 O4 @SiO2 nanoparticles, as interesting fluorescent organic-inorganic hybrid materials for sensing applications toward essential and toxic metal ions. Selective examples of other types of silica/silicon materials, such as periodic mesoporous organosilicas, solid SiO2 nanoparticles, fibrous silica spheres, silica nanowires, silica nanotubes, and silica hollow microspheres, are also mentioned. Finally, relevant perspectives of metal-ion-sensing-oriented silica-fluorescent probe hybrid materials are provided.