1. The causal relationship between blood cell indices and 28-day mortality in sepsis: a retrospective study and bidirectional Mendelian randomization analysis
- Author
-
Tao Zeng, Yina Sun, Shuru Chen, Jiahui Pang, Heping Wang, Xianghao Cai, Yingying Liao, Xiaolong Xiao, Yibo Zhang, Yutian Chong, Jiao Gong, and Xinhua Li
- Subjects
Blood cell indices ,28-day mortality in sepsis ,Mendelian randomization analysis ,Retrospective study ,Platelet distribution width ,Infectious and parasitic diseases ,RC109-216 - Abstract
Abstract Background Despite emerging evidence linking blood cell indices (BCIs) to sepsis mortality, the inconsistency of observational studies obscures the clarity of these associations. This study aims to clarify the causal influence of BCIs on 28-day mortality rates in sepsis patients. Methods Utilizing univariable and multivariable Mendelian randomization (MR) analyses, we examined the impact of BCIs on sepsis mortality by analyzing data from extensive genome-wide association studies. The inverse-variance weighted (IVW) method was our primary analytic tool, complemented by several robustness checks to mitigate pleiotropy, including weighted median, mode-based estimates, MR-Egger regression, and MR-PRESSO. Subsequently, we conducted a retrospective study to further explore the correlation between platelet indices and 28-day mortality of sepsis using real-world data. Results Our findings highlight a significant causal relationship between platelet distribution width (PDW) and 28-day mortality in sepsis, with the univariable Mendelian randomization approach yielding an odds ratio of 1.12 (95% CI, 1.06–1.26; P
- Published
- 2024
- Full Text
- View/download PDF