Search

The intestine is the central organ of early weaning stress in piglets; however, the response of intestinal stem cells (ISCs) that drive epithelial renewal between the different breeds of piglets is not yet known. Therefore, this investigation was to explore the sensitivity of ISCs to early weaning stress. Taoyuan Black and Duroc piglets were slaughtered at 21 days of age (on the day of weaning) and 24 days of age (3 days after weaning) with 10 pigs, respectively. And the results showed that Taoyuan Black pigs are more tolerant to early weaning stress, while the mucosal mass of jejunum was significantly decreased in 24-day-old Duroc piglets compared with the 21-day-old Duroc piglets (P < 0.05). The weaning stress damaged the jejunal structure, decreased the expression of tight junction related proteins ZO-1, Occludin, and Claudin-1, and increased intestinal permeability in Duroc piglets (P < 0.05). The ex vivo intestinal organoids (IOs) derived from the jejunal crypt of Duroc piglets after weaning exhibited lower expansion efficiency (P < 0.05). Furthermore, the levels of proliferating cell marker PCNA, terminally differentiated cell marker KRT20, absorptive cell marker Villin, goblet cell marker MUC2, and Paneth cell marker lysozyme were significantly reduced in the jejunum, crypt, and jejunal organoids of 24-day-old Duroc (P < 0.05). ROS levels in the jejunum of Duroc piglets were increased along with the inhibition of the Nrf2 pathway compared with 21-day-old Duroc piglets (P < 0.05). Collectively, the Taoyuan Black pigs had stronger tolerance to weaning stress; however early weaning suppressed the Nrf2 pathway, decreased proliferation and differentiation activity of ISCs, and disrupted intestinal homeostasis in Duroc piglets.

Objective: To explore the changes and significance of homocysteine (Hcy), high sensitivity C reactive protein (hs-CRP) and coagulation function indexes in patients with acute cerebral infarction. Methods: A total of 110 patients with acute cerebral infarction were selected as the observation group, According to the symptoms of acute cerebral infarction to 96 h, whether the symptoms of neurological deficit were aggravated, the patients in the observation group could be divided into the progressive group (n=65 case) and the non progressive group (n=45 case), and 110 cases with normal physical examination results were selected as control group at the same time. The levels of blood lipid metabolism, Hcy, hs-CRP and blood coagulation function were compared in each group. Results: Single factor analysis showed a statistically significant difference in blood lipid metabolism, Hcy, hs-CRP and coagulation function between groups. Compared with the index level in the control group, the levels of TG, TC, LDL, Hcy, hs-CRP, D-dime and FIB in the observation group were significantly higher than those in the control group, and the HDL level was significantly decreased, the difference was statistically significant. The levels of TG, TC, LDL, Hcy, hs-CRP, D-dime and FIB in the progression group were significantly higher than those in the non progressive group, HDL level was significantly lower than that in the non progressive group showing significant difference. Correlation analysis showed that the severity of acute cerebral infarction was positively correlated with the levels of TG, TC, LDL, Hcy, hs-CRP, D-dime and FIB, and negatively correlated with HDL level. Conclusion: There are abnormalities of blood lipid metabolism and coagulation function in patients with acute cerebral infarction, and the levels of Hcy and hsCRP increase significantly. Detection of all indexes is of great significance for evaluating the severity of acute cerebral infarction.

This paper designs a Vessel Remote Video Monitoring System based on internet protocol. The system uses positioning and network transmission technology to transmit real-time images of ships offshore to the server, to set up the client and visual monitoring ends. Ships monitoring personnel enter WEB monitoring platform with different permissions, to monitor and process ships image data through the network view, scheduling, monitoring terminals and other system modules. It also adds density ratio-based automatic alarm module to realize the intelligent early warning of offshore Ships density. Experiments show that the system has a better result to achieve vessel images' intelligent remote monitoring and early warning.

The galvanic and potential distributions of carbon steel immersed in seawater were studied by wire beam electrode (WBE) technique. Results indicated that the corrosion of carbon steel in seawater tended to local corrosion. With immersion time increasing, local corrosion was more and more serious. During the initial immersion period, the top of the coupon near the water surface was main cathode. With the corrosion extended, corrosion products gradually gathered on the surface of the carbon steel. Potential differences between cathode and anode gradually became small. Cathode and anode redistributed on the surface of carbon steel. At last, the top and the bottom were cathode while the middle was anode. The areas of anode first increased and then decreased. The areas of cathode were in contrast.

In this paper, a kind of advanced gear body form is proposed, which has the structure characteristics of no weight reducing wholethin spoke platesthick rim and large fillet. The optimization effect is confirmated by comparative analyzing the structure before and after optimization on strengthstiffnessweight and frequency adjustment performance of gear. The results show that the kind of optimization gear body is suitable for application in aviation, for which has the features of high strength, good stiffness and light weight and which is easy to adjust gear frequency.

Aim to the working properties of aviation accessory transmission gear, such as high speed and heavy load, temperature field distribution regularity of standard involute cylindrical gear is analyzed based on indirect coupling analysis method of ANSYS software. And gear surface contact stress distribution regularity under the action of thermal loading and mechanical load is also analyzed. Gear surface real contact condition under working station is analyzed. It is shown from the result that the high speed and heavy loading on the gear teeth produces the bigger temperature gradient, and thermal deformation regularity of gear teeth is determined by temperature field distribution style, while thermal deformation of gear teeth changes contact condition and stress distribution regularity between meshing gear surfaces.

The mathematical model of steady state thermal analysis of accessory transmission system is built according to heat transfer theory, the governing equation functional of the steady state temperature field of accessory transmission system is derived on the basis of the variation principle, and the method to calculate the steady state temperature field of accessory transmission system is proposed with the finite element software ANSYS and its secondary switching language APDL. The result shows that the prediction of temperature field fit in with the heat flow law, then the correctness and validity of the proposed thermal analysis method is verified.

The corrosion products formed on carbon steel exposed to seawater were studied. Morphology, composition, structure and porosity of the rust were analysed by different methods: OM, SEM, FTIR, XRD and BET. The results indicate that the inner and outer rust layers formed on carbon steel in seawater are different in morphology, composition and structure. With increasing of exposure periods, the rust layers become more and more compact, which exhibit a high resistance to corrosion.

The thermo-elastic contact characteristics of standard spur gears with the ANSYS software's Indirect coupling analysis method and achieve the limit state function of contact strength of tooth surface with the response surface method. It also studies the probabilistic sensitivity of the limit state function to the random variable with the reliable and sensitive analysis method of Monte Carlo and to achieve the Sensitivity information of various random factors on the reliability of contact strength of tooth surface under thermo elastic coupling state. Research results show that in the reliability design process the randomness of the temperature of the oil gas mixture in the accessory casing can be neglected and the constant treatment. It can effectively improve the gear tooth contact strength reliability through Increase the contact stress of the tooth surface, Reduce gear torque, Choose the gear material with smaller linear expansion coefficient and lower oil supply temperature and reduce the discrete range of random variable at the same time.

A partial rice (Oryza sativa L.) cDNA clone, OsPI4K1c, was isolated through screening of a cDNA library constructed from tillering materials. OsPI4K1c encoded a peptide of 608 amino acids with a calculated molecular mass of 68.4 kDa. The OsPI4K1c peptide shared high homology and possessed the highly conserved domains present in most isolated cloned PI4-kinases, i.e. a lipid kinase unique (LKU) domain and a catalytic (CAT) domain. A region with similarity to pleckstrin homology (PH) domain was present in OsPI4K1c as well. Further comparison with genomic sequences in databases revealed that OsPI4K1c is located at the 3'-end of a putative rice PI 4-kinase coding gene OsPI4K1, and its coding region corresponded to the C-terminal half of OsPI4K1 protein. Twelve exons (49-562 bp in size) and 11 introns (77-974 bp in size) were identified in OsPI4K1c. The recombinant protein expressed in Escherichia coli phosphorylates phosphatidylinositol at the D4 position of the inositol ring. OsPI4K1 transcript levels were detected in a low but constitutive manner in shoot, stem, leaf, spike and root tissues and did not change upon treatment with different hormones, calcium and jasmonic acid (JA). However, treatment with salicylic acid (SA) elevated the mRNA level of the OsPI4K1 gene, which suggested the involvement of OsPI4K1 in wounding responses.