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Your search keyword '"Xiang, Xingxian"' showing total 4 results
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4 results on '"Xiang, Xingxian"'

3. A Metal-Free TBHP-Triggered Cascade Cyclization of 2-Arylindoles with Alcohols: Synthesis of Hydroxyalkylated Indolo[2,1- a ]isoquinoline Derivatives.

Author

Li, Min, Tang, Yucai, Xiang, Xingxian, Yang, Yiting, Zhou, Qian, Dai, Kaiming, and Wang, Feifei

Subjects
ISOQUINOLINE, PHTHALAZINE, RING formation (Chemistry), ALCOHOL, FUNCTIONAL groups
Abstract

A practical method for the synthesis of hydroxyalkylated indolo[2,1- a ]isoquinoline derivatives through the metal-free cascade cyclization of 2-arylindoles with alcohols in the presence of tert -butyl hydroperoxide (TBHP) is disclosed. The present method features transition-metal-free conditions and exceptional functional group tolerance. A series of valuable hydroxyalkylated indolo[2,1- a ]isoquinoline derivatives bearing various functional groups is synthesized in moderate to excellent yields. [ABSTRACT FROM AUTHOR]

Published
2022
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4. Synthesis of ester-functionalized indolo[2,1- a ]isoquinolines via iron-catalyzed radical cascade cyclization of 2-aryl- N -acryloyl indoles with carbazates.

Author

Tang Y, Dai K, Xiang X, Yang Y, and Li M

Subjects
Catalysis, Cyclization, Esters, Hydrazines, Isoquinolines, Indoles, Iron
Abstract

An FeCl 2 ·4H 2 O-catalyzed oxidative alkoxycarbonylation/cyclization reaction of 2-aryl- N -acryloyl indoles with carbazates leading to ester-functionalized indolo[2,1- a ]isoquinoline derivatives has been developed. The reaction features mild reaction conditions and broad functional group tolerance. Moreover, the ester group could be easily converted to the corresponding free acid and alcohol, and has high potential applications in organic and pharmaceutical synthesis. A radical pathway was proposed to explain this experiment.

Published
2022
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