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4 results on '"Xianfan Chen"'

1. Concrete mechanical properties and pore structure influenced by high permeability water pressure

Author

Guohui Zhang, Hao Zheng, Xiong Wei, Zongli Li, Zhuang Yan, and Xianfan Chen

Subjects
Concrete strength, High permeability water pressure, Porosity, Strength damage, Engineering (General). Civil engineering (General), TA1-2040, Building construction, TH1-9745
Abstract

Based on the self-developed high permeability water pressure loading system, the physical and mechanical properties and pore structure evolution under various high permeability water pressures were studied. This study aims to reveal the microscopic damage mechanism of concrete when subjected to high permeability water pressures. The results indicate that the internal water content increases with the rising of water pressure under various high permeability conditions. Furthermore, the higher the water pressure, the greater the reduction in strength, particularly evident in low-strength-grade concrete. High permeability water pressure causes to the expansion of gelatinized pores with small sizes into transition pores. Moreover, there is a concurrent alteration in both pore size and pore number under high permeability water pressure.

Published
2024
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3. Vasopressin V1A receptor mediates cell proliferation through GRK2-EGFR-ERK1/2 pathway in A7r5 cells

Author

Xiaojun Wang, Anthony Yiu-Ho Woo, Yifan Wang, Hong Cao, Xianfan Chen, Yunxuan Chen, Weizhong Zhu, Lingling Zhang, Feifei Xu, and Xi Zhao

Subjects
0301 basic medicine, Pharmacology, Arginine vasopressin receptor 1B, medicine.medical_specialty, Tropomyosin receptor kinase B, Biology, Interleukin-13 receptor, Tropomyosin receptor kinase C, Cell biology, 03 medical and health sciences, 030104 developmental biology, Endocrinology, Growth factor receptor, Internal medicine, Arginine vasopressin receptor 2, medicine, Insulin-like growth factor 1 receptor, Vasopressin receptor
Abstract

Abnormal proliferation and hypertrophy of vascular smooth muscle (VSMC), as the main structural component of the vasculature, is an important pathological mechanism of hypertension. Recently, increased levels of arginine vasopressin (AVP) and copeptin, the C-terminal fragment of provasopressin, have been shown to correlate with the development of preeclampsia. AVP targets on the Gq-coupled vasopressin V1A receptor and the Gs-coupled V2 receptor in VSMC and the kidneys to regulate vascular tone and water homeostasis. However, the role of the vasopressin receptor on VSM cell proliferation during vascular remodeling is unclear. Here, we studied the effects of AVP on the proliferation of the rat VSMC-derived A7r5 cells. AVP, in a time- and concentration-dependent manner, promoted A7r5 cell proliferation as indicated by the induction of proliferating cell nuclear antigen expression, methylthiazolyldiphenyl-tetrazolium reduction and incorporation of 5'-bromodeoxyuridine into cellular DNA. These effects, coupled with the phosphorylation of extracellular signal-regulated kinase 1/2 (ERK1/2), were blocked by a V1A receptor antagonist SR45059 but not by a V2 receptor antagonist lixivaptan. Although acute activation of V1A receptor induced ERK1/2 phosphorylation via a protein kinase C-dependent pathway, this effect was not involved in cell proliferation. Cell proliferation and ERK1/2 phosphorylation in response to prolonged stimulation with AVP were abolished by inhibition of G protein-coupled receptor kinase 2 (GRK2) and epidermal growth factor receptor (EGFR) using specific inhibitors or small hairpin RNA knock-down. These results suggest that activation of V1A, but not V2 receptor, produces a cell proliferative signal in A7r5 cells via a GRK2/EGFR/ERK1/2-dependent mechanism.

Published
2016
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4. Vasopressin V

Author

Lingling, Zhang, Xiaojun, Wang, Hong, Cao, Yunxuan, Chen, Xianfan, Chen, Xi, Zhao, Feifei, Xu, Yifan, Wang, Anthony Yiu-Ho, Woo, and Weizhong, Zhu

Subjects
Flavonoids, Mitogen-Activated Protein Kinase 1, Transcriptional Activation, Receptors, Vasopressin, Mitogen-Activated Protein Kinase 3, G-Protein-Coupled Receptor Kinase 2, MAP Kinase Signaling System, Muscle, Smooth, Vascular, Cell Line, Rats, Arginine Vasopressin, ErbB Receptors, Animals, Phosphorylation, Protein Kinase C, Cell Proliferation
Abstract

Abnormal proliferation and hypertrophy of vascular smooth muscle (VSMC), as the main structural component of the vasculature, is an important pathological mechanism of hypertension. Recently, increased levels of arginine vasopressin (AVP) and copeptin, the C-terminal fragment of provasopressin, have been shown to correlate with the development of preeclampsia. AVP targets on the G

Published
2016

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