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Your search keyword '"Xian-ming Zheng"' showing total 4 results
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4 results on '"Xian-ming Zheng"'

1. (E)-Ethyl 2-cyano-3-(3,4-dihydroxy-5-nitrophenyl)acrylate

Author

Shi-Jie Zhang, Xian-Ming Zheng, and Wei-Xiao Hu

Subjects
Crystallography, QD901-999
Abstract

The title compound, C12H10N2O6, was synthesized via a Knoevenagel condensation and crystallized from ethanol. In the crystal, strong classical intermolecular O—H...O hydrogen bonds and weak C—H...N contacts link the molecules into ribbons extending along [010]. Intramolecular O—H...O and C—H...N contacts support the planar conformation of the molecules (mean deivation 0.0270 Å).

Published
2009
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3. The synthesis and biological evaluation of some caffeic acid amide derivatives: E-2-cyano-(3-substituted phenyl)acrylamides

Author

Wei-Xiao Hu, Wei Zhou, Chun-Nian Xia, Xian-ming Zheng, and Hai-bo Li

Subjects
Nitrile, Stereochemistry, Clinical Biochemistry, Pharmaceutical Science, Crystallography, X-Ray, Biochemistry, Chemical synthesis, chemistry.chemical_compound, Inhibitory Concentration 50, Structure-Activity Relationship, Caffeic Acids, Amide, Cell Line, Tumor, Drug Discovery, Nitriles, Caffeic acid, Structure–activity relationship, Humans, Molecular Biology, Acrylamides, Chemistry, Organic Chemistry, Biological activity, Phenolic acid, Molecular Medicine, Knoevenagel condensation
Abstract

A series of caffeic acid amide derivatives 2-cyano-(3-substituted phenyl)acrylamides were synthesized via Knoevenogal condensation of substituted benzaldehydes with cyanoacetamides. The structure of compound 1f was determined as E-isomer by X-ray diffractive analysis. The biological screening tests in vitro showed that compound 1b has obvious inhibitory activities against human gastric carcinoma cell line BGC-823, human nasopharyngeal carcinoma cell line KB and human hepatoma cell line BEL-7402 with IC(50) values of 5.6 microg/mL, 13.1 microg/mL and 12.5 microg/mL, respectively. Some preliminary structure-activity relationships (SAR) were also proposed which may provide a direction for further study.

Published
2008

4. N-(3-Chlorophenyl)-2-cyano-3-(4-hydroxy-3-methoxy-2-nitrophenyl)prop-2-enamide

Author

Xian-Ming Zheng, Feng Xu, and Wei-Xiao Hu

Subjects
chemistry.chemical_classification, chemistry.chemical_compound, chemistry, Double bond, Plane (geometry), Nitro, General Materials Science, General Chemistry, Meth, Dihedral angle, Condensed Matter Physics, Benzene, Medicinal chemistry
Abstract

In the title compound, C17H12ClN3O5, the benzene rings are twisted out of the central –Car–C–C(–CN)–C(=O)–N–plane. The dihedral angles between this plane and the aromatic planes are 31.2 (4) and 4.8 (3)°. The C=C double bond is in an E configuration.

Published
2007
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