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Cerebral circulation time (CCT) and collateral score (CS) are associated with functional outcomes in acute ischemic stroke (AIS) patients after endovascular treatment (EVT), and may be related to each other. We aim to determine the relationship between CS and CCT on functional outcomes.We retrospectively enrolled consecutive patients with anterior circulation large vessel occlusion (LVO) AIS who received EVT. CS and CCT were measured based on digital subtraction angiography (DSA). We defined CS 0-2 and 3-4 as poor and good collateral status, respectively, and used change of CCT (cCCT), which was defined as the change of stroke side CCT (sCCT) versus healthy side CCT (hCCT). Mediating analysis was used to evaluate the influence of cCCT on the association between CS and functional outcomes, and ROC curves were further used to explore the predictive ability of the interaction between cCCT and CS for functional outcomes.A total of 100 patients were enrolled in the final analysis. A higher cCCT (r = -0.239; p = 0.017) was associated with lower CS, and cCCT mediated the association of CS with functional outcome. Logistic regression analysis found that CS, cCCT and cCCT-CS interactions were independently associated with functional outcome, and cCCT-CS interaction has better predictive performance, with a higher area under curve value than CS or cCCT alone (0.79 vs. 0.75 or 0.75).To our knowledge, this study provides the first report of the association of collateral status with cCCT, and their interaction effect on functional outcome in AIS-LVO patients receiving EVT.

Endovascular treatment (EVT) is the best treatment for acute ischemic stroke with large vessel occlusion (LVO) and makes it possible to analyze the blood contents from the occluded vascular compartments. In this study, we attempted to evaluate regional changes in blood gas values and electrolytes in the occluded vessels, aiming to determine whether these changes can predict outcomes in LVO patients receiving EVT.We prospectively observed 45 consecutive ischemic stroke patients with LVO of the anterior circulation who underwent EVT. We collected the arterial blood proximal to the occlusion site before and after EVT, and the blood within the core of the occluded vascular compartment (distal to the thrombus) and evaluated the labs for blood gas values and electrolytes. Femoral samples were obtained under physiological flow conditions to represent systemic arterial blood.Compared with the femoral arterial blood samples, significant decreases in K+, Ca2+, HCO3-, BE, HCT, tHbc, and TCO2 levels were observed in the proximal luminal blood before EVT. Decreases in K+ and Ca2+ levels were also observed in the proximal luminal blood after EVT. Proximal/femoral ratio of pH and Na+ was associated with short-term clinical outcomes at 72 hours after EVT. A higher proximal/femoral Na+ ratio was associated with successful recanalization. Further analysis after propensity score matching showed significant changes in blood gas and electrolyte among different arterial locations in ICA and MCA LVO participants. Linear regression analyses indicated that the proximal/femoral ratio of pH, Na+, pCO2, HCO3, and TCO2 before EVT were associated with decrease in NIHSS score at 72 hours in ICA-LVO group.Obvious changes in several parameters of arterial blood gas and electrolyte from the ischemic vasculature occur during hyperacute stroke. Proximal/femoral pH and Na+ ratio before EVT may be associated with short-term clinical outcome, which deserve to be further investigated.

Soybean polypeptide mixture was decolorized by adopting activated carbon adsorption decolourization process. Anion/cation exchange process was used in the desalination processing of soybean polypeptide. It was showed that excellent decolorizing and desalting effect to soybean peptide solution was gained in the decolourization and desalination process adopted in this experiment. Optimal dosage of activated carbon was 1.2% solution amount (w/w). After decolorizing soybean polypeptide solution color was yellow. Proportion of anion resin and cation resin of ion exchange resin was 2:3(V/V). The volume of solution processed was 5 times as the volume of anion exchange resin. After desalination processing, ash content of soybean peptide solution reduced to 2.11% (dry basis), salinity decreased by 86%, on the other hand taste of soybean polypeptide was lite.

Soybean protein Alcalase hydrolysate was further hydrolyzed by adopting Flavourzyme. From this further hydrolysis reaction, bitter of soybean polypeptide mixture was reduced distinctly. The optimal hydrolysis conditions of Flavourzyme was determined as that pH was 7.0 at temperature 50°C and E/S(ratio of enzyme and substrate) was 20LAPU/g. Bitter taste value was reduced to 2 after Flavourzyme hydrolysis reaction for 2 hours in optimal hydrolysis conditions. The change of molecular weight distribution range from Alcalase hydrolysate to Flavourzyme hydrolysate was not obvious. DH (Degree of hydrolysis) of soybean protein hydrolysate was increased to 24.2% which was improved 3.5% than Alcalase hydrolysate. Protein recovery proportion was increased to 73.2% which was improved 0.8% than Alcalase hydrolysate.

Emulsion copolymerization of acrylamide (AM) and cationic monomer DMC (methyl acrylacyl oxyethyl trimethyl ammonium chloride) was studied. A series of cationic polyacrylamide (CPAM) emulsion were synthesized using Water in water emulsion polymerization. Influence of polymerization conditions such as cationic monomer (DMC) ratio, reaction time, the initiator dosage on synthetic product strengthening effect to paper pulp was studied. It was showed that the CPAM emulsion optimal synthetic conditions was that AM monomer second adding amount was 60% AM total amount, ammonium persulfate initiator and sodium hydrogen sulfite initiator dosage was 0.138g and 0.03g respectively, mass ratio of DMC and AM was 15:85, reaction time was 7 hours. When the dosage of CPAM emulsion was 1.0% to absolute dry bleached wheat straw pulp, distinct strengthening effect was acquired, tensile index and tearing index of handsheet was increased by 27.2% and 26.8% respectively.

Application in paper pulp as dry strengthening agent of homemade water in water cationic polyacrylamide (CPAM) emulsion was studied. Good collaborative effect was achieved when Homemade CPAM was used in bleached wheat straw pulp with strengthening agent E and with cationic additives L as paper pulp strengthening agent. It was also showed that distinct strengthening effect was obtained when homemade CPAM emulsion was applied in mixture of wood pulp which was needle bleached kraft pulp (NBKP) and straw pulp, breaking length and tearing index of hand sheet made of mix pulp was respectively increased by 22.2% and17.0% when the dosage of CPAM was 0.8% of dry fiber. Through analysis of handsheet section scanning electron microscopy (SEM) photos, strengthening mechanism of CPAM emulsion to paper pulp was preliminary studied.

The cationic polymethyl acrylate (CPMA) emulsion which was prepared with no soap emulsion polymerization was used with petroleum resin sizing agent in bleached wheat straw pulp and wood pulp as papermaking sizing agent. It was showed that by the experimental results that when the dosage of composite sizing agent composed of CPMA emulsion and anionic petroleum resin sizing agent was 0.2% absolute dry pulp, sizing degree and white degree of handsheet made of bleached wheat straw pulp were improved 33% and 5.2%ISO respectively. It was also showed that when the dosage of composite sizing agent was 0.2% absolute dry pulp, sizing degree and white degree of handsheet made of wood pulp were improved 37% and 4.2%ISO respectively.

Emulsion copolymerization of methyl acrylate, styrene, acrylamide, acrylonitrile and homemade cationic monomer was studied. A series of clean cationic polymethyl acrylate emulsion were synthesized using no soap emulsion polymerization. Influence of polymerization conditions such as cationic monomer ratio, electrolyte addition amount, the dosage of initiator on synthetic latex performance and the strengthening effect to paper pulp was studied. It was showed by experimental results that sample No.3 which particle size and zeta potential was 0.142 μm and +29.2 mv respectively was the optimal sample latex. When the dosage of latex No.3 was 1.0% to absolute dry pulp, tensile index and ring crush index of paper was increased by 14.6% and 17.8% respectively.

Cationic polymethyl acrylate emulsion which was prepared with no soap emulsion polymerization was used in bleached wheat straw pulp as papermaking retention agent. The main influence factors on retention effect, such as dosage of polymethyl acrylate emulsion, pH value of the bleached wheat straw pulp, reaction time after adding the polymethyl acrylate emulsion and stir velocity were discussed in detail. Experimental results showed that optimal application conditions were that first step was adding cationic emulsion which dosage was 0.64% relative to dry fiber, stir velocity was 1400r/min, 90s for reaction, second step was adding anion components which dosage was 0.16% relative to dry fiber, stir velocity was 750r/min, 60s for reaction, pH value was 4.5~5.0. The cationic organic particles system has good retention aid effect which one pass retention was 96.4%.

Soybean concentration proteins were extracted from defatted soybean meals with ethanol agent method. Crude soybean oligosaccharides were gained after recovery the alcohol by concentration with the soybean whey water as row material. Then a series of purification process such as precipitating proteins, desalting with ion exchange and decolorizing carbon were used to obtain soybean oligosaccharides end product. The soybean oligosaccharides refining process technique and parameters were presented in this paper and could be applied to large-scale industrial production. Physical chemical quality index of soybean oligosaccharides after refining was that concentration was 70%, total sugar purity was no less than 85%, protein content was 1.3% (dry base content), ash content was 0.73% (dry base content).

Graft copolymerization of chitosan and vinyl monomer (such as acryamide and acrylic acid) and application study of the copolymer used as papermaking additive were paid more and more attention in papermaking chemical industry. Chitosan and acrylamide(AM) monomer were graft copolymerizing in inverse emulsion. Several factors such as oil-water proportion, mass ratio of chitosan and AM, emulsifier types and ratio, and initiator concentration that affect the stability of inverse emulsion were elementarily studied. Stable latex can be gained when reaction condition was that the volume ratio of oil phase and water phase was 1:1, the weight ratio of chitosan and AM was 1:8, the initiator concentration was 0.8mmol/L, the dosage of emulsification agent was 8% of the oil phase weight and the weight ratio of 1227 and OP-10 was 1:1.

Organosilicon compound are widely used in pulping and papermaking industry. The quality and capability of paper sheet are distinctly affected by the use of organosilicon. The application of organosilicon used as softening agent, defoamer agent, strengthening agent were introduced one by one in this paper.

Preservative was very necessary used in coated paper coating. Preservative was typical paper additive which was low dosage and high yield. Preservative classification, function mechanism and application technology of coated paper coating was introduced and summarized by the numbers in this paper. Finally the development direction and prospect of preservative used in coated paper coating was prospected.

It is usually reported that chitosan is used as paper strengthening agent. However, it is sorry that the study choosing chitosan which DD (degree of de-acetyl )and viscosity is filtered by experiments is blank. Many chitosan samples of wide viscosity range and wide DD range were tested by their strengthening effect on bleched wheat straw pulp. Then a few sample of chitosan is selected because of their obvious strengthening effect on pulp. This study could be as the foundation of further research of chitosan used as paper strengthening agent.

Recycling of waste paper is demanded because of the shortage of forest resources, the pollution of environment and the scarcity of papermaking materials. It is important to raise the proportion of waste paper in the fiber materials in papermaking industry. Floating/washing method was used here with imported Old Newspaper (ONP) as elementary material. This article studied the deinking performances of many kinds of surfactants primarily. Among them several surfactants were picked out as deinking agent of Old Newspaper (ONP) because of their better deinking effect.

The application of water in water cationic polyacylamide emulsion (CPAM) was studied used in bleached soda reed pulp. The main effects, such as adding amount of CPAM, the dosage of sulfate aluminium, pH value of the bleached soda reed pulp, reaction time after adding the CPAM and the concentration of the electrolyte were discussed here in detailed. The optimal application conditions of CPAM in bleached soda reed pulp were finally gained-CPAM 0.04% relative to dry fiber, 2 minutes for reaction, whip velocity 200r/min, sulfate aluminium 3%relative to dry fiber, pH value 4.0 and sodium chloride 0 relative to dry fiber.

Recycling of waste paper is one of pop topics of pulping and papermaking industry. Deinking technology is the key of recycling of waste paper. It is briefly introduced that methods of waste paper deinking and mechanism of deinking and constitute of deinking agent.

Graft copolymerization of acrylamide (AM) and methyl acrylacyl oxyethyl trimethyl ammonium chloride (DMC) onto gelatin under microwave radiation was studied. The resultant ternary graft copolymer was used as wood pulp dry-strengthening agent. The application results showed that the optimum synthesis conditions was that microwave radiation power was 500W, microwave radiation time was 120S, the concentration of CAN(initiator) was 3mmol/L, m(CS): m(AM): m(DMC) =1:6:2. The breaking length and broken index of hand sheet made of wood pulp was respectively increased by 24.5% and 22.3% when the dosage of the graft copolymer was 0.8% of dry fiber weight.

Graft copolymerization of acrylamide (AM) and diallyl dimethyl ammonium chloride (DMDAAC) onto chitosan in inverse emulsion was studied. The effect on Zeta potential and average granularity of synthetic inverse latex of the main reaction conditions such as the proportion of cationic monomer in total monomers, concentration of potassium persulfate (KPS) used as initiating agent were investigated in detail. It was shown that when the weight ratio of chitosan, AM and DMDAAC was 1:6:2, KPS concentration was 4.0mmol/L, NaHSO3 concentration was 2.0mmol/L, stable inverse latex which had optimal performance could be gained. Good retention effect was obtained when a novel organic microparticle retention system composed of the above-mentioned chitosan-AM-DMDAAC inverse latex and anicnic polyacryamide (APAM) was applied to the deink pulp. First Pass Retention retention percentage of deink pulp was improved from 83.2% to 95.0% with the organic microparticle retention system when the dosage of inverse latex was from 0 to 0.4% of absolute dry pulp.

The collagen was blended with polyvinyl alcohol (PVA) with the maximum maintenance of the natural structure as precondition. The apparent viscosity and rheology property of PVA-collagen blended solution were studied. the mechanical properties of the blend membrane formed from PVA-collagen blended solution were also determined. The PVA-collagen blended solution was wet spinned with the sodium sulfate as coagulant to prepare PVA-collagen composite fibers. SEM analysis and X-ray diffraction analysis of the PVA-collagen composite fibers were studied. The results indicated that, blended with PVA, the spinning property and mechanical properties of collagen were improved. The figure of the aim fiber transect structure was similar as the kidney, and it had a uniform size. The crystallization degree of the fiber was 55.7%, and it was increased with the increase of the hot extending temperature and the extending ratio.