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Your search keyword '"Xian, Yansi"' showing total 17 results
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17 results on '"Xian, Yansi"'

3. Inflammatory Fibroblast‐Like Synoviocyte‐Derived Exosomes Aggravate Osteoarthritis via Enhancing Macrophage Glycolysis (Adv. Sci. 14/2024)

Author

Liu, Bin, primary, Xian, Yansi, additional, Chen, Xiang, additional, Shi, Yong, additional, Dong, Jian, additional, Yang, Lin, additional, An, Xueying, additional, Shen, Tao, additional, Wu, Wenshu, additional, Ma, Yuze, additional, He, Yi, additional, Gong, Wang, additional, Peng, Rui, additional, Lin, Jiaquan, additional, Liu, Na, additional, Guo, Baosheng, additional, and Jiang, Qing, additional

Published
2024
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7. Elevated Circulating CD4.sup.+CD25.sup.+CD127.sup.-/low Regulatory T Cells in Patients with Non-asthmatic Eosinophilic Bronchitis

Author

Huang, Jieru, Liu, Jiaxing, Xian, Yansi, Liu, Bixia, Wu, Yinglin, Zhan, Chen, and Liang, Wanqin

Subjects
T cells -- Health aspects, Bronchitis -- Development and progression -- Care and treatment, Immune response -- Observations -- Health aspects, Health
Abstract

Purpose Non-asthmatic eosinophilic bronchitis (NAEB) is a common cause of chronic cough. It is characterized by sputum eosinophilia like asthma but lacks airway hyperresponsiveness. Regulatory T cells (Tregs) are recognized as immune suppressors and are involved in the pathogenesis of asthma. However, the relationship between Tregs and NAEB remains unknown. This study aimed to preliminarily explore the role of Tregs in NAEB by comparing circulating Tregs levels to asthma and healthy controls. Methods Fractional exhaled nitric oxide (FeNO), spirometry with bronchial provocation test, sputum induction and blood routine test were performed in all subjects. Peripheral blood mononuclear cells were used to detect the Tregs (CD4.sup.+CD25.sup.+CD127.sup.-/low) by flow cytometry. Relationship between the levels of circulating Tregs and clinical indexes was also observed. Results A total of 15 patients with NAEB, 20 patients with asthma and 11 healthy controls were included. The absolute numbers of circulating Tregs in the NAEB group (49.8 ± 18.9 x 10.sup.3 cells/ml) and asthma group (53.3 ± 18.7 x 10.sup.3 cells/ml) were higher than that in healthy control group (32.7 ± 11.6 x 10.sup.3 cells/ml) (both P < 0.01). In total, the level of circulating Tregs showed positive correlation with FeNO (r = 0.30, P < 0.05). Conclusion Tregs may play a key role not only in asthmatic patients, but also in patients with NAEB, as reflected by the elevated Tregs in peripheral blood., Author(s): Jieru Huang [sup.1] [sup.2] , Jiaxing Liu [sup.1] , Yansi Xian [sup.1] [sup.2] , Bixia Liu [sup.1] [sup.2] , Yinglin Wu [sup.1] [sup.2] , Chen Zhan [sup.1] , Wanqin [...]

Published
2020
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8. UPLC/Q‐TOF–MS‐based metabolomics evaluate the efficacy of oroxylin A against postmenopausal osteoporosis

Author

Xian, Yansi, primary, Nong, Yunyuan, additional, Gao, Yijie, additional, Su, Yuangang, additional, Lei, Zhiqiang, additional, Lian, Haoyu, additional, Cheng, Jianwen, additional, Liang, Jiamin, additional, Feng, Xiaoliang, additional, Liu, Zhijuan, additional, Zhao, Jinmin, additional, Zhao, Tongling, additional, Su, Zhiheng, additional, Liu, Qian, additional, and Song, Fangming, additional

Published
2023
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10. Onc201 reduces osteoclastogenesis and prevents ovariectomy-induced bone loss via inhibiting RANKL-induced NFATc1 activation and the integrin signaling pathway

Author

Wu, Liwei, primary, Liang, Jiamin, additional, Li, Jing, additional, Xu, Yang, additional, Chen, Junchun, additional, Su, Yuangang, additional, Xian, Yansi, additional, Wei, Jiyong, additional, Xu, Jiake, additional, Zhao, Jinmin, additional, Liu, Qian, additional, and Yang, Yuan, additional

Published
2022
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15. Oroxylin A reduces osteoclast formation and bone resorption via suppressing RANKL-induced ROS and NFATc1 activation

Author

Jinmin Zhao, Feng Xiaoliang, Qian Liu, Jiamin Liang, Jiake Xu, Haoyu Lian, Feng Long, Yu Xiao, Fangming Song, Yuangang Su, and Xian Yansi

Subjects
musculoskeletal diseases, Lipopolysaccharide, Cell Survival, Osteoporosis, Osteoclasts, Pharmacology, Biochemistry, Bone resorption, Mice, Random Allocation, chemistry.chemical_compound, Osteoclast, medicine, Animals, Bone Resorption, Cytotoxicity, Flavonoids, NFATC Transcription Factors, biology, Macrophages, RANK Ligand, Cell Differentiation, biology.organism_classification, medicine.disease, Mice, Inbred C57BL, medicine.anatomical_structure, Gene Expression Regulation, chemistry, RANKL, Podosomes, biology.protein, Scutellaria baicalensis, Oroxylin A, Female, Reactive Oxygen Species
Abstract

Excessive bone erosion by osteoclasts is associated with osteoporosis, rheumatoid arthritis, and periprosthetic osteolysis. Targeting osteoclasts may serve as an effective treatment for osteolytic diseases. Although drugs are currently available for the treatment of these diseases, exploring potential anti-osteoclast natural compounds with safe and effective treatment remains needed. Oroxylin A (OA), a natural flavonoid isolated from the root of Scutellaria baicalensis Georgi, has numerous beneficial pharmacological characteristics, including anti-inflammatory and antioxidant activity. However, its effects and mechanisms on osteoclast formation and bone resorption have not yet been clarified. Our research showed that OA attenuated the formation and function of osteoclast induced by RANKL in a time- and concentration-dependent manner without any cytotoxicity. Mechanistically, OA suppressed intracellular reactive oxygen species (ROS) levels through the Nrf2-mediated antioxidant response. Moreover, OA inhibited the activity of NFATc1, the master transcriptional regulator of RANKL-induced osteoclastogenesis. OA exhibited protective effects in mouse models of post-ovariectomy (OVX)- and lipopolysaccharide (LPS)-induced bone loss, in accordance with its in vitro anti-osteoclastogenic effect. Collectively, our findings highlight the potential of OA as a pharmacological agent for the prevention of osteoclast-mediated osteolytic diseases.

Published
2021

17. D(-)-salicin inhibits RANKL-induced osteoclast differentiation and function in vitro.

Author

Xiao, Yu, Xian, Yansi, Hu, Xinmei, and Qi, Zhongquan

Subjects
*IN vitro studies, *OSTEOCLASTS, *OSTEOPOROSIS, *BARK, *DNA-binding proteins, *PLANT extracts, *MEMBRANE proteins, *REACTIVE oxygen species, *MITOGEN-activated protein kinases
Abstract

Osteoporosis is a disease, which causes huge economic and social burden. Using natural compound to treat such disease is beneficial for the fewer side effects and effectiveness. D-(-)-salicin (DSA) is a component extracted from the bark of Populus and Salix species. In our research, we discovered that DSA suppressed RANKL-induced differentiation of osteoclast in vitro in a dose-dependent manner. It was also found that the mineral resorbing activity by osteoclasts was depressed via DSA. For the mechanism, we confirmed the inhibitory effect, by which DSA suppressed osteoclast formation and function, was through the inhibition of ROS signaling, MAPK and NF-κB cascades. DSA also suppressed the expression and activity of NFATc1. Therefore, by inhibiting the ROS production, MAPK and NF-κB signal cascade, DSA inhibited the osteoclast differentiation and function in vitro. [Display omitted] • D(-)-Salicin inhibited the MAPK and NF-κB signaling pathways activated and suppressed the expression of NFATc1 and c-Fos. [ABSTRACT FROM AUTHOR]

Published
2022
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