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In recent times, the research on the synthesis of highly functionalized piperidines has become a challenge and an attractive research field among synthetic chemists because these compounds have many biological, pharmaceutical and industrial applications. In this regard, in this paper we would like to report a green, rapid and efficient method for the synthesis of highly functionalized piperidines based on the use of zinc (II) chloride supported on Fe3O4 NPs modified with Dopamine and 5H-Cyclopenta[2,1-b:3,4-b′]dipyridin-5-one [Fe3O4@Dop/CP-diPy-ZnCl2 as a novel magnetically reusable catalyst. The structure of Fe3O4@Dop/CP-diPy-ZnCl2 nanocatalyst was well identified by several spectroscopic techniques including: FT-IR, TEM, SEM, EDX, ICP-OES, TGA, XRD, VSM and Elemental mapping technique. One-pot three-component reactions of aromatic amines with different aryl aldehydes and β-ketoesters were performed in water and all desired highly functionalized piperidines were synthesized with high to excellent yields, which indicates the high efficiency of this catalytic system. The reusability tests shown that that Fe3O4@Dop/CP-diPy-ZnCl2 catalyst is a reusable and stable catalyst. [ABSTRACT FROM AUTHOR]

Molecules containing sulfonamide groups possess significant bioactivity in medicinal and pharmaceutical chemistry, showcasing valuable anti-bacterial and anti-parasitic properties. In recent years, the immobilization of metallic catalysts, including copper, palladium, nickel, and zinc, onto the surface of Fe3O4 nanoparticles modified with ligands, has emerged as an effective and captivating catalytic strategy for enhancing chemical reactions. In this study, we successfully fabricated a novel and highly efficient magnetically recoverable nanocatalyst [Fe3O4@Dopamine-PO-CuBr2] by immobilizing CuBr2 on magnetic Fe3O4 nanoparticles coated with dopamine. This nanocatalyst was utilized for the synthesis of N-aryl sulfonamides via a convenient one-pot three-component reaction involving aryl boronic acids, aryl amines, and DABSO as the SO2 source. The spectroscopic techniques employed thoroughly validated the successful preparation of the [Fe3O4@Dopamine-PO-CuBr2] nanocomposite.Notably, our research adds significant scientific value by presenting a well-designed nanocatalyst that efficiently promotes the synthesis of N-aryl sulfonamides. The ease of recovery and reusability of the [Fe3O4@Dopamine-PO-CuBr2] nanocatalyst, which maintained its catalytic efficiency for up to 8 cycles without any substantial loss, further emphasizes its practicality and sustainability.This study introduces a promising and eco-friendly approach to produce bioactive N-aryl sulfonamides using a magnetically recoverable nanocatalyst. The reported findings hold great potential in the field of medicinal and pharmaceutical chemistry, demonstrating a significant step forward in the development of innovative catalytic strategies. [ABSTRACT FROM AUTHOR]

In the title compound, [Cu(SO(4))(C(15)H(11)N(5))(H(2)O)]·CH(3)OH·2H(2)O, the Cu(II) ion is in a distorted square-pyramidal geometry, in which three N atoms from the chelating 1-(1,10-phenanthrolin-2-yl)-1H-pyrazol-3-amine ligand and one O atom from a sulfate anion define the basal plane and the O atom from the coordinating water mol-ecule is located at the apex. In the crystal, hydrogen-bonding inter-actions involving the coordinating and solvent water mol-ecules, the methanol solvent mol-ecule and the amine group (one with an intra-molecular inter-action to one of the sulfate O atoms) of the complex are observed. π-π inter-actions between symmetry-related phenantroline moieties, with a shortest centroid-centroid inter-action of 3.573 (2)°, are also present.