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In order to meet the growing demand of lymphotherapists, training and patients, guidance, a specific model was designed for training manual lymphatic drainage therapy. The design and application effect of this model is described and discussed in this study. The model can easily let the operator know whether the manipulation is accurate, whether the operation pressure is stable and whether the drainage effect is satisfactory for further adjustments. The design is very close to the clinical practice and the operation of the model is simple and convenient. Preliminary application of this training model showed good effect in better understanding and mastering manipulation technique both in therapists and the patients, as well as their family members. (本研究针对当前淋巴治疗师培训及患者指导上的缺陷, 设计了一种淋巴水肿手法淋巴引流培训教具装置, 并对设计思路及使用效果加以分析。通过使用手法淋巴引流培训教具装置进行操作练习, 可以直观的感受到操作手法的准确性、操作压力的稳定性及引流操作的效果, 增强治疗师的培训成效, 提高患者或者家属掌握的可控性, 进而提升淋巴水肿治疗师培训及患者指导的应用效果。该手法淋巴引流培训教具装置操作简单方便, 应用效果显著。)

This study aims to predict the mechanical response of crumb rubber-modified (CRM) asphalt pavements under traffic loads using three-dimensional (3D) discrete element method (DEM). First, irregular-shaped aggregates were generated in Python language, and discrete element models of six different asphalt layers, which considered the temperature gradient and fatigue damage, were established using 3D DEM. Then, model parameters were obtained through the uniaxial creep test for asphalt mastics at different temperatures. The fatigue damage was implemented by introducing a damage factor into the Burgers model. Finally, three mechanical response parameters (namely, permanent deformation, shear stress and transverse strain) of the six asphalt layers under traffic loads were analysed and compared. Results show that the mechanical response of CRM asphalt layers under traffic loads is significantly influenced by number of repeated loads, temperature, and asphalt layer materials. The shear stress and transverse strain at the wheel centre vary along the depth of asphalt layers, and the middle layer is the principal area of shear stresses in asphalt pavements. [ABSTRACT FROM AUTHOR]

Introduction: This report aims to present our initial miniseries of successful thoracoscopic repair for esophageal atresia (EA) and distal tracheoesophageal fistula (TEF) of Kluth type Ⅲb3 in accordance with Kluth's classification., Methods: From January 2012 to January 2024, ten patients with Kluth type Ⅲb3 EA-TEF were treated by thoracoscopic surgery. The therapeutic methods and surgical outcomes were retrospectively reviewed., Results: All procedures were completed thoracoscopically without conversions. A preoperative bronchoscopy assessment was conducted in four of the cases, revealing that the fistula from the distal segment was located high on the trachea at the level of T2 vertebral. The mean age of the patients at the time of operation was 2.0 ± 0.7 d (range, 1-3 d), and the mean weight at operation was 2.6 ± 0.4 kg (range, 1.8-3.0 kg). The mean operative time (skin to skin) for the entire series was 137.0 ± 8.9 min (range, 120-150 min). Oral feeding was initiated on the postoperative day 8.0 ± 1.9 (range, 6-12 d), and the mean duration for patients after surgery was 14.0 ± 2.4 d (range, 12-20 d). The postoperative period has been uneventful with no occurrences of mortality or morbidity to date. Three cases of formatted anastomotic stricture required at least one esophageal dilation after surgery., Conclusions: Pediatric surgeons should be aware of the rare variants of EA-TEF to avoid the diagnostic and management pitfalls. Patients with Kluth type Ⅲb3 EA-TEF were amenable to repair by thoracoscopic surgery., (Copyright © 2024 Elsevier Inc. All rights reserved.)

In this study, based on network pharmacology and molecular docking method, the mechanism of anti-hyperplasia of mammary glands of Xihuang Pills blood-entering components was explored, and the efficacy and key targets of Xihuang Pills blood-entering components were experimentally verified by MCF-10A proliferation model of human mammary epithelial cells. In order to clarify the material basis and mechanism of Xihuang Pills in realizing anti-hyperplasia of mammary glands, the blood-entering components of Xihuang Pills were qualitatively analyzed by UPLC-Q-TOF-MS, and 22 blood-entering components were identified. By taking the blood-entering components as the research object, the network pharmacology prediction and molecular docking verification were carried out, and finally, three key targets were screened out, namely JAK1, SRC, and CDK1. In vitro experiments show that Xihuang Pills can inhibit the proliferation of MCF-10A cells, promote the apoptosis of MCF-10A cells, and reduce the expression of JAK1, SRC, and CDK1 targets in cells. To sum up, Xihuang Pills can promote the apoptosis of mammary epithelial cells by regulating the expression of JAK1, SRC, and CDK1 and then play an anti-hyperplasia role, which provides an experimental basis for clarifying the material basis of Xihuang Pills for anti-hyperplasia effect.

Caused by endocrine disorder, hyperplasia of mammary glands(HMG) tends to occur in the young with increasing incidence, putting patients at the risk of cancer and threatening the health of women. Therefore, the prevention and treatment of HMG is attracting more and more attention. Amid the modernization of traditional Chinese medicine(TCM), many scholars have found that Chinese patent medicine has unique advantages and huge potential in treatment of endocrine disorder. Particularly, Chinese patent medicine with the function of blood-activating and mass-dissipating, such as Xiaojin Pills and Xiaozheng Pills, has been commonly used in clinical treatment of HMG, which features multiple targets, obvious efficacy, small side effect, and ease of taking and carrying around. Clinical studies have found that the combination of Chinese patent medicine with other medicine can not only improve the efficacy and relieve symptoms such as hyperplasia and pain but also reduce the toxic and side effects of western medicine. Therefore, based on precious pharmacological research and clinical research, this study reviewed the mechanisms of blood-activating mass-dissipating Chinese patent medicine alone and in combination with other medicine, such as regulating levels of in vivo hormones and receptors, promoting apoptosis, inhibiting angiogenesis, improving hemorheology indexes, enhancing immunity, and boosting antioxidant ability. In addition, limitations and problems were summarized. Thereby, this study is expected to lay a theoretical basis for the further study and clinical application of blood-activating mass-dissipating Chinese patent medicine alone or in combination with other medicine against HMG.

Objective: To summarize the experiences and advantages of laparoendoscopic single-site (LESS) surgery for neonatal intestinal atresia and stenosis., Methods: Twenty patients of neonatal intestinal atresia and stenosis were treated with LESS procedure in Huai'an Women and Children's Hospital of Jiangsu Province between October 2010 and April 2012. The clinical data were retrospectively analyzed., Results: Among these patients, 13 were male, 7 were female. Age at admission ranged from 10 min to 1 d. Four cases were premature, and 3 were born with low birth weight (<2500 g). One was diagnosed with duodenal atresia, 1 with duodenal stenosis, 9 with jejunal atresia, 2 with jejunal stenosis, and 7 with ileal atresia. Laparoscopic exploration was performed in all the cases by transumbilical procedure, the proximal and distal ends were exteriorized from the umbilical port site for anastomosis. Twenty neonates with intestinal atresia and stenosis were performed using this new minimally invasive approach, with no cases converted to open operation or standard laparoscopy. The operative time was 35-60 (mean, 40) min. The intraoperative bleeding was 3-5 ml. Two cases were given up treatment by their parents on the second postoperative day. For the other 18 patients, oral intake started on postoperative day 5-10 (mean, 7), and discharged from hospital on the postoperative day 10-20 (mean, 13). The follow up ranged from 1 to 11 months, during which 1 case died, 3 cases were managed with conservative treatment for diarrhea or malnutrition. The other 14 cases grew up healthily., Conclusion: The technique of LESS in the treatment of neonatal atresia and stenosis is simple and the outcomes are satisfactory.

This article used support vector machine (SVM) algorithm to recognize the particles in urine sediment in this paper. After feature extraction, cross-validation method and the contour chart of the accuracy were implemented to select the kernel function and the parameters of SVM, and according to the characteristics of SVM classifier and sample data, Multi-SVMs with two-level-classifier was successfully designed and A classification matrix was eventually obtained. The evaluation by using clinical data and comparative results with the artificial neural network have demonstrated that the proposed algorithm gets better results.

After extracting definition measurements by different focus functions from the images, a novel autofocus algorithm which combines them with principal component analysis (PCA) and considers the first principal component as the final measurement, is presented in this paper. The experiment results with 70 groups of images show that this algorithm increases the difference between the definition measurements of the images and provides higher focusing accuracy in comparison with other single ones.

According to the patient examination criterion and the demands of all related departments, the DSA digital subtraction workstation has been successfully designed and is introduced in this paper by analyzing the characteristic of video source of DSA which was manufactured by GE Company and has no DICOM standard interface. The workstation includes images-capturing gateway and post-processing software. With the developed workstation, all images from this early DSA equipment are transformed into DICOM format and then are shared in different machines.

A fast microscopic image mosaicing method is proposed in this paper by making a study of the mosaic methods and the characteristics of microscopic images. In the paper, invariant local features based on normalized moment of inertia (NMI) are used to select the matching points and calculate the spatial translation. The experimental results demonstrate that this algorithm can achieve fast, effective microscopic image mosaicing.

Objective: To establish a method of determining the residual epoxyethane in medical instruments., Method: An HP-5 capillary column (30 m x 0.32 mm x 0.25 microm), an FID detecter and an oven were used in the determination. The oven temperature was kept at 120 degrees C for 8 minutes, the example inlet temperature was kept at 200 degrees C, while the detecter temperature was kept at 250 degrees C., Result: The method has a linear range between 5.1920-51.920 microg, (r = 0.997, n = 6). The average rate of recovery of the injecter is 103.3%. The average rate of recovery of the infusion devices is 81.04%., Conclusion: The method has been proved to be convenient, sensitive and accurate. It is suitable for the determination of residual organic solvents in medical instruments.

This paper introduces the design and implementation of a system which can get the NEMA2.0 image data from the hard disks of the imaging equipments directly,then analyzes and transforms these image data into the DICOM3.0 image data and sends them to the image server. The design has the advantages of reliable image quality, low cost and information.

A new algorithm using the geometric active contour model with the fusion of color and intensity priors to segment medical images is presented in this paper. The prior knowledge used here are firstly defined in different color spaces and represented as thresholds searched by the genetic algorithm. Then the prior knowledge is merged into active contour model with its contour evolution by the level set technique. The experiments on clinical marrow images and mammograms have successfully demonstrated its superiority of the proposed algorithm over the existing active contour models which deal with image gradient information.

In recent years, image processing technique based on deformable models has been widely used in the field of medical image processing and analysis. This survey demonstrates the principle of two kinds of basic deformable models, i.e. parametric deformable model and geometric deformable model. The design of model in application is also discussed. By incorporating prior knowledge and modeling global properties, several new extensions of basic deformable model are then reviewed. At last, some prospects of possible research are given.