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16 results on '"Xia, Daqing"'

4. Tocilizumab in patients with moderate or severe COVID-19: a randomized, controlled, open-label, multicenter trial

Author

Wang, Dongsheng, Fu, Binqing, Peng, Zhen, Yang, Dongliang, Han, Mingfeng, Li, Min, Yang, Yun, Yang, Tianjun, Sun, Liangye, Li, Wei, Shi, Wei, Yao, Xin, Ma, Yan, Xu, Fei, Wang, Xiaojing, Chen, Jun, Xia, Daqing, Sun, Yubei, Dong, Lin, Wang, Jumei, Zhu, Xiaoyu, Zhang, Min, Zhou, Yonggang, Pan, Aijun, Hu, Xiaowen, Mei, Xiaodong, Wei, Haiming, and Xu, Xiaoling

Published
2021
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11. Neutrophil-to-Lymphocyte Ratios Are Closely Associated With the Severity and Course of Non-mild COVID-19

Author

Qun, Sen, primary, Wang, Yulan, additional, Chen, Jun, additional, Huang, Xiang, additional, Guo, Hui, additional, Lu, Zhaohui, additional, Wang, Jinquan, additional, Zheng, Changcheng, additional, Ma, Yan, additional, Zhu, Yuyou, additional, Xia, Daqing, additional, Wang, Yinzhong, additional, He, Hongliang, additional, Wang, Yong, additional, Fei, Mingming, additional, Yin, Yihong, additional, Zheng, Mao, additional, Xu, Yehong, additional, Ge, Wei, additional, Hu, Fuyong, additional, and Zhou, Jian, additional

Published
2020
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12. Tocilizumab Ameliorates the Hypoxia in COVID-19 Moderate Patients with Bilateral Pulmonary Lesions: A Randomized, Controlled, Open-Label, Multicenter Trial

Author

Wang, Dongsheng, primary, Fu, Binqing, additional, Peng, Zhen, additional, Yang, Dongliang, additional, Han, Mingfeng, additional, Li, Min, additional, Yang, Yun, additional, Yang, Tianjun, additional, Sun, Liangye, additional, Li, Wei, additional, Shi, Wei, additional, Yao, Xin, additional, Ma, Yan, additional, Wang, Xiao jing, additional, Chen, Jun, additional, Xia, Daqing, additional, Sun, Yubei, additional, Dong, Lin, additional, Wang, Jumei, additional, Zhu, Xiaoyu, additional, Zhou, Yonggang, additional, Pan, Aijun, additional, Hu, Xiaowen, additional, Mei, Xiaodong, additional, Wei, Haiming, additional, and Xu, Xiaoling, additional

Published
2020
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13. Photothermally triggered melting and perfusion: responsive colloidosomes for cytosolic delivery of membrane-impermeable drugs in tumor therapy.

Author

Ding, Tao, Zhu, Jing, Guan, Haidi, Xia, Daqing, Xing, Yuxin, Huang, Jixi, Wang, Zhenqiang, Cai, Kaiyong, and Zhang, Jixi

Abstract

A cell membrane barrier which dominates the therapeutic efficacy and systemic side effects is a major bottleneck in the field of drug delivery. Herein, a therapeutic system capable of photothermally triggered on-demand and cytosolic delivery was achieved by polydopamine (PDA) nanoparticle-stabilized colloidosomes. An organic phase change material (PCM, saturated fatty acids) was employed as the lipid core for Pickering emulsification and drug encapsulation, and arginine was utilized as a linker to induce the directional interactions between nanoemulsion droplets and heterogeneously nucleated PDA nanoparticles. Moreover, the PDA particle stabilizers concomitantly mediated the grafting of hydrophilic polymer PEG to further improve dispersibility. The resultant colloidosomes after cooling possess lowered melting points and superior dispersion stability over 7 days. When irradiated with near-infrared light (808 nm), sequential processes of fatty acid melting and direct drug perfusion into the cytosol took place within 10 min. The employment of vorinostat (SAHA, histone deacetylase inhibitor) as a model membrane-impermeable drug resulted in remarkable enhancement of anti-cancer effects both in vitro (5.2 fold reduction in IC50) and in vivo (7.3 fold increase in tumor inhibition rate) with respect to the free drug. The remotely triggered transformable nanoplatform paves a new avenue of responsive and efficient cytosolic perfusion to overcome biological membrane barriers on the basis of colloidosomes. [ABSTRACT FROM AUTHOR]

Published
2022
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14. The water-bearing numerical model and its operational forecasting experiments part ii: The operational forecasting experiments

Author

Qian Yueying, Xu Youping, and Xia Daqing

Subjects
Atmospheric Science, Bearing (mechanical), Operations research, law, Computer science, Operational forecasting, Industrial engineering, Technology forecasting, law.invention
Abstract

The water-bearing numerical model is undergone all round examinations during the operational forecasting experiments from 1994 to 1996. A lot of difficult problems arising from the model's water-bearing are successfully resolved in these experiments through developing and using a series of technical measures. The operational forecasting running of the water-bearing numerical model is realized stably and reliably, and satisfactory forecasts are obtained.

Published
1998

15. The water-bearing numerical model and its operational forecasting experiments part I: the water-bearing numerical model

Author

Xu Youping and Xia Daqing

Subjects
Atmospheric Science, Bearing (mechanical), Series (mathematics), Meteorology, Computer science, law, Applied mathematics, Operational forecasting, Computational problem, Hydrostatic equilibrium, Mixing (physics), law.invention
Abstract

In first paper of articles, the physical and calculating schemes of the water-bearing numerical model are described. The model is developed by bearing all species of hydrometeors in a conventional numerical model in which the dynamic framework of hydrostatic equilibrium is taken. The main contributions are: the mixing ratios of all species of hydrometeors are added as the prognostic variables of model, the prognostic equations of these hydrometeors are introduced, the cloud physical framework is specially designed, some technical measures are used to resolve a series of physical, mathematical and computational problems arising from water-bearing; and so on.

Published
1998

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