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1. Targeting Patient-Derived Orthotopic Gastric Cancers with a Fluorescent Humanized Anti-CEA Antibody

2. EWS-WT1 fusion isoforms establish oncogenic programs and therapeutic vulnerabilities in desmoplastic small round cell tumors.

3. Entinostat as a combinatorial therapeutic for rhabdomyosarcoma.

4. Manzamine A reduces androgen receptor transcription and synthesis by blocking E2F8-DNA interactions and effectively inhibits prostate tumor growth in mice.

5. Development and application of genetic ancestry reconstruction methods to study diversity of patient-derived models in the NCI PDXNet Consortium

6. Plexin D1 emerges as a novel target in the development of neural lineage plasticity in treatment-resistant prostate cancer

7. Assessment of Patient-Derived Xenograft Growth and Antitumor Activity: The NCI PDXNet Consensus Recommendations.

8. A deep learning model of tumor cell architecture elucidates response and resistance to CDK4/6 inhibitors.

9. A Kinome-Wide Synthetic Lethal CRISPR/Cas9 Screen Reveals That mTOR Inhibition Prevents Adaptive Resistance to CDK4/CDK6 Blockade in HNSCC.

10. N-Myristoytransferase Inhibition Causes Mitochondrial Iron Overload and Parthanatos in TIM17A-Dependent Aggressive Lung Carcinoma

11. Discovery of CDC42 Inhibitors with a Favorable Pharmacokinetic Profile and Anticancer In Vivo Efficacy.

12. Activation of the Mevalonate Pathway in Response to Anti-cancer Treatments Drives Glioblastoma Recurrences Through Activation of Rac-1

13. PLX038A, a long-acting SN-38, penetrates the blood-tumor-brain-barrier, accumulates and releases SN-38 in brain tumors to increase survival of tumor bearing mice.

14. IRX4204 Induces Senescence and Cell Death in HER2-positive Breast Cancer and Synergizes with Anti-HER2 Therapy.

15. Mediator kinase inhibition reverses castration resistance of advanced prostate cancer

16. Repurposing mebendazole against triple-negative breast cancer CNS metastasis

17. Enhancing CAR-T cell metabolism to overcome hypoxic conditions in the brain tumor microenvironment

18. Osteosarcoma PDX-Derived Cell Line Models for Preclinical Drug Evaluation Demonstrate Metastasis Inhibition by Dinaciclib through a Genome-Targeted Approach

19. 3D small-scale dosimetry and tumor control of 225Ac radiopharmaceuticals for prostate cancer

20. Designing combination therapies for cancer treatment: application of a mathematical framework combining CAR T-cell immunotherapy and targeted radionuclide therapy

21. Manuka Honey Inhibits Human Breast Cancer Progression in Preclinical Models

22. Development of a Simple and Reproducible Cell-derived Orthotopic Xenograft Murine Model for Neuroblastoma

23. Single protein encapsulated SN38 for tumor-targeting treatment.

24. Targeting de novo lipid synthesis induces lipotoxicity and impairs DNA damage repair in glioblastoma mouse models.

25. A dendritic/tumor fusion cell vaccine enhances efficacy of nanobody-based CAR-T cells against solid tumor

26. SF3B1 inhibition disrupts malignancy and prolongs survival in glioblastoma patients through BCL2L1 splicing and mTOR/ß-catenin pathways imbalances

27. CBFA2T3-GLIS2 model of pediatric acute megakaryoblastic leukemia identifies FOLR1 as a CAR T cell target

28. A Genomically and Clinically Annotated Patient-Derived Xenograft (PDX) Resource for Preclinical Research in Non-Small Cell Lung Cancer

29. STAT3 Activation as a Predictive Biomarker for Ruxolitinib Response in Head and Neck Cancer.

30. Brain-restricted mTOR inhibition with binary pharmacology

31. RASA2 ablation in T cells boosts antigen sensitivity and long-term function

32. Engineered IL13 variants direct specificity of IL13Rα2-targeted CAR T cell therapy

33. Spatial organization of heterogeneous immunotherapy target antigen expression in high-grade glioma

34. RESEARCH PROGRESS IN INDIVIDUALIZED DRUG SCREENING TECHNOLOGY FOR PATIENTS WITH TUMORS

35. Translocon-associated Protein Subunit SSR3 Determines and Predicts Susceptibility to Paclitaxel in Breast Cancer and Glioblastoma.

36. Targeted siRNA nanocarrier: a platform technology for cancer treatment

37. Alternative Splicing of EZH2 pre-mRNA by SF3B3 Contributes to the Tumorigenic Potential of Renal CancerEZH2 Gene Is Regulated by SF3B3

38. HLA-independent T cell receptors for targeting tumors with low antigen density.

39. Phospho-Aspirin (MDC-22) inhibits pancreatic cancer growth in patient-derived tumor xenografts and KPC mice by targeting EGFR: Enhanced efficacy in combination with irinotecan

40. Reprogramming of nucleotide metabolism by interferon confers dependence on the replication stress response pathway in pancreatic cancer cells

41. Fluorescent Anti-MUC5AC Brightly Targets Pancreatic Cancer in a Patient-derived Orthotopic Xenograft

42. Receptor-interacting protein kinase 2 (RIPK2) stabilizes c-Myc and is a therapeutic target in prostate cancer metastasis

43. MAPK4 promotes triple negative breast cancer growth and reduces tumor sensitivity to PI3K blockade

44. Transcriptional Reprogramming Differentiates Active from Inactive ESR1 Fusions in Endocrine Therapy-Refractory Metastatic Breast Cancer.

45. Activation of Notch and Myc signaling via B cell-restricted depletion of Dnmt3a generates a consistent murine model of chronic lymphocytic leukemia

46. Human iPSC-derived fallopian tube organoids with BRCA1 mutation recapitulate early-stage carcinogenesis.

47. Selective targeting of MYC mRNA by stabilized antisense oligonucleotides

48. Targeting glioblastoma signaling and metabolism with a re-purposed brain-penetrant drug

49. A patch of positively charged residues regulates the efficacy of clinical DR5 antibodies in solid tumors.

50. A protein network map of head and neck cancer reveals PIK3CA mutant drug sensitivity

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