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Your search keyword '"Xander M.R. van Wijk"' showing total 5 results
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5 results on '"Xander M.R. van Wijk"'

1. Implementation of pharmacogenomics into inpatient general medicine

Author

Thomas Chen, Peter H. O’Donnell, Merisa Middlestadt, Gregory W. Ruhnke, Keith Danahey, Xander M.R. van Wijk, Anish Choksi, Randall Knoebel, Seth Hartman, Kiang-Teck Jerry Yeo, Paula N. Friedman, Mark J. Ratain, Edith A. Nutescu, Kevin J. O’Leary, Minoli A. Perera, and David O. Meltzer

Subjects
Genetics, Molecular Medicine, General Pharmacology, Toxicology and Pharmaceutics, Molecular Biology, Genetics (clinical)
Published
2022

2. The stability of blood gases and CO-oximetry under slushed ice and room temperature conditions

Author

Gerald S. Zavorsky and Xander M.R. van Wijk

Subjects
Biochemistry (medical), Clinical Biochemistry, General Medicine
Abstract

Objectives Human blood gas stability data is limited to small sample sizes and questionable statistical techniques. We sought to determine the stability of blood gases under room temperature and slushed iced conditions in patients using survival analyses. Methods Whole blood samples from ∼200 patients were stored in plastic syringes and kept at room temperature (22–24 °C) or in slushed ice (0.1–0.2 °C) before analysis. Arterial and venous pO2 (15–150 mmHg), pCO2 (16–72 mmHg), pH (6.73–7.52), and the CO-oximetry panel [total hemoglobin (5.4–19.3 g/dL), percentages of oxyhemoglobin (O2Hb%, 20–99%), carboxyhemoglobin (COHb, 0.1–5.4%) and methemoglobin (MetHb, 0.2–4.6%)], were measured over 5-time points. The Royal College of Pathologists of Australasia’s (RCPA’s) criteria determined analyte instability. Survival analyses identified storage times at which 5% of the samples for various analytes became unstable. Results COHb and MetHb were stable up to 3 h in slushed ice and at room temperature; pCO2, pH was stable at room temperature for about 60 min and 3 h in slushed ice. Slushed ice shortened the storage time before pO2 became unstable (from 40 to 20 min), and the instability increased when baseline pO2 was ≥60 mmHg. The storage time for pO2, pCO2, pH, and CO-oximetry, when measured together, were limited by the pO2. Conclusions When assessing pO2 in plastic syringes, samples kept in slushed ice harm their stability. For simplicity’s sake, the data support storage times for blood gas and CO-oximetry panels of up to 40 min at room temperature if following RCPA guidelines.

Published
2023

3. Oncology

Author

Maximo J. Marin and Xander M.R. van Wijk

Published
2021

4. Contributors

Author

Zane D. Amenhotep, Wayne B. Anderson, Jason M. Baron, Carey-Ann D. Burnham, Jing Cao, Janine D. Cook, Gyorgy Csako, Sarah Delaney, Anand S. Dighe, Shu-Ling Fan, Wieslaw Furmaga, Putuma P. Gqamana, Dina N. Greene, Neil Harris, Ibrahim Hashim, Erika M. Hissong, Paul J. Jannetto, Michael Karasick, Adil I. Khan, Rasoul A. Koupaei, Kent Lewandrowski, Chuanyi Mark Lu, Maximo J. Marin, Yvette McCarter, Qing H. Meng, James H. Nichols, Anthony Okorodudu, Octavia M. Peck Palmer, Hanna Rennert, Luke Rodda, Lusia Sepiashvili, Christine L.H. Snozek, Carole A. Spencer, John Toffaletti, Nam Tran, Greg Tsongalis, Priya D. Velu, Jeffrey Whitman, Xander M.R. van Wijk, Alison Woodworth, Alan H.B. Wu, Melanie L. Yarbrough, He Sarina Yang, Brandy Young, Y. Victoria Zhang, and Zhen Zhao

Published
2021

5. List of Contributors

Author

Fatima Ahmad, Imoigele P. Aisiku, Peter Allfather, Henriette Beyer, S. Bezek, Peter Biberthaler, Viktoria Bogner-Flatz, Jeffrey Brennan, Victoria J. Dardov, Mahasweta Das, Elvisha Dhamala, Clara E. Dismuke-Greer, Ryan Duggan, Donna J. Edmonds, Daniel Fatovich, Justyna Fert-Bober, Melinda Fitzgerald, L. Foerschner, Aleksandra Gozt, Putuma P. Gqamana, Samar Abdel Hady, Hiba Hasan, Houssein Hajj Hassan, Ayah Istanbouli, Damir Janigro, K.-G. Kanz, Harry Kerasidis, Firas H. Kobeissy, Barry Kosofsky, Milin Kurup, Bernd A. Leidel, Harvey Levin, Kent Lewandrowski, Tobias Lindner, Maximo J. Marin, I. Martinez-Espina, Audrey McKinlay, Gary James Mitchell, Shyam S. Mohapatra, Subhra Mohapatra, Robert M. Murcko, Ryuta Nakae, Takahito Nakagawa, Leila Nasrallah, David O. Okonkwo, Rakhi Pandey, W. Frank Peacock, Julian Pohlan, Ava M. Puccio, Zubaid Rafique, Lakshman Ramamurthy, Claudia S. Robertson, Richard Rubenstein, Daisuke Saito, George A. Sarkis, Abdullah Shaito, Nour Shaito, Jerald H. Simmons, Rodmond Singleton, Deborah Snell, Karina M. Soto-Ruiz, Šárka O. Southern, Richard M. Sweet, Martin Paul Than, James W.G. Thompson, Pablo Tovar, Jennifer E. Van Eyk, Timothy E. Van Meter, Xander M.R. van Wijk, Kevin K.W. Wang, Jolewis Washington, Douglas S. Webber, Robert J. Webber, Stanley L. Wu, Hamad Yadikar, Zhihui Yang, Shoji Yokobori, Hiroyuki Yokota, John K. Yue, Y. Victoria Zhang, and Kazem Zibara

Published
2020

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