Search

In industries such as aircraft or train manufacturing, large-scale manufacturing companies often manage several complex projects. Each of these projects includes multiple tasks that share a set of limited resources. Typically, these tasks are also subject to time dependencies among them. One frequent goal in these scenarios is to minimize the makespan, or total time required to complete all the tasks within the entire project. Decisions revolve around scheduling these tasks, determining the sequence in which they are processed, and allocating shared resources to optimize efficiency while respecting the time dependencies among tasks. This problem is known in the scientific literature as the Resource-Constrained Project Scheduling Problem (RCPSP). Being an NP-hard problem with time dependencies and resource constraints, several optimization algorithms have already been proposed to tackle the RCPSP. In this paper, a novel discrete-event heuristic is introduced and later extended into an agile biased-randomized algorithm complemented with an adaptive capability to tune the parameters of the algorithm. The results underscore the effectiveness of the algorithm in finding competitive solutions for this problem within short computing times.

In this paper, we introduce a novel sim-learnheuristic method designed to address the team orienteering problem (TOP) with a particular focus on its application in the context of unmanned aerial vehicles (UAVs). Unlike most prior research, which primarily focuses on the deterministic and stochastic versions of the TOP, our approach considers a hybrid scenario, which combines deterministic, stochastic, and dynamic characteristics. The TOP involves visiting a set of customers using a team of vehicles to maximize the total collected reward. However, this hybrid version becomes notably complex due to the presence of uncertain travel times with dynamically changing factors. Some travel times are stochastic, while others are subject to dynamic factors such as weather conditions and traffic congestion. Our novel approach combines a savings-based heuristic algorithm, Monte Carlo simulations, and a multiple regression model. This integration incorporates the stochastic and dynamic nature of travel times, considering various dynamic conditions, and generates high-quality solutions in short computational times for the presented problem.

The adoption of electric vehicles (EVs) has gained significant momentum in recent years as a sustainable alternative to traditional internal combustion engine vehicles. However, the efficient utilization of batteries in EVs, coupled with the growing demand for sustainable transportation, has posed complex challenges for battery management in the context of electric vehicle routing problems in a broad sense, which includes vehicle routing problems, team orienteering problems, and arc routing problems, all of them using EVs. This paper presents a comprehensive review of the state-of-the-art approaches, methodologies, and strategies for battery management in each of the aforementioned optimization problems. We explore the relevant factors influencing battery performance and the interplay between routing, charging, and energy management in the context of EVs. The paper also discusses the advances in optimization algorithms, vehicle-to-grid integration, and intelligent decision-making techniques aimed at enhancing the range, reliability, and sustainability of EV operations. Key findings indicate a paradigm shift towards addressing uncertainties, dynamic conditions, and synchronization challenges inherent in large-scale and dynamic routing problems within the context of EVs that require efficient battery management.

Automated guided vehicles (AGVs) stand out as a paradigmatic application of Industry 4.0, requiring the seamless integration of new concepts and technologies to enhance productivity while reducing labor costs, energy consumption, and emissions. In this context, specific industrial use cases can present a significant technological and scientific challenge. This study was inspired by a real industrial application for which the existing AGV literature did not contain an already well-studied solution. The problem is related to the sequencing of assigned tasks, where the queue formation dynamics and the resource sharing define the scheduling. The combinatorial nature of the problem requires the use of advanced mathematical tools such as heuristics, simulations, or a combination of both. A heuristic procedure was developed that generates candidate task sequences, which are, in turn, evaluated in a discrete-event simulation model developed in Simul8. This combined approach allows high-quality solutions to be generated and realistically evaluated, even graphically, by stakeholders and decision makers. A number of computational experiments were developed to validate the proposed method, which opens up some future lines of research, especially when considering stochastic settings.

The use of simulation and reinforcement learning can be viewed as a flexible approach to aid managerial decision-making, particularly in the face of growing complexity in manufacturing and logistic systems. Efficient supply chains heavily rely on steamlined warehouse operations, and therefore, having a well-informed storage location assignment policy is crucial for their improvement. The traditional methods found in the literature for tackling the storage location assignment problem have certain drawbacks, including the omission of stochastic process variability or the neglect of interaction between various warehouse workers. In this context, we explore the possibilities of combining simulation with reinforcement learning to develop effective mechanisms that allow for the quick acquisition of information about a complex environment, the processing of that information, and then the decision-making about the best storage location assignment. In order to test these concepts, we will make use of the FlexSim commercial simulator.

This paper discusses an orienteering optimization problem where a vehicle using electric batteries must travel from an origin depot to a destination depot while maximizing the total reward collected along its route. The vehicle must cross several consecutive regions, with each region containing different types of charging nodes. A charging node has to be selected in each region, and the reward for visiting each node—in terms of a ‘satisfactory’ charging process—is a binary random variable that depends upon dynamic factors such as the type of charging node, weather conditions, congestion, battery status, etc. To learn how to efficiently operate in this dynamic environment, a hybrid methodology combining simulation with reinforcement learning is proposed. The reinforcement learning component is able to make informed decisions at each stage, while the simulation component is employed to validate the learning process. The computational experiments show how the proposed methodology is capable of design routing plans that are significantly better than non-informed decisions, thus allowing for an efficient management of the vehicle’s battery under such dynamic conditions.

The popularity of blockchain technology stems largely from its association with cryptocurrencies, but its potential applications extend beyond this. Fungible tokens, which are interchangeable, can facilitate value transactions, while smart contracts using non-fungible tokens enable the exchange of digital assets. Utilizing blockchain technology, tokenized platforms can create virtual markets that operate without the need for a central authority. In principle, blockchain technology provides these markets with a high degree of security, trustworthiness, and dependability. This article surveys recent developments in these areas, including examples of architectures, designs, challenges, and best practices (case studies) for the design and implementation of tokenized platforms for exchanging digital assets.

An efficient management of production plants has to consider several external and internal factors, such as potential interruptions of the ongoing processes. Automated guided vehicles (AGVs) are becoming a widespread technology that offers many advantages. These AGVs can perform complex tasks in an autonomous way. However, an inefficient schedule of the tasks assigned to an AGV can suffer from unwanted interruptions and idle times, which in turn will affect the total time required by the AGV to complete its assigned tasks. In order to avoid these issues, this paper proposes a heuristic-based approach that: (i) makes use of a delay matrix to estimate circuit delays for different daily times; (ii) employs these estimates to define an initial itinerary of tasks for an AGV; and (iii) dynamically adjusts the initial agenda as new information on actual delays is obtained by the system. The objective is to minimize the total time required for the AGV to complete all the assigned tasks, taking into account situations that generate unexpected disruptions along the circuits that the AGV follows. In order to test and validate the proposed approach, a series of computational experiments utilizing real-life data are carried out. These experiments allow us to measure the improvement gap with respect to the former policy used by the system managers.

Stochastic, as well as fuzzy uncertainty, can be found in most real-world systems. Considering both types of uncertainties simultaneously makes optimization problems incredibly challenging. In this paper, we analyze the permutation flow shop problem (PFSP) with both stochastic and fuzzy processing times. The main goal is to find the solution (permutation of jobs) that minimizes the expected makespan. However, due to the existence of uncertainty, other characteristics of the solution are also taken into account. In particular, we illustrate how survival analysis can be employed to enrich the probabilistic information given to decision-makers. To solve the aforementioned optimization problem, we extend the concept of a simheuristic framework so it can also include fuzzy elements. Hence, both stochastic and fuzzy uncertainty are simultaneously incorporated in the PFSP. In order to test our approach, classical PFSP instances have been adapted and extended, so that processing times become either stochastic or fuzzy. The experimental results show the effectiveness of the proposed approach when compared with more traditional ones.

The transcriptome of every cell is orchestrated by the complex network of interaction between transcription factors (TFs) and their binding sites on DNA. Disruption of this network can result in many forms of organism malfunction but also can be the substrate of positive natural selection. However, understanding the specific determinants of each of these individual TF-DNA interactions is a challenging task as it requires integrating the multiple possible mechanisms by which a given TF ends up interacting with a specific genomic region. These mechanisms include DNA motif preferences, which can be determined by nucleotide sequence but also by DNA’s shape; post-translational modifications of the TF, such as phosphorylation; and dimerization partners and co-factors, which can mediate multiple forms of direct or indirect cooperative binding. Binding can also be affected by epigenetic modifications of putative target regions, including DNA methylation and nucleosome occupancy. In this review, we describe how all these mechanisms have a role and crosstalk in one specific family of TFs, the basic helix-loop-helix (bHLH), with a very conserved DNA binding domain and a similar DNA preferred motif, the E-box. Here, we compile and discuss a rich catalog of strategies used by bHLH to acquire TF-specific genome-wide landscapes of binding sites.