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Interaction exists in lung cancer and microbiota. Lung microecological homeostasis can improve the immune tolerance, enhance immune suppression, and inhibit inflammatory responses, to reduce the lung cancer; while lung cancer can lead to pulmonary microecological imbalance, change the lung environment, and promote tumor cell proliferation. Therefore, modulating microbial flora and microecological immunotherapy may be a potential and preventive treatment for lung cancer, to restore tumor immunosuppression and improve patient survival. However, the individual differences in the lung microecology, because of different genetics, ethnic characteristics, and dietary habits, increasing the difficulty of precise diagnosis and treatment, which is also the current bottleneck in the application of microecological immunotherapy. Otherwise, the effectiveness of regulatory measures such as probiotics, prebiotics or antimicrobials is questionable. The research on microbial flora is still in its infancy, and further exploration is needed to form a standardized, effective, and precise treatment plan. So, standardized, effective, and precise microbial flora treatment strategies need to be further explored.肺癌与肺部微生物菌群存在相互影响。肺部微生态稳态可提高机体的免疫耐受，增强免疫抑制能力，抑制炎症反应，从而减少肺癌发生；而肺癌则可导致肺部微生态失衡和菌群失调，改变肺部环境，形成有利于肿瘤细胞增殖的肿瘤微环境。因此，调节微生物菌群及微生态免疫疗法可能是潜在的新型治疗和预防治疗肺癌的方案，有利于恢复肿瘤免疫抑制，提高患者生存率。然而，肺部微生态因宿主遗传、种族特征及饮食习惯不同而存在个体化差异，增加了精准诊疗的难度，也是目前微生态免疫疗法的应用瓶颈，益生菌、益生元或抗微生物药物等调节措施的有效性也值得商榷。微生物菌群的研究还处于起步阶段，形成规范、有效、精准的治疗方案还需进一步探索。.

Various strand concept for high-temperature superconductor (HTS) flat tapes have been developed in the past few years for fusion magnet applications. We developed a round HTS strand with soldered multilayer copper tapes as filler and support called SaMiT following the technic path of twisted stacked-tape cable. DC tests performed under bending and twisting condition demonstrated that the proposed design of the HTS strand is promising in the high current cable and magnet application, but the study on electromechanical properties against the transverse and cyclic load is still needed. A press device was designed to measure the critical current of SaMiT sample at 77 K and self-field as a function of transverse and cyclic load to simulate the electromagnetic force load during the magnet operation. Transverse load amplitudes have been applied up to 40 MPa and cyclic load up to 1000 cycles at certain load amplitude. The experimental results are presented and structural optimization suggestions are discussed with visual inspection and analysis.

Preparing an epoxy resin with biomass resources as an alternative for bisphenol A is significant for sustainable and renewable development under great pressure of limited fossil resources and urgent environmental issues. Herein, we synthesized an epoxy oligomer P-DBP-EP-n derived from biomass magnolol through an efficient one-step glycidylation. P-DBP-EP-n exhibited a low viscosity of 11.7 Pa・s at room temperature, endowing it with excellent processability as diglycidyl ether of bisphenol A (DGEBA) and magnolol-based epoxy monomer EDBP. Then P-DBP-EP-n was cured with a diamine curing agent, 4,4′-diaminodiphenyl methane (DDM), and following thermal addition polymerization of allyl units. Compared with DGEBA/DDM and EDBP/DDM, P-DBP-EP-n/DDM possessed a higher glass transition temperature (Tg) (304 to 167 and 226 °C), implying distinguished heat resistance. Furthermore, the tensile properties and notched impacted strength of P-DBP-EP-n/DDM were better than EDBP/DDM (20.7 to 19.4 MPa, 2.0 to 1.6 GPa, and 2.5 to 2.0 kJ/m2). The initial degradation temperature and char residue of P-DBP-EP-n/DDM were 421 °C and 35.2%, with a 13.5 and 101% increase compared with those of DGEBA/DDM, respectively. Additionally, P-DBP-EP-n/DDM displayed outstanding flame retardancy with V-0 rate for the vertical burning test and limiting oxygen index value of 47.7%, which was almost twice as much as that of DGEBA/DDM. This study offers a promising and feasible pathway to obtain a fully bio-based epoxy resin substituted for petroleum-based DGEBA with distinguished processability, heat resistance, and flame retardancy. Comprehensive properties of the bio-based thermosets are expected to be further regulated by the thermal addition polymerization of allyl units.

Design and feasible verification of the round high-temperature superconducting (HTS) strand with REBCO tapes is the key technology for future fusion magnet application such as China Fusion Engineering Test Reactor (CFETR). Flat tape configuration of REBCO tapes and incompatibility with cable design based on round low-temperature superconducting (LTS) strand lead to the development of new cable technology. In this article, a HTS strand variant with soldered multilayer copper tapes as filler and tube called SaMiT is developed following the technology path of twisted stacked-tape cable (TSTC). Due to the use of a milling process to form the round strand, the probability of REBCO tapes damage is reduced greatly in the manufacturing process. Meanwhile, the tapes delamination problem and solution is also discussed. The bending and twisting test of the samples are performed to verify the electromechanical characteristics. The measurement result shows the SaMiT has great potential in HTS cable application. Future tests at transverse load and high field are needed for fusion magnet application.

We explored a simple approach to grow needle-like polyphosphazene nanotubes (PZSNT) on carbon fibers (CFPZSNT) via in-situ polycondensation under mild reaction conditions, to form a PZSNT-based multiscale reinforcement. PZSNT with abundant free hydroxyl groups can significantly change the chemical surface and increase the specific surface area of carbon fibers. A significant improvement of interfacial shear strength was obtained from 39.7 MPa for the virgin CF/polyamide 6 composites to 69.6 MPa for the CF-PZSNT/polyamide 6 composites.

The halophyte Kalidium foliatum (Pall.) Moq. exhibits strong tolerance to salinity. Salt stress leads to reactive oxygen species (ROS) production, and high contents of ROS are harmful to plants. The phospholipid hydroperoxide glutathione peroxidase (PHGPx) responds positively to damage induced by ROS. To understand the mechanism of tolerance to salt stress in halophytes, a PHGPx gene of K. foliatum was cloned, and its expression pattern was analysed under salt treatment. Treatments of whole plants were carried out with 0, 150, 200, 250, 300, 350 or 400 mM sodium chloride for 72 h. The extraction of total RNA from 4‑month-old seedlings was conducted using the leaves of both treated and untreated plants. The full-length cDNA of KfPHGPx was cloned with reverse transcription PCR (RT-PCR), the KfPHGPx expression patterns were analysed using semi-quantitative RT-PCR and real-time PCR, and the activities of phospholipid hydroperoxide glutathione peroxidase enzyme in K. foliatum were examined. The full-length cDNA clone encoding the full-length sequence consisted of 714 bp of nucleotides and included an open reading frame (ORF) that encoded a polypeptide of 237 amino acids. The deduced amino acid sequence of the KfPHGPx gene has significant similarity with Spinacia oleracea (XP_021837527.1) and Sesuvium portulacastrum (ADE07246.1). The semi-quantitative RT-PCR and real-time PCR analyse showed that KfPHGPx expression can be markedly induced by moderate salt treatment.

A great progress in the electrical performance of high-temperature superconductor (HTS) REBCO tapes allows for a much increased transport current capability in cables especially at high magnet fields. This is of interest to future fusion magnet applications. A variant type of twisted stacked-tape cable called quasi-round twisted stacked-tapes conductor (QisTac) is proposed and developed for the superconducting conductor of the China fusion engineering test reactor. The stack of the twisted HTS tapes is wrapped by a tight spiral made with copper wires. The stack with the copper wire is, then, soldered to form the solid round conductor, which is reliable and easy to manufacture in long lengths. A QisTac sample with four REBCO tapes was prepared and measured at 77 K and in the self-field condition. The measurement result shows the expected critical current calculated from the individual tapes considering the self-field effect. The bending characteristic of the sample was also tested under different bending radii. The critical current is reduced by roughly 5% at 0.54% bending strain. Some residual bending strain is maintained when the maximal bending force is released. This result is promising, but reproducibility testing and tests at high field and current are needed for future high field application.

We explored a facile method for grafting bi-functional groups terminated branched polyphosphazene on carbon fibers via direct epoxy amination with an aqueous ammonia solution. The branched polyphosphazene with abundant β-hydroxyl groups and amino groups significantly changes the chemical composition of carbon fibers surface. A significant improvement in interfacial shear strength was obtained from 43.6 MPa for virgin carbon fibers (C.F.) composites to 89.6 MPa for branched polyphosphazene grafted C.F. composites.

Exploration of precious-metal-free catalysts for water splitting is of great importance in developing renewable energy conversion and storage technologies. In this paper, on the basis of density functional theory calculations, we reveal the link between the oxygen evolution reaction (OER) activities and the electronic properties of pure and first-row transition-metal (TM)-doped AlN and GaN two-dimensional monolayers. We find that Ni-doped layers are singularly appealing because they lead to a low overpotential (0.4 V). Early TM dopants are not suited for the OER because they bind the intermediate species OH or O too strongly, which leads to very large overpotentials, or no OER activity at all. The late TM dopants Cu and Zn show less or no OER activity as they bind the intermediate species too weakly. Although in many cases the overpotential can be traced back to an OOH intermediate species being adsorbed too weakly compared to an OH species, the Ni dopant breaks this rule by stabilizing the OOH adsorbant. The stabilization can be correlated with a switch from a high-spin to a low-spin state of the dopant atom. This ability to change spin states offers an exciting ingredient for the design of OER catalysts.

Current voltage curves and electrochemical impedance spectra (EIS) are crucial for investigating the performance and the electrochemical limitations of electrochemical cells. Therefore, we developed an approach which allows the direct simulation of such data based on microkinetic modeling. This approach allows us to assess the influence of various input parameters on the EIS and on the current-voltage curves and, hence, the overall performance of electrochemical cells. We develop our approach for the oxygen evolution reaction (OER) taking place at the semiconductor-electrolyte interface. At this interface, the microkinetic equations, that is, electrochemical reactions, for the multiple steps in OER are formulated and the resulting set of equations are modeled in a state-space form. As an input to the state-space model, we use the theoretical reaction rates calculated using density functional theory and Gerischer theory for semiconductors. Then, the electrochemical data are simulated as a function of applied potential. Next to the theory and the model development, a case study on the hematite-electrolyte interface which is a typical interface in photoelectrochemical cells is presented. Current voltage curves and EIS data for the hematite interface are simulated from the electrochemical model. The data are compared to experimental measurements. Apart from the current density and the EIS, the model can simulate the coverage of intermediate species as a function of applied potential which is highly demanded for identifying the limiting processes at the interface, but not available from experimental studies. This approach is generic and can be used for other electrochemical interfaces, such as present in fuel cells, electrolysers, or batteries.

Density functional theory (DFT) calculations are performed to study the oxygen evolution reaction (OER) on tungsten oxide (WO3) surfaces. The free energies of the proton coupled electron transfer (PCET) steps are calculated and from these the OER overpotential is calculated as the characteristic parameter for the electrochemical activity. The effects of surface orientation, oxygen vacancies, and doping by Chromium (Cr) and Molybdenum (Mo), on the OER activities are analyzed. The difference in OER overpotential for the three surface orientations, (200), (002) and (020), is found to be very small (0.07 V). The presence of oxygen vacancies in the first WO3 sub-layer do not favor OER, while vacancies in the second sub-layer do reduce the OER overpotential. A volcano plot with all overpotentials calculated in this study shows that the OER is favored at the Mo doped (200) surface (reactions happen at the Mo site). This paper demonstrates that DFT calculations of the electrochemical activity are an efficient method to identify active surfaces and can therefore save a lot of experimental effort in designing more efficient photoelectrodes for water splitting.

Based on general Ackermann’s formula, the MIMO system’s pole configuration design has free parameters that can be adjusted to optimize the system performance. We proposed an improved grey wolf algorithm with adaptive spiral search, proportional weight encirclement, and intergenerational competition mechanism to adjust free parameters to solve this problem. Aiming at the shortcomings that traditional grey wolf optimization algorithm isn’t stable and the convergence accuracy is low later. First, the spiral search mode is introduced to improve the algorithm’s ability by increasing the search trajectory of the wolf pack. The later stage of the algorithm is gradually switched to the proportionally weighted encirclement to achieve an accurate local search. Besides, an intergenerational competition mechanism is introduced to ensure the wolf pack’s leadership ability to improve convergence accuracy and algorithm stability. The algorithm is then benchmarked on 12 well-known benchmark functions. Its stableness and accuracy are verified compared to basic grey wolf optimizer, PSO, whale optimization algorithm, and firefly algorithm. Numerical experiments show that the improved grey wolf algorithm has advantageous searchability and fast convergence. Based on the improved algorithm, the pole configuration design of the MIMO system of the generalized Ackermann’s formula has better output performance.

The PID controller based on the Ziegler-Nichols Tuning Rules to obtain the parameters cannot achieve the best control performance. This paper proposes an optimization method of the PID controller parameters based on the improved firefly algorithm with community and migration strategies. The traditional firefly algorithm will cause the calculation to stagnate because the far distance between individuals induces the attraction term to approach zero. Therefore, community and migration strategies are introduced to solve the problem . And the comparative analysis is conducted through several typical evaluation functions. The simulation results show that the improved firefly algorithm can effectively avoid the algorithm stagnation and reduce the evaluation function’s evaluation times. Finally, it is applied to the PID controller’s parameter optimization to achieve a better control effect.

Pseudomonas aeruginosa is one of the common multidrug-resistant bacteria in the clinic. Because it can produce a "protective" biofilm, it can affect the penetration and killing efficacy of antibacterial drugs, leading to the formation of a persistent and persistent chronic infection in the host. Biofilms make Pseudomonas aeruginosa resistant to antibacterials and evasive to the host's immune system. Therefore, traditional conventional antibacterials are difficult to achieve effective bactericidal treatment. Understanding the process of P. aeruginosa biofilm formation and the regulatory mechanisms that affect biofilms can provide ideas and methods for our future research on new antibacterial drugs.铜绿假单胞菌是临床上常见的多重耐药菌之一，因其可以通过产生具有“保护作用”的生物膜从而影响抗菌药物的渗透杀伤效能，导致宿主形成顽固而持久的慢性感染。生物被膜使得铜绿假单胞菌产生对抗菌药物的耐药性和对宿主免疫系统的逃避性，因此传统常规的抗菌药物很难达到有效的杀菌治疗效果。了解铜绿假单胞菌生物被膜形成的过程及影响生物被膜的调控机制可以为我们今后研究新的抗菌药物提供思路和方法。.

患儿 女，4.5月龄，以“腹泻2周、咳嗽10 d、发热1 d”就诊，结合既往史、临床表现及外周淋巴细胞绝对计数、淋巴细胞亚群、基因检测，诊断为白细胞介素7受体α（IL7R）基因缺陷导致重症联合免疫缺陷病。患儿IL7R基因存在复合杂合突变， c.169TC，p.C57R和c.799AG，p.R267G(NM_002185）既往均未见报道。.

To investigate the prevalence and the clinical feature of essential tremor (ET) in a community cohort in Beijing. Using a door-to-door, two-phase approach, we investigated 2,835 residents aged ≥55 years old from rural, urban, and mountain areas. The prevalence rate of ET was 4.29%, 2.85%, and 2.29% in rural, urban, and mountain areas, respectively. The overall age- and sex-adjusted prevalence was 3.29%. Among those aged ≥75 years, the prevalence rate in the urban area was higher than those in the rural and mountain areas. The prevalence rate increased with age, and the prevalence was higher among men (6.0%) than among women (3.6%). There was a correlation of ET prevalence with age, sex, and habitation area, but not with alcohol, tea drinking, and occupation. Women (25%) with ET were more likely to have head tremor than men (16.9%). The ET prevalence in the elderly of Beijing was 3.29% which is higher in the urban area and in men.

在医学领域，医疗数据电子化、信息互联性增强、生理信号采集终端设备普及为医疗人工智能（AI）的研究和应用奠定了基础。医学AI应用在耳鼻咽喉头颈外科学领域主要前景包括：（1）数字化影像和生理数据的识别与分析；（2）基于大样本患者组群，智能选择治疗护理方案；（3）AI疾病识别和验证模型；（4）医疗信息的智能无障碍链接等。可以期待，AI技术将在本领域推动高效利用有限的医疗资源，大规模延伸医疗健康服务供给，颠覆性地促进诞生新的健康管理和医疗服务模式。.

To elucidate the role of morphine in inducing apoptosis of mouse hippocampal neurons HT-22 by upregulating microRNA-181-5p (miR-181-5p).After treatment of different doses of morphine, changes in proliferative ability, apoptosis, and expression levels of miR-181-5p and MAPK1 in HT-22 cells were assessed through a series of functional experiments. Regulatory effects of miR-181-5p on morphine-induced phenotype changes of HT-22 cells were examined. The interaction between miR-181-5p and MAPK1, and their involvement in morphine-induced neuron apoptosis were explored by Luciferase assay and rescue experiments, respectively.Morphine treatment markedly attenuated viability and proliferative ability in HT-22 cells, while apoptotic rate increased. MiR-181-5p was upregulated and MAPK1 was downregulated in HT-22 cells by morphine induction. Knockdown of miR-181-5p enhanced viability and proliferative ability, as well as reduced apoptosis in morphine-induced HT-22 cells. MiR-181-5p could specifically bind MAPK1 and negatively regulate its expression level. Knockdown of MAPK1 was able to reverse the regulatory effects of miR-181-5p on morphine-induced phenotype changes of HT-22 cells.Morphine induces apoptosis of hippocampal neurons HT-22 by upregulating miR-181-5p to suppress the level of MAPK1.

肺朗格汉斯细胞组织细胞增生症是肺间质性疾病的少见类型之一，它以肺内朗格汉斯细胞增生为主要特点，常常被漏诊或误诊，临床-影像-组织病理综合分析以及病理医师准确的认识朗格汉斯细胞对疾病的早期诊断和治疗具有重要意义。该文对近期确诊的1例31岁男性肺朗格汉斯细胞组织细胞增生症患者进行报道，探讨其临床病理特征，以提高对该疾病的认识。.

To study the effect of atorvastatin on pulmonary hypertension (PAH) rats through regulating the Notch signaling pathway.The rat model of PAH was established via hypoxic feeding and the Control group (n=10), PAH model group (Model group, n=10) and atorvastatin treatment group (ATO group, n=10) were set up. The right ventricular systolic pressure (RVSP) and right ventricular hypertrophy index (RVHI) in each group were determined, the wet/dry weight (W/D) ratio of lung tissues was determined, and the tumor necrosis factor-α (TNF-α), myeloperoxidase (MPO) and interleukin-6 (IL-6) were detected via enzyme-linked immunosorbent assay (ELISA). Moreover, the pathological changes in lung tissues of rats were detected via hematoxylin-eosin (HE) staining and the apoptosis level was detected via terminal deoxynucleotidyl transferase-mediated dUTP nick-end labeling (TUNEL) assay. Finally, the Notch signaling pathway and apoptosis level in tissues were detected via quantitative Polymerase Chain Reaction (qPCR), and the protein expression level of Notch pathway in lung tissues was determined through Western blotting.Both RVSP and RVHI in Model group were significantly higher than those in Control group and ATO group (p0.05). In Model group, the levels of inflammatory factors MPO, IL-6, and TNF-α were significantly increased, and the W/D ratio was also significantly increased compared with those in Control group (p0.05). The results of HE staining showed that the lung tissue injury in Model group was severe (p0.05). According to the TUNEL staining results, the number of apoptotic cells in lung tissues was markedly larger in Model group than that in ATO group (p0.05), and the expression levels of Caspase-3 and IL-6 in Model group were remarkably higher than those in ATO group (p0.05), while the expression level of B-cell lymphoma-2 (Bcl-2) in Model group was remarkably lower than that in ATO group (p0.05). Besides, the gene and protein expression levels of Notch1 in ATO group were evidently lower than those in Model group (p0.05), indicating that atorvastatin can effectively suppress the expression of Notch.Atorvastatin can inhibit PAH in rats by suppressing the Notch pathway.

Centrosymmetric (CS) nonmagnetic materials with hidden spin polarization induced by non-CS site symmetries and spin-orbit coupling are promising candidates for spintronic applications, in light of the zero net spin polarization and modulatable spin effects hidden in the local structures. There is, however, an open issue regarding the possible spin splitting induced by broken inversion symmetry at the sample surface. Here, we performed combinatorial experimental and theoretical studies on the potentially hidden spin polarization in 2H-MoTe2 and its mechanism. A large spin splitting of 236 meV and opposite spin polarizations up to 80% along out-of-plane direction (z axis) in K and K′ valleys were observed from both spin- and angle-resolved photoemission spectroscopy (spin-ARPES) and density functional theory (DFT). We further found from the DFT calculations that a medium dipole field mimicked the surface symmetry breaking in ARPES measurements induces negligible variation of spin polarization. Our study demonstrates the existence of the intrinsic hidden spin effects in 2H-MoTe2 and opens a way of utilizing these effects in spintronic devices.

Reports on the efficacy and safety of long-term entecavir treatment in chronic hepatitis B (CHB) predominantly genotype B or C are insufficient. This study presents the efficacy and safety of entecavir maleate in Chinese CHB patients. Patients were randomly assigned to receive 48-week treatment with either 0.5 mg/day entecavir (group A) or 0.5 mg/day entecavir maleate (group B), and then all patients received treatment with 0.5 mg/day entecavir maleate from week 49. Two hundred and seventy-five patients with CHB (HBeAg-positive: 218) were analysed, predominantly (98.5%) with genotype B or C. Baseline characteristics were balanced. For the HBeAg-positive CHB patients, the mean HBV DNA level decreased similarly (A: by 6.36 log10 IU/mL vs B: by 6.31 log10 IU/mL) between groups at week 144. The percentages of patients who achieved undetectable HBV DNA were similar (A: 70.59% vs B: 66.67%) between groups. Similar HBeAg loss rates (A: 43.53% vs B: 40.23%; P>.05) and HBeAg seroconversion rates (A: 21.52% vs B: 21.18%) were achieved. For the HBeAg-negative CHB patients, similar reductions in HBV DNA levels from baseline (A: by 6.13 log10 IU/mL vs B: by 5.65 log10 IU/mL) and percentages of patients who achieved undetectable HBV DNA (A: 100% vs B: 100%) were achieved. The overall incidence of adverse events was comparable between groups. In conclusions, 48-week administration of entecavir maleate and entecavir showed similar efficacy and safety in Chinese patients with CHB. Long-term entecavir maleate treatment was effective and safe in CHB patients.

By incorporating high-density markers into breeding value prediction models, the whole genomic prediction (WGP) method can effectively accelerate genetic improvement in livestock breeding. However, the performance of WGP varies across species and populations and is affected by the underlying genetic architecture. In particular, very little is known about the performance of WGP for many chicken breeds. Here we estimate the genetic parameters and evaluate the performance of WGP for 18 growth and carcass traits in a Chinese quality chicken population. In total, 435 chickens were systematically phenotyped and genotyped using a 600K genotyping array. Two variance component estimation scenarios, 3 breeding value prediction methods, and 2 validation procedures were compared. The results showed that the heritability of these 18 traits was medium to high (ranging from 0.28 to 0.60) and that deviations existed between the heritability estimated from pedigrees and markers. Compared with conventional breeding methods, WGP could potentially increase the selection accuracy by 20% or more depending on the prediction model used, the trait under consideration, and the genetic connectedness between the training and validation individuals. Our results showed the potential of implementing genomic selection in small breeding herds.

The structures of transition metal surfaces and metal oxides are commonly believed to have a significant effect on the catalytic reactions. Density functional theory calculations are therefore used in this study to investigate the oxygen evolution reaction (OER) over nanostructured, i.e. nanocluster and nanocavity, surfaces of hematite (Fe2O3). The calculated results demonstrate an optimum nanocluster size with respect to the OER overpotential. The presence of nanoclusters on the electrode is regarded as an attractive strategy for increasing the activity in photoelectrochemical water splitting. However, in this work, we found that the presence of a nanocavity is a more effective strategy for lowering the overpotential compared to nanoclusters. This finding of the nanocavity-favoured OER for hematite surfaces is verified by similar simulations of WO3 surfaces.

The sensitivity of the surface orientation on photoelectrochemical water oxidation has recently been reported by experimental studies. However, a detailed theoretical understanding is still missing. Density functional theory + Hubbard U (DFT + U) calculations are therefore carried out in order to investigate the oxygen evolution reaction (OER) on hematite (Fe2O3) surfaces for five surface orientations, namely (100), (210), (101), (021), and (211). The free energies of four proton-coupled electron transfer steps and the OER overpotential were calculated, and the trend in activity was analyzed. For the (100) orientation, two adsorbate–adsorbate distances were studied. Interestingly, a very low overpotential of 0.52 V was found for the (100) surface with a bridge site (adsorbate on a bridge of two Fe atoms) configuration that benefited from adsorbate–adsorbate interactions.

The objective of the present study was to investigate the relationship between adiponectin (APN)+45T/G and +276G/T polymorphisms and in-stent restenosis (ISR).A total of 150 patients treated with percutaneous coronary intervention (PCI) were divided into the ISR group and non-ISR group. The levels of blood biochemical indicators were measured, and APN+45T/G and +276G/T polymorphisms were detected by TaqMan probes.Cholesterol levels in the IRS group were significantly higher than those in the non-ISR group (p0.05). The frequency of the GG genotype and G allele of the APN+45T/G locus in the ISR group were significantly higher than those in the non-ISR group (p0.05). The frequency of the GG genotype and G allele of the APN+276G/T locus in the ISR group were significantly higher than those in the non-ISR group (p0.05).APN+45T/G and +276G/T polymorphisms were associated with susceptibility to ISR, and carrying the G allele of the APN+45T/G and +276G/T loci can significantly increase the risk of ISR.